Publications by authors named "Aysenur Elmali"

8 Publications

  • Page 1 of 1

In Regard to Helm et al.

Int J Radiat Oncol Biol Phys 2021 Apr;109(5):1658

Hacettepe University Faculty of Medicine, Department of Radiation Oncology, Ankara, Turkey.

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http://dx.doi.org/10.1016/j.ijrobp.2020.12.017DOI Listing
April 2021

Parotid gland stem cells: Mini yet mighty.

Head Neck 2021 Apr 27;43(4):1122-1127. Epub 2020 Nov 27.

Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Background: Our aim was to evaluate the correlation between the radiation doses to parotid gland (PG) stem cells and xerostomia.

Methods: Patients diagnosed with head and neck cancer (HNC) were retrospectively evaluated, and xerostomia inventory (XI) was applied to these patients. PG stem cells were delineated on the treatment planning CT, and the mean doses to the PG stem cells calculated.

Results: The total test score and mean doses to bilateral PGs were significantly correlated (r = .34, P = .001), and the mean doses to bilateral PG stem cell niches were significantly correlated with the total test score (r = .32, P = .002).

Conclusions: In this study, we found that the mean dose to PG stem cells can predict dry mouth as much as the mean dose to the PG.
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http://dx.doi.org/10.1002/hed.26556DOI Listing
April 2021

In Regard to Aksnessætheret al.

Int J Radiat Oncol Biol Phys 2020 06 26;107(2):387-388. Epub 2020 Feb 26.

Department of Radiation Oncology, Hacettepe University Medical School, Ankara, Turkey.

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http://dx.doi.org/10.1016/j.ijrobp.2020.02.028DOI Listing
June 2020

Comments on "Prognostic factors for survival in patients with metastatic malign melanoma treated with ipilimumab: Turkish Oncology Group study".

J Oncol Pharm Pract 2019 12 21;25(8):2060-2062. Epub 2019 Jun 21.

Faculty of Medicine, Department of Radiation Oncology, Hacettepe University, Ankara, Turkey.

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http://dx.doi.org/10.1177/1078155219858177DOI Listing
December 2019

Abscopal Effect, From Myth to Reality: From Radiation Oncologists' Perspective.

Cureus 2019 Jan 9;11(1):e3860. Epub 2019 Jan 9.

Radiation Oncology, Hacettepe University Medical School, Ankara, TUR.

The abscopal effect is mediated by a systemic anti-tumor immune response and reflects the regression of non-irradiated metastatic lesions at a distance from the primary site of irradiation. This review will focus on understanding the biological rationale behind the abscopal effect of radiotherapy (RT), which has a recently renewed interest as a result of the successes achieved with immunotherapy and RT in combination. Both RT and immunotherapy are standard components of modern treatment regimens. Combination of these two modalities results in an increased response in the irradiated lesions themselves and the metastatic regions distant from the site of irradiation. We will summarize the abscopal effect of radiotherapy, in particular, the synergistic effect of RT and immunotherapy.
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http://dx.doi.org/10.7759/cureus.3860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414182PMC
January 2019

The Synergistic Effect of Immune Checkpoint Blockade and Radiotherapy in Recurrent/Metastatic Sinonasal Cancer.

Cureus 2018 Oct 29;10(10):e3519. Epub 2018 Oct 29.

Radiation Oncology, Hacettepe University Medical School, Ankara, TUR.

Treatment options for recurrent/metastatic sinonasal cancer (RMSNC) patients are limited. We present two cases with RMSNC treated with a combination of immune checkpoint blockade and hypo-fractionated stereotactic radiotherapy (HSRT).  Case 1 presented with RMSNC three months after the primary treatment. The patient progressed under first-line chemotherapy and pembrolizumab was offered. The disease progressed after the sixth cycle. We performed reirradiation with HSRT to the primary site. Case 2 presented with local recurrence eight years after the primary treatment for maxillary sinus cancer. He refused surgery and chemotherapy and was offered nivolumab treatment. After two doses, we performed reirradiation with HSRT. Case 1 showed regression at both the local and the metastatic sites after radiotherapy. The second patient's symptoms resolved completely three months after radiotherapy. The HSRT and immune checkpoint blockade combination is a promising treatment option for patients with RMSNC.
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http://dx.doi.org/10.7759/cureus.3519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318133PMC
October 2018

Comments on "High lymphocyte count during neoadjuvant chemoradiotherapy is associated with improved pathologic complete response in esophageal cancer".

Radiother Oncol 2019 02 17;131:239. Epub 2018 Oct 17.

Hacettepe University, Faculty of Medicine, Department of Radiation Oncology, Ankara, Turkey.

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http://dx.doi.org/10.1016/j.radonc.2018.10.001DOI Listing
February 2019