Publications by authors named "Andrew P Jackson"

100Publications

DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain.

Nat Commun 2020 08 7;11(1):3951. Epub 2020 Aug 7.

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-17449-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414851PMC
August 2020

Growth in individuals with Saul-Wilson syndrome.

Am J Med Genet A 2020 09 11;182(9):2110-2116. Epub 2020 Jul 11.

Division of Orthogenetics, Nemours/A.I. duPont Hospital for Children, Wilmington, Delaware, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.61754DOI Listing
September 2020

Variant antigen diversity in Trypanosoma vivax is not driven by recombination.

Nat Commun 2020 02 12;11(1):844. Epub 2020 Feb 12.

Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, 146 Brownlow Hill, Liverpool, L3 5RF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-020-14575-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015903PMC
February 2020

VAPPER: High-throughput variant antigen profiling in African trypanosomes of livestock.

Gigascience 2019 09;8(9)

Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool Science Park Ic2, 146 Brownlow Hill, Liverpool L3 5RF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/gigascience/giz091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735694PMC
September 2019

Clinical expression and antigenic profiles of a Plasmodium vivax vaccine candidate: merozoite surface protein 7 (PvMSP-7).

Malar J 2019 Jun 13;18(1):197. Epub 2019 Jun 13.

Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, 146 Brownlow Hill, Liverpool, L3 5RF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12936-019-2826-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567670PMC
June 2019

Clinical and Molecular Characterization of Familial Exudative Vitreoretinopathy Associated With Microcephaly.

Am J Ophthalmol 2019 11 8;207:87-98. Epub 2019 May 8.

UCL Institute of Ophthalmology, University College London, London, United Kingdom; Moorfields Eye Hospital, London, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajo.2019.05.001DOI Listing
November 2019

UDP-glycosyltransferase genes in trypanosomatid genomes have diversified independently to meet the distinct developmental needs of parasite adaptations.

BMC Evol Biol 2018 03 14;18(1):31. Epub 2018 Mar 14.

Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool Science Park Ic2, 146 Brownlow Hill, Liverpool, L3 5RF, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12862-018-1149-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853035PMC
March 2018

Erratum to: Microcephalic Osteodysplastic Primordial Dwarfism, Type II: a Clinical Review.

Curr Osteoporos Rep 2017 08;15(4):399

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11914-017-0389-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728284PMC
August 2017

Microcephalic Osteodysplastic Primordial Dwarfism, Type II: a Clinical Review.

Curr Osteoporos Rep 2017 04;15(2):61-69

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11914-017-0348-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561166PMC
April 2017

Gene family phylogeny and the evolution of parasite cell surfaces.

Authors:
Andrew P Jackson

Mol Biochem Parasitol 2016 Sep - Oct;209(1-2):64-75. Epub 2016 Mar 21.

Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, Liverpool Science Park Ic2, 146 Brownlow Hill, Liverpool L3 5RF, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molbiopara.2016.03.007DOI Listing
November 2017

Two novel mutations in RNU4ATAC in two siblings with an atypical mild phenotype of microcephalic osteodysplastic primordial dwarfism type 1.

Clin Dysmorphol 2016 Apr;25(2):68-72

aDepartment of Clinical Genetics bH.C. Andersen Children's Hospital, Odense University Hospital, Odense, Denmark cMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh dUniversity of Southampton, Southampton, UK eDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCD.0000000000000110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772811PMC
April 2016

Meier-Gorlin syndrome.

Orphanet J Rare Dis 2015 Sep 17;10:114. Epub 2015 Sep 17.

Department of Human Genetics 836, Institute for Genetic and Metabolic Disease, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13023-015-0322-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574002PMC
September 2015

Genome-wide mapping of embedded ribonucleotides and other noncanonical nucleotides using emRiboSeq and EndoSeq.

Nat Protoc 2015 Sep 27;10(9):1433-44. Epub 2015 Aug 27.

Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2015.099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876909PMC
September 2015

Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax.

PLoS Negl Trop Dis 2015 12;9(8):e0003975. Epub 2015 Aug 12.

Pathogen Genomics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0003975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534299PMC
April 2016

Acute molecular responses to concurrent resistance and high-intensity interval exercise in untrained skeletal muscle.

Physiol Rep 2015 Apr;3(4)

School of Sport Exercise and Health Sciences Loughborough University, Loughborough, UK College of Life and Environmental Sciences University of Birmingham, Birmingham, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14814/phy2.12364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425969PMC
April 2015

Preface. The evolution of parasite genomes and the origins of parasitism.

Authors:
Andrew P Jackson

Parasitology 2015 Feb;142 Suppl 1:S1-5

Department of Infection Biology,Institute of Infection and Global health, University of Liverpool,Ic2 Building, 146 Brownlow Hill,Merseyside,Liverpool,L3 5RF.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0031182014001516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413782PMC
February 2015

Lagging-strand replication shapes the mutational landscape of the genome.

Nature 2015 Feb 26;518(7540):502-506. Epub 2015 Jan 26.

MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, University of Edinburgh, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature14183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374164PMC
February 2015

Appetite-regulatory hormone responses on the day following a prolonged bout of moderate-intensity exercise.

Physiol Behav 2015 Mar 3;141:23-31. Epub 2015 Jan 3.

College of Life and Environmental Sciences, The University of Birmingham, Birmingham B15 2TT, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.physbeh.2014.12.050DOI Listing
March 2015

Ribonuclease H2 in health and disease.

Biochem Soc Trans 2014 Aug;42(4):717-25

*Medical Research Council Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, U.K.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20140079DOI Listing
August 2014

Genome evolution in trypanosomatid parasites.

Authors:
Andrew P Jackson

Parasitology 2015 Feb 28;142 Suppl 1:S40-56. Epub 2014 Jul 28.

Department of Infection Biology, Institute of Infection and Global Health,University of Liverpool,Liverpool Science Park Ic2, 146 Brownlow Hill, Liverpool L3 5RF,UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0031182014000894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413820PMC
February 2015

The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data.

Nucleic Acids Res 2014 Jan 11;42(Database issue):D966-74. Epub 2013 Nov 11.

Institute for Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany, Berlin-Brandenburg Center for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany, Lawrence Berkeley National Laboratory, Mail Stop 84R0171, Berkeley, CA 94720, USA, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK, Department of Medical Genetics, Cambridge University Addenbrooke's Hospital, Cambridge CB2 2QQ, UK, Université Paul Sabatier, Faculté de Chirurgie Dentaire, CHU Toulouse, France, Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre (MAHSC), Manchester, UK, Centre for Genomic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, MAHSC, Manchester M13 9WL, UK, Institute of Genetic Medicine. Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK, Department of Computer Science, University of Toronto, Ontario, Canada, Centre for Computational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Clinical Genetics, Leeds Teaching Hospitals NHS Trust, Leeds LS2 9NS, UK, MRC Human Genetics Unit, MRC Institute of Genetic and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK, The Jackson Laboratory, Bar Harbor, ME 04609, USA, Center for Molecular and Vascular Biology, University of Leuven, Belgium, Department of Neuropediatrics, University Medical Center Schleswig-Holstein, Kiel Campus, 24105 Kiel, Germany, NE Thames Genetics Service, Great Ormond Street Hospital, London WC1N 3JH, UK, Drexel University College of Medicine, Philadelphia, PA 19102, USA, Department of Haematology, University of Cambridge and NHS Blood and Transplant Cambridge, CB2 0PT Cambridge, UK, Autism and Developmental Medicine Institute, Geisinger Health System

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkt1026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965098PMC
January 2014

ECAT-V: where clinical and research training meet.

Vet Rec 2013 Oct;173(15):364-5

Royal (Dick) School of Veterinary Studies, Roslin Institute.

View Article

Download full-text PDF

Source
http://veterinaryrecord.bmj.com/lookup/doi/10.1136/vr.f6185
Publisher Site
http://dx.doi.org/10.1136/vr.f6185DOI Listing
October 2013

Cerebral organoids model human brain development and microcephaly.

Nature 2013 Sep 28;501(7467):373-9. Epub 2013 Aug 28.

Institute of Molecular Biotechnology of the Austrian Academy of Science, Vienna 1030, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817409PMC
September 2013

Replication proteins and human disease.

Cold Spring Harb Perspect Biol 2014 Jan 1;6(1). Epub 2014 Jan 1.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a013060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941220PMC
January 2014

Quantifying single nucleotide variant detection sensitivity in exome sequencing.

BMC Bioinformatics 2013 Jun 18;14:195. Epub 2013 Jun 18.

MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2105-14-195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695811PMC
June 2013

Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair.

Mol Cell 2013 May 18;50(3):323-32. Epub 2013 Apr 18.

Institute of Molecular Cancer Research of the University of Zurich and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2013.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653069PMC
May 2013

A cell-surface phylome for African trypanosomes.

PLoS Negl Trop Dis 2013 21;7(3):e2121. Epub 2013 Mar 21.

Pathogen Genomics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, England, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0002121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605285PMC
August 2013

Identification of small-molecule inhibitors of the ribonuclease H2 enzyme.

J Biomol Screen 2013 Jun 20;18(5):610-20. Epub 2013 Feb 20.

MRC Human Genetics Unit, MRC IGMM, University of Edinburgh, Edinburgh, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1087057113476550DOI Listing
June 2013

Biomarkers in liver disease: emerging methods and potential applications.

Int J Hepatol 2012 7;2012:437508. Epub 2012 Nov 7.

NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham NG7 2UH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2012/437508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502848PMC
December 2012

Growth in individuals with Majewski osteodysplastic primordial dwarfism type II caused by pericentrin mutations.

Am J Med Genet A 2012 Nov 20;158A(11):2719-25. Epub 2012 Jul 20.

Division of Medical Genetics, Alfred I. duPont Hospital for Children, Wilmington, Delaware 19083, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.35447DOI Listing
November 2012

Exploring microcephaly and human brain evolution.

Dev Med Child Neurol 2012 Jul 9;54(7):580-1. Epub 2012 May 9.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1469-8749.2012.04330.xDOI Listing
July 2012

Mechanisms and pathways of growth failure in primordial dwarfism.

Genes Dev 2011 Oct;25(19):2011-24

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gad.169037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197200PMC
October 2011

SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation.

J Biol Chem 2011 Jun 22;286(24):21393-400. Epub 2011 Apr 22.

Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.208793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122199PMC
June 2011

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome.

Nat Genet 2011 Feb 27;43(4):350-5. Epub 2011 Feb 27.

Medical Research Council (MRC) Human Genetics Unit (HGU), Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.776DOI Listing
February 2011

PCNA directs type 2 RNase H activity on DNA replication and repair substrates.

Nucleic Acids Res 2011 May 17;39(9):3652-66. Epub 2011 Jan 17.

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

View Article

Download full-text PDF

Source
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
Publisher Site
http://dx.doi.org/10.1093/nar/gkq980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089482PMC
May 2011

The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease.

J Biol Chem 2011 Mar 22;286(12):10530-9. Epub 2010 Dec 22.

Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.

View Article

Download full-text PDF

Source
http://www.jbc.org/lookup/doi/10.1074/jbc.M110.177394
Publisher Site
http://dx.doi.org/10.1074/jbc.M110.177394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060506PMC
March 2011

Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition.

PLoS Negl Trop Dis 2010 Sep 28;4(9):e829. Epub 2010 Sep 28.

Centre for Immunology and Infection, Department of Biology, Hull York Medical School, University of York, York, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0000829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946902PMC
September 2010

Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement.

BMC Genomics 2009 Dec 7;10:584. Epub 2009 Dec 7.

The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2164-10-584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935791PMC
December 2009

The evolution of amastin surface glycoproteins in trypanosomatid parasites.

Authors:
Andrew P Jackson

Mol Biol Evol 2010 Jan;27(1):33-45

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/molbev/msp214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794310PMC
January 2010

BRIT1/MCPH1 links chromatin remodelling to DNA damage response.

Nat Cell Biol 2009 Jul 14;11(7):865-72. Epub 2009 Jun 14.

Department of Systems Biology, The University of Texas M. D. Anderson Cancer Center, Houston, 77054, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb1895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714531PMC
July 2009

Diversifying microtubules in brain development.

Authors:
Andrew P Jackson

Nat Genet 2009 Jun;41(6):638-40

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng0609-638DOI Listing
June 2009

Insights into the genome sequence of a free-living Kinetoplastid: Bodo saltans (Kinetoplastida: Euglenozoa).

BMC Genomics 2008 Dec 9;9:594. Epub 2008 Dec 9.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2164-9-594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621209PMC
December 2008