Bernd Bohrmann

Bernd Bohrmann

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Bernd Bohrmann

Bernd Bohrmann

Publications by authors named "Bernd Bohrmann"

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Brain Shuttle Antibody for Alzheimer's Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode.

Cell Rep 2018 01;22(1):149-162

Pharma Research and Early Development (pRED), Neurodegeneration and Regeneration, Roche Innovation Center, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.019DOI Listing
January 2018

Reproductive and developmental toxicology studies with gantenerumab in PS2APP transgenic mice.

Reprod Toxicol 2017 10 25;73:362-371. Epub 2017 Jul 25.

Roche Pharmaceutical Research and Early Development, F. Hoffmann-La-Roche, Ltd., Basel, Switzerland.

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http://dx.doi.org/10.1016/j.reprotox.2017.07.014DOI Listing
October 2017

Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease.

J Pharmacol Exp Ther 2017 09 22;362(3):413-423. Epub 2017 Jun 22.

Roche Innovation Center Basel, Pharma Research and Early Development, F. Hoffmann-La Roche Ltd., Basel, Switzerland (E.B., B.B., F.G., E.P., S.N., H.L., J.M., A.P., and R.W.); Buck Institute for Research on Aging, Novato, California (S.C., S.R., A.R., A.S., and J.A.); and Evotec International GmbH, Hamburg, Germany (A.M.C. and B.E.).

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http://dx.doi.org/10.1124/jpet.117.241653DOI Listing
September 2017

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance.

EMBO Mol Med 2016 09 1;8(9):992-1004. Epub 2016 Sep 1.

Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany Munich Cluster for Systems Neurology (SyNergy), Munich, Germany German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany

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http://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201
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http://dx.doi.org/10.15252/emmm.201606370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009806PMC
September 2016

A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies.

Brain 2016 05 8;139(Pt 5):1587-604. Epub 2016 Mar 8.

Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1093/brain/aww036DOI Listing
May 2016

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.

Brain 2014 Oct 31;137(Pt 10):2834-46. Epub 2014 Jul 31.

1 Roche Pharmaceutical Research and Early Development, Neuroscience Ophthalmology and Rare Diseases Discovery & Translational Area, Roche Innovation Center Basel, Grenzacherstrasse 124, CH-4070 Basel, Switzerland

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http://dx.doi.org/10.1093/brain/awu213DOI Listing
October 2014

Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.

Neuron 2014 Jan;81(1):49-60

Pharma Research and Early Development, Neuroscience Discovery and Translation Area, F. Hoffmann-La Roche, Basel 4070, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2013.10.061DOI Listing
January 2014

Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab.

Arch Neurol 2012 Feb 10;69(2):198-207. Epub 2011 Oct 10.

F. Hoffmann-La Roche Ltd, Neuroscience, Grenzacherstrasse 124, CH-4070 Basel, Switzerland.

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http://dx.doi.org/10.1001/archneurol.2011.1538DOI Listing
February 2012

Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422.

Mol Cell Biochem 2011 Nov 3;357(1-2):199-207. Epub 2011 Jun 3.

CNS Discovery and Translation Pharma Research and Exploratory Development, F. Hoffmann-La Roche AG, Basel, Switzerland.

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http://dx.doi.org/10.1007/s11010-011-0890-6DOI Listing
November 2011

Altered distribution of mGlu2 receptors in β-amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice.

Brain Res 2010 Dec 25;1363:180-90. Epub 2010 Sep 25.

Preclinical Neuroscience Research, F Hoffmann-La Roche Ltd, 4070 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.brainres.2010.09.072DOI Listing
December 2010

Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.

Neurobiol Dis 2010 Feb 23;37(2):294-306. Epub 2009 Sep 23.

F. Hoffmann-La-Roche Ltd, Pharmaceutical Research Neuroscience, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.nbd.2009.09.004DOI Listing
February 2010

Thermodynamic studies on the interaction of antibodies with beta-amyloid peptide.

J Phys Chem B 2007 Feb;111(5):1238-43

Department PRBD, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland, and Department of Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.

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http://dx.doi.org/10.1021/jp0664059DOI Listing
February 2007

Acute renal effects of intravenous bisphosphonates in the rat.

Basic Clin Pharmacol Toxicol 2005 Dec;97(6):374-81

Preclinical Research and Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland.

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http://dx.doi.org/10.1111/j.1742-7843.2005.pto_160.xDOI Listing
December 2005

3D structure of Alzheimer's amyloid-beta(1-42) fibrils.

Proc Natl Acad Sci U S A 2005 Nov 17;102(48):17342-7. Epub 2005 Nov 17.

The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0506723102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297669PMC
November 2005

Quantification of the A beta peptide in Alzheimer's plaques by laser dissection microscopy combined with mass spectrometry.

J Mass Spectrom 2005 Feb;40(2):193-201

Pharma Research Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland.

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http://dx.doi.org/10.1002/jms.739DOI Listing
February 2005