Andrei V Gudkov

Andrei V Gudkov

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Andrei V Gudkov

Andrei V Gudkov

Publications by authors named "Andrei V Gudkov"

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99Publications

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Cells exhibiting strong promoter activation in vivo display features of senescence.

Proc Natl Acad Sci U S A 2019 02 25;116(7):2603-2611. Epub 2019 Jan 25.

Curriculum in Genetics and Molecular Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599;

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http://dx.doi.org/10.1073/pnas.1818313116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377452PMC
February 2019

Novel mouse models of hepatic artery infusion.

J Surg Res 2017 11 21;219:25-32. Epub 2017 Jun 21.

Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York; Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2017.05.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986560PMC
November 2017

p53 and the Carcinogenicity of Chronic Inflammation.

Cold Spring Harb Perspect Med 2016 Nov 1;6(11). Epub 2016 Nov 1.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263.

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http://dx.doi.org/10.1101/cshperspect.a026161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088512PMC
November 2016

Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis.

Proc Natl Acad Sci U S A 2016 Feb 1;113(7):E874-83. Epub 2016 Feb 1.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263; Cleveland BioLabs, Inc., Buffalo, NY 14203

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http://dx.doi.org/10.1073/pnas.1521359113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763744PMC
February 2016

Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells.

Proc Natl Acad Sci U S A 2015 Dec 2;112(49):15154-9. Epub 2015 Nov 2.

Tisch Cancer Institute, Department of Medicine, Hematology, and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; The Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029

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http://dx.doi.org/10.1073/pnas.1517584112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679042PMC
December 2015

Peptides genetically selected for NF-κB activation cooperate with oncogene Ras and model carcinogenic role of inflammation.

Proc Natl Acad Sci U S A 2014 Jan 13;111(4):E474-83. Epub 2014 Jan 13.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263.

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http://dx.doi.org/10.1073/pnas.1311945111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910623PMC
January 2014

Dysregulation of the mTOR pathway in p53-deficient mice.

Cancer Biol Ther 2013 Dec 1;14(12):1182-8. Epub 2013 Nov 1.

Department of Cell Stress Biology; Roswell Park Cancer Institute; Buffalo, NY USA.

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http://dx.doi.org/10.4161/cbt.26947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912042PMC
December 2013

A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease.

J Immunol 2012 Nov 8;189(10):4719-27. Epub 2012 Oct 8.

Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.4049/jimmunol.1201206DOI Listing
November 2012

Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism.

Proc Natl Acad Sci U S A 2012 Nov 5;109(47):19392-6. Epub 2012 Nov 5.

Department of Biology, University of Rochester, Rochester, NY 14627, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1217211109
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http://dx.doi.org/10.1073/pnas.1217211109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511137PMC
November 2012

Core circadian protein CLOCK is a positive regulator of NF-κB-mediated transcription.

Proc Natl Acad Sci U S A 2012 Sep 15;109(37):E2457-65. Epub 2012 Aug 15.

Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.1073/pnas.1206274109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443185PMC
September 2012

Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice.

Cancer Prev Res (Phila) 2012 Aug 11;5(8):1025-35. Epub 2012 Jun 11.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY, 14263, USA.

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http://cancerpreventionresearch.aacrjournals.org/cgi/doi/10.
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http://dx.doi.org/10.1158/1940-6207.CAPR-11-0529DOI Listing
August 2012

Hypoxia suppresses conversion from proliferative arrest to cellular senescence.

Proc Natl Acad Sci U S A 2012 Aug 30;109(33):13314-8. Epub 2012 Jul 30.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.1073/pnas.1205690109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3421205PMC
August 2012

CBLB613: a TLR 2/6 agonist, natural lipopeptide of Mycoplasma arginini , as a novel radiation countermeasure.

Radiat Res 2012 May 16;177(5):628-42. Epub 2011 Dec 16.

Radiation Countermeasures Program, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889-5603, USA.

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http://dx.doi.org/10.1667/rr2657.1DOI Listing
May 2012

Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin.

PLoS One 2011 11;6(10):e26126. Epub 2011 Oct 11.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026126PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191182PMC
February 2012

Structural basis of TLR5-flagellin recognition and signaling.

Science 2012 Feb;335(6070):859-64

Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1215584
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http://dx.doi.org/10.1126/science.1215584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406927PMC
February 2012

A TLR5 agonist inhibits acute renal ischemic failure.

J Immunol 2011 Oct 2;187(7):3831-9. Epub 2011 Sep 2.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.4049/jimmunol.1003238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178726PMC
October 2011

Histone methyltransferase KMT1A restrains entry of alveolar rhabdomyosarcoma cells into a myogenic differentiated state.

Cancer Res 2011 Jun 14;71(11):3921-31. Epub 2011 Apr 14.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107367PMC
June 2011

Inflammation and p53: A Tale of Two Stresses.

Genes Cancer 2011 Apr;2(4):503-16

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://dx.doi.org/10.1177/1947601911409747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135644PMC
April 2011

Weak p53 permits senescence during cell cycle arrest.

Cell Cycle 2010 Nov 10;9(21):4323-7. Epub 2010 Nov 10.

Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.9.21.13584
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http://dx.doi.org/10.4161/cc.9.21.13584DOI Listing
November 2010

Radioprotection: smart games with death.

J Clin Invest 2010 Jul 23;120(7):2270-3. Epub 2010 Jun 23.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

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http://dx.doi.org/10.1172/JCI43794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898620PMC
July 2010

Pathologies associated with the p53 response.

Cold Spring Harb Perspect Biol 2010 Jul 7;2(7):a001180. Epub 2010 Apr 7.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA.

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http://dx.doi.org/10.1101/cshperspect.a001180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890204PMC
July 2010

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway.

Aging (Albany NY) 2010 Jun;2(6):344-52

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, L3-312, Buffalo, NY 14263, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919254PMC
http://dx.doi.org/10.18632/aging.100160DOI Listing
June 2010

Paradoxical suppression of cellular senescence by p53.

Proc Natl Acad Sci U S A 2010 May 10;107(21):9660-4. Epub 2010 May 10.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.1073/pnas.1002298107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906905PMC
May 2010

Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.

Proc Natl Acad Sci U S A 2010 Jan 22;107(1):46-51. Epub 2009 Dec 22.

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1073/pnas.0912493107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806709PMC
January 2010

Pseudo-DNA damage response in senescent cells.

Cell Cycle 2009 Dec 1;8(24):4112-8. Epub 2009 Dec 1.

Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.

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http://dx.doi.org/10.4161/cc.8.24.10215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970747PMC
December 2009

Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A.

Cell Cycle 2009 Nov 23;8(22):3777-81. Epub 2009 Nov 23.

Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, Buffalo, NY, USA.

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http://dx.doi.org/10.4161/cc.8.22.10121DOI Listing
November 2009

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.

Proc Natl Acad Sci U S A 2009 Sep 1;106(38):16339-44. Epub 2009 Sep 1.

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1073/pnas.0908560106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736141PMC
September 2009

Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis.

Proc Natl Acad Sci U S A 2008 Sep 16;105(38):14453-8. Epub 2008 Sep 16.

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

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http://dx.doi.org/10.1073/pnas.0807549105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567220PMC
September 2008

Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin.

DNA Cell Biol 2008 Apr;27(4):191-8

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1089/dna.2007.0682DOI Listing
April 2008

Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication.

PLoS One 2008 Apr 2;3(4):e1887. Epub 2008 Apr 2.

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001887PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268745PMC
April 2008

In regard to Schuller et Al. (Int J Radiat Oncol Biol Phys 2007;68:205-210).

Int J Radiat Oncol Biol Phys 2008 Mar;70(3):800-1; author reply 802-3

Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2007.07.2396DOI Listing
March 2008

Prostate cancer cells tolerate a narrow range of androgen receptor expression and activity.

Prostate 2007 Dec;67(16):1801-15

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

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http://dx.doi.org/10.1002/pros.20662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914504PMC
December 2007

p53 determines multidrug sensitivity of childhood neuroblastoma.

Cancer Res 2007 Nov;67(21):10351-60

Children's Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4345DOI Listing
November 2007

Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation.

Eur J Immunol 2007 Aug;37(8):2257-67

Department of Immunology, Cleveland Clinic, Cleveland, OH 44195-0001, USA.

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http://dx.doi.org/10.1002/eji.200636708DOI Listing
August 2007

Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.

Blood 2007 May 9;109(9):3803-11. Epub 2007 Jan 9.

Laboratory of Pediatric Immunology, Center for Biomedicine, Department of Clinical-Biological Sciences, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1182/blood-2006-10-049767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1874572PMC
May 2007

Dangerous habits of a security guard: the two faces of p53 as a drug target.

Hum Mol Genet 2007 Apr;16 Spec No 1:R67-72

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

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http://dx.doi.org/10.1093/hmg/ddm052DOI Listing
April 2007

Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3.

Cancer Res 2006 Mar;66(6):3169-76

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3832DOI Listing
March 2006

Serologically defined colon cancer antigen 3 is necessary for the presentation of TNF receptor 1 on cell surface.

DNA Cell Biol 2005 Dec;24(12):777-85

Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA.

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http://dx.doi.org/10.1089/dna.2005.24.777DOI Listing
December 2005

Poliovirus protein 3A binds and inactivates LIS1, causing block of membrane protein trafficking and deregulation of cell division.

Cell Cycle 2005 Oct 20;4(10):1403-10. Epub 2005 Oct 20.

Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.

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http://dx.doi.org/10.4161/cc.4.10.2041DOI Listing
October 2005

p53 is a suppressor of inflammatory response in mice.

FASEB J 2005 Jun 5;19(8):1030-2. Epub 2005 Apr 5.

Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1096/fj.04-3213fjeDOI Listing
June 2005

Proteolytic cleavage of the p65-RelA subunit of NF-kappaB during poliovirus infection.

J Biol Chem 2005 Jun 21;280(25):24153-8. Epub 2005 Apr 21.

Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1074/jbc.M502303200DOI Listing
June 2005

Prospective therapeutic applications of p53 inhibitors.

Biochem Biophys Res Commun 2005 Jun;331(3):726-36

Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1016/j.bbrc.2005.03.153DOI Listing
June 2005

Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex.

Proc Natl Acad Sci U S A 2005 Mar 2;102(9):3407-12. Epub 2005 Feb 2.

Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1073/pnas.0409897102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC546637PMC
March 2005

Cancer drug discovery: the wisdom of imprecision.

Authors:
Andrei V Gudkov

Nat Med 2004 Dec;10(12):1298-9

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http://dx.doi.org/10.1038/nm1204-1298DOI Listing
December 2004

Selection-subtraction approach (SSA): a universal genetic screening technique that enables negative selection.

Proc Natl Acad Sci U S A 2004 Jun 8;101(25):9327-32. Epub 2004 Jun 8.

Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.1073/pnas.0403080101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC438976PMC
June 2004