Publications by authors named "Bin Qian"

101 Publications

Parity-Symmetry-Protected Multiphoton Bundle Emission.

Phys Rev Lett 2021 Aug;127(7):073602

School of Physics, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China.

We demonstrate symmetry protected multiphoton bundle emission in the cavity QED system under the ultrastrong coupling regime. Our proposal only enables the super-Rabi oscillations with periodic generation of even correlated photons in the cavity, which is realized by combining the laser driven flip of qubit and the symmetry conserved transitions induced by Rabi interaction with parity symmetry. Combined with dissipation, only 2n-photon bundle emissions are allowed, due to the almost perfect suppression of bundle emissions with odd correlated photons. Meanwhile, the corresponding purities are significantly enhanced by the parity symmetry. This work extends multiphoton bundle emission to the ultrastrong coupling regime, and offers the prospect of exploring symmetry-protected multiphoton physics.
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http://dx.doi.org/10.1103/PhysRevLett.127.073602DOI Listing
August 2021

Ultrasound-Guided Thoracic Paravertebral Block Enhances the Quality of Recovery After Modified Radical Mastectomy: A Randomized Controlled Trial.

J Pain Res 2021 20;14:2563-2570. Epub 2021 Aug 20.

Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.

Purpose: Ultrasound-guided thoracic paravertebral block (TPVB) has become increasingly popular for postoperative analgesia after breast surgery. We designed this prospective, randomized, double-blind, placebo-controlled trial to test the hypothesis that TPVB is superior to placebo in improving the patient quality of recovery following modified radical mastectomy.

Patients And Methods: Sixty-eight female patients undergoing elective unilateral modified radical mastectomy were enrolled. Patients were randomized to receive preoperative ultrasound-guided TPVB with 0.5% ropivacaine (TPVB group, n=34) or 0.9% saline (Control group, n=34). The primary outcome was quality of recovery, measured 24 h after surgery using the 40-item Quality of recovery questionnaire (QoR-40). Secondary outcomes were the area under the curve of the visual analog scale pain scores over 24 h, postoperative 24-h morphine consumption, time to first rescue analgesia, length of post-anesthesia care unit stay, postoperative nausea and vomiting, and patient satisfaction.

Results: The global QoR-40 score 24 h postoperatively (median [interquartile range]) was 173 [170-177] in the TPVB group and 161 [160-164] in the control group (<0.001), respectively, with a median difference (95% confidence interval) of 11 (9-14). Compared with the control group, preoperative TPVB decreased the area under the curve of the visual analog scale pain scores over 24 h, reduced postoperative 24-h morphine consumption, prolonged the time to first rescue analgesia, shortened the length of post-anesthesia care unit stay, lessened postoperative nausea and vomiting, and improved the patient satisfaction.

Conclusion: A single preoperative injection of TPVB with ropivacaine enhances the quality of recovery and postoperative analgesia in patients following modified radical mastectomy.
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http://dx.doi.org/10.2147/JPR.S325627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385420PMC
August 2021

A FeO-FeC heterostructure encapsulated into a carbon matrix for the anode of lithium-ion batteries.

Chem Commun (Camb) 2021 Sep 12;57(70):8818-8821. Epub 2021 Aug 12.

School of Electronic and Information Engineering, Changshu Institute of Technology, Changshu 215500, China.

A novel FeO-FeC heterostructure encapsulated into a carbon matrix was designed as an anode material for lithium-ion batteries. The composite had the high specific capacity of metal oxides, and maintained the stability of metal carbides. The unique heterostructure and tubular structure were conducive to charge transfer and ion diffusion.
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http://dx.doi.org/10.1039/d1cc03945hDOI Listing
September 2021

Serratus anterior plane block reduces the prevalence of chronic postsurgical pain after modified radical mastectomy: A randomized controlled trial.

J Clin Anesth 2021 Jun 24;74:110410. Epub 2021 Jun 24.

Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China. Electronic address:

Study Objective: To determine whether ultrasound-guided serratus anterior plane block (SAPB) is associated with decreased prevalence of chronic postsurgical pain (CPSP) after modified radical mastectomy.

Design: Randomized, double-blind, placebo-controlled study.

Setting: University hospital.

Patients: We enrolled 198 patients aged 18-65 years with American Society of Anesthesiologists physical status I to II, undergoing unilateral modified radical mastectomy.

Interventions: Patients were randomly allocated to receive SAPB with 30 ml of 0.5% ropivacaine (SAPB group) or 0.9% normal saline (Control group).

Measurements: The primary outcome was the prevalence of CPSP three months after surgery. Secondary outcomes were area under the curve of the numeric rating scale pain scores over 24 h, postoperative 24-h morphine consumption, quality of recovery, length of post-anesthesia care unit stay, postoperative nausea and vomiting, dizziness, SAPB-related adverse events, the prevalence of CPSP at six months, and pain-related function at three and six months.

Main Results: Preoperative SAPB with 0.5% ropivacaine reduced the prevalence of CPSP at three postoperative months from 46/89 (51.7%) to 22/90 (25.6%), relative risk (95% confidence interval): 0.47 (0.31-0.72), P < 0.001. The prevalence of CPSP was reduced at six months from 37/89 (41.6%) to 17/90 (18.9%), relative risk (95% confidence interval): 0.72 (0.58-0.88), P = 0.001. Moreover, SAPB decreased the area under the curve of the numeric rating scale pain scores over 24 h, shortened the length of post-anesthesia care unit stay, reduced postoperative 24-h morphine consumption and the occurrence of postoperative nausea and vomiting, and improved quality of recovery and patient satisfaction, with P < 0.05 for all. No SAPB-related complications occurred.

Conclusions: Preoperative SAPB with ropivacaine improved acute postoperative analgesia and quality of recovery and decreased the prevalence of CPSP at three and six months after modified radical mastectomy.
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http://dx.doi.org/10.1016/j.jclinane.2021.110410DOI Listing
June 2021

M1 macrophage-derived exosomes impair beta cell insulin secretion via miR-212-5p by targeting SIRT2 and inhibiting Akt/GSK-3β/β-catenin pathway in mice.

Diabetologia 2021 Sep 11;64(9):2037-2051. Epub 2021 Jun 11.

Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, China.

Aims/hypothesis: Macrophage levels are elevated in pancreatic islets, and the resulting inflammatory response is a major contributor to beta cell failure during obesity and type 2 diabetes mellitus. Previous studies by us and others have reported that exosomes released by macrophages play important roles in mediating cell-to-cell communication, and represent a class of inflammatory factors involved in the inflammatory process associated with type 2 diabetes mellitus. However, to date, no reports have demonstrated the effect of macrophage-derived exosomes on beta cells, and little is known regarding their underlying mechanisms in beta cell injury. Thus, we aimed to study the impact of macrophage-derived exosomes on islet beta cell injury in vitro and in vivo.

Methods: The phenotypic profiles of islet-resident macrophages were analysed in C57BL/6J mice fed a high-fat diet (HFD). Exosomes were collected from the medium of cultured bone marrow-derived macrophages (BMDMs) and from isolated islet-resident macrophages of HFD-fed mice (HFD-Exos). The role of exosomes secreted by inflammatory M1 phenotype BMDMs (M1-Exos) and HFD-Exos on beta cell function was assessed. An miRNA microarray and quantitative real-time PCR (qPCR) were conducted to test the level of M1-Exos-derived miR-212-5p in beta cells. Then, miR-212-5p was overexpressed or inhibited in M1-Exos or beta cells to determine its molecular and functional impact.

Results: M1-polarised macrophages were enriched in the islets of obese mice. M1 macrophages and islet-resident macrophages of HFD-fed mice impaired beta cell insulin secretion in an exosome-dependent manner. miR-212-5p was notably upregulated in M1-Exos and HFD-Exos. Enhancing the expression of miR-212-5p impaired beta cell insulin secretion. Blocking miR-212-5p elicited a significant improvement in M1-Exos-mediated beta cell insulin secretion during injury. Mechanistically, M1-Exos mediated an intercellular transfer of the miR-212-5p, targeting the sirtuin 2 gene and regulating the Akt/GSK-3β/β-catenin pathway in recipient beta cells to restrict insulin secretion.

Conclusions/interpretation: A novel exosome-modulated mechanism was delineated for macrophage-beta cell crosstalk that drove beta cell dysfunction and should be explored for its therapeutic utility.
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http://dx.doi.org/10.1007/s00125-021-05489-1DOI Listing
September 2021

Is flexible bronchoscopy necessary in the preoperative workup of patients with peripheral cT1N0 subsolid lung cancer? -a prospective multi-center cohort study.

Transl Lung Cancer Res 2021 Apr;10(4):1635-1641

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Background: Necessity of flexible bronchoscopy (FB) examination as a routine preoperative work-up for peripheral clinical T1N0 subsolid lung cancer was unknown.

Methods: This was a prospective, multi-center clinical trial (NCT03591445). Patients with peripheral GGO nodules (GGNs) who were candidates for surgical resection were enrolled. FB examination was performed preoperatively. Surgical plan could be changed if any aberrant histologic and anatomic findings were detected by FB examination. Primary endpoint was the rate that surgical plan was changed by positive FB findings. Secondary endpoints were rate of positive FB findings and rate of procedural complications.

Results: Six hundred and fifteen patients with peripheral subsolid nodules detected by thoracic CT were enrolled. There were 187 (30.4%) male and 428 (69.6%) female patients, mean age was 54.85±10.41 y (range, 26-78). 262 (42.6%) patients had pure GGNs and 353 (57.4%) patients had part-solid nodules. Mean size of nodules was 13.87±6.37 mm (range, 5-30). FB examinations confirmed one (0.16%) adenocarcinoma, seven (1.14%) bronchial variations, one (0.16%) segmental bronchostenosis, one (0.16%) segmental bronchial occlusion and one (0.16%) bronchial inflammation. No complications of FB examinations occurred. 568 (92.35%) thoracoscopic and 47 (7.65%) open surgeries were performed. No established surgical plan was changed by positive FB findings. Final pathologies revealed 26 (4.2%) adenocarcinoma (AIS), 240 (39%) minimal invasive adenocarcinomas (MIAs), 343 (55.8%) invasive adenocarcinomas (IADs), one (0.2%) adenosquamous cell carcinoma, one (0.2%) squamous cell carcinoma, two (0.3%) atypical adenoid hyperplasia and two (0.3%) inflammations.

Conclusions: FB examination was unnecessary in the preoperative assessment of peripheral clinical T1N0 subsolid lung cancer.
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http://dx.doi.org/10.21037/tlcr-20-1122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107749PMC
April 2021

MicroRNA-497-5p Is Downregulated in Hepatocellular Carcinoma and Associated with Tumorigenesis and Poor Prognosis in Patients.

Int J Genomics 2021 16;2021:6670390. Epub 2021 Mar 16.

Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China.

Background: MicroRNAs (miRNAs) have been demonstrated to exhibit important regulatory roles in multiple malignancies, including hepatocellular carcinoma (HCC). hsa-miR-497-5p was reported to involve in cancer progression and poor prognosis in many kinds of tumors. However, the expression and its clinical significance of hsa-miR-497-5p in HCC remain unclear.

Methods: In the present study, we investigated the expression of hsa-miR-497-5p in HCC and analyzed the correction of clinical features with prognosis. The expression levels of hsa-miR-497-5p and potential target genes were analyzed in HCC and adjacent noncancerous tissues using The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) datasets. Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to analyze hsa-miR-497-5p levels in 328 HCC tissues and 30 paired adjacent noncancer tissues. Overall survival (OS) and progression-free survival (PFS) of patients with HCC were assessed using the Kaplan-Meier method and the log-rank test.

Results: The hsa-miR-497-5p expression levels were decreased, and its target genes ACTG1, CSNK1D, PPP1CC, and BIRC5 were upregulated in HCC tissues compared with normal tissues. Lower levels of hsa-miR-497-5p expression and higher levels of the four target genes were significantly associated with higher tumor diameter. Moreover, patients with lower hsa-miR-497-5p expression and higher target genes levels had shorter OS.

Conclusion: The expression levels of hsa-miR-497-5p may play an important regulatory role in HCC and are closely correlated with HCC progression and poor prognosis in patients. The hsa-miR-497-5p may be a specific therapeutic target for the treatment of HCC.
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http://dx.doi.org/10.1155/2021/6670390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987441PMC
March 2021

The prognostic value of IL-8 for the death of severe or critical patients with COVID-19.

Medicine (Baltimore) 2021 Mar;100(11):e23656

Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Abstract: Inflammation has been believed to contribute to coronavirus disease 2019 (COVID-19). Risk factors for death of COVID-19 pneumonia have not yet been well established.In this retrospective cohort study, we included the deceased patients in COVID-19 specialized ICU with laboratory-confirmed COVID-19 from Guanggu hospital area of Tongji Hospital from February 8th to March 30th. Demographic, clinical, laboratory, and outcome data were extracted from electronic medical records using a standard data collection form. We used Spearman rank correlation and Cox regression analysis to explore the risk factors associated with in-hospital death, especially the association between inflammatory cytokines and death.A total of 205 severe/critical COVID-19 pneumonia patients were admitted in the COVID-19 specialized ICU and 75 deceased patients were included in the final analysis. The median age of the deceasing patients was 70 years (IQR 65-79). The common symptoms were fever (78.9%), cough (70.4%), and expectoration (39.4%). The BNP and CRP levels were far beyond the normal reference range. In the Spearman rank correlation analysis, IL-8 was found to be significantly associated with the time from onset to death (rs= -0.30, P = .034) and that from admission to death (rs= -0.32, P = .019). Cox regression showed after adjusting age and sex, IL-8 levels were still significantly associated with the time from onset to death (P = .003) and that from admission to death (P  = .01).IL-8 levels were associated with in-hospital death in severe/critical COVID-19 patients, which could help clinicians to identify patients with high risk of death at an early stage.
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http://dx.doi.org/10.1097/MD.0000000000023656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982189PMC
March 2021

KDM5A silencing transcriptionally suppresses the FXYD3-PI3K/AKT axis to inhibit angiogenesis in hepatocellular cancer via miR-433 up-regulation.

J Cell Mol Med 2021 04 23;25(8):4040-4052. Epub 2021 Feb 23.

Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Hepatocellular cancer (HCC) has been reported to belong to one of the highly vascularized solid tumours accompanied with angiogenesis of human umbilical vein endothelial cells (HUVECs). KDM5A, an attractive drug target, plays a critical role in diverse physiological processes. Thus, this study aims to investigate its role in angiogenesis and underlying mechanisms in HCC. ChIP-qPCR was utilized to validate enrichment of H3K4me3 and KDM5A on the promotor region of miR-433, while dual luciferase assay was carried out to confirm the targeting relationship between miR-433 and FXYD3. Scratch assay, transwell assay, Edu assay, pseudo-tube formation assay and mice with xenografted tumours were conducted to investigate the physiological function of KDM5A-miR-433-FXYD3-PI3K-AKT axis in the progression of HCC after loss- and gain-function assays. KDM5A p-p85 and p-AKT were highly expressed but miR-433 was down-regulated in HCC tissues and cell lines. Depletion of KDM5A led to reduced migrative, invasive and proliferative capacities in HCC cells, including growth and a lowered HUVEC angiogenic capacity in vitro. Furthermore, KDM5A suppressed the expression of miR-433 by demethylating H3K4me3 on its promoterregion. miR-433 negatively targeted FXYD3. Depleting miR-433 or re-expressing FXYD3 restores the reduced migrative, invasive and proliferative capacities, and lowers the HUVEC angiogenic capacity caused by silencing KDM5A. Therefore, KDM5A silencing significantly suppresses HCC tumorigenesis in vivo, accompanied with down-regulated miR-433 and up-regulated FXYD3-PI3K-AKT axis in tumour tissues. Lastly, KDM5A activates the FXYD3-PI3K-AKT axis to enhance angiogenesis in HCC by suppressing miR-433.
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http://dx.doi.org/10.1111/jcmm.16371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051710PMC
April 2021

Anesthetic effect of ultrasound-guided multiple-nerve blockade in modified radical mastectomy in patients with breast cancer.

Medicine (Baltimore) 2021 Feb;100(7):e24786

Department of Anesthesiology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, No. 166 West Yulong Road, Yancheng, P. R. China.

Introduction: Routine anesthesia modality for modified radical mastectomy (MRM) includes general anesthesia (GA), epidural blockade-combined GA and nerve blockade-combined GA. However, GA has been associated with postoperative adverse effects such as vertigo, postoperative nausea and vomiting and requirement for postoperative analgesia, which hinders recovery and prognosis. Moreover, combined blockade of thoracic paravertebral nerves or intercostal nerves and adjuvant basic sedation for massive lumpectomy provided perfect anesthesia and reduced opioid consumption, whereas the excision coverage did not attain the target of MRM. Regional anesthesia strategies involving supplementation of analgesics in ultrasound-guided multiple nerve blocks have garnered interests of clinicians. Nevertheless, the precise effects of intercostal nerves, brachial plexus and supraclavicular nerves in MRM in patients with breast cancer remain obscure.

Methods: Eighty female patients with breast cancer scheduled for MRM were recruited in the present trial between May, 2019 and Dec., 2019 in our hospital. The patients ranged from 30 to 65 years of age and 18∼30 kg/m2 in body-mass index, with the American Society of Anesthesiologists I or II. The patients were randomized to ultrasound-guided multiple nerve blocks group and GA group. The patients in multiple nerve blocks group underwent ultrasound guided multiple intercostal nerve blocks, interscalene brachial plexus and supraclavicular nerve blocks, (local anesthesia with 0.3% ropivacaine: 5 ml for each intercostal nerve block, 8 ml for brachial plexus block, 7 mL for supraclavicular nerve block) and basic sedation and intraoperative mask oxygen inhalation. The variations of hemodynamic parameters such as mean arterial pressure, heart rate (HR) and pulse oxygen saturation were monitored. The visual analog scale scores were recorded at postoperative 0 hour, 3 hour, 6 hour, 12 hour and 24 hour in resting state. The postoperative adverse effects, including vertigo, postoperative nausea, and vomiting, pruritus, and urinary retention and so on, as well as the analgesic consumption were recorded.

Conclusions: The ultrasound guided multiple intercostal nerve blocks, brachial plexus and supraclavicular nerve blocks could provide favorable anesthesia and analgesia, with noninferiority to GA and the reduced incidence of adverse effects and consumption of postoperative analgesics.
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http://dx.doi.org/10.1097/MD.0000000000024786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899908PMC
February 2021

Electrocatalytically inactive copper improves the water adsorption/dissociation on NiS for accelerated alkaline and neutral hydrogen evolution.

Nanoscale 2021 Feb;13(4):2456-2464

Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

Nickel dichalcogenides, especially Ni3S2, present inferior alkaline and neutral hydrogen evolution activity due to their sluggish water dissociation kinetics. Although these materials hold promise as non-noble metal-based electrocatalysts for the hydrogen evolution reaction (HER) in acidic media, developing efficient strategies to enhance the water dissociation processes of nickel dichalcogenides in alkaline and neutral solutions is also an important area of research. The present work discloses an electrocatalytically inactive copper doping strategy to promote the water adsorption and dissociation process of Ni3S2 (Cu-Ni3S2) nanoparticles supported on nickel foam (NF) towards improving the alkaline and neutral hydrogen evolution reactions. Based on combined density functional theory calculations and electrochemical characterizations, the doping of Cu can accelerate the Volmer step and therefore strengthen the water adsorption/dissociation on the respective Ni sites and S sites during the HER process. As a result, the electrocatalyst exhibits superior and stable HER performance in both 1 M KOH and 1 M phosphate-buffered saline (PBS) solutions, with much lower overpotentials of 121 and 228 mV at a current density of 10 mA cm-2, respectively, in comparison to bare Ni3S2. We therefore conclude that the tailored control of the water adsorption/dissociation capability of Ni3S2 will open significant opportunities for the rational design of alkaline and neutral electrocatalysts from earth-abundant and stable materials.
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http://dx.doi.org/10.1039/d0nr07275cDOI Listing
February 2021

A self-balancing circuit centered on MoOsm1 kinase governs adaptive responses to host-derived ROS in .

Elife 2020 12 4;9. Epub 2020 Dec 4.

Department of Plant Pathology, College of Plant Protection, Nanjing Agricultural University, and Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing, China.

The production of reactive oxygen species (ROS) is a ubiquitous defense response in plants. Adapted pathogens evolved mechanisms to counteract the deleterious effects of host-derived ROS and promote infection. How plant pathogens regulate this elaborate response against ROS burst remains unclear. Using the rice blast fungus , we uncovered a self-balancing circuit controlling response to ROS in planta and virulence. During infection, ROS induces phosphorylation of the high osmolarity glycerol pathway kinase MoOsm1 and its nuclear translocation. There, MoOsm1 phosphorylates transcription factor MoAtf1 and dissociates MoAtf1-MoTup1 complex. This releases MoTup1-mediated transcriptional repression on oxidoreduction-pathway genes and activates the transcription of MoPtp1/2 protein phosphatases. In turn, MoPtp1/2 dephosphorylate MoOsm1, restoring the circuit to its initial state. Balanced interactions among proteins centered on MoOsm1 provide a means to counter host-derived ROS. Our findings thereby reveal new insights into how utilizes a phosphor-regulatory circuitry to face plant immunity during infection.
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http://dx.doi.org/10.7554/eLife.61605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717906PMC
December 2020

Is Tc bone scintigraphy necessary in the preoperative workup for patients with cT1N0 subsolid lung cancer? A prospective multicenter cohort study.

Thorac Cancer 2021 02 19;12(4):415-419. Epub 2020 Nov 19.

Departments of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: Tc bone scintigraphy (BS) is still the most common approach for the evaluation of bone metastasis in China. The purpose of this study was to investigate the necessity of BS as part of a routine preoperative workup for patients with cT1N0 subsolid lung cancer.

Methods: This was a prospective multicenter clinical trial (NCT03689439). Patients with cT1N0 subsolid nodules who were candidates for surgical resection were consecutively enrolled into the study. BS was performed preoperatively. The surgical plan could be changed if a positive result was detected. The primary endpoint was the incidence rate of the surgical plan being changed because of positive BS results. The secondary endpoint was the rate of positive BS findings and the rate of related complications.

Results: From November 2018 to July 2019, 691 patients were enrolled into the study. None of the patients had positive BS results and no surgical plans were changed by BS findings. There were 222 male and 469 female patients. The average age was 54.8 ± 3.7 years old. The average tumor diameter was 14.9 ± 4.2 mm. There were 282 patients with pure GGO nodules and 409 with part-solid nodules. A total of 470 patients had a single nodule, while 221 patients had multifocal lesions. The number of patients whose pathological diagnosis was invasive adenocarcinoma, minimally invasive adenocarcinoma, adenocarcinoma in situ and mucinous adenocarcinoma was 357, 293, 32 and nine, respectively. The number of patients who underwent lobectomy, segmentectomy and wedge resection was 234, 199 and 258, respectively.

Conclusions: Tc bone scintigraphy is unnecessary in the preoperative workup for patients with cT1N0 subsolid lung cancer.

Key Points: SIGNIFICANT FINDINGS OF THE STUDY: In this prospective study of 691 patients with cT1N0 subsolid lung cancer, no surgical plans were affected by positive bone scan findings.

What This Study Adds: We suggest physicians consider canceling BS from preoperative workup for cT1 subsolid lung cancer patients. Clinical trial registry number: NCT03689439.
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http://dx.doi.org/10.1111/1759-7714.13752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882389PMC
February 2021

Rational design of hierarchical FeSe encapsulated with bifunctional carbon cuboids as an advanced anode for sodium-ion batteries.

Nanoscale 2020 Nov;12(43):22210-22216

School of Electronic and Information Engineering, Jiangsu Laboratory of Advanced Functional Materials, Changshu Institute of Technology, Changshu 215500, China.

Earth-abundant transition-metal selenides (TMSs) have aroused great interest towards their application in sodium-ion batteries (SIBs). Herein, we present Fe-based Prussian blue analogs (PBA) modified by graphene oxide as precursors to synthesize FeSe2 nanoparticles within a nitrogen-doped carbon (NC) matrix and graphene layer (FeSe2/[email protected]). The bifunctional carbon wrapped FeSe2/[email protected] shows excellent sodium-storage performance with a large reversible capacity of 331 mA h g-1 at 5.0 A g-1 and a high cyclability of 323 mA h g-1 at the current density of 2.0 A g-1 after 1000 cycles (82% capacity retention). Furthermore, full SIBs are also fabricated and exhibit superior capacities and stabilities. The remarkable electrochemical properties result from the formation of an Fe-O-C chemical bond in the composite with enhanced electronic/ionic diffusion kinetics and structural integrity. This study paves the way for the successful synthesis of novel nanostructural TMSs which can be utilized in energy storage system application.
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http://dx.doi.org/10.1039/d0nr06359bDOI Listing
November 2020

Intravenously injected lidocaine or magnesium improves the quality of early recovery after laparoscopic cholecystectomy: A randomised controlled trial.

Eur J Anaesthesiol 2021 Mar;38(Suppl 1):S1-S8

From the The Yancheng Clinical College of Xuzhou Medical University, The First people's Hospital of Yancheng, Yancheng (JL, BQ), The Affiliated Hospital of Xuzhou Medical University (JL, QY, WC), Xuzhou Central Hospital (JFW) and the People's Hospital of Kizilsu Kirghiz Autonomous Prefecture, Xinjiang, PR China (CLG, WC).

Background: Previous data show that lidocaine or magnesium has unique characteristics of stress inhibition and antiinflammation.

Objective: We aimed to observe the effects of lidocaine or magnesium on the quality of recovery (QoR) after laparoscopic cholecystectomy.

Design: Single-centre, prospective, randomised, double-blind study.

Setting: The Affiliated Hospital of Xuzhou Medical University from March 2019 to October 2019.

Patients: One hundred and fourteen patients scheduled for laparoscopic cholecystectomy.

Intervention: The enrolled patients were randomly divided into three groups. Lidocaine (group L), magnesium sulphate (group M) or 0.9% saline (group C) was administered intravenously 10 min before induction.

Main Outcome Measures: The quality of recovery 15 (QoR-15) score, the Hospital Anxiety and Depression Scale (HADS), and the Numerical Rating Scale (NRS) score were selected. The usage of propofol and remifentanil, haemodynamic parameters, anaesthesia recovery parameters and adverse events were also evaluated.

Results: The QoR-15 scores for group L (132.0) and group M (134.0) were 6 and 8 points higher than that of group C (126.0) on POD1 (postoperative day 1) (adjP < 0.05). However, the decrease of QoR-15 in Group L is less than the minimal clinically important difference (8).The NRS scores on POD1 in group C 3, were higher than other two groups (adjP < 0.05). The dosage of remifentanil in group L was lower than other two groups (adjP < 0.05).The physical independence of group L and group M and physical comfort of group M were improved compared with group C.

Conclusion: The results show that magnesium sulphate improved the QoR through improving physical comfort and physical independence in patients after laparoscopic cholecystectomy. However, lidocaine had limited effects on QoR under current conditions.

Trial Registration: ChiCTR1800019092 (www.chictr.org.cn).

Clinical Trial Number And Registry Url: The study was registered in the Chinese Clinical Trials Register (ChiCTR1800019092) https://www.chictr.org.cn.
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http://dx.doi.org/10.1097/EJA.0000000000001348DOI Listing
March 2021

Ketamine Enhances Intranasal Dexmedetomidine-Induced Sedation in Children: A Randomized, Double-Blind Trial.

Drug Des Devel Ther 2020 26;14:3559-3565. Epub 2020 Aug 26.

Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, People's Republic of China.

Purpose: To compare the efficacy of intranasal dexmedetomidine and dexmedetomidine-ketamine premedication in preschool children undergoing tonsillectomy.

Patients And Methods: We enrolled 66 children with American Society of Anesthesiologists physical status I or II, aged 3-7 years undergoing tonsillectomy. Patients were randomly allocated to receive intranasal premedication with either dexmedetomidine 2 μg kg (Group D) or dexmedetomidine 2 μg kg and ketamine 2 mg kg (Group DK). The primary outcome was the sedation level assessed by the Modified Observer's Assessment of Alertness/Sedation Scale (MOAA/S) 30 min after intervention. The minimal clinically relevant difference in the MOAA/S score was 0.5. Secondary outcomes included sedation onset time, parental separation anxiety, acceptance of mask induction, emergence time, emergence delirium, postoperative pain intensity, length of stay in the post-anesthesia care unit (PACU), and adverse effects.

Results: At 30 min after premedication, the MOAA/S score was lower in Group DK than in Group D patients (median: 1.0, interquartile range [IQR]: 1.0-2.0 vs median: 3.0, IQR: 2.0-3.0; <0.001), with a median difference of 1.0 (95% confidence interval [CI]: 1.0-2.0, <0.001). Patients in Group DK showed considerably faster onset of sedation (15 min, 95% CI: 14.2-15.8 min) than Group D (24 min, 95% CI: 23.2-24.8 min), with a median difference of 8.0 min (95% CI: 7.0-9.0 min, <0.001). Both parental separation and facemask acceptance scores were lower in Group DK than in Group D patients (=0.012 and =0.001, respectively). There was no significant difference in emergence time, incidence of emergence delirium, postoperative pain scores, and length of stay in the PACU between the two groups.

Conclusion: Intranasal premedication with a combination of dexmedetomidine and ketamine produced better sedation for pediatric tonsillectomy than dexmedetomidine alone.
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http://dx.doi.org/10.2147/DDDT.S269765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457813PMC
July 2021

Anisotropic Transport and Quantum Oscillations in the Quasi-One-Dimensional TaNiTe: Evidence for the Nontrivial Band Topology.

J Phys Chem Lett 2020 Sep 2;11(18):7782-7789. Epub 2020 Sep 2.

Department of Applied Physics, Zhejiang University of Technology, Hangzhou 310023, China.

The past decade has witnessed the burgeoning discovery of a variety of topological states of matter with distinct nontrivial band topologies. Thus far, most materials that have been studied possess two-dimensional or three-dimensional electronic structures, with only a few exceptions that host quasi-one-dimensional (quasi-1D) topological electronic properties. Here we present clear-cut evidence for Dirac Fermions in the quasi-1D telluride TaNiTe. We show that its transport behaviors are highly anisotropic, and we observe nontrivial Berry phases via quantum oscillation measurements. The nontrivial band topology is further corroborated by first-principles calculations. Our results may help to guide the future quest for topological states in this new family of quasi-1D ternary chalcogenides.
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http://dx.doi.org/10.1021/acs.jpclett.0c02382DOI Listing
September 2020

MOF-derived ultrasmall CoSe nanoparticles encapsulated by an N-doped carbon matrix and their superior lithium/sodium storage properties.

Chem Commun (Camb) 2020 Aug 14;56(64):9218-9221. Epub 2020 Jul 14.

School of Electronic and Information Engineering, Changshu Institute of Technology, Changshu 215500, China.

Ultrasmall CoSe nanoparticles encapsulated by an N-doped carbon matrix were prepared by selenizing a novel Co-metal organic framework precursor. The excellent electrochemical performance may be due to the synergistic effect of the N-doped carbon matrix and the ultrasmall CoSe.
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http://dx.doi.org/10.1039/d0cc03113eDOI Listing
August 2020

Primary and Secondary Succession Mediate the Accumulation of Biogenic Amines during Industrial Semidry Chinese Rice Wine Fermentation.

Appl Environ Microbiol 2020 08 18;86(17). Epub 2020 Aug 18.

Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, People's Republic of China

The use of exogenous functional microorganisms to regulate biogenic amine (BA) content is a common approach in fermentation systems. Here, to better understand the microbial traits of succession trajectories in resource-based and biotic interference systems, the BA-related primary and secondary succession were tracked during industrial semidry Chinese rice wine (CRW) fermentation. Dominant abundance and BA-associated microbial functionality based on phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) indicated that , , , , and spp. prominently contributed to the decarboxylase gene family in CRW. The expression levels of tyrosine decarboxylase (), ornithine decarboxylase (), and agmatine deiminase () genes were assessed by quantitative PCR (qPCR). The transcription levels of these genes did not correlate with the BA formation rate during postfermentation, indicating that acidification and carbon source depletion upregulated the expression and microbes launch the dormancy strategy to respond to unfavorable conditions. Furthermore, microbial interference with CRW fermentation by (ACBC271) and (CGMCC1.8382) coinoculated at a ratio of 1:2 exhibited the best synergetic control of BA content. Spearman correlations revealed that and exhibited influence on BA-associated microbiota (|ρ| > 0), and were strongly suppressed by (ρ = -0.867 and ρ = -0.782, respectively;  < 0.05), and showed the strongest inhibitory effect toward (ρ = -0.115) and (ρ = -0.188) in the coinoculated 1:2 group. The high inhibitory effect of exogenous added strains on specific bacteria presented evidence for the obtained BA-associated contributors. Overall, this work provides important insight into the microbial traits that rely on resource usage and functional microbiota within food microbial ecology. Understanding the shifting patterns of substance usage and microbial interactions is a fundamental objective within microbiology and ecology. Analyses of primary and secondary microbial succession allow for determinations of taxonomic diversity, community traits, and functional transformations over time or after a disturbance. The kinetics of BA generation and the patterns of resource consumption, functional metagenome prediction, and microbial interactions were profiled to elucidate the equilibrium mechanism of microbial systems. Secondary succession after a disturbance triggers a change in resource usage, which in turn affects primary succession and metabolism. In this study, the functional potential of exogenous microorganisms under disturbance synergized with secondary succession strategies, including rebalancing and dormancy, which ultimately reduced BA accumulation. Thus, this succession system could facilitate the settling of essential issues with respect to microbial traits that rely on resource usage and microbial interactions that occur in natural ecosystems.
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http://dx.doi.org/10.1128/AEM.01177-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440807PMC
August 2020

Phosphatase-associated protein MoTip41 interacts with the phosphatase MoPpe1 to mediate crosstalk between TOR and cell wall integrity signalling during infection by the rice blast fungus Magnaporthe oryzae.

Environ Microbiol 2021 02 22;23(2):791-809. Epub 2020 Jul 22.

Department of Plant Pathology, College of Plant Protection, Nanjing Agricultural University, and Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing, China.

The type 2A (PP2A) and type 2A-like (PP4 and PP6) serine/threonine phosphatases participate in a variety of cellular processes, such as cell cycle progression, signal transduction and apoptosis. Previously, we reported that the PP6 catalytic subunit MoPpe1, which interacts with and is suppressed by type 2A associated protein of 42 kDa (MoTap42), an essential protein involved in the target of rapamycin (TOR) signalling pathway, has important roles in development, virulence and activation of the cell wall integrity (CWI) pathway in the rice blast fungus Magnaporthe oryzae. Here, we show that Tap42-interacting protein 41 (MoTip41) mediates crosstalk between the TOR and CWI signalling pathways; and participates in the TOR pathway via interaction with MoPpe1, but not MoTap42. The deletion of MoTIP41 resulted in disruption of CWI signalling, autophagy, vegetative growth, appressorium function and plant infection, as well as increased sensitivity to rapamycin. Further investigation revealed that MoTip41 modulates activation of the CWI pathway in response to infection by interfering with the interaction between MoTap42 and MoPpe1. These findings enhance our understanding of how crosstalk between TOR and CWI signalling modulates the development and pathogenicity of M. oryzae.
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http://dx.doi.org/10.1111/1462-2920.15136DOI Listing
February 2021

Radiotherapy Enhancement for Human Pancreatic Carcinoma Using a Peptide-Gold Nanoparticle Hybrid.

J Biomed Nanotechnol 2020 Mar;16(3):352-363

Pancreatic ductal adenocarcinoma (PDAC) is radioresistant. Due to their strong X-ray absorption capacity, gold nanoparticles (AuNPs) have been used as radiosensitizers for cancer therapeutics. Herein, we describe a novel conjugate complex consisting of a peptide for targeting plectin-1 (PTP) specifically expressed on the PDAC cell membrane and AuNPs, termed AuNP-PTP, to be used for PDAC radiotherapy and . Previous studies revealed that compared with unmodified AuNPs, AuNP-PTP along with relevant low-energy X-ray irradiation of 6 MV at a dose of 2 Gy (RF) increased the targeting efficiency and induced apoptosis in treated PANC-1 cells and tumours. Importantly, extensive histopathological examination did not reveal evidence of acute or chronic injury in mice due to AuNPs or AuNP-PTP for up to six weeks despite the presence of X-ray exposure. The delicate AuNP-PTP hybrid provides a novel strategy to enhance radiotherapy efficiency in PDAC treatment.
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http://dx.doi.org/10.1166/jbn.2020.2898DOI Listing
March 2020

N-Phonon Bundle Emission via the Stokes Process.

Phys Rev Lett 2020 Feb;124(5):053601

School of Physics, Huazhong University of Science and Technology, Wuhan, 430074, People's Republic of China.

We demonstrate theoretically the bundle emission of n strongly correlated phonons in an acoustic cavity QED system. The mechanism relies on Stokes resonances that generate super-Rabi oscillations between states with a large difference in their number of excitations, which, combined with dissipation, transfer coherently pure n-phonon states outside of the cavity. This process works with close to perfect purity over a wide range of parameters and is tunable optically with well-resolved operation conditions. This broadens the realm of quantum phononics, with potential applications for on-chip quantum information processing, quantum metrology, and engineering of new types of quantum devices, such as optically heralded n-phonon guns.
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http://dx.doi.org/10.1103/PhysRevLett.124.053601DOI Listing
February 2020

Pressure engineering of the Dirac fermions in quasi-one-dimensional TlMoSe.

J Phys Condens Matter 2020 May;32(21):215402

College of Electronic and Optical Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210023, People's Republic of China.

Topological band dispersions other than the standard Dirac or Weyl fermions have garnered the increasing interest in materials science. Among them, the cubic Dirac fermions were recently proposed in the family of quasi-one-dimensional (q-1D) conductors AMoX (A  =  Na, K, In, Tl; X  =  S, Se, Te), where the band crossing is characterized by a linear dispersion in one k-space direction but the cubic dispersion in the plane perpendicular to it. It is not yet clear, however, how the external perturbations can alter these nontrivial carriers and ultimately induce a new distinct quantum phase. Here we study the evolution of Dirac fermions, in particular the cubic Dirac crossing, under external pressure in the representative q-1D TlMoSe via the first-principles calculations. Specifically, it is found that the topological properties, including the bulk Dirac crossings and the topological surface states, change progressively under pressure up to 50 GPa where it undergoes a structural transition from the hexagonal phase to body-centered tetragonal phase. Above 50 GPa, the system is more likely to be topologically trivial. Further, we also investigate its phonon spectra, which reveals a gradual depletion of the negative phonon modes with pressure, consistent with the more three-dimensional Fermi surface in the high-pressure phase. Our work may provide a useful guideline for further experimental search and the band engineering of the topologically nontrivial fermions in this intriguing state of matter.
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http://dx.doi.org/10.1088/1361-648X/ab73a8DOI Listing
May 2020

Sevoflurane anesthesia-mediated oxidative stress and cognitive impairment in hippocampal neurons of old rats can be ameliorated by expression of brain derived neurotrophic factor.

Authors:
Zhe Xu Bin Qian

Neurosci Lett 2020 03 3;721:134785. Epub 2020 Feb 3.

Department of Anesthesia, Yancheng First Peoples' Hospital, Yancheng, Jiangsu, 224006, China. Electronic address:

Postoperative cognitive dysfunction in elderly patients has been related to neurodegenerative disorders and mortality. Sevoflurane anesthesia has been implicated in both postoperative cognitive dysfunction and neurotoxicity. Given the advantages of using inhaled anesthetics like sevoflurane, it is important to understand how their usage results in neurotoxicity and subsequently devise ways to circumvent or attenuate the anesthetic-mediated induction in neurotoxicity. We have used an aged rat model to investigate the molecular mechanisms by which sevoflurane inhalation results in neurotoxicity and whether modulation of these molecular mechanisms can inhibit or attenuate neurotoxicity and cognitive learning and memory impairment in these animals. Low- or high-dose of sevoflurane resulted in reactive oxygen species generation, increased NADPH oxidase protein expression, apoptosis and autophagy. Sevoflurane inhalation resulted in significant inhibition of brain derived neurotrophic factor (BDNF) and cognitive impairment. And the activation of PI3K/Akt/mTOR signaling pathways are attenuated in sevoflurane-mediated anesthesia. Adeno-associated virus (AAV)-mediated expression of Bdnf, but not controls EGFP, attenuated sevoflurane-induced oxidative stress and cognitive impairment in the rats. Our results highlight that AAV-mediated gene therapy might offer a potential therapeutic opportunity to treat post-operative cognitive impairment resulting from inhaled anesthetics.
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http://dx.doi.org/10.1016/j.neulet.2020.134785DOI Listing
March 2020

Results of low-dose computed tomography as a regular health examination among Chinese hospital employees.

J Thorac Cardiovasc Surg 2020 Sep 14;160(3):824-831.e4. Epub 2019 Nov 14.

Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Institute of Biomedical Sciences, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China. Electronic address:

Objective: Lung cancer is traditionally more prevalent in the elderly patients, men, and smokers. However, as low-dose computed tomography (LDCT) is increasingly popular, we hypothesized the disease spectrum might change.

Methods: LDCT was performed as a part of regular health examinations in 8392 of 15,686 employees from 6 hospitals in different regions of China in 2012 to 2018. Clinicopathologic characteristics, including age, sex, smoking status, radiologic features, tumor histology, and pathologic stage, were retrospectively analyzed.

Results: LDCT incidentally detected lung cancer (pathologically confirmed) in a total of 179 (2.1%) hospital employees. The lung cancer detection rate was significantly greater in female than male (2.5% vs 1.3%, P = .001) patients. There was also a greater detection rate among nonsmokers than smokers, although statistical significance was not reached (2.2% vs 1.4%, P = .092). The lung cancer detection rate was 1.0% in the "age ≤40 years" group, 2.6% in the "40 < age ≤55 years" group, and 2.9% in the "age >55 years" group (P < .001). Among the hospital employees with lung cancer, 171 (95.5%) presented as ground-glass opacity, 177 (98.9%) were lung adenocarcinoma, 170 (95.0%) were early stage 0/IA, and 177 (98.9%) received curative surgical resection as the initial treatment. After a median follow-up of 38 months, no disease recurrence or death was observed among these patients.

Conclusions: LDCT detected lung cancer in a significant proportion of young, female, and nonsmoking employees. The vast majority of these lung cancers were early stage, with extremely good prognosis.
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http://dx.doi.org/10.1016/j.jtcvs.2019.10.145DOI Listing
September 2020

Does [18F] fluorodeoxyglucose-positron emission tomography/computed tomography have a role in cervical nodal staging for esophageal squamous cell carcinoma?

J Thorac Cardiovasc Surg 2020 Aug 11;160(2):544-550. Epub 2019 Dec 11.

Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Objective: Accurate nodal staging is crucial for esophageal cancer. A prospective study was performed to assess the value of [18F] fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) for diagnosing cervical lymph node metastasis (LNM) of esophageal squamous cell carcinoma.

Methods: From June 2018 to November 2018, 110 patients with resectable esophageal cancer were prospectively enrolled. Esophagectomy with 3-field lymphadenectomy was performed after FDG-PET/CT scanning. The primary end point was cervical LNM determined via postoperative histologic examination. The sensitivity (SE), specificity (SP), positive predictive value (PPV), negative predictive value (NPV), and accuracy (AC) of FDG-PET/CT for the assessment of LNM were determined using histologic results as reference standards.

Results: Positive lymph nodes as determined via FDG-PET/CT were detected in 61 patients (55.5%), of whom 13 (11.8%) had positive cervical lymph nodes. After surgery, 59 patients (53.6%) exhibited pathologic LNM, of whom 20 (18.2%) had cervical LNM. SE, SP, PPV, NPV, and AC were 65.6%, 61.2%, 67.8%, 58.8%, and 63.6%, respectively, with regards to diagnosing overall LNM, and were 45.0%, 95.6%, 69.2%, 88.7%, and 86.4%, respectively, for diagnosing cervical LNM. Of the 110 patients, 90 underwent both FDG-PET/CT scanning and ultrasonography in the neck, and there were no significant differences in SE, SP, PPV, NPV, or AC with respect to cervical LNM diagnosis between FDG-PET/CT and ultrasonography.

Conclusions: For cervical LNM of esophageal squamous cell carcinoma, FDG-PET/CT scanning exhibited high specificity but low sensitivity, suggesting that it is of limited value for this purpose.
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http://dx.doi.org/10.1016/j.jtcvs.2019.11.046DOI Listing
August 2020

The Design and Synthesis of Fluorescent Coumarin Derivatives and Their Study for Cu Sensing with an Application for Aqueous Soil Extracts.

Molecules 2019 Oct 2;24(19). Epub 2019 Oct 2.

School of Engineering, RMIT University, GPO Box 2476, Melbourne, Victoria 3001, Australia.

A series of fluorescent coumarin derivatives - were systematically designed, synthesized and studied for their Cu sensing performance in aqueous media. The sensitivities and selectivities of the on-to-off fluorescent Cu sensing signal were in direct correlation with the relative arrangements of the heteroatoms within the coordinating moieties of these coumarins. Probes and exhibited Cu concentration dependent and selective fluorescence quenching, with linear ranges of 0-80 μM and 0-10 μM, and limits of detection of 0.14 μM and 0.38 μM, respectively. Structural changes of upon Cu coordination were followed by fluorescence titration, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), mass spectrometry, and single crystal X-ray diffraction on the isolated Cu-coumarin complex. The results revealed a 1:1 stoichiometry between and Cu, and that the essential structural features for Cu-selective coordination are the coumarin C=O and a three-bond distance between the amide NH and heterocyclic N. Probe was also used to determine copper (II) levels in aqueous soil extracts, with recovery rates over 80% when compared to the standard soil analysis method: inductively coupled plasma-mass spectrometry (ICP-MS).
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http://dx.doi.org/10.3390/molecules24193569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804054PMC
October 2019

Ultrafine Co O Nanoparticles within Nitrogen-Doped Carbon Matrix Derived from Metal-Organic Complex for Boosting Lithium Storage and Oxygen Evolution Reaction.

Small 2019 Nov 29;15(46):e1904260. Epub 2019 Sep 29.

National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230029, China.

Transition metal oxides have recently received great attention for application in advanced lithium-ion batteries (LIBs) and oxygen evolution reaction (OER). Herein, the ethylenediaminetetraacetic cobalt complex as a precursor to synthesize ultrafine Co O nanoparticles encapsulated into a nitrogen-doped carbon matrix (NC) composites is presented. The as-prepared Co O /NC-350 obtained by pyrolysis at 350 °C demonstrates superior rate performance (372 mAh g at 5.0 A g ) and high cycling stability (92% capacity retention after 300 cycles at 1.0 A g ) as anode for LIBs. When evaluated as an electrocatalyst for OER, the Co O /NC-350 achieves an overpotential of 298 mV at a current density of 10 mA cm . The NC-encapsualted porous hierarchical structure assures fast and continuous electron transportation, high activity sites, and strong structural integrity. This works offers novel complex precursors for synthesizing transition metal-based electrodes for boosting electrochemical energy conversion and storage.
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http://dx.doi.org/10.1002/smll.201904260DOI Listing
November 2019

In situ synthesis of ultrasmall MnO nanoparticles encapsulated by a nitrogen-doped carbon matrix for high-performance lithium-ion batteries.

Chem Commun (Camb) 2019 Jul;55(62):9184-9187

Department of Physics and Electronic Engineering, Jiangsu Laboratory of Advanced Functional Materials, Changshu Institute of Technology, Changshu 215500, China.

Herein, ultrasmall MnO nanoparticles encapsulated by nitrogen-rich doped carbon matrix hybrids are synthesized by annealing ethylenediaminetetraacetic manganese [Mn2(EDTA)] precursors for the first time. The resulting [email protected] composite exhibits excellent rate capability and outstanding cycling stability as an advanced anode material for lithium-ion batteries.
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http://dx.doi.org/10.1039/c9cc03617bDOI Listing
July 2019

Preoperative ultrasound-guided multilevel paravertebral blocks reduce the incidence of postmastectomy chronic pain: a double-blind, placebo-controlled randomized trial.

J Pain Res 2019 5;12:597-603. Epub 2019 Feb 5.

Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China,

Purpose: Chronic postsurgical pain is a challenging problem after breast cancer surgery. This prospective, randomized, double-blinded, parallel-group, placebo-controlled trial was conducted to evaluate the influence of preoperative ultrasound-guided multilevel paravertebral blocks (PVBs) on chronic pain following mastectomy.

Patients And Methods: One hundred eighty-four women were randomized to receive ultrasound-guided multilevel (T1-T5) PVBs with 5 mL of ropivacaine 0.5% or normal saline per level. The primary end point was the incidence of chronic pain at 3 months following mastectomy assessed by the brief pain inventory (BPI), while the secondary end points were the acute postoperative pain, the number of patients requiring rescue analgesia, postoperative nausea and vomiting (PONV), side effects, and chronic pain at 6 months after surgery assessed by the BPI.

Results: A total of 172 patients completed the study. Ultrasound-guided multilevel PVBs significantly decreased immediate postoperative pain for the first 12 hours (<0.001). Additionally, fewer patients in the PVB group required rescue analgesia in the first 48 hours post-operatively compared to the control group (5/86 vs 28/86, OR =0.128, 95% CI: 0.047-0.351, <0.001). No statistically significant difference was tested between the two groups (9.3% vs 17.4%, OR =0.419, 95% CI: 0.162-1.087, =0.068) in the incidence of PONV. At 3 months, the incidence of chronic pain (BPI average pain score ≥3) was 34.5% and 51.2% (OR =0.511, 95% CI: 0.277-0.944, =0.031) in the PVB and control groups, respectively, and at 6 months, the incidence was 22.1% and 37.2% (OR =0.479, 95% CI: 0.245-0.936, =0.03), respectively. No complications occurred during the study.

Conclusion: This study indicated that perioperative ultrasound-guided multilevel PVBs with ropivacaine improved acute postoperative pain and decreased postmastectomy chronic pain at 3 and 6 months postoperatively.
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http://dx.doi.org/10.2147/JPR.S190201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368114PMC
February 2019
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