Ana Saavedra

Ana Saavedra

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Ana Saavedra

Ana Saavedra

Publications by authors named "Ana Saavedra"

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[Dyslipidemia Secondary to Hypothyroidism and Cholestasis].

Acta Med Port 2020 Mar 2;33(3):204-207. Epub 2020 Mar 2.

Serviço de Endocrinologia, Diabetes e Metabolismo. Centro Hospitalar de S. João. Porto. Instituto de Investigação e Inovação em Saúde. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

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http://dx.doi.org/10.20344/amp.9944DOI Listing
March 2020

Proteolytic Degradation of Hippocampal STEP in LTP and Learning.

Mol Neurobiol 2019 Feb 12;56(2):1475-1487. Epub 2018 Jun 12.

Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, C/ Casanova, 143 08036, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1007/s12035-018-1170-1DOI Listing
February 2019

Malignant paraganglioma and somatotropinoma in a patient with germline SDHB mutation-genetic and clinical features.

Endocrine 2019 01 28;63(1):182-187. Epub 2018 Aug 28.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar S. João, Porto, Portugal.

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http://dx.doi.org/10.1007/s12020-018-1726-xDOI Listing
January 2019

Social Memory and Social Patterns Alterations in the Absence of STriatal-Enriched Protein Tyrosine Phosphatase.

Front Behav Neurosci 2018 25;12:317. Epub 2019 Jan 25.

Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.3389/fnbeh.2018.00317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362413PMC
January 2019

Huntington's disease: novel therapeutic perspectives hanging in the balance.

Expert Opin Ther Targets 2018 05 26;22(5):385-399. Epub 2018 Apr 26.

a Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències , Universitat de Barcelona , Barcelona , Spain.

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http://dx.doi.org/10.1080/14728222.2018.1465930DOI Listing
May 2018

Age-related changes in STriatal-Enriched protein tyrosine Phosphatase levels: Regulation by BDNF.

Mol Cell Neurosci 2018 01 6;86:41-49. Epub 2017 Nov 6.

Departament de Biomedicina, Facultat de Medicina i Ciències de la Salut, Institut de Neurociències, Universitat de Barcelona, Catalonia; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2017.11.003DOI Listing
January 2018

Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling.

Addict Biol 2017 Nov 25;22(6):1706-1718. Epub 2016 Jul 25.

Laboratory of Neurophysiology and Synaptic Plasticity, Castilla-La Mancha Science and Technology Park (PCYTCLM), Institute for Research in Neurological Disabilities (IDINE), University of Castilla-La Mancha, Spain.

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http://dx.doi.org/10.1111/adb.12433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697621PMC
November 2017

Validation and Reliability of the Portuguese Version of the Michigan Neuropathy Screening Instrument.

Pain Pract 2017 04 19;17(4):514-521. Epub 2016 Aug 19.

I3S Institute of Research and Innovation in Health, University of Porto, Portugal, Portugal.

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http://dx.doi.org/10.1111/papr.12479DOI Listing
April 2017

Chelerythrine promotes Ca-dependent calpain activation in neuronal cells in a PKC-independent manner.

Biochim Biophys Acta Gen Subj 2017 Apr 24;1861(4):922-935. Epub 2017 Jan 24.

Departament de Biomedicina, Facultat de Medicina, Institut de Neurociències, Universitat de Barcelona, Catalonia, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2017.01.021DOI Listing
April 2017

Preoperative Beta Cell Function Is Predictive of Diabetes Remission After Bariatric Surgery.

Obes Surg 2017 02;27(2):288-294

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.

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http://dx.doi.org/10.1007/s11695-016-2300-3DOI Listing
February 2017

Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF.

Brain Pathol 2016 11;26(6):752-771

Departament de Biomedicina, Facultat de Medicina, Universitat de Barcelona, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1111/bpa.12432DOI Listing
November 2016

BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.

Mol Neurobiol 2016 08 30;53(6):4261-4273. Epub 2015 Jul 30.

Departament de Biologia Cel · lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Casanova 143, 08036, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1007/s12035-015-9335-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738169PMC
August 2016

Effect of different bariatric surgery type on the leukocyte formula.

Surg Obes Relat Dis 2016 Aug 3;12(7):1418-1423. Epub 2016 Feb 3.

Serviço de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar de São João, Porto, Portugal; Faculdade de Medicina da Universidade do Porto, Porto, Portugal.

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http://dx.doi.org/10.1016/j.soard.2016.02.002DOI Listing
August 2016

The Effect of Bariatric Surgery Type on Lipid Profile: An Age, Sex, Body Mass Index and Excess Weight Loss Matched Study.

Obes Surg 2016 May;26(5):1041-7

Serviço de Endocrinologia, Diabetes e Metabolismo do Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.

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http://dx.doi.org/10.1007/s11695-015-1825-1DOI Listing
May 2016

Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report.

J Med Case Rep 2016 Mar 31;10:70. Epub 2016 Mar 31.

Serviço de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.

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http://dx.doi.org/10.1186/s13256-016-0878-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815244PMC
March 2016

Cognitive Dysfunction in Huntington's Disease: Humans, Mouse Models and Molecular Mechanisms.

J Huntingtons Dis 2012 ;1(2):155-73

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.

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http://dx.doi.org/10.3233/JHD-120023DOI Listing
February 2016

Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition.

Pain 2016 Feb;157(2):377-86

aDepartament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Catalonia, Spain bInstitut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain cCentro de Investigaciones Biomédicas en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain dDepartment of Neurosciences, School of Medicine and Dentistry, University of the Basque Country (UPV/EHU), Bizkaia, Spain eDepartament de Ciències Mèdiques, Facultat de Medicina, Universitat de Girona, Girona, Catalonia, Spain fDepartment of Chemistry, Yale University, New Haven, CT, USA gChild Study Center, Yale School of Medicine, Yale University, New Haven, CT, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000000329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809206PMC
February 2016

Permanent neonatal diabetes by a new mutation in KCNJ11: unsuccessful switch to sulfonylurea.

Arch Endocrinol Metab 2015 Dec 28;59(6):559-61. Epub 2015 Aug 28.

Departamento de Pediatria, Faculdade de Medicina, Universidade do Porto, Porto, Portugal.

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http://dx.doi.org/10.1590/2359-3997000000076DOI Listing
December 2015

Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease.

Neurobiol Dis 2015 Feb 11;74:41-57. Epub 2014 Nov 11.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.11.004DOI Listing
February 2015

Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease.

PLoS One 2013 5;8(9):e73664. Epub 2013 Sep 5.

Departament de Biologia Cel·lular, Immunologia Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain ; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain ; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073664PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764028PMC
July 2014

H2O2- or l-DOPA-injured dopaminergic neurons trigger the release of soluble mediators that up-regulate striatal GDNF through different signalling pathways.

Biochim Biophys Acta 2014 Jul 12;1842(7):927-34. Epub 2014 Mar 12.

CICS-UBI-Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.03.003DOI Listing
July 2014

PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model.

Hippocampus 2013 Aug 29;23(8):684-95. Epub 2013 Apr 29.

Departament de Biologia Cellular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1002/hipo.22128DOI Listing
August 2013

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease.

Hum Mol Genet 2011 Nov 11;20(21):4232-47. Epub 2011 Aug 11.

Departament de Biologia Cel.lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, 08036 Barcelona, Spain.

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http://dx.doi.org/10.1093/hmg/ddr351DOI Listing
November 2011

Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.

Mol Neurodegener 2011 Oct 31;6:74. Epub 2011 Oct 31.

Departament de Biologia Cel·lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, Spain.

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http://dx.doi.org/10.1186/1750-1326-6-74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217046PMC
October 2011

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity.

J Neurosci 2011 Jun;31(22):8150-62

Departament de Biologia Cellular, Facultat de Medicina, Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi-Sunyer, 08036 Barcelona, Spain.

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http://dx.doi.org/10.1523/JNEUROSCI.3446-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3472648PMC
June 2011

Microglia of rat ventral midbrain recovers its resting state over time in vitro: let microglia rest before work.

J Neurosci Res 2010 Feb;88(3):552-62

Health Sciences Research Center, University of Beira Interior, Covilhã, Portugal.

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http://doi.wiley.com/10.1002/jnr.22219
Publisher Site
http://dx.doi.org/10.1002/jnr.22219DOI Listing
February 2010

Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: role in excitotoxicity.

Neurobiol Dis 2009 Dec 4;36(3):461-9. Epub 2009 Sep 4.

Departament de Biologia Cel.lular, Immunologia i Neurociències, Facultat de Medicina, Universitat de Barcelona, IDIBAPS, Casanova 143, E-08036 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.nbd.2009.08.012DOI Listing
December 2009

Driving GDNF expression: the green and the red traffic lights.

Prog Neurobiol 2008 Nov 7;86(3):186-215. Epub 2008 Sep 7.

Department of Cell Biology, Immunology and Neurosciences, Faculty of Medicine, University of Barcelona, Carrer Casanova 143, 08036 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.pneurobio.2008.09.006DOI Listing
November 2008

Why facilitate patient access to medical records.

Stud Health Technol Inform 2007 ;127:77-90

Computer Laboratory at the University of Kent.

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October 2007

Interleukin-1beta mediates GDNF up-regulation upon dopaminergic injury in ventral midbrain cell cultures.

Neurobiol Dis 2007 Jan 5;25(1):92-104. Epub 2006 Oct 5.

Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.nbd.2006.08.019DOI Listing
January 2007

Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: role of neuron-glia crosstalk.

Neurobiol Dis 2006 Sep;23(3):533-42

Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.nbd.2006.04.008DOI Listing
September 2006

GDNF modulates HO-1 expression in substantia nigra postnatal cell cultures.

Free Radic Biol Med 2005 Dec 24;39(12):1611-9. Epub 2005 Aug 24.

Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.freeradbiomed.2005.08.005DOI Listing
December 2005