Ann E Eakin

Ann E Eakin

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Ann E Eakin

Ann E Eakin

Publications by authors named "Ann E Eakin"

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17Publications

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Generating Robust and Informative Nonclinical and Bacterial Infection Model Efficacy Data To Support Translation to Humans.

Antimicrob Agents Chemother 2019 05 25;63(5). Epub 2019 Apr 25.

Antibacterial Discovery Performance Unit, GlaxoSmithKline, Collegeville, Pennsylvania, USA

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http://dx.doi.org/10.1128/AAC.02307-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6496039PMC
May 2019

Pharmacokinetic Data Are Predictive of Efficacy for Cefixime and Ceftriaxone against Susceptible and Resistant Strains in the Gonorrhea Mouse Model.

Antimicrob Agents Chemother 2019 03 26;63(3). Epub 2019 Feb 26.

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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http://aac.asm.org/lookup/doi/10.1128/AAC.01644-18
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http://dx.doi.org/10.1128/AAC.01644-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395893PMC
March 2019

Pharmacokinetics/pharmacodynamics of a β-lactam and β-lactamase inhibitor combination: a novel approach for aztreonam/avibactam.

J Antimicrob Chemother 2015 Sep 29;70(9):2618-26. Epub 2015 May 29.

AstraZeneca Infection Innovative Medicines, 35 Gatehouse Drive, Waltham, MA 02451, USA.

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http://dx.doi.org/10.1093/jac/dkv132DOI Listing
September 2015

Fragment-to-hit-to-lead discovery of a novel pyridylurea scaffold of ATP competitive dual targeting type II topoisomerase inhibiting antibacterial agents.

J Med Chem 2013 Nov 29;56(21):8712-35. Epub 2013 Oct 29.

Infection Innovative Medicines, AstraZeneca R&D Boston , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.

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http://dx.doi.org/10.1021/jm401208bDOI Listing
November 2013

A high-throughput fluorescence resonance energy transfer-based assay for DNA ligase.

J Biomol Screen 2011 Jun 11;16(5):486-93. Epub 2011 Mar 11.

AstraZeneca R&D Boston, Waltham, Massachusetts 02451, USA.

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http://dx.doi.org/10.1177/1087057111398295DOI Listing
June 2011

Steady-state kinetics of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi.

Biochim Biophys Acta 2004 Jul;1700(1):11-8

Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA.

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http://dx.doi.org/10.1016/j.bbapap.2004.03.009DOI Listing
July 2004

Saturation mutagenesis, complement selection, and steady-state kinetic studies illuminate the roles of invariant residues in active site loop I of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi.

Biochim Biophys Acta 2004 Jun;1699(1-2):87-94

Department of Molecular and Cell Biology, University of Connecticut, 91 Eagleville Road, Storrs, CT 06269-3125, USA.

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http://dx.doi.org/10.1016/j.bbapap.2004.01.006DOI Listing
June 2004

Functional roles for amino acids in active site loop II of a hypoxanthine phosphoribosyltransferase.

Biochim Biophys Acta 2003 Aug;1650(1-2):105-16

Department of Molecular and Cell Biology, University of Connecticut, Laboratory of Molecular Parasitology and Drug Design, Storrs, CT, USA.

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http://dx.doi.org/10.1016/s1570-9639(03)00206-1DOI Listing
August 2003