Publications by authors named "Caroline A Heckman"

39Publications

Characterization of p190-Bcr-Abl chronic myeloid leukemia reveals specific signaling pathways and therapeutic targets.

Leukemia 2020 Nov 9. Epub 2020 Nov 9.

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41375-020-01082-4DOI Listing
November 2020

A candid view of CANDOR.

Lancet 2020 07;396(10245):147-148

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/S0140-6736(20)30901-6DOI Listing
July 2020

KIT pathway upregulation predicts dasatinib efficacy in acute myeloid leukemia.

Leukemia 2020 10 17;34(10):2780-2784. Epub 2020 Jul 17.

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41375-020-0978-7DOI Listing
October 2020

Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition.

Leukemia 2020 Dec 10;34(12):3186-3196. Epub 2020 Jul 10.

Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41375-020-0972-0DOI Listing
December 2020

Corrigendum to 'Combined gene essentiality scoring improves the prediction of cancer dependency maps' [EBioMedicine 50 (2019) 66-79].

EBioMedicine 2020 01 3;51:102594. Epub 2020 Jan 3.

Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, FI-0 0 014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948202PMC
January 2020

Combined gene essentiality scoring improves the prediction of cancer dependency maps.

EBioMedicine 2019 Dec 12;50:67-80. Epub 2019 Nov 12.

Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, FI-00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.10.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923492PMC
December 2019

Elevated expression of S100A8 and S100A9 correlates with resistance to the BCL-2 inhibitor venetoclax in AML.

Leukemia 2019 10 7;33(10):2548-2553. Epub 2019 Jun 7.

Institute for Molecular Medicine Finland, FIMM, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41375-019-0504-yDOI Listing
October 2019

Drug combination sensitivity scoring facilitates the discovery of synergistic and efficacious drug combinations in cancer.

PLoS Comput Biol 2019 05 20;15(5):e1006752. Epub 2019 May 20.

Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1371/journal.pcbi.1006752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544320PMC
May 2019

Dasatinib and navitoclax act synergistically to target NUP98-NSD1/FLT3-ITD acute myeloid leukemia.

Leukemia 2019 06 19;33(6):1360-1372. Epub 2018 Dec 19.

Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/s41375-018-0327-2DOI Listing
June 2019

A Multiplexed Screening Assay to Evaluate Chemotherapy-Induced Myelosuppression Using Healthy Peripheral Blood and Bone Marrow.

SLAS Discov 2018 08 4;23(7):687-696. Epub 2018 Jun 4.

1 Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1177/2472555218777968DOI Listing
August 2018

The impact of RNA sequence library construction protocols on transcriptomic profiling of leukemia.

BMC Genomics 2017 Aug 17;18(1):629. Epub 2017 Aug 17.

Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science, University of Helsinki, P.O. Box 20, Tukholmankatu 8, FI-00014, Helsinki, Finland.

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http://dx.doi.org/10.1186/s12864-017-4039-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561555PMC
August 2017

Chimeric NUP98-NSD1 transcripts from the cryptic t(5;11)(q35.2;p15.4) in adult de novo acute myeloid leukemia.

Leuk Lymphoma 2018 03 4;59(3):725-732. Epub 2017 Aug 4.

a Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science , University of Helsinki , Helsinki , Finland.

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http://dx.doi.org/10.1080/10428194.2017.1357174DOI Listing
March 2018

Statistical detection of quantitative protein biomarkers provides insights into signaling networks deregulated in acute myeloid leukemia.

Proteomics 2014 Nov 15;14(21-22):2443-53. Epub 2014 Oct 15.

Department of Mathematics and Statistics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, Turku, Finland.

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http://dx.doi.org/10.1002/pmic.201300460DOI Listing
November 2014

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

Cancer Discov 2013 Dec 20;3(12):1416-29. Epub 2013 Sep 20.

1Institute for Molecular Medicine Finland, FIMM; 2Hematology Research Unit Helsinki, Helsinki University Central Hospital, University of Helsinki, Helsinki; 3Department of Clinical Chemistry and TYKSLAB, Turku University Central Hospital, University of Turku, Turku; 4Department of Internal Medicine, Tampere University Hospital, Tampere, Finland; 5Department of Clinical Science, Hematology Section, University of Bergen; and 6Department of Internal Medicine, Hematology Section, Haukeland University Hospital, Bergen, Norway.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0350DOI Listing
December 2013

Phosphoprotein profiling predicts response to tyrosine kinase inhibitor therapy in chronic myeloid leukemia patients.

Exp Hematol 2012 Sep 1;40(9):705-714.e3. Epub 2012 Jun 1.

Hematology Research Unit Helsinki, Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.exphem.2012.05.010DOI Listing
September 2012

The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.

Cancer Res 2008 Jun;68(12):4754-62

Molecular/Cancer Biology Laboratory, Biomedicum Helsinki and Ludwig Institute for Cancer Research, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5809DOI Listing
June 2008

Functional interaction of VEGF-C and VEGF-D with neuropilin receptors.

FASEB J 2006 Jul;20(9):1462-72

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, P.O.B. 63, FI-00014 University of Helsinki, Helsinki, Finland.

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http://www.fasebj.org/doi/10.1096/fj.05-5646com
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http://dx.doi.org/10.1096/fj.05-5646comDOI Listing
July 2006

Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas.

Mol Cell Biol 2005 Mar;25(5):1608-19

Center for Molecular Biology in Medicine, Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA, USA.

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http://dx.doi.org/10.1128/MCB.25.5.1608-1619.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC549348PMC
March 2005

Critical elements of the immunoglobulin heavy chain gene enhancers for deregulated expression of bcl-2.

Cancer Res 2003 Oct;63(20):6666-73

Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.

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October 2003

Regulation of Bcl-2 expression by C/EBP in t(14;18) lymphoma cells.

Oncogene 2003 Sep;22(39):7891-9

Center for Molecular Biology in Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1038/sj.onc.1206639DOI Listing
September 2003

Allele-specific analysis of transcription factors binding to promoter regions.

Methods 2002 Jan;26(1):19-26

Center for Molecular Biology in Medicine, Veterans Affairs Palo Alto Health Care System and the Department of Medicine, Stanford University School of Medicine, CA 94305, USA.

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http://dx.doi.org/10.1016/S1046-2023(02)00004-XDOI Listing
January 2002

NF-kappaB activates Bcl-2 expression in t(14;18) lymphoma cells.

Oncogene 2002 May;21(24):3898-908

Center for Molecular Biology in Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94305, USA.

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http://dx.doi.org/10.1038/sj.onc.1205483DOI Listing
May 2002