Dr. Arati Sharma, MDS  - BP Koirala  Institute  of  Health  Sciences

Dr. Arati Sharma

MDS

BP Koirala Institute of Health Sciences

Dharan | Nepal

Main Specialties: Dentistry

Additional Specialties: MDS (PROSTHODONTICS )

ORCID logohttps://orcid.org/0000-0002-8530-5975

Dr. Arati Sharma, MDS  - BP Koirala  Institute  of  Health  Sciences

Dr. Arati Sharma

MDS

Introduction

Primary Affiliation: BP Koirala Institute of Health Sciences - Dharan , Nepal

Specialties:

Additional Specialties:

Education

Feb 2015
BPKIHS
MDS
Prosthodontics

Experience

Feb 2015
BPKIHS
Assistant Professor
Prosthodontics

Publications

41Publications

783Reads

273Profile Views

3PubMed Central Citations

Identification of WEE1 as a target to make AKT inhibition more effective in melanoma.

Cancer Biol Ther 2018 01 30;19(1):53-62. Epub 2017 Nov 30.

a The Pennsylvania State University College of Medicine , Department of Pharmacology , Hershey , PA.

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http://dx.doi.org/10.1080/15384047.2017.1360446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790369PMC
January 2018
12 Reads
3 Citations
3.072 Impact Factor

Cost-effectiveness of pazopanib versus sunitinib for metastatic renal cell carcinoma in the United Kingdom.

PLoS One 2017 21;12(6):e0175920. Epub 2017 Jun 21.

Research, Policy Analysis Inc. (PAI), Brookline, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175920PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479501PMC
October 2017
36 Reads
3.234 Impact Factor

Improving pharmacological targeting of AKT in melanoma.

Cancer Lett 2017 09 11;404:29-36. Epub 2017 Jul 11.

Department of Pharmacology, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA; Department of Pathology, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA; Department of Dermatology, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA; Department of Surgery, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA; The Melanoma Center, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.07.001DOI Listing
September 2017
19 Reads
5.621 Impact Factor

Electrochemical immunosensor based on poly (3,4-ethylenedioxythiophene) modified with gold nanoparticle to detect aflatoxin B.

Mater Sci Eng C Mater Biol Appl 2017 Jul 18;76:802-809. Epub 2017 Mar 18.

Analytical Chemistry Division, CSIR-North East Institute of Science & Technology, Academy of Scientific and Innovative Research, Jorhat 785006, Assam, India. Electronic address:

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http://dx.doi.org/10.1016/j.msec.2017.03.146DOI Listing
July 2017
19 Reads
3.090 Impact Factor

Nanoparticle-Based Celecoxib and Plumbagin for the Synergistic Treatment of Melanoma.

Mol Cancer Ther 2017 03 21;16(3):440-452. Epub 2016 Dec 21.

Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821064PMC
March 2017
33 Reads
5.683 Impact Factor

Synergistic inhibitory effects of Celecoxib and Plumbagin on melanoma tumor growth.

Cancer Lett 2017 01 18;385:243-250. Epub 2016 Oct 18.

Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United states; Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United states; Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United states; Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United states; The Penn State Melanoma Center, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United states; Penn State Melanoma Therapeutics Program, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United states; Foreman Foundation for Melanoma Research, The Pennsylvania State University College of Medicine, Hershey, PA 17033, United states. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.10.016DOI Listing
January 2017
9 Reads
5.621 Impact Factor

Current State of Animal (Mouse) Modeling in Melanoma Research.

Cancer Growth Metastasis 2015 6;8(Suppl 1):81-94. Epub 2015 Oct 6.

Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.4137/CGM.S21214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597587PMC
October 2015
14 Reads

Fabrication of Closed Hollow Bulb Obturator Using Thermoplastic Resin Material.

Case Rep Dent 2015 27;2015:504561. Epub 2015 Sep 27.

Department of Prosthodontics & Crown and Bridge, College of Dental Surgery, BPKIHS, Dharan, Nepal.

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http://dx.doi.org/10.1155/2015/504561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600497PMC
October 2015
13 Reads

Nanolipolee-007, a novel nanoparticle-based drug containing leelamine for the treatment of melanoma.

Mol Cancer Ther 2014 Oct 31;13(10):2328-40. Epub 2014 Jul 31.

Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania. The Penn State Melanoma Center, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Penn State Melanoma Therapeutics Program, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Foreman Foundation for Melanoma Research, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Department of Pathology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377120PMC
October 2014
8 Reads
5.683 Impact Factor

Targeting multiple key signaling pathways in melanoma using leelamine.

Mol Cancer Ther 2014 Jul 31;13(7):1679-89. Epub 2014 Mar 31.

Authors' Affiliations: Departments of Pharmacology, Pathology, Dermatology, and Surgery, Penn State Hershey Melanoma Center, Penn State Melanoma Therapeutics Program, The Foreman Foundation for Melanoma Research, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377161PMC
July 2014
12 Reads
5.683 Impact Factor

Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport.

Mol Cancer Ther 2014 Jul 31;13(7):1690-703. Epub 2014 Mar 31.

Authors' Affiliations: Departments of Pharmacology, Pathology, Dermatology, and Surgery; Penn State Hershey Melanoma Center; Penn State Melanoma Therapeutics Program; and The Foreman Foundation for Melanoma Research, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373557PMC
July 2014
7 Reads
5.683 Impact Factor

Identification of glycogen synthase kinase 3α as a therapeutic target in melanoma.

Pigment Cell Melanoma Res 2013 Nov 19;26(6):886-99. Epub 2013 Sep 19.

Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA, USA; Penn State Melanoma Center, The Pennsylvania State University College of Medicine, Hershey, PA, USA; Penn State Melanoma Therapeutics Program, The Pennsylvania State University College of Medicine, Hershey, PA, USA.

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http://dx.doi.org/10.1111/pcmr.12156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010947PMC
November 2013
11 Reads
4.620 Impact Factor

Intravenous delivery of siRNA targeting CD47 effectively inhibits melanoma tumor growth and lung metastasis.

Mol Ther 2013 Oct 18;21(10):1919-29. Epub 2013 Jun 18.

Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1038/mt.2013.135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808133PMC
October 2013
22 Reads
6.230 Impact Factor

Identification of aurora kinase B and Wee1-like protein kinase as downstream targets of (V600E)B-RAF in melanoma.

Am J Pathol 2013 Apr 12;182(4):1151-62. Epub 2013 Feb 12.

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1016/j.ajpath.2012.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620396PMC
April 2013
10 Reads
4.591 Impact Factor

Realizing the clinical potential of cancer nanotechnology by minimizing toxicologic and targeted delivery concerns.

Cancer Res 2012 Nov 8;72(22):5663-8. Epub 2012 Nov 8.

Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616627PMC
November 2012
8 Reads
9.330 Impact Factor

Toxicological considerations when creating nanoparticle-based drugs and drug delivery systems.

Expert Opin Drug Metab Toxicol 2012 Jan 19;8(1):47-69. Epub 2011 Nov 19.

The Pennsylvania State University College of Medicine, Department of Pharmacology, R130, 500 University Drive, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1517/17425255.2012.637916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245366PMC
January 2012
9 Reads
2.831 Impact Factor

eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206.

Cancer Res 2011 Apr 9;71(7):2654-63. Epub 2011 Feb 9.

Department of Pharmacology and The Penn State Hershey Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210447PMC
April 2011
11 Reads
9.330 Impact Factor

Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4.

Cancer Prev Res (Phila) 2011 Feb 19;4(2):248-58. Epub 2010 Nov 19.

Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210697PMC
February 2011
9 Reads

Propagation of undifferentiated human embryonic stem cells with nano-liposomal ceramide.

Stem Cells Dev 2009 Jan-Feb;18(1):55-65

Department of Pharmacology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033-0850, USA.

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http://dx.doi.org/10.1089/scd.2007.0271DOI Listing
October 2010
8 Reads
3.730 Impact Factor

Robust activation of the human but not mouse telomerase gene during the induction of pluripotency.

FASEB J 2010 Aug 30;24(8):2702-15. Epub 2010 Mar 30.

Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1096/fj.09-148973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909285PMC
August 2010
27 Reads
5.043 Impact Factor

Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development.

Cancer Res 2010 Jul 7;70(14):6071-82. Epub 2010 Jul 7.

Departments of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905495PMC
July 2010
10 Reads
9.330 Impact Factor

Macrophage inhibitory cytokine-1 regulates melanoma vascular development.

Am J Pathol 2010 Jun 29;176(6):2948-57. Epub 2010 Apr 29.

The Pennsylvania State College of Medicine, Department of Pharmacology, Hershey, PA 17033, USA.

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http://dx.doi.org/10.2353/ajpath.2010.090963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877855PMC
June 2010
7 Reads
4.591 Impact Factor

Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer.

Bioorg Med Chem Lett 2010 Mar 22;20(6):2038-43. Epub 2009 Sep 22.

Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.09.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892985PMC
March 2010
14 Reads
2.420 Impact Factor

Targeting Akt3 signaling in malignant melanoma using isoselenocyanates.

Clin Cancer Res 2009 Mar 10;15(5):1674-85. Epub 2009 Feb 10.

Department of Pharmacology, The Foreman Foundation for Melanoma Research, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766355PMC
March 2009
10 Reads
8.722 Impact Factor

Synthesis and anticancer activity comparison of phenylalkyl isoselenocyanates with corresponding naturally occurring and synthetic isothiocyanates.

J Med Chem 2008 Dec;51(24):7820-6

Department of Pharmacology, Penn State Hershey College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1021/jm800993rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629797PMC
December 2008
10 Reads
5.450 Impact Factor

Targeting V600EB-Raf and Akt3 using nanoliposomal-small interfering RNA inhibits cutaneous melanocytic lesion development.

Cancer Res 2008 Sep;68(18):7638-49

Department of Pharmacology, The Pennsylvania State University, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628540PMC
September 2008
23 Reads
9.330 Impact Factor

Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.

Cancer Res 2008 May;68(9):3429-39

Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603082PMC
May 2008
7 Reads
9.330 Impact Factor

PBISe, a novel selenium-containing drug for the treatment of malignant melanoma.

Mol Cancer Ther 2008 May;7(5):1297-308

Department of Pharmacology, The Pennsylvania State University College of Medicine, 500 University Drive, R130, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-2267DOI Listing
May 2008
6 Reads
5.683 Impact Factor

Models of melanoma metastasis: using a transient siRNA-based protein inhibition strategy in mice to validate the functional relevance of pharmacological agents.

Curr Protoc Pharmacol 2007 Sep;Chapter 14:Unit 14.6

The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania, USA.

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http://dx.doi.org/10.1002/0471141755.ph1406s38DOI Listing
September 2007
9 Reads

Targeting mutant (V600E) B-Raf in melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation.

Cancer Res 2007 Jun;67(12):5814-20

Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724629PMC
June 2007
10 Reads
9.330 Impact Factor

PRAS40 deregulates apoptosis in malignant melanoma.

Cancer Res 2007 Apr;67(8):3626-36

Department of Pharmacology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4234DOI Listing
April 2007
7 Reads
9.330 Impact Factor

Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma.

Clin Cancer Res 2005 May;11(9):3465-74

Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-1770DOI Listing
May 2005
8 Reads
8.722 Impact Factor

Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.

Cancer Res 2005 Mar;65(6):2412-21

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey 17033, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2423DOI Listing
March 2005
8 Reads
9.330 Impact Factor

Deregulated Akt3 activity promotes development of malignant melanoma.

Cancer Res 2004 Oct;64(19):7002-10

Department of Pharmacology, The Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-1399DOI Listing
October 2004
7 Reads
9.330 Impact Factor

Loss of PTEN promotes tumor development in malignant melanoma.

Cancer Res 2003 Jun;63(11):2881-90

Department of Pharmacology, The Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA.

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June 2003
10 Reads
9.330 Impact Factor

Top co-authors

Gavin P Robertson
Gavin P Robertson

The Pennsylvania State University College of Medicine

33
Subbarao V Madhunapantula
Subbarao V Madhunapantula

Pennsylvania State University College of Medicine

11
Raghavendra Gowda
Raghavendra Gowda

The Pennsylvania State University College of Medicine

10
Shantu Amin
Shantu Amin

Penn State College of Medicine

8
Mark Kester
Mark Kester

Penn State College of Medicine

7
Dhimant Desai
Dhimant Desai

Penn State College of Medicine

7
Omer F Kuzu
Omer F Kuzu

Penn State College of Medicine

6
Sung Jin Huh
Sung Jin Huh

The Pennsylvania State University College of Medicine

6
Mitchell Cheung
Mitchell Cheung

The Pennsylvania State College of Medicine

4
Cheng Dong
Cheng Dong

University Park

3