Publications by authors named "Caiyun Wang"

114 Publications

Abuse-Tolerant Electrolytes for Lithium-Ion Batteries.

Adv Sci (Weinh) 2021 Jun 18;8(11):e2003694. Epub 2021 Mar 18.

ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, Innovation Campus, University of Wollongong, Wollongong, NSW, 2500, Australia.

Safety issues currently limit the development of advanced lithium-ion batteries (LIBs) and this is exacerbated when they are misused or abused. The addition of small amounts of fillers or additives into common liquid electrolytes can greatly improve resistance to abuse without impairing electrochemical performance. This review discusses the recent progress in such abuse-tolerant electrolytes. It covers electrolytes with shear thickening properties for tolerating mechanical abuse, electrolytes with redox shuttle additives for suppressing electrochemical abuse, and electrolytes with flame-retardant additives for resisting thermal abuse. It aims to provide insights into the functioning of such electrolytes and the understanding of electrolyte composition-property relationship. Future perspectives, challenges, and opportunities towards practical applications are also presented.
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http://dx.doi.org/10.1002/advs.202003694DOI Listing
June 2021

CmNAC73 Mediates the Formation of Green Color in Chrysanthemum Flowers by Directly Activating the Expression of Chlorophyll Biosynthesis Genes and .

Genes (Basel) 2021 May 8;12(5). Epub 2021 May 8.

Key Laboratory for Biology of Horticultural Plants, Ministry of Education, College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan 430070, China.

Chrysanthemum is one of the most beautiful and popular flowers in the world, and the flower color is an important ornamental trait of chrysanthemum. Compared with other flower colors, green flowers are relatively rare. The formation of green flower color is attributed to the accumulation of chlorophyll; however, the regulatory mechanism of chlorophyll metabolism in chrysanthemum with green flowers remains largely unknown. In this study, we performed Illumina RNA sequencing on three chrysanthemum materials, and cultivars 'Chunxiao' and 'Green anna', which produce white, light green and dark green flowers, respectively. Based on the results of comparative transcriptome analysis, a gene encoding a novel NAC family transcription factor, CmNAC73, was found to be highly correlated to chlorophyll accumulation in the outer whorl of ray florets in chrysanthemum. The results of transient overexpression in chrysanthemum leaves showed that CmNAC73 acts as a positive regulator of chlorophyll biosynthesis. Furthermore, transactivation and yeast one-hybrid assays indicated that CmNAC73 directly binds to the promoters of chlorophyll synthesis-related genes and . Thus, this study uncovers the transcriptional regulation of chlorophyll synthesis-related genes and by CmNAC73 and provides new insights into the development of green flower color in chrysanthemum and chlorophyll metabolism in plants.
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http://dx.doi.org/10.3390/genes12050704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151904PMC
May 2021

6:2 Cl-PFESA has the potential to cause liver damage and induce lipid metabolism disorders in female mice through the action of PPAR-γ.

Environ Pollut 2021 May 10;287:117329. Epub 2021 May 10.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, 310032, China. Electronic address:

6:2 Cl-PFESA is a polyfluoroalkyl ether with high environmental persistence that has been confirmed to have significant adverse effects on animals. In this study, 6-week-old female C57BL/6 mice were exposed to 0, 1, 3 and 10 μg/L 6:2 Cl-PFESA for 10 weeks to estimate the hepatotoxicity of 6:2 Cl-PFESA and explore its underlying molecular mechanism. The results indicated that 6:2 Cl-PFESA preferentially bioaccumulated in the liver and induced hepatic cytoplasmic vacuolation and hepatomegaly in mice. In addition, serum metabolic profiling showed that 6:2 Cl-PFESA exposure caused an abnormal increase in amino acids and an abnormal decrease in acyl-carnitine, which interfered with fatty acid transport and increased the risk of metabolic diseases. Further experiments showed that 6:2 Cl-PFESA formed more hydrogen bonds with PPAR-γ than PFOS, Rosi and GW9662, and the binding affinity of 6:2 Cl-PFESA toward PPAR-γ was the highest among the ligands. 6:2 Cl-PFESA promoted the differentiation of 3T3-L1 cells by increasing PPAR-γ expression. Therefore, our results showed that 6:2 Cl-PFESA has the potential to induce liver damage and dysfunction in female mice, and this effect was achieved through PPAR-γ. This study is the first to reveal the hepatic toxicity of 6:2 Cl-PFESA in female mammals and provides new insights for subsequent in-depth research.
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http://dx.doi.org/10.1016/j.envpol.2021.117329DOI Listing
May 2021

Maternal exposure of mice to sodium p-perfluorous nonenoxybenzene sulfonate causes endocrine disruption in both dams and offspring.

Endocr J 2021 May 11. Epub 2021 May 11.

Department of Biotechnology, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.

The toxicity of certain novel perfluoroalkyl substances (PFCs) has attracted increasing attention. However, the toxic effects of sodium p-perfluorous nonenoxybenzene sulfonate (OBS) on the endocrine system have not been elucidated. In this study, OBS was added to the drinking water during the pregnancy and lactation of the healthy female mice at dietary levels of 0.0 mg/L (CON), 0.5 mg/L (OBS-L), and 5.0 mg/L (OBS-H). OBS exposure during the pregnancy and lactation resulted in the presence of OBS residues in the placenta and fetus. We also analyzed physiological and biochemical parameters and gene expression levels in mice of the F0 and F1 generations after maternal OBS exposure. The total serum cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were significantly increased in female mice of the F0 generation. The androgen levels in the serum and the ovarian mRNA levels of androgen receptor (AR) also tended to increase after maternal OBS exposure in the F0 generation mice. Moreover, maternal OBS exposure altered the mRNA expression of endocrine-related genes in male mice of F1 generation. Notably, the serum TC and LDL-C levels were significantly increased in 8-weeks-old male mice of the F1 generation, and the serum high-density lipoprotein cholesterol (HDL-C) levels were decreased in 24-week-old male mice of the F1 generation. These results indicated that maternal OBS exposure can interfere with endocrine homeostasis in the F0 and F1 generations. Therefore, exposure to OBS during pregnancy and lactation has the potential toxic effects on the dams and male offspring, which cannot be overlooked.
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http://dx.doi.org/10.1507/endocrj.EJ20-0781DOI Listing
May 2021

Tissue specificity of (E)-β-farnesene and germacrene D accumulation in pyrethrum flowers.

Phytochemistry 2021 Jul 28;187:112768. Epub 2021 Apr 28.

Key Laboratory of Horticultural Plant Biology, Ministry of Education, Huazhong Agricultural University, Wuhan, 430070, China. Electronic address:

Plant defensive mimicry based on the aphid alarm pheromone (E)-β-farnesene (EβF) was previously shown to operate in Tanacetum cinerariifolium (Asteraceae) flowers. Germacrene D (GD), is another dominant volatile of T. cinerariifolium flowers and may modulate both defense and pollination. Here, we find that the increase in GD/EβF ratio at later developmental stages is correlated with the tissue distribution in the flower head: the total content of EβF and GD is similar, but GD accumulates comparatively more in the upper disk florets. Naphthol and N, N-dimethyl-p-phenylenediamine dihydrochloride (NADI)-stained purple ducts containing EβF and GD, were observed in the five petal lips of the corolla and two-lobed stigma of disk florets. By contrast in the peduncle, EβF accounts for nearly 80% of total terpenes, compared to 5% for GD. EβF is accumulated inside inner cortex cells and parenchyma cells of the pith in young peduncle. This is followed by the formation of terpene-filled axial secretory cavities parallel to the vascular bundles. In conclusion, the observed developmental and diurnal emissions of different EβF/GD ratios appear to be regulated by their tissue distribution.
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http://dx.doi.org/10.1016/j.phytochem.2021.112768DOI Listing
July 2021

Whole-genome resequencing of Osmanthus fragrans provides insights into flower color evolution.

Hortic Res 2021 May 1;8(1):98. Epub 2021 May 1.

Key Laboratory of Horticultural Plant Biology, Ministry of Education, Huazhong Agricultural University, Wuhan, 430070, China.

Osmanthus fragrans is a well-known ornamental plant that has been domesticated in China for 2500 years. More than 160 cultivars have been found during this long period of domestication, and they have subsequently been divided into four cultivar groups, including the Yingui, Jingui, Dangui, and Sijigui groups. These groups provide a set of materials to study genetic evolution and variability. Here, we constructed a reference genome of O. fragrans 'Liuyejingui' in the Jingui group and investigated its floral color traits and domestication history by resequencing a total of 122 samples, including 119 O. fragrans accessions and three other Osmanthus species, at an average sequencing depth of 15×. The population structure analysis showed that these 119 accessions formed an apparent regional cluster. The results of linkage disequilibrium (LD) decay analysis suggested that varieties with orange/red flower color in the Dangui group had undergone more artificial directional selection; these varieties had the highest LD values among the four groups, followed by the Sijigui, Jingui, and Yingui groups. Through a genome-wide association study, we further identified significant quantitative trait loci and genomic regions containing several genes, such as ethylene-responsive transcription factor 2 and Arabidopsis pseudoresponse regulator 2, that are positively associated with petal color. Moreover, we found a frameshift mutation with a 34-bp deletion in the first coding region of the carotenoid cleavage dioxygenase 4 gene. This frameshift mutation existed in at least one site on both alleles in all varieties of the Dangui group. The results from this study shed light on the genetic basis of domestication in woody plants, such as O. fragrans.
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http://dx.doi.org/10.1038/s41438-021-00531-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087690PMC
May 2021

Strategic Structure Tuning of Yolk-Shell Microcages for Efficient Nitrogen Fixation.

ChemSusChem 2021 Apr 8. Epub 2021 Apr 8.

Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Renewable Energy Conversion and Storage Center, College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.

The electrocatalytic nitrogen reduction reaction (ENRR) under ambient conditions is considered as a promising process to produce ammonia. Towards highly efficient catalysts, here an optimized one-step pyrolysis strategy was tailored to design yolk-shell microcages (YS [email protected]/BLCNTs), consisting of Co nanocrystals encapsulated in N-doped carbon framework and bridged by bamboo-like carbon nanotubes (BLCNTs). The cavity created between yolk and shell not only served as a "micro-bag" to store the reactant N and enhance its dissolution, but also induced a "cage effect" to confine the diffusion of reaction intermediate, hence making the reaction proceed in the direction of producing NH . This catalyst displayed excellent catalytic activities for ENRR: a high NH yield of 12.87 μg mg  h at a high faradaic efficiency of 20.7 % at -0.45 V (vs. reversible hydrogen electrode, RHE). After 5 cycles of consecutive ENRR process, the NH yield rate was 11.29 μg mg  h , indicating the excellent electrocatalytic stability. These results provide a structural engineering for ENRR catalyst with doped N, cooperating with non-precious metal to activate the inert triple bond of N and achieve NH fixation.
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http://dx.doi.org/10.1002/cssc.202100502DOI Listing
April 2021

Identification of Chlorophyll Metabolism- and Photosynthesis-Related Genes Regulating Green Flower Color in Chrysanthemum by Integrative Transcriptome and Weighted Correlation Network Analyses.

Genes (Basel) 2021 Mar 21;12(3). Epub 2021 Mar 21.

Key Laboratory for Biology of Horticultural Plants, Ministry of Education, College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan 430070, China.

Green chrysanthemums are difficult to breed but have high commercial value. The molecular basis for the green petal color in chrysanthemum is not fully understood. This was investigated in the present study by RNA sequencing analysis of white and green ray florets collected at three stages of flower development from the F progeny of the cross between "Lüdingdang" with green-petaled flowers and with white-petaled flowers. The chlorophyll content was higher and chloroplast degradation was slower in green pools than in white pools at each developmental stage. Transcriptome analysis revealed that genes that were differentially expressed between the two pools were enriched in pathways related to chlorophyll metabolism and photosynthesis. We identified the transcription factor genes , , , and as regulators of the green flower color in chrysanthemum by differential expression analysis and weighted gene co-expression network analysis. These findings can guide future efforts to improve the color palette of chrysanthemum flowers through genetic engineering.
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http://dx.doi.org/10.3390/genes12030449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004015PMC
March 2021

Genome-wide scan for runs of homozygosity identifies candidate genes in Wannan Black pigs.

Anim Biosci 2021 Mar 10. Epub 2021 Mar 10.

College of Animal Science and Technology, Anhui Agricultural University, Hefei, Anhui 230036, P. R. China.

Objective: Runs of homozygosity (ROH) are contiguous lengths of homozygous genotypes that can reveal inbreeding levels, selection pressure, and mating schemes. In this study, ROHs were evaluated in Wannan Black pigs to assess the inbreeding levels and the genome regions with high ROH frequency.

Methods: In a previous study, we obtained 501.52 g of raw data from resequencing (10×) of the genome and identified 21,316,754 single-nucleotide variants (SNVs) in 20 Wannan Black pig samples. We investigated the number, length, and frequency of ROH using resequencing data to characterize the homozygosity in Wannan Black pigs and identified genomic regions with high ROH frequencies.

Results: In this work, 1,813 ROHs (837 ROHs in 100-500 kb, 449 ROHs in 500-1,000 kb, 527 ROHs in >1,000 kb) were identified in all samples, and the average genomic inbreeding coefficient (FROH) in Wannan Black pigs was 0.5234. Sixty-one regions on chromosomes 2, 3, 7, 8, 13, 15, and 16 harbored ROH islands. In total, 105 genes were identified in 42 ROH islands, among which some genes were related to production traits.

Conclusion: This is the first study to identify ROH across the genome of Wannan Black pigs, the Chinese native breed of the Anhui province. Overall, Wannan Black pigs have high levels of inbreeding due to the influence of ancient and recent inbreeding on the genome. These findings are a reliable resource for future studies and contribute to save and use the germplasm resources of Wannan Black pigs.
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http://dx.doi.org/10.5713/ab.20.0679DOI Listing
March 2021

Hydrogen Generation and Degradation of Organic Dyes by New Piezocatalytic 0.7BiFeO-0.3BaTiO Nanoparticles with Proper Band Alignment.

ACS Appl Mater Interfaces 2021 Mar 26;13(9):11050-11057. Epub 2021 Feb 26.

Institute for Superconducting and Electronic Materials, Australian Institute for Innovative Materials, University of Wollongong, North Wollongong, New South Wales 2500, Australia.

Piezoelectric materials have recently demonstrated their potential applications in clean energy exploration and environmental remediation through triggering a number of catalytic reactions by harvesting waste vibrational energy in the environment. In this work, unique lead-free 0.7BiFeO-0.3BaTiO (BF-BT) nanoparticles with tuned band structure were synthesized by the hydrothermal method for use as piezoelectric catalysts to generate hydrogen by splitting water; a high production rate of 1.322 mmol/g was achieved in 1 h, which is 10 times higher than the production rate of pure BiFeO. Of particular interest, BF-BT particles attached to nickel mesh have the ability to degrade rhodamine B in flowing water, demonstrating their potential to treat polluted water by anchoring BF-BT in drains. Finally, we propose novel insight on the piezocatalytic mechanism, which is based on the internal electric field (the sum of the depolarization field and the screening charge field) that drives electron/hole separation and movement.
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http://dx.doi.org/10.1021/acsami.1c01407DOI Listing
March 2021

One-Pot Hydrothermal Synthesis of Solution-Processable MoS/PEDOT:PSS Composites for High-Performance Supercapacitors.

ACS Appl Mater Interfaces 2021 Feb 2;13(6):7285-7296. Epub 2021 Feb 2.

Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, AIIM Facility, Innovation Campus, University of Wollongong, Wollongong, New South Wales 2522, Australia.

It is challenging to hydrothermally synthesize solution-processable MoS, as the strong van der Waals force between MoS nanosheets induces self-assembly of agglomerates. Here, we introduce poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) into the precursor to impede aggregate formation in the hydrothermal process. A hybrid MoS/PEDOT:PSS (MP) hydrogel is formed due to the electrostatic interactions between the negatively charged MoS and positively charged PEDOT chains. This hydrogel can be easily dispersed in water for subsequent solution processing such as vacuum filtration to form free-standing flexible films or extrusion 3D printing to create novel patterns. The MP film with a fracture strength of 18.59 MPa displays excellent electrochemical performance in both aqueous NaSO electrolyte (474 mF cm) and solid-state PVA-HPO electrolyte (360 mF cm). Flexibility and robustness can be evidenced by high capacitance retention rates of 94 and 89% after being repeatedly bent to 180° for 5000 cycles in aqueous and solid-state electrolytes, respectively.
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http://dx.doi.org/10.1021/acsami.0c21439DOI Listing
February 2021

Visible light-induced antibacterial and osteogenic cell proliferation properties of hydrogenated TiO nanotubes/Ti foil composite.

Nanotechnology 2021 May;32(19):195101

Laboratory of Biomaterials and Biomechanics, School of Stomatology, Capital Medical University, Beijing 100050, People's Republic of China.

We successfully fabricated the hydrogenated TiO nanotubes/Ti foil (H-TNTs/f-Ti) composite via one-step anodization and two-step annealing. H-TNTs/f-Ti composite had a higher visible light-induced photoelectric response and more hydroxyl functional groups compared with Ti foil and unmodified TiO nanotubes/Ti foil composite, which contributed to limiting the proliferation of Streptococcus mutans and Porphyromonas gingivalis, promoting the proliferation of MC3T3-E1 cell on the hydroxylated surface, and improving the biocompatibility with osteogenic cells. Our study provides a simple and effective method for significantly improving dental implant efficacy.
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http://dx.doi.org/10.1088/1361-6528/abe156DOI Listing
May 2021

The complete chloroplast genome of .

Mitochondrial DNA B Resour 2020 1;5(3):2233-2234. Epub 2020 Jun 1.

School of Life Sciences, Guizhou Normal University, Guiyang, China.

, a perennial plant of the genus, cultivated as a natural pesticide or ornamental plant widely distributed in many countries. In this research, the complete chloroplast genome sequence of was determined to comprise a 150,143 bp double-stranded circular DNA, including a pair of 24,416 bp inverted repeat regions (IRs), small single copy (SSC) region of 18,389 bp and large single copy (LCS) region of 82,922 bp. An overall GC content was 37.49%, and the corresponding values in IRs, SSC, and LSC regions are 43.16%, 30.88%, and 35.61%, respectively. A total of 129 genes include 84 protein-coding genes, 37 tRNA, and eight rRNA. Four rRNA genes and seven tRNA genes were duplicated in IRs. A phylogenetic tree reconstructed by 38 Composite family chloroplast genomes sequence reveals that is mostly related to .
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http://dx.doi.org/10.1080/23802359.2020.1768915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510654PMC
June 2020

Similarity and Specificity of Traditional Chinese Medicine Formulas for Management of Coronavirus Disease 2019 and Rheumatoid Arthritis.

ACS Omega 2020 Dec 18;5(47):30519-30530. Epub 2020 Nov 18.

State Key Laboratory of Quality Research in Chinese Medicines and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa 999078, Macau, China.

The pathogenesis similarity is leading to the introduction of drugs commonly used in rheumatoid arthritis (RA) into coronavirus disease (COVID-19) treatment. Traditional Chinese medicine (TCM) was widely used for the treatment of infectious diseases and rheumatic diseases. However, there is little knowledge of the relationship between COVID-19 and RA treatment employing TCM formulas. The present work was aimed to compare the similarity and specificity of TCM formulas for the management of COVID-19 and RA, as well as to deduce the potential mechanism of TCM for COVID-19 treatment. Two formulas including lianhuaqingwen (LHQW) and duhuojisheng (DHJS) were selected as the representatives of TCM for COVID-19 and RA treatment, respectively. An integrated network pharmacology was used to investigate their similarity and specificity. Although different herbs are present in the two formulas, they generated fairly similar ingredients, targets, interaction networks and enriched pathways, which were mainly involved in virus infection, inflammation, and immune dysregulation. Undoubtedly, they also exhibited their respective specificity. LHQW showed the cold property and lung channel tropism which dominated heat-clearing and lung-freeing, while DHJS showed the warm property and liver channel tropism. Herbal compatibility of LHQW was more in line with the rules of the TCM formula against coronavirus disease. Although both formulas suggested multifunctionality in virus infection and inflammation, LHQW was inclined to cope with virus infection, while DHJS was inclined to cope with inflammation. Therefore, LHQW was reliable for providing the desired efficacy in COVID-19 management because of its cold property, lung channel tropism, and multifunctionality for coping with virus infection and inflammation.
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http://dx.doi.org/10.1021/acsomega.0c04377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7711705PMC
December 2020

Responses of human gingival fibroblasts to superhydrophilic hydrogenated titanium dioxide nanotubes.

Colloids Surf B Biointerfaces 2021 Feb 24;198:111489. Epub 2020 Nov 24.

Laboratory of Biomaterials and Biomechanics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China. Electronic address:

Soft tissue integration is critical for the long-term retention of dental implants. The surface properties including topography and wettability can impact soft tissue sealing. In our work, a thermal hydrogenation technique was applied to modify anodized titanium dioxide nanotubes (TNTs). However, the effects of the hydrogenated surface on soft-tissue cells remain unclear. The aim of the present study was to investigate the bioactivities of human gingival fibroblasts (HGFs) on structured surfaces, which determine the early formation of soft tissue sealing. Three groups were examined: commercially pure titanium (Ti), anodized TNTs (air-TNTs) and hydrogenated TNTs (H-TNTs). Scanning electron microscopy showed the nanotubular topography on the titanium surfaces after anodization. Then, hydrogenation ensured that the H-TNTs were superhydrophilic with a contact angle of 3.5 ± 0.8°. In vitro studies such as cell adhesion assays, cell morphology, immunocytochemistry, wound healing assays, real-time PCR and enzyme-linked immunosorbent assays displayed enhanced adhesion, migration, relative gene expression levels, and extracellular matrix synthesis of the HGFs on H-TNTs. Interestingly, focal adhesion kinase activation and integrin-mediated adhesion seemed to be induced by the H-TNT surface. Our results revealed that a superhydrophilic nanostructure modified by anodization and hydrogenation can improve the bioactivity of HGFs and connective tissue regeneration, which will further promote and expand the application of titanium dioxide nanotubes in dental implants.
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http://dx.doi.org/10.1016/j.colsurfb.2020.111489DOI Listing
February 2021

Immobilization of cell membrane onto a glucose-Zn-based porous coordination polymer and its application to rapid screening of potentially active compounds from Vaccinium corymbosum L. leaves.

Mikrochim Acta 2020 Oct 30;187(11):630. Epub 2020 Oct 30.

State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, 999078, China.

A novel glucose-Zn-based porous coordination polymer (PCP) was selected as a carrier of cell membranes (CMs) to fabricate CM-coated PCP (CMPCP) for rapid screening of potentially active compounds from natural products. The cell disruption and the amount of maximum CMs adsorbed on PCP were optimized according to the amount of immobilized protein. This new kind of matrix exhibited good reproducibility and stability, and was applied for fishing potentially active compounds from the extracts of Vaccinium corymbosum L. leaves (VCL). Using LC-MS/MS, chlorogenic acid and quercetin were identified as the potentially active compounds through comparison of normal and non-alcoholic fatty liver disease (NAFLD)-modeled CMPCP. Our results suggested that the proposed approach based on CMPCP was environmentally friendly, cost-effective, and convenient in terms of green porous material, stable protein loading capacity, and accessible operation process. The developed method could provide a promising platform for efficient drug discovery from natural product resources.Graphical abstract.
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http://dx.doi.org/10.1007/s00604-020-04612-0DOI Listing
October 2020

Integration of bubble phobicity, gas sensing and friction alleviation into a versatile MoS/SnO/CNF heterostructure by an impressive, simple and effective method.

Nanoscale 2020 Sep 10;12(36):18629-18639. Epub 2020 Sep 10.

Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering and Hubei Key Laboratory of Polymer Materials, Hubei University, Wuhan 430062, People's Republic of China.

The engineering of composite surfaces and interfaces of materials at the micro/nano-hierarchical level with multiple functionalities is attracting increasing attention due to their biomimetic technological applications, especially the self-cleaning with gas bubbles, gas sensing and sustainable anti-friction performances. Herein, the ternary MoS/SnO/CNF (CNF: carbon nanofiber) was designed and assembled by an in situ facile method. Interestingly, its microstructure exhibits a necklace-like morphology. The MoS/SnO/CNF shows desirable bubble phobicity under water and in a PAO4 environment on various substrates, an acceptable gas-sensing ability to target gas with a detection limit of 5 ppm and fascinating tribological performances for additives in different kinds of base/lubricating oils. These results demonstrate that the necklace-like ternary MoS/SnO/CNF structure could have numerous applications in one system and may provide a new perspective in composite surface and interface materials engineering.
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http://dx.doi.org/10.1039/d0nr05378cDOI Listing
September 2020

ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.

iScience 2020 Aug 20;23(9):101472. Epub 2020 Aug 20.

Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Sciences, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China. Electronic address:

ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) are secreted metalloproteinases that play a major role in the assembly and degradation of the extracellular matrix (ECM). In this study, we show that ADAMTS18, produced by the epithelial cells of distal airways and mesenchymal cells in lung apex at early embryonic stages, serves as a morphogen in lung development. ADAMTS18 deficiency leads to reduced number and length of bronchi, tipped lung apexes, and dilated alveoli. These developmental defects worsen lipopolysaccharide-induced acute lung injury and bleomycin-induced lung fibrosis in adult Adamts18-deficient mice. ADAMTS18 deficiency also causes increased levels of fibrillin1 and fibrillin2, bronchial microfibril accumulation, decreased focal adhesion kinase signaling, and disruption of F-actin organization. Our findings indicate that ECM homeostasis mediated by ADAMTS18 is pivotal in airway branching morphogenesis.
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http://dx.doi.org/10.1016/j.isci.2020.101472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476315PMC
August 2020

Maternal exposure to imazalil disrupts intestinal barrier and bile acids enterohepatic circulation tightly related IL-22 expression in F, F and F generations of mice.

J Hazard Mater 2021 02 9;403:123668. Epub 2020 Aug 9.

Department of Biotechnology, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

There is a growing body of evidence linking maternal exposure of environmental pollutants to intestinal and metabolic diseases that can be conserved across multiple generations. Here, female C57BL/6 mice were treated imazalil (IMZ) at dietary levels of 0, 0.025‰ and 0.25‰ during the gestation and lactation periods. The results demonstrated that IMZ treatment not only induced significant changes in the mucus secretion and ionic transport, but also disrupted the expression of antimicrobial peptides in the intestine of F, F and F generations. In addition, IMZ exposure altered BAs metabolism and the affected the expression levels of critical genes involved in BAs synthesis, signaling, transportation and apical uptake. The immune cell-produced cytokines were displaying extraordinary changes after IMZ exposure. In particular, whether it was in F0, F1-20d, F1-7 w or F2-20d, the expression of IL-22 had the trend of markedly increasing upon IMZ exposure. Correlation analyses revealed that the expression of IL-22 was positively correlated with the change of BAs metabolites. Together, all these results indicated that IMZ exposure was perceived as a major stress by the intestinal epithelium that strongly affected the intestinal barrier function (including mucus, CFTR, AMPs, inflammation), largely in response to an alteration of BAs metabolism.
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http://dx.doi.org/10.1016/j.jhazmat.2020.123668DOI Listing
February 2021

Total alkaloids from Alstonia scholaris inhibit influenza a virus replication and lung immunopathology by regulating the innate immune response.

Phytomedicine 2020 Oct 29;77:153272. Epub 2020 Jun 29.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, 510120, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau (SAR), 519020, China; KingMed Virology Diagnostic & Translational Center, 510000, China; Guangdong-Hong Kong-Macao Joint Laboratory of Infectious Respiratory Disease, 510000, China. Electronic address:

Background: Alstonia scholaris is a folk medicine used to treat cough, asthma and chronic obstructive pulmonary disease in China. Total alkaloids (TA) from A. scholaris exhibit anti-inflammatory properties in acute respiratory disease, which suggests their possible anti-inflammatory effect on influenza virus infection.

Purpose: To assess the clinical use of TA by demonstrating their anti-influenza and anti-inflammatory effects and the possible mechanism underlying the effect of TA on influenza A virus (IAV) infection in vitro and to reveal the inhibitory effect of TA on lung immunopathology caused by IAV infection.

Methods: Antiviral and anti-inflammatory activities were assessed in Madin-Darby canine kidney (MDCK) and A549 cells and U937-derived macrophages infected with influenza A/PR/8/34 (H1N1) virus. Proinflammatory cytokine levels were measured by real-time quantitative PCR and Bio-Plex assays. The activation of innate immune signaling induced by H1N1 virus in the absence or presence of TA was detected in A549 cells by Western blot. Furthermore, mice were infected intranasally with H1N1 virus and treated with TA (50, 25 and 12.5 mg/kg/d) or oseltamivir (60 mg/kg/d) for 5 days in vivo. The survival rates and body weight were recorded, and the viral titer, proinflammatory cytokine levels, innate immune cell populations and histopathological changes in the lungs were analyzed.

Results: TA significantly inhibited viral replication in A549 cells and U937-derived macrophages and markedly reduced cytokine and chemokine production at the mRNA and protein levels. Furthermore, TA blocked the activation of pattern recognition receptor (PRR)- and IFN-activated signal transduction in A549 cells. Critically, TA also increased the survival rate, reduced the viral titer, suppressed proinflammatory cytokine production and innate immune cell infiltration and improved lung histopathology in a lethal PR8 mouse model.

Conclusion: TA exhibits anti-viral and anti-inflammatory effects against IAV infection by interfering with PRR- and IFN-activated signal transduction.
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http://dx.doi.org/10.1016/j.phymed.2020.153272DOI Listing
October 2020

A Self-Assembled CO Reduction Electrocatalyst: Posy-Bouquet-Shaped Gold-Polyaniline Core-Shell Nanocomposite.

ChemSusChem 2020 Sep 10;13(18):5023-5030. Epub 2020 Aug 10.

ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, North Wollongong, NSW, 2500, Australia.

Here it was demonstrated that the decoration of gold (Au) with polyaniline is an effective approach in increasing its electrocatalytic reduction of CO to CO. The core-shell-structured gold-polyaniline (Au-PANI) nanocomposite delivered a CO -to-CO conversion efficiency of 85 % with a high current density of 11.6 mA cm . The polyaniline shell facilitated CO adsorption, and the subsequent formation of reaction intermediates on the gold core contributed to the high efficiency observed.
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http://dx.doi.org/10.1002/cssc.202001248DOI Listing
September 2020

β -Cypermethrin promotes the adipogenesis of 3T3-L1 cells via inducing autophagy and shaping an adipogenesis-friendly microenvironment.

Acta Biochim Biophys Sin (Shanghai) 2020 Aug;52(8):821-831

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.

The toxicity of synthetic pyrethroids has garnered attention, and studies have revealed that pyrethroids promote fat accumulation and lead to obesity in mice. Nevertheless, the effect of β-cypermethrin (β-CYP) on adipogenesis and its underlying mechanism remains largely unknown. In this study, mouse embryo fibroblasts 3T3-L1 cells were exposed to β-CYP, and the cell viability, intracellular reactive oxygen species (ROS) level, autophagy, and adipogenesis were assessed to investigate the roles of oxidative stress and autophagy in the toxic effects of β-CYP on adipogenesis. The results demonstrated that treatment with 100 μΜ β-CYP elevated the ROS level, decreased mitochondrion membrane potential, stimulated autophagy, and enhanced the adipogenesis induced by the mixture of insulin, dexamethasone, and 3-isobutyl-1-methylxanthine. However, co-treatment with N-acetyl-L-cysteine partially blocked the abovementioned effects of β-CYP in 3T3-L1 cells. In addition, co-treatment with rapamycin, an autophagy agonist, enhanced the inductive effect of β-CYP on adipogenesis, whereas co-treatment with 3-methyladenine blocked the enhancement of adipogenesis caused by β-CYP. Moreover, β-CYP also altered the microenvironment of 3T3-L1 cells to an adipogenesis-friendly one by reducing the extracellular expression of miR-34a, suggesting that the culture media of β-CYP-treated 3T3-L1 cells could shift macrophages to M2 type. Taken together, the data obtained in the present study demonstrated that β-CYP promoted adipogenesis via oxidative stress-mediated autophagy disturbance, and it caused macrophage M2 polarization via the alteration of miR-34a level in the microenvironment. The study demonstrated the adipogenesis-promoting effect of β-CYP and unveiled the potential mechanism.
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http://dx.doi.org/10.1093/abbs/gmaa049DOI Listing
August 2020

Ionic liquid assisted molecular self-assemble and molecular imprinting on gold nanoparticles decorated boron-doped ordered mesoporous carbon for the detection of zearalenone.

Talanta 2020 Sep 14;217:121032. Epub 2020 Apr 14.

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 30072, Hubei Province, PR China. Electronic address:

Accurate and early diagnosis of zearalenone (ZEN) is particularly significant to the food safety. Herein, we propose an ionic liquid assisted self-assembly molecular imprinting strategy for ZEN based on ionic liquid functionalized boron-doped ordered mesoporous carbon -gold nanoparticles composite (BOMC-IL-Au NPs). During the composite synthesis, increased well-dispersed and uniform Au NPs are deposited on the surface of IL modified BOMC, due to the strong electrostatic interaction between AuCl and positively charged IL. For molecular imprinting, the BOMC-IL-Au NPs/GCE is immersed into p-aminothiophenol (p-ATP) solution and template solution in turn. Thus, the mercapto group contained p-ATP self-assembles on the Au NPs. Subsequently, the template molecules self-assemble onto the composite to form dense template layer, because of the hydrophobic interaction, π-π and hydrogen bond between template and IL/or p-ATP. After electropolymerization, the template layer is embedded into the p-ATP polymer membrane and produces lots of imprinting sites. Hence, the obtained sensor exhibits high sensitivity and selectivity. Under the optimal conditions, zearalenone can be quantified from 5 × 10 to 1 ng mL with the low detection limit of 1 × 10 ng mL, by using [Fe(CN)] probe and square wave voltammetry. This strategy can also be employed to construct sensors for the detection of other substances.
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http://dx.doi.org/10.1016/j.talanta.2020.121032DOI Listing
September 2020

Mechanically Robust, Self-Healing, Polymer Blends and Polymer/Small Molecule Blend Materials with High Antibacterial Activity.

ACS Appl Mater Interfaces 2020 Jun 8;12(24):26966-26972. Epub 2020 Jun 8.

Key Laboratory of Micro-systems and Micro-structures Manufacturing, Ministry of Education, Harbin Institute of Technology, Harbin 150080, P. R. China.

There is a growing demand for antibacterial materials around the world in recent years because they can be used for preventing pathogen infection, which is one of the major threats to human health. However, the mechanical damage of the antibacterial materials may weaken their protective effect since bacteria can invade through the cracks of the material. Therefore, antibacterial materials with self-healing ability, in which the mechanical damage can be spontaneously healed, exhibit better reliability and a longer lifespan. In this article, we prepared a series of low-cost antibacterial polymer blends and polymer/small molecule blend materials with excellent self-healing ability and high mechanical strength by a one-pot reaction under mild conditions. These materials were facilely obtained by blending a tiny amount of commercialized cationic antibacterial chemicals, poly(ethylene imine) (PEI) or cetyltrimethylammonium bromide (CTAB), into a self-healing, mechanically robust polymer, poly(ether-thioureas) (PETU). It can be found that they can effectively kill (Gram-negative) and (Gram-positive) on their surface. Meanwhile, the distinguished advantages of PETU, including self-healing property, excellent mechanical robustness, recyclability, and transparency, were perfectively maintained. Furthermore, it was shown that their cytotoxicity was satisfactory and their hemolytic activity was insignificant. The above advantages of the blend materials suggested their potential applications in health care, food industry, and environmental hygiene.
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http://dx.doi.org/10.1021/acsami.0c06591DOI Listing
June 2020

Highly Sensitive Strain Sensor Based on a Stretchable and Conductive Poly(vinyl alcohol)/Phytic Acid/NH-POSS Hydrogel with a 3D Microporous Structure.

ACS Appl Mater Interfaces 2020 Jun 28;12(23):26496-26508. Epub 2020 May 28.

College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China.

Conductive hydrogel-based wearable strain sensors with tough, stretchable, self-recoverable, and highly sensitive properties are highly demanded for applications in electronic skin and human-machine interface. However, currently, hydrogel-based strain sensors put forward higher requirements on their biocompatibility, mechanical strength, and sensitivity. Herein, we report a poly(vinyl alcohol)/phytic acid/amino-polyhedral oligomeric silsesquioxane (PVA/PA/NH-POSS) conductive composite hydrogel prepared via a facile freeze-thaw cycle method. Within this hydrogel, PA acts as a cross-linking agent and ionizes hydrogen ions to endow the material with ionic conductivity, while NH-POSS acts as a second cross-linking agent by increasing the cross-linking density of the three-dimensional network structure. The effect of the content of NH-POSS is investigated, and the composite hydrogel with 2 wt % NH-POSS displays a uniform and dense three-dimensional (3D) network microporous structure, high conductivity of 2.41 S/m, and tensile strength and elongation at break of 361 kPa and 363%, respectively. This hydrogel is biocompatible and has demonstrated the application as a strain sensor monitoring different human movements. The assembled sensor is stretchable, self-recoverable, and highly sensitive with fast response time (220 ms) and excellent sensitivity (GF = 3.44).
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http://dx.doi.org/10.1021/acsami.0c07717DOI Listing
June 2020

Phytotherapy using blueberry leaf polyphenols to alleviate non-alcoholic fatty liver disease through improving mitochondrial function and oxidative defense.

Phytomedicine 2020 Apr 18;69:153209. Epub 2020 Mar 18.

State Key Laboratory of Quality Research in Chinese Medicines and Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China. Electronic address:

Background: Since non-alcoholic fatty liver disease (NAFLD) pathogenesis is multi-factorial, pharmacotherapy with a specific target commonly exhibits limited efficacy. Phytotherapy, whose therapeutic efficacy is based on the combined action of several active compounds, offers new treatment opportunity for NAFLD. As a representative, many natural polyphenols could be utilized in phytotherapy for NAFLD.

Purpose: In present work, we aimed to investigate the therapeutic effects and underlying mechanism of polyphenols in blueberry leaves (PBL) on NAFLD from a mitochondria-centric perspective since mitochondrial dysfunction could play a dominant role in NAFLD.

Methods: Identification and quantification of PBL were performed using liquid chromatography coupled with tandem mass spectrometry. The beneficial effects, especially improving mitochondrial function, and potential mechanism of PBL on NAFLD were studied by in vitro and in vivo study.

Results: Polyphenols were abundant in blueberry leaves making it advantaged in NAFLD phytotherapy. PBL effectively alleviated hepatic steatosis, oxidative stress and inflammation as indicated by both in vitro and in vivo study. Furthermore, PBL mediated improvement of mitochondrial dysfunction and antioxidant capability through activation of AMPK/PGC-1α/SIRT3 signaling axis.

Conclusion: Considering that mitochondrial dysfunction takes precedence over hepatic steatosis and induces NAFLD development, we conclude that PBL improve mitochondrial dysfunction and oxidative defense, subsequently alleviate hepatic steatosis, oxidative stress and inflammation, and eventually alleviate NAFLD.
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http://dx.doi.org/10.1016/j.phymed.2020.153209DOI Listing
April 2020

β-Cypermethrin Alleviated the Inhibitory Effect of Medium from RAW 264.7 Cells on 3T3-L1 Cell Maturation into Adipocytes.

Lipids 2020 05 31;55(3):251-260. Epub 2020 Mar 31.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310032, China.

Studies have elucidated that pyrethroids induce adipogenesis. It is also known that macrophages can affect the homeostasis of adipose tissue. However, whether and how the β-cypermethrin (β-CYP)-mediated inhibition of the macrophages affects adipogenesis remain unknown. To explore the effects of β-CYP on adipogenesis through modulating the function of macrophages, 3T3-L1 cells, a preadipocyte cell line, were exposed to culture medium from either RAW 264.7 cells, a macrophage cell line (RM), or β-CYP-treated RAW 264.7 cells (CRM). CRM decreased the inhibitory effects of RM treatment on cell proliferation and adipogenesis, as lipid accumulation, the CEBPA content, and Fasn and Acaca expression in 3T3-L1 cells were higher following CRM treatment than following RM treatment through the higher levels of the demethylated CEBPA promoter in 3T3-L1 cells. However, the medium from β-CYP- and N-acetyl-L-cysteine-cotreated RAW 264.7 cells (CNRM) partially restored the inhibitory effects of RAW 264.7 cells on 3T3-L1 cells that had been reduced by CRM, indicating that β-CYP might reduce the cytotoxicity and inhibitory effects of RAW 264.7 cells on the adipogenesis of 3T3-L1 cells through elevating ROS levels in RAW 264.7 cells. Moreover, exposure to β-CYP downregulated the TNF-α secretion in RAW 264.7 cells. In conclusion, these data demonstrated that β-CYP affected the function of RAW 264.7 cells, alleviating their inhibitory effects on adipogenesis and CEBPA demethylation in 3T3-L1 cells. β-CYP might achieve these effects through downregulating the secretion of TNF-α via elevating ROS levels in RAW 264.7 cells. Our experiments provide a new perspective on the obesogenic effect of pyrethroids.
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http://dx.doi.org/10.1002/lipd.12234DOI Listing
May 2020

Immune response of macrophages on super-hydrophilic TiO nanotube arrays.

J Biomater Appl 2020 04 30;34(9):1239-1253. Epub 2020 Jan 30.

Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1177/0885328220903249DOI Listing
April 2020

Study on the anti-tumor mechanism related to immune microenvironment of Bombyx Batryticatus on viral and non-viral infections of hepatocellular carcinoma.

Biomed Pharmacother 2020 Apr 22;124:109838. Epub 2020 Jan 22.

The First Hospital of Lanzhou University, Lanzhou, China; The First Clinical Medical College of Lanzhou University, Lanzhou, China; Evidence Based Medicine Center, School of Basic Medical Science of Lanzhou University, Lanzhou, 730000, China; Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, China. Electronic address:

Hepatocellular carcinoma (HCC) is a malignant primary liver cancer with poor prognosis. Most previous studies on anti-HCC effects of traditional Chinese medicines (TCM) have focused on the mechanism of direct action and few researchers considered that TCM can inhibit tumor progression and improve prognosis of HCC patients through regulating tumor microenvironment (TME). In this study, network pharmacology combined bioinformatics methods were employed to analysis mechanism of Bombyx batryticatus (B. batryticatus, one of the most frequently used traditional Chinese animal medicines, has been used in some Asian countries for centuries as an anticancer agent, anti-inflammatory agent, and antioxidant.) in regulating TME of HCC. The results showed that 24 core targets and 2 compounds were identified from overlapping between differential expression genes related to HCC in the cancer genome atlas (TCGA) database and targets of B. batryticatus in TCMSP database. For further analyzing the role of TME heterogeneity of HCC on anti-HCC mechanism of B. batryticatus, the correlation of core targets related with overall survival of HCC with TME cells in hepatitis C or hepatitis B virus-associated hepatocellular carcinoma (VIR) and non-hepatitis C or hepatitis B virus-associated hepatocellular carcinoma (NVIR) were calculated, respectively. The results showed that AKR1C3, SPP1 were significantly related with macrophages in VIR and other targets including NR1I2, CYP1A2 and CYP3A4 were significantly associated with macrophages in NVIR; the target protein AKR1C3 was significantly negative correlated with macrophages M1 in VIR (cor=-0.35, P-value<0.001) and the correlation between AKR1C3 and macrophages M1 was poor in NVIR group (cor = 0.064, P-value = 0.36). Additionally, survival curve of AKR1C3 showed that poor prognosis in VIR group can be related to high level of AKR1C3 (HR = 2.32, 95 % CI: 1.18-4.56, P-value = 0.012), and no signified gene can be found in NVIR group (P-value>0.05). In conclusion, the molecular mechanism of anti-HCC of B. batryticatus can be related to the tumor microenvironment to some extent. B. batryticatus may exert its anti-cancer effects and improve prognosis of patients by regulating macrophages M1 in VIR and NVIR through acting on different targets.
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http://dx.doi.org/10.1016/j.biopha.2020.109838DOI Listing
April 2020

Effects of elevated CO and temperature on survival and wing dimorphism of two species of rice planthoppers (Hemiptera: Delphacidae) under interaction.

Pest Manag Sci 2020 Jun 31;76(6):2087-2094. Epub 2020 Jan 31.

Department of Entomology, College of Plant Protection, Nanjing Agriculture University, Nanjing, P. R. China.

Background: Anthropogenic climate change (ACC) may have significant impacts on insect herbivore communities including pests. Two of the most important climate-change related factors are increased atmospheric concentrations of carbon dioxide (CO ), and increasing mean global temperature. Although increasing attention is being paid to the biological and ecological effects of ACC, important processes such as interspecific interaction between insect herbivores have been little explored. Here, in a field experiment using the FACE (free-air CO enrichment) system, we investigated the effect of elevated CO and temperature on survival and wing dimorphism of two species of rice planthoppers, Laodelphax striatellus and Nilaparvata lugens under interaction.

Results: The two species were grouped into five treatments of relative density (0/50, 13/37, 25/25, and 37/13, 50/0), each of which was allocated to one of a factorial combination of two CO concentrations and two temperature treatments (elevated and ambient levels). Our results revealed that climatic treatment has no effects on survivorship of interspecific competing planthoppers. However, climatic treatment affected wing-form of planthoppers under interspecific interaction. For females of N. lugens, in the 37/13 ratio, proportion macropterours form was lower under elevated CO  + temperature than under the ambient environment or than under elevated temperature. For females of L. striatellus, proportion macropterous form did not differ among climatic treatments at each ratio treatment.

Conclusion: These findings illustrate that climate change-related factors, by affecting the macropetry of interspecific competing planthoppers, may influence planthopper fitness. We provide new information that could assist with forecasting outbreaks of these migratory pests. © 2020 Society of Chemical Industry.
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http://dx.doi.org/10.1002/ps.5747DOI Listing
June 2020