Alexander Strong

Alexander Strong

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Alexander Strong

Alexander Strong

Publications by authors named "Alexander Strong"

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PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice.

Authors:
Julia Weber Jorge de la Rosa Carolyn S Grove Markus Schick Lena Rad Olga Baranov Alexander Strong Anja Pfaus Mathias J Friedrich Thomas Engleitner Robert Lersch Rupert Öllinger Michael Grau Irene Gonzalez Menendez Manuela Martella Ursula Kohlhofer Ruby Banerjee Maria A Turchaninova Anna Scherger Gary J Hoffman Julia Hess Laura B Kuhn Tim Ammon Johnny Kim Günter Schneider Kristian Unger Ursula Zimber-Strobl Mathias Heikenwälder Marc Schmidt-Supprian Fengtang Yang Dieter Saur Pentao Liu Katja Steiger Dmitriy M Chudakov Georg Lenz Leticia Quintanilla-Martinez Ulrich Keller George S Vassiliou Juan Cadiñanos Allan Bradley Roland Rad

Nat Commun 2019 03 29;10(1):1415. Epub 2019 Mar 29.

Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Technische Universität München, Munich, 81675, Germany.

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http://dx.doi.org/10.1038/s41467-019-09180-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440946PMC
March 2019

Predicting the mutations generated by repair of Cas9-induced double-strand breaks.

Authors:
Felicity Allen Luca Crepaldi Clara Alsinet Alexander J Strong Vitalii Kleshchevnikov Pietro De Angeli Petra Páleníková Anton Khodak Vladimir Kiselev Michael Kosicki Andrew R Bassett Heather Harding Yaron Galanty Francisco Muñoz-Martínez Emmanouil Metzakopian Stephen P Jackson Leopold Parts

Nat Biotechnol 2018 Nov 27. Epub 2018 Nov 27.

Wellcome Sanger Institute, Hinxton, UK.

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http://www.nature.com/doifinder/10.1038/nbt.4317
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http://dx.doi.org/10.1038/nbt.4317DOI Listing
November 2018

A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes.

Authors:
Jorge de la Rosa Julia Weber Mathias Josef Friedrich Yilong Li Lena Rad Hannes Ponstingl Qi Liang Sandra Bernaldo de Quirós Imran Noorani Emmanouil Metzakopian Alexander Strong Meng Amy Li Aurora Astudillo María Teresa Fernández-García María Soledad Fernández-García Gary J Hoffman Rocío Fuente George S Vassiliou Roland Rad Carlos López-Otín Allan Bradley Juan Cadiñanos

Nat Genet 2017 May 20;49(5):730-741. Epub 2017 Mar 20.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409503PMC
May 2017

Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice.

Authors:
Mathias J Friedrich Lena Rad Iraad F Bronner Alexander Strong Wei Wang Julia Weber Matthew Mayho Hannes Ponstingl Thomas Engleitner Carolyn Grove Anja Pfaus Dieter Saur Juan Cadiñanos Michael A Quail George S Vassiliou Pentao Liu Allan Bradley Roland Rad

Nat Protoc 2017 Feb 12;12(2):289-309. Epub 2017 Jan 12.

Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1038/nprot.2016.164DOI Listing
February 2017

Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.

Authors:
Roman Maresch Sebastian Mueller Christian Veltkamp Rupert Öllinger Mathias Friedrich Irina Heid Katja Steiger Julia Weber Thomas Engleitner Maxim Barenboim Sabine Klein Sandra Louzada Ruby Banerjee Alexander Strong Teresa Stauber Nina Gross Ulf Geumann Sebastian Lange Marc Ringelhan Ignacio Varela Kristian Unger Fengtang Yang Roland M Schmid George S Vassiliou Rickmer Braren Günter Schneider Mathias Heikenwalder Allan Bradley Dieter Saur Roland Rad

Nat Commun 2016 Feb 26;7:10770. Epub 2016 Feb 26.

Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.

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http://dx.doi.org/10.1038/ncomms10770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773438PMC
February 2016

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.

Authors:
Julia Weber Rupert Öllinger Mathias Friedrich Ursula Ehmer Maxim Barenboim Katja Steiger Irina Heid Sebastian Mueller Roman Maresch Thomas Engleitner Nina Gross Ulf Geumann Beiyuan Fu Angela Segler Detian Yuan Sebastian Lange Alexander Strong Jorge de la Rosa Irene Esposito Pentao Liu Juan Cadiñanos George S Vassiliou Roland M Schmid Günter Schneider Kristian Unger Fengtang Yang Rickmer Braren Mathias Heikenwälder Ignacio Varela Dieter Saur Allan Bradley Roland Rad

Proc Natl Acad Sci U S A 2015 Nov 27;112(45):13982-7. Epub 2015 Oct 27.

Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;

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http://dx.doi.org/10.1073/pnas.1512392112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653208PMC
November 2015

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

Authors:
Felix Dietlein Bastian Kalb Mladen Jokic Elisa M Noll Alexander Strong Lars Tharun Luka Ozretić Helen Künstlinger Kato Kambartel Winfried J Randerath Christian Jüngst Anna Schmitt Alessandro Torgovnick André Richters Daniel Rauh Florian Siedek Thorsten Persigehl Cornelia Mauch Jirina Bartkova Allan Bradley Martin R Sprick Andreas Trumpp Roland Rad Dieter Saur Jiri Bartek Jürgen Wolf Reinhard Büttner Roman K Thomas H Christian Reinhardt

Cell 2015 Jul;162(1):146-59

Department I of Internal Medicine, University Hospital Cologne, Weyertal 115B, 50931 Cologne, Germany; CECAD, University of Cologne, Weyertal 115B, 50931 Cologne, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.05.053DOI Listing
July 2015

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.

Authors:
Roland Rad Lena Rad Wei Wang Alexander Strong Hannes Ponstingl Iraad F Bronner Matthew Mayho Katja Steiger Julia Weber Maren Hieber Christian Veltkamp Stefan Eser Ulf Geumann Rupert Öllinger Magdalena Zukowska Maxim Barenboim Roman Maresch Juan Cadiñanos Mathias Friedrich Ignacio Varela Fernando Constantino-Casas Aaron Sarver Jelle Ten Hoeve Haydn Prosser Barbara Seidler Judith Bauer Mathias Heikenwälder Emmanouil Metzakopian Anne Krug Ursula Ehmer Günter Schneider Thomas Knösel Petra Rümmele Daniela Aust Robert Grützmann Christian Pilarsky Zemin Ning Lodewyk Wessels Roland M Schmid Michael A Quail George Vassiliou Irene Esposito Pentao Liu Dieter Saur Allan Bradley

Nat Genet 2015 Jan 8;47(1):47-56. Epub 2014 Dec 8.

The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1038/ng.3164DOI Listing
January 2015

A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

Authors:
Roland Rad Juan Cadiñanos Lena Rad Ignacio Varela Alexander Strong Lydia Kriegl Fernando Constantino-Casas Stefan Eser Maren Hieber Barbara Seidler Stacey Price Mario F Fraga Vincenzo Calvanese Gary Hoffman Hannes Ponstingl Günter Schneider Kosuke Yusa Carolyn Grove Roland M Schmid Wei Wang George Vassiliou Thomas Kirchner Ultan McDermott Pentao Liu Dieter Saur Allan Bradley

Cancer Cell 2013 Jul;24(1):15-29

Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, 81675, München, Germany.

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http://dx.doi.org/10.1016/j.ccr.2013.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706745PMC
July 2013

PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice.

Authors:
Roland Rad Lena Rad Wei Wang Juan Cadinanos George Vassiliou Stephen Rice Lia S Campos Kosuke Yusa Ruby Banerjee Meng Amy Li Jorge de la Rosa Alexander Strong Dong Lu Peter Ellis Nathalie Conte Fang Tang Yang Pentao Liu Allan Bradley

Science 2010 Nov 14;330(6007):1104-7. Epub 2010 Oct 14.

Wellcome Trust Sanger Institute, Genome Campus, Hinxton-Cambridge CB10 1SA, UK.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1193004
Publisher Site
http://dx.doi.org/10.1126/science.1193004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719098PMC
November 2010