Publications by authors named "Annarita Fiorillo"

38 Publications

Structural basis of ubiquitination mediated by protein splicing in early Eukarya.

Biochim Biophys Acta Gen Subj 2021 May 11;1865(5):129844. Epub 2021 Jan 11.

Institute of Molecular Biology and Pathology of The National Research Council of Italy (CNR), P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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May 2021

Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases.

Molecules 2020 Apr 21;25(8). Epub 2020 Apr 21.

Department of Biochemical Sciences, Sapienza University, P. le A. Moro 5, 00185 Rome, Italy.

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April 2020

Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome.

Biochim Biophys Acta Gen Subj 2020 08 17;1864(8):129618. Epub 2020 Apr 17.

Department of Chemistry - BMC, Uppsala University, Husargatan 3, 751 23 Uppsala, Sweden.

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August 2020

Roles of Sorcin in Drug Resistance in Cancer: One Protein, Many Mechanisms, for a Novel Potential Anticancer Drug Target.

Cancers (Basel) 2020 Apr 6;12(4). Epub 2020 Apr 6.

Institute of Molecular Biology and Pathology, Italian National Research Council, Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche (IBPM-CNR), c/o Department of Biochemical Sciences, Sapienza University, P.le A.Moro 5, 00185 Rome, Italy.

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April 2020

The protein 14-3-3: A functionally versatile molecule in Giardia duodenalis.

Adv Parasitol 2019 3;106:51-103. Epub 2019 Sep 3.

Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, Rome, Italy.

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January 2020

Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening.

PLoS Negl Trop Dis 2018 11 26;12(11):e0006969. Epub 2018 Nov 26.

Istituto di Biologia e Patologia Molecolari-CNR, and Dipartimento di Scienze Biochimiche, "Sapienza" Università di Roma P.le A. Moro, Roma, Italy.

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November 2018

Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors.

Mol Pharm 2018 08 27;15(8):3069-3078. Epub 2018 Jun 27.

Institute of Molecular Biology and Pathology, Italian National Research Council (IBPM CNR), Department of Biochemical Sciences , Sapienza University , P.le A. Moro 5 , 00185 Rome , Italy.

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August 2018

Study of manganese binding to the ferroxidase centre of human H-type ferritin.

J Inorg Biochem 2018 05 9;182:103-112. Epub 2018 Feb 9.

INSTM, Department of Physics and Astronomy, University of Florence, Via Sansone 1, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

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May 2018

Metal- and metalloid-containing drugs for the treatment of trypanosomatid diseases.

Front Biosci (Landmark Ed) 2018 Jan 1;23:954-966. Epub 2018 Jan 1.

CNR-Institute of Molecular Biology and Pathology, c/o Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185 Roma, Italy,

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January 2018

Binding of doxorubicin to Sorcin impairs cell death and increases drug resistance in cancer cells.

Cell Death Dis 2017 07 20;8(7):e2950. Epub 2017 Jul 20.

IBPM-CNR Institute of Molecular Biology and Pathology, Italian National Research Council, Rome, Italy.

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July 2017

Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX.

Eur J Med Chem 2017 Jul 24;135:479-490. Epub 2017 Apr 24.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Department of Biotechnology, Chemistry, and Pharmacy, Università di Siena via Aldo Moro 2, 53100 Siena, Italy.

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July 2017

Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure?

Amino Acids 2017 07 10;49(7):1147-1157. Epub 2017 Apr 10.

National Research Council of Italy (CNR), Institute of Molecular Biology and Pathology c/o Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.

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July 2017

Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives.

J Enzyme Inhib Med Chem 2017 Dec;32(1):304-310

b Istituto di Biologia e Patologia Molecolari - CNR , and Dipartimento di Scienze Biochimiche , " Sapienza" Università di Roma , Roma , Italia.

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December 2017

Polyamine-trypanothione pathway: an update.

Future Med Chem 2017 01 13;9(1):61-77. Epub 2016 Dec 13.

CNR - National Research Council of Italy, Institute of Molecular Biology & Pathology, c/o Department of Biochemical Sciences "A. Rossi Fanelli", University Sapienza, P.le Aldo Moro 5, 00185 - Rome, Italy.

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January 2017

Structural basis of Sorcin-mediated calcium-dependent signal transduction.

Sci Rep 2015 Nov 18;5:16828. Epub 2015 Nov 18.

Institute of Molecular Biology and Pathology CNR; Dept. Biochemical Sciences, Sapienza University, P.le A. Moro 5, 00185, Rome, Italy.

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November 2015

Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions.

J Chem Inf Model 2015 Dec 19;55(12):2611-22. Epub 2015 Nov 19.

Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità , Viale Regina Elena 299, 00161 Roma, Italy.

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December 2015

Folding propensity of anoplin: A molecular dynamics study of the native peptide and four mutated isoforms.

Biopolymers 2015 Dec;103(12):692-701

Department of Biotechnological and Applied Clinical Sciences, University of L'aquila, L'aquila, Italy.

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December 2015

Structure-based discovery of the first non-covalent inhibitors of Leishmania major tryparedoxin peroxidase by high throughput docking.

Sci Rep 2015 May 7;5:9705. Epub 2015 May 7.

1] European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100, Siena [2] Dip. di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100, Siena, Italy.

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May 2015

Targeting polyamine metabolism for finding new drugs against leishmaniasis: a review.

Mini Rev Med Chem 2015 ;15(3):243-52

CNR- Istituto di Biologia e Patologia Molecolari (IBPM), c/o Dipartimento di Scienze Biochimiche, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy.

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December 2015

Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells.

Molecules 2014 Sep 5;19(9):13976-89. Epub 2014 Sep 5.

Institute of Biology, Molecular Medicine and Nanobiotechnology, Consiglio Nazionale delle Ricerche, P.le A Moro 5, Rome 00185, Italy.

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September 2014

The crystal structure of Giardia duodenalis 14-3-3 in the apo form: when protein post-translational modifications make the difference.

PLoS One 2014 21;9(3):e92902. Epub 2014 Mar 21.

Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanità, Rome, Italy.

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November 2014

Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.

Future Med Chem 2013 Oct;5(15):1861-75

National Research Council of Italy, Institute of Molecular Biology & Pathology, Rome, Italy c/o Department of Biochemical Sciences 'A. Rossi Fanelli', University Sapienza, Rome, Italy.

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October 2013

Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes.

ChemMedChem 2013 Oct 23;8(10):1634-7. Epub 2013 Aug 23.

Institute of Molecular Biology & Pathology; National Research Council (CNR); Institute Pasteur Fondazione Cenci Bolognetti; Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome (Italy).

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October 2013