Antonio Iavarone

Antonio Iavarone

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Antonio Iavarone

Antonio Iavarone

Publications by authors named "Antonio Iavarone"

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66Publications

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Hypermutagenesis in untreated adult gliomas due to inherited mismatch mutations.

Int J Cancer 2019 Jun 7;144(12):3023-3030. Epub 2019 Jan 7.

Institute for Refractory Cancer Research, Samsung Medical Center, Seoul, Republic of Korea.

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http://dx.doi.org/10.1002/ijc.32054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590456PMC
June 2019

Diffuse gliomas with FGFR3-TACC3 fusion have characteristic histopathological and molecular features.

Brain Pathol 2018 09 21;28(5):674-683. Epub 2017 Nov 21.

AP-HP, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Service de Neuropathologie Raymond Escourolle, Paris, France.

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http://dx.doi.org/10.1111/bpa.12563DOI Listing
September 2018

Conditional deletion of Id2 or Notch1 in oligodendrocyte progenitor cells does not ameliorate disease outcome in SOD1 mice.

Neurobiol Aging 2018 08 3;68:1-4. Epub 2018 Apr 3.

Department of Neurosciences, KU Leuven-University of Leuven, Experimental Neurology, Leuven, Belgium; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium; Department of Neurology, University Hospitals Leuven, Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183011
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998381PMC
August 2018

A new method of identifying glioblastoma subtypes and creation of corresponding animal models.

Oncogene 2018 08 17;37(35):4781-4791. Epub 2018 May 17.

Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, 650223, Kunming, Yunnan, China.

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http://dx.doi.org/10.1038/s41388-018-0305-1DOI Listing
August 2018

An anatomic transcriptional atlas of human glioblastoma.

Science 2018 05;360(6389):660-663

Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA 98122, USA.

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http://dx.doi.org/10.1126/science.aaf2666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414061PMC
May 2018

Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response.

Endocrinology 2017 11;158(11):4000-4016

Department of Medicine, McGill University and McGill University Health Centre Research Institute, Montreal, Quebec H4A 3J1, Canada.

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http://dx.doi.org/10.1210/en.2017-00396DOI Listing
November 2017

Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3- Cascade.

Cancer Res 2017 09 7;77(18):4773-4784. Epub 2017 Jul 7.

Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2597DOI Listing
September 2017

FGFR-TACC gene fusions in human glioma.

Neuro Oncol 2017 04;19(4):475-483

Institute for Cancer Genetics, Department of Neurology and Pathology, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1093/neuonc/now240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464372PMC
April 2017

A tree shrew glioblastoma model recapitulates features of human glioblastoma.

Oncotarget 2017 Mar;8(11):17897-17907

Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China.

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http://dx.doi.org/10.18632/oncotarget.15225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392295PMC
March 2017

Detection of statistically significant network changes in complex biological networks.

BMC Syst Biol 2017 03 4;11(1):32. Epub 2017 Mar 4.

QCRI - Qatar Computing Research Institute, HBKU, Doha, Qatar.

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http://dx.doi.org/10.1186/s12918-017-0412-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336651PMC
March 2017

CNS Anticancer Drug Discovery and Development Conference White Paper.

Neuro Oncol 2015 Nov;17 Suppl 6:vi1-26

Kaiser Permanente, Redwood City, California, USA (V.A.L.); University of Texas MD Anderson Cancer Center, Houston, TX, USA (V.A.L.); University of California, San Francisco, CA, USA (V.A.L.); SUNY Stony Brook University, Stony Brook, NY, USA (P.J.T.); Icahn School of Medicine at Mount Sinai, New York, NY, USA (J.M.G., M.R.B., A.C.D.); Columbia University Institute for Cancer Genetics, New York, NY, USA (A.I.); Fred Hutchinson Cancer Research Center, Seattle, WA, USA (P.J.P.); Genentech, Inc., South San Francisco, CA, USA (T.P.H.); University of Minnesota School of Pharmacy, Minneapolis, MN, USA (W.F.E.); Angiochem, Inc., Montreal, Quebec, Canada (J.E.L.); Pfizer Oncology, San Diego, CA, USA (T.W.J.); Massachusetts Institute of Technology, Cambridge, MA, USA (F.M.W.); US Food and Drug Administration, Silver Spring, MD, USA (J.S.); Texas Tech University School of Pharmacy, Amarillo, TX, USA (Q.R.S., R.S.); NewGen Therapeutics, Inc., Menlo Park, CA, USA (W.S.); Mayo Clinic, Rochester, MN, USA (J.N.S.); Dana-Farber Cancer Institute, Boston, MA, USA (P.Y.W.); University of Texas MD Anderson Cancer Center, Houston, TX, USA (D.A.B.); Celgene Avilomics Research, Bedford, MA, USA (R.C.P.).

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http://dx.doi.org/10.1093/neuonc/nov169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581696PMC
November 2015

VEGAWES: variational segmentation on whole exome sequencing for copy number detection.

BMC Bioinformatics 2015 Sep 29;16:315. Epub 2015 Sep 29.

Computational Sciences and Engineering, Qatar Computing Research Institute, Doha, P. O. Box 5825, Qatar.

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http://dx.doi.org/10.1186/s12859-015-0748-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587906PMC
September 2015

An information theoretic method to identify combinations of genomic alterations that promote glioblastoma.

J Mol Cell Biol 2015 Jun 4;7(3):203-13. Epub 2015 May 4.

Department of Systems Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA Department of Biomedical Informatics, Columbia University College of Physicians and Surgeons, New York, NY, USA

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https://academic.oup.com/jmcb/article-lookup/doi/10.1093/jmc
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http://dx.doi.org/10.1093/jmcb/mjv026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565985PMC
June 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Myc and differentiation: going against the current.

EMBO Rep 2014 Apr 10;15(4):324-5. Epub 2014 Mar 10.

Departments of Neurology and Pathology & Cell Biology, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1002/embr.201438509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989660PMC
April 2014

The ID proteins: master regulators of cancer stem cells and tumour aggressiveness.

Nat Rev Cancer 2014 Feb 20;14(2):77-91. Epub 2014 Jan 20.

Institute for Cancer Genetics, Department of Pathology and Neurology, Columbia University Medical Center, 1130 St. Nicholas Avenue, New York, 10032 New York, USA.

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http://dx.doi.org/10.1038/nrc3638DOI Listing
February 2014

Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.

Nat Rev Cancer 2014 Feb;14(2):92-107

1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany. [2] Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nrc3655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003223PMC
February 2014

RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation.

Cancer Res 2013 Aug 17;73(16):5140-50. Epub 2013 Jun 17.

Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1168-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805507PMC
August 2013

Id proteins synchronize stemness and anchorage to the niche of neural stem cells.

Nat Cell Biol 2012 Apr 22;14(5):477-87. Epub 2012 Apr 22.

Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/ncb2490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635493PMC
April 2012

E protein transcription factors are required for the development of CD4(+) lineage T cells.

Immunity 2012 Mar 15;36(3):348-61. Epub 2012 Mar 15.

Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.immuni.2012.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431168PMC
March 2012

Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F.

Cancer Res 2010 May 13;70(9):3823-32. Epub 2010 Apr 13.

Department of Surgery, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862101PMC
May 2010

Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum.

Proc Natl Acad Sci U S A 2010 Mar 15;107(13):5875-80. Epub 2010 Mar 15.

Department of Pathology, Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0912874107
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http://dx.doi.org/10.1073/pnas.0912874107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851916PMC
March 2010

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.

Nature 2008 Mar;452(7185):365-9

Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, New York 10016, USA.

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http://www.nature.com/articles/nature06641
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http://dx.doi.org/10.1038/nature06641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707768PMC
March 2008

ID proteins as targets in cancer and tools in neurobiology.

Trends Mol Med 2006 Dec 30;12(12):588-94. Epub 2006 Oct 30.

Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S147149140600243
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http://dx.doi.org/10.1016/j.molmed.2006.10.007DOI Listing
December 2006

Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth.

Nature 2006 Jul 28;442(7101):471-4. Epub 2006 Jun 28.

Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/nature04895DOI Listing
July 2006

E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells.

Mol Cell Biol 2006 Jun;26(11):4351-61

Institute for Cancer Genetics, 1150 St. Nicholas Ave., Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1128/MCB.01743-05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1489106PMC
June 2006

The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system.

Proc Natl Acad Sci U S A 2006 Mar 20;103(13):4976-81. Epub 2006 Mar 20.

Institute for Cancer Genetics, Department of Pathology, Pediatrics, and Neurology, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.0600168103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458780PMC
March 2006

Id family of helix-loop-helix proteins in cancer.

Nat Rev Cancer 2005 08;5(8):603-14

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue Box 241, New York 10021, USA.

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http://www.nature.com/articles/nrc1673
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http://dx.doi.org/10.1038/nrc1673DOI Listing
August 2005

Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice.

Mol Cell Biol 2005 May;25(9):3563-74

Institute for Cancer Genetics, Columbia University, 1150 St. Nicholas Avenue, New York, NY 10032, USA.

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http://dx.doi.org/10.1128/MCB.25.9.3563-3574.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1084294PMC
May 2005

Xenopus Id3 is required downstream of Myc for the formation of multipotent neural crest progenitor cells.

Development 2005 Apr 16;132(8):1831-41. Epub 2005 Mar 16.

Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.

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http://dx.doi.org/10.1242/dev.01734DOI Listing
April 2005

Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages.

Nature 2004 Dec;432(7020):1040-5

Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA.

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http://www.nature.com/articles/nature03068
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http://dx.doi.org/10.1038/nature03068DOI Listing
December 2004

Id2 drives differentiation and suppresses tumor formation in the intestinal epithelium.

Cancer Res 2004 Oct;64(20):7220-5

Lombardi Cancer Center, Department of Oncology, Georgetown University, Washington, D. C., USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2095DOI Listing
October 2004

Id proteins in neural cancer.

Cancer Lett 2004 Feb;204(2):189-96

Department of Pathology, Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, 10032 New York, USA.

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http://dx.doi.org/10.1016/S0304-3835(03)00455-5DOI Listing
February 2004

Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma.

Cancer Res 2002 Jan;62(1):301-6

Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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January 2002