Alicja Bielawska

Alicja Bielawska

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Alicja Bielawska

Publications by authors named "Alicja Bielawska"

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Dietary palmitate cooperates with Src kinase to promote prostate tumor progression.

Prostate 2019 06 22;79(8):896-908. Epub 2019 Mar 22.

Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia.

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http://dx.doi.org/10.1002/pros.23796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502658PMC
June 2019

Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites.

Bioorg Med Chem 2018 12 10;26(23-24):6067-6075. Epub 2018 Nov 10.

Departments of Medicine, Biochemistry and Cell Biology, and Pharmacology and the Stony Brook Cancer Center at Stony Brook University, Stony Brook, NY 11794, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183145
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http://dx.doi.org/10.1016/j.bmc.2018.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323005PMC
December 2018

Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase.

PLoS One 2017 14;12(6):e0177805. Epub 2017 Jun 14.

Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177805PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470663PMC
September 2017

Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.

Prostaglandins Other Lipid Mediat 2017 05 2;130:47-56. Epub 2017 Apr 2.

Department of Medicine and the, Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA; Northport Veterans Affairs Medical Center, Northport, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509055PMC
May 2017

Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line.

J Lipid Res 2016 11 13;57(11):2028-2039. Epub 2016 Sep 13.

Departments of Neuroscience Medical University of South Carolina, Charleston, SC 29425

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http://dx.doi.org/10.1194/jlr.M070664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087870PMC
November 2016

Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy-generated vaccine.

Int J Cancer 2016 09 18;139(6):1372-8. Epub 2016 May 18.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI.

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http://dx.doi.org/10.1002/ijc.30171DOI Listing
September 2016

Enhanced apoptotic cancer cell killing after Foscan photodynamic therapy combined with fenretinide via de novo sphingolipid biosynthesis pathway.

J Photochem Photobiol B 2016 Jun 16;159:191-5. Epub 2016 Mar 16.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave., Detroit, MI 48201, USA; Karmanos Cancer Institute, Wayne State University, 4100 John R, Detroit, MI 48201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jphotobiol.2016.02.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123833PMC
June 2016

Enhanced killing of SCC17B human head and neck squamous cell carcinoma cells after photodynamic therapy plus fenretinide via the de novo sphingolipid biosynthesis pathway and apoptosis.

Int J Oncol 2015 May 26;46(5):2003-10. Epub 2015 Feb 26.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.

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http://dx.doi.org/10.3892/ijo.2015.2909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383026PMC
May 2015

C6-pyridinium ceramide sensitizes SCC17B human head and neck squamous cell carcinoma cells to photodynamic therapy.

J Photochem Photobiol B 2015 Feb 10;143:163-8. Epub 2015 Jan 10.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave., Detroit, MI 48201, USA; Karmanos Cancer Institute, Wayne State University, 4100 John R, Detroit, MI 48201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jphotobiol.2015.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662378PMC
February 2015

Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.

Bioorg Med Chem 2014 Dec 22;22(24):6933-44. Epub 2014 Oct 22.

Department of Biochemistry & Molecular Biology, Medical University of South Carolina, 173 Ashley Ave., Charleston, SC 29425, USA; Lipidomics Facility, Medical University of South Carolina, 173 Ashley Ave., Charleston, SC 29425, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443482PMC
December 2014

Cognitive and social function in girls with congenital adrenal hyperplasia -- influence of prenatally administered dexamethasone.

Child Neuropsychol 2014 27;20(1):60-70. Epub 2012 Nov 27.

a Laboratory of Developmental Neuropsychology, Children's Memorial Health Institute , Warsaw , Poland.

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http://dx.doi.org/10.1080/09297049.2012.745495DOI Listing
June 2014

2'-hydroxy C16-ceramide induces apoptosis-associated proteomic changes in C6 glioma cells.

J Proteome Res 2013 Oct 12;12(10):4366-75. Epub 2013 Sep 12.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina , Charleston, South Carolina 29425, United States.

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http://dx.doi.org/10.1021/pr4003432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123328PMC
October 2013

Plasma sphingolipids and lung cancer: a population-based, nested case-control study.

Cancer Epidemiol Biomarkers Prev 2013 Aug 7;22(8):1374-82. Epub 2013 Jun 7.

Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-12-1424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733124PMC
August 2013

Beneficial cardiac effects of caloric restriction are lost with age in a murine model of obesity.

J Cardiovasc Transl Res 2013 Jun 2;6(3):436-45. Epub 2013 Mar 2.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Carnegie 568, Baltimore, MD 21287, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs12265-013-94
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http://link.springer.com/10.1007/s12265-013-9453-4
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http://dx.doi.org/10.1007/s12265-013-9453-4DOI Listing
June 2013

Bax and Bcl-xL exert their regulation on different sites of the ceramide channel.

Biochem J 2012 Jul;445(1):81-91

Department of Biology, University of Maryland, College Park, MD 20742, USA.

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http://biochemj.org/lookup/doi/10.1042/BJ20112103
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http://dx.doi.org/10.1042/BJ20112103DOI Listing
July 2012

Dihydroceramide-based response to hypoxia.

J Biol Chem 2011 Nov 13;286(44):38069-78. Epub 2011 Sep 13.

Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1074/jbc.M111.297994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207482PMC
November 2011

Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization.

Biochem Biophys Res Commun 2011 Jun 24;409(3):372-7. Epub 2011 Apr 24.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Ave., Detroit, MI 48201, USA.

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http://dx.doi.org/10.1016/j.bbrc.2011.04.091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123537PMC
June 2011

Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.

J Lipid Res 2011 Feb 16;52(2):278-88. Epub 2010 Nov 16.

Department of Pharmacology, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, P R China.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M012161
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http://dx.doi.org/10.1194/jlr.M012161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023548PMC
February 2011

Ceramide and ceramide 1-phosphate are negative regulators of TNF-α production induced by lipopolysaccharide.

J Immunol 2010 Dec 1;185(11):6960-73. Epub 2010 Nov 1.

Laboratory of Plasma Membrane Receptors, Department of Cell Biology, Nencki Institute of Experimental Biology, Warsaw, Poland.

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http://dx.doi.org/10.4049/jimmunol.0902926DOI Listing
December 2010

Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells.

Bioorg Med Chem 2010 Nov 28;18(21):7565-79. Epub 2010 Sep 28.

Lipidomics Shared Resource, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/j.bmc.2010.08.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2956829PMC
November 2010

Sphingolipid analysis by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).

Adv Exp Med Biol 2010 ;688:46-59

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Ave., P.O. Box 250509, Charleston, South Carolina 29425, USA.

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http://link.springer.com/content/pdf/10.1007/978-1-4419-6741
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http://dx.doi.org/10.1007/978-1-4419-6741-1_3DOI Listing
November 2010

Comprehensive quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry.

Methods Mol Biol 2009 ;579:443-67

Department of Biochemistry and Molecular Biology, Lipidomic Core Mass Spectrometry Lab, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1007/978-1-60761-322-0_22DOI Listing
January 2010

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.

J Lipid Res 2009 Dec 15;50(12):2389-97. Epub 2009 Jun 15.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1194/jlr.M900119-JLR200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781311PMC
December 2009

Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy.

Expert Opin Ther Targets 2009 Dec;13(12):1449-58

Medical University of South Carolina (MUSC), Division of Basic Sciences, Department of Biochemistry & Molecular Biology, 173 Ashley Avenue, MSC 504, Charleston, South Carolina 29425-5040, USA.

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http://www.tandfonline.com/doi/full/10.1517/1472822090335751
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http://dx.doi.org/10.1517/14728220903357512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796572PMC
December 2009

Synthesis and bioevaluation of omega-N-amino analogs of B13.

Bioorg Med Chem 2009 Mar 31;17(5):1840-8. Epub 2009 Jan 31.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/j.bmc.2009.01.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696190PMC
March 2009

Long-term cognitive outcome in teenage survivors of arrhythmic cardiac arrest.

Resuscitation 2008 Apr 18;77(1):46-50. Epub 2008 Jan 18.

Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland.

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http://dx.doi.org/10.1016/j.resuscitation.2007.10.024DOI Listing
April 2008

Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells.

Cancer Chemother Pharmacol 2008 Feb 12;61(2):231-42. Epub 2007 Apr 12.

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29403, USA.

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http://dx.doi.org/10.1007/s00280-007-0465-0DOI Listing
February 2008

Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents.

Bioorg Med Chem 2008 Jan 24;16(2):1015-31. Epub 2007 Aug 24.

Department of Biochemistry & Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, POB 250509, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/j.bmc.2007.08.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2287182PMC
January 2008

Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids.

Bioorg Med Chem 2008 Jan 24;16(2):1032-45. Epub 2007 Aug 24.

Department of Biochemistry & Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, PO Box 250509, Charleston, SC 29425, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096808960700736
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http://dx.doi.org/10.1016/j.bmc.2007.08.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268750PMC
January 2008

Acid ceramidase inhibition: a novel target for cancer therapy.

Front Biosci 2008 Jan 1;13:2293-8. Epub 2008 Jan 1.

Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.2741/2843DOI Listing
January 2008

Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells.

Biochim Biophys Acta 2007 Dec 9;1771(12):1407-17. Epub 2007 Nov 9.

John Wayne Cancer Institute at Saint John's Health Center, Department of Experimental Therapeutics, Santa Monica, CA 90404, USA.

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http://dx.doi.org/10.1016/j.bbalip.2007.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569095PMC
December 2007

Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens.

Eukaryot Cell 2007 Oct 10;6(10):1715-26. Epub 2007 Aug 10.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1128/EC.00208-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043385PMC
October 2007

Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice.

J Clin Invest 2007 Oct;117(10):2993-3006

Genetics of Development and Disease Branch, NIDDK, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI30674
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http://dx.doi.org/10.1172/JCI30674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978422PMC
October 2007

The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy.

Cancer Biol Ther 2007 Sep 23;6(9):1455-60. Epub 2007 Jun 23.

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.4161/cbt.6.9.4623DOI Listing
September 2007

JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction.

J Biol Chem 2007 Aug 3;282(35):25940-9. Epub 2007 Jul 3.

Ralph H. Johnson Veterans Affairs Medical Center, and the Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M701812200DOI Listing
August 2007

Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.

J Biol Chem 2007 Jun 5;282(23):16718-28. Epub 2007 Feb 5.

Division of Hematology/Oncology, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M700647200
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http://dx.doi.org/10.1074/jbc.M700647200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2084375PMC
June 2007

Tailoring structure-function and targeting properties of ceramides by site-specific cationization.

Bioorg Med Chem 2006 Nov 17;14(21):7083-104. Epub 2006 Aug 17.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, 29425, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096808960600548
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http://dx.doi.org/10.1016/j.bmc.2006.07.016DOI Listing
November 2006

Involvement of sphingolipids in apoptin-induced cell killing.

Mol Ther 2006 Nov 22;14(5):627-36. Epub 2006 Aug 22.

Department of Microbiology and Immunology, Medical University of South Carolina, P.O. Box 250504, 173 Ashley Avenue, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1016/j.ymthe.2006.07.001DOI Listing
November 2006

Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells.

Mol Cancer Ther 2006 Jun;5(6):1520-9

Swiss HPB Center, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Rämistrasse 100, CH-8091 Zurich, Switzerland.

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http://dx.doi.org/10.1158/1535-7163.MCT-05-0513DOI Listing
June 2006

Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry.

Methods 2006 Jun;39(2):82-91

Lipidomics Core, Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S104620230600072
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http://dx.doi.org/10.1016/j.ymeth.2006.05.004DOI Listing
June 2006

Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids.

J Biol Chem 2006 Mar 27;281(11):7324-31. Epub 2005 Dec 27.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M508382200
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http://dx.doi.org/10.1074/jbc.M508382200DOI Listing
March 2006

Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.

Biochem J 2006 Jan;393(Pt 2):513-21

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1042/BJ20051083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360701PMC
January 2006

Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.

FASEB J 2006 Jan 8;20(1):184-6. Epub 2005 Nov 8.

Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1096/fj.05-4646fjeDOI Listing
January 2006

Substrate specificity of human ceramide kinase.

J Lipid Res 2005 Dec 18;46(12):2706-16. Epub 2005 Sep 18.

Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA.

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http://dx.doi.org/10.1194/jlr.M500313-JLR200DOI Listing
December 2005

Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine.

J Biol Chem 2005 May 1;280(18):17601-7. Epub 2005 Mar 1.

Department of Biochemistry, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0614, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M414173200
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http://dx.doi.org/10.1074/jbc.M414173200DOI Listing
May 2005

Positively charged ceramide is a potent inducer of mitochondrial permeabilization.

J Biol Chem 2005 Apr 18;280(16):16096-105. Epub 2005 Feb 18.

Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina 29401, USA.

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http://dx.doi.org/10.1074/jbc.M411707200DOI Listing
April 2005

Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.

J Biol Chem 2004 Dec 12;279(52):53994-4001. Epub 2004 Oct 12.

Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC 29725, USA.

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http://dx.doi.org/10.1074/jbc.M410144200DOI Listing
December 2004

The human FA2H gene encodes a fatty acid 2-hydroxylase.

J Biol Chem 2004 Nov 27;279(47):48562-8. Epub 2004 Aug 27.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M406649200DOI Listing
November 2004

The structural requirements for ceramide activation of serine-threonine protein phosphatases.

J Lipid Res 2004 Mar 1;45(3):496-506. Epub 2003 Dec 1.

Department of Biochemistry & Molecular Biology, Medical University of South Carolina, and Ralph H Johnson Veterans Administration Mecial Center, Charleston, SC, USA.

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http://dx.doi.org/10.1194/jlr.M300347-JLR200DOI Listing
March 2004

Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2.

J Biol Chem 2004 Mar 15;279(12):11320-6. Epub 2003 Dec 15.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://www.jbc.org/content/279/12/11320.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M309262200
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http://dx.doi.org/10.1074/jbc.M309262200DOI Listing
March 2004

The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts.

Prostate 2004 Mar;58(4):382-93

Research Service, Baltimore Veterans Affairs Medical Center, and Department of Pathology, University of Marland School of Medicine, Baltimore, 21201, USA.

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http://doi.wiley.com/10.1002/pros.10350
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http://dx.doi.org/10.1002/pros.10350DOI Listing
March 2004

Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release.

J Biol Chem 2003 Oct 10;278(40):38206-13. Epub 2003 Jul 10.

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M304816200DOI Listing
October 2003

Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.

J Biol Chem 2003 Mar 6;278(11):9276-82. Epub 2003 Jan 6.

Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

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http://dx.doi.org/10.1074/jbc.M211529200DOI Listing
March 2003

Structural determinants of sphingolipid recognition by commercially available anti-ceramide antibodies.

J Lipid Res 2002 Dec;43(12):2042-8

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1194/jlr.m200241-jlr200DOI Listing
December 2002

Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes.

FEBS Lett 2002 Apr;516(1-3):47-52

Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, 14195, Berlin, Germany.

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http://dx.doi.org/10.1016/s0014-5793(02)02472-9DOI Listing
April 2002

Substrate specificity of rat brain ceramidase.

J Lipid Res 2002 Jan;43(1):141-8

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA.

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January 2002