Publications by authors named "Alex R Tanner"

2 Publications

  • Page 1 of 1

Influenza vaccination: protecting the most vulnerable.

Eur Respir Rev 2021 Mar 13;30(159). Epub 2021 Jan 13.

School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

Influenza virus infection causes seasonal epidemics and occasional pandemics, leading to huge morbidity and mortality worldwide. Vaccination against influenza is needed annually as protection from constantly mutating strains is required. Groups at high risk of poor outcomes include the elderly, the very young, pregnant women and those with chronic health conditions. However, vaccine effectiveness in the elderly is generally poor due to immunosenescence and may be altered due to "original antigenic sin". Strategies to overcome these challenges in the elderly include high-dose or adjuvant vaccines. Other options include vaccinating healthcare workers and children as this reduces community-level influenza transmission. Current guidelines in the UK are that young children receive a live attenuated nasal spray vaccine, adults aged >65 years receive an adjuvanted trivalent inactivated vaccine and adults aged <65 years with comorbidities receive a quadrivalent inactivated vaccine. The goal of a universal influenza vaccine targeting conserved regions of the virus and avoiding the need for annual vaccination is edging closer with early-phase trials under way.
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http://dx.doi.org/10.1183/16000617.0258-2020DOI Listing
March 2021

Physical distancing in schools for SARS-CoV-2 and the resurgence of rhinovirus.

Lancet Respir Med 2020 12 22;8(12):e92-e93. Epub 2020 Oct 22.

School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK; Department of Infection, University Hospital Southampton NHS Foundation Trust, Southampton, UK; NIHR Southampton Biomedical Research Centre, Southampton, UK; NIHR Post-Doctoral Fellowship Programme, UK.

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http://dx.doi.org/10.1016/S2213-2600(20)30502-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581315PMC
December 2020