Carlos Santos-Ocaña

Carlos Santos-Ocaña

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Carlos Santos-Ocaña

Carlos Santos-Ocaña

Publications by authors named "Carlos Santos-Ocaña"

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28Publications

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Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging.

Aging (Albany NY) 2019 Sep 13;11(18):7746-7779. Epub 2019 Sep 13.

Department of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain.

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http://dx.doi.org/10.18632/aging.102285DOI Listing
September 2019

The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q biosynthesis.

Biochim Biophys Acta Bioenerg 2018 11 26;1859(11):1235-1248. Epub 2018 Sep 26.

Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-CSIC-JA, and CIBERER Instituto de Salud Carlos III, 41013 Sevilla, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00052728183023
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http://dx.doi.org/10.1016/j.bbabio.2018.09.369DOI Listing
November 2018

Molecular diagnosis of coenzyme Q deficiency: an update.

Expert Rev Mol Diagn 2018 06 30;18(6):491-498. Epub 2018 May 30.

a Department of Genetic and Clinical Biochemistry , Institut de Recerca Sant Joan de Déu, and CIBER de Enfermedades Raras (CIBERER) , Barcelona , Spain.

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http://dx.doi.org/10.1080/14737159.2018.1478290DOI Listing
June 2018

Generation, genome edition and characterization of iPSC lines from a patient with coenzyme Q deficiency harboring a heterozygous mutation in COQ4 gene.

Stem Cell Res 2017 10 16;24:144-147. Epub 2016 Sep 16.

Josep Carreras Leukemia Research Institute, Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain; Instituciò Catalana de Recerca I Estudis Avançats (ICREA), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.09.007DOI Listing
October 2017

Balanced CoQ biosynthesis is required for lifespan and mitophagy in yeast.

Microb Cell 2017 Feb 3;4(2):38-51. Epub 2017 Feb 3.

Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-CSIC, CIBERER Instituto de Salud Carlos III, Sevilla, 41013, Spain.

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http://dx.doi.org/10.15698/mic2017.02.556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349121PMC
February 2017

Molecular diagnosis of coenzyme Q10 deficiency.

Expert Rev Mol Diagn 2015 4;15(8):1049-59. Epub 2015 Jul 4.

Department of Genetic and Molecular Medicine, and Pediatric Institute for Rare Diseases (IPER), Hospital Sant Joan de Déu, and CIBER de Enfermedades Raras (CIBERER), Barcelona, Spain.

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http://dx.doi.org/10.1586/14737159.2015.1062727DOI Listing
April 2016

Mitochondrial responsibility in ageing process: innocent, suspect or guilty.

Biogerontology 2015 Oct 24;16(5):599-620. Epub 2015 Jun 24.

Centro Andaluz de Biología del Desarrollo, CABD-CSIC, CIBERER, Instituto Carlos III, Universidad Pablo de Olavide, Carretera de Utrera km. 1, 41013, Seville, Spain,

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http://dx.doi.org/10.1007/s10522-015-9585-9DOI Listing
October 2015

Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis.

Biochim Biophys Acta 2014 Nov 23;1841(11):1628-38. Epub 2014 Aug 23.

Clinical Genetics Unit, Dept. of Pediatrics, University of Padova, Via Giustiniani 3, Padova 35128, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2014.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331671PMC
November 2014

The regulation of coenzyme q biosynthesis in eukaryotic cells: all that yeast can tell us.

Mol Syndromol 2014 Jul;5(3-4):107-18

Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide - CSIC, and CIBERER Instituto de Salud Carlos III, Seville, Spain.

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http://dx.doi.org/10.1159/000362897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112530PMC
July 2014

Regulation of coenzyme Q biosynthesis in yeast: a new complex in the block.

IUBMB Life 2014 Feb 27;66(2):63-70. Epub 2014 Jan 27.

Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-CSIC, CIBERER Instituto de Salud Carlos III, Sevilla, Spain.

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http://dx.doi.org/10.1002/iub.1243DOI Listing
February 2014

Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency.

Biochim Biophys Acta 2014 Jan 18;1842(1):1-6. Epub 2013 Oct 18.

Clinical Genetics Unit, Department of Woman and Child Health, University of Padova, Padova, Italy; IRP Città della Speranza, Padova, Italy.

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http://dx.doi.org/10.1016/j.bbadis.2013.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898990PMC
January 2014

The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast.

J Biol Chem 2013 Sep 12;288(39):28126-37. Epub 2013 Aug 12.

From the Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-Consejo Superior de Investigaciones Científicas (CSIC), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) Instituto de Salud Carlos III, Sevilla 41013, Spain.

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http://dx.doi.org/10.1074/jbc.M113.474494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784724PMC
September 2013

Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p.

Biochem J 2011 Nov;440(1):107-14

Departamento de Fisiología, Anatomía y Biología Celular, Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-CSIC, CIBERER Instituto de Salud Carlos III, Sevilla 41013, Spain.

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http://dx.doi.org/10.1042/BJ20101422DOI Listing
November 2011

Is coenzyme Q a key factor in aging?

Mech Ageing Dev 2010 Apr 1;131(4):225-35. Epub 2010 Mar 1.

Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide, CIBERER-Instituto de Salud Carlos III, Carretera de Utrera, Km 1, 41013 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.mad.2010.02.003DOI Listing
April 2010

Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae.

Biochim Biophys Acta 2009 Jun 2;1788(6):1238-48. Epub 2009 Apr 2.

Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-CSIC and Centre for Biomedical Research on Rare Diseases (CIBERER), ISCIII, E-41013 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.bbamem.2009.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070215PMC
June 2009

NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.

Aging Cell 2009 Apr 23;8(2):140-51. Epub 2009 Feb 23.

Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-CSIC and Centre for Biomedical Research on Rare Diseases (CIBERER), ISCIII, E-41013 Sevilla, Spain.

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http://dx.doi.org/10.1111/j.1474-9726.2009.00461.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699585PMC
April 2009

Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis elegans.

FEBS Lett 2006 Mar 20;580(7):1740-6. Epub 2006 Feb 20.

Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Ctra. de Utrera, km 1, E-41013 Sevilla, Spain.

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http://dx.doi.org/10.1016/j.febslet.2006.02.025DOI Listing
March 2006

Stabilization of extracellular ascorbate mediated by coenzyme Q transmembrane electron transport.

Methods Enzymol 2004 ;378:207-17

Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide, Seville, Spain.

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http://dx.doi.org/10.1016/S0076-6879(04)78017-9DOI Listing
April 2004

Uptake of exogenous coenzyme Q and transport to mitochondria is required for bc1 complex stability in yeast coq mutants.

J Biol Chem 2002 Mar 11;277(13):10973-81. Epub 2002 Jan 11.

Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569, USA.

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http://dx.doi.org/10.1074/jbc.M112222200DOI Listing
March 2002