Publications by authors named "Alessandra Moretti"

53Publications

Precise Correction of Heterozygous SHOX2 Mutations in hiPSCs Derived from Patients with Atrial Fibrillation via Genome Editing and Sib Selection.

Stem Cell Reports 2020 Oct 24;15(4):999-1013. Epub 2020 Sep 24.

Department of Human Molecular Genetics, Institute of Human Genetics, University of Heidelberg, 69120 Heidelberg, Baden-Wuerttemberg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2020.08.015DOI Listing
October 2020

Domain zipping and unzipping modulates TRPM4's properties in human cardiac conduction disease.

FASEB J 2020 Jul 17. Epub 2020 Jul 17.

Molecular Cell Biology, Centre for Molecular Signaling (PZMS), Medical Faculty, Saarland University, Homburg, Germany.

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http://dx.doi.org/10.1096/fj.202000097RRDOI Listing
July 2020

Transcriptome Analysis of Reticulated Platelets Reveals a Prothrombotic Profile.

Thromb Haemost 2019 Nov 1;119(11):1795-1806. Epub 2019 Sep 1.

Medical Department 1, Cardiology, Klinikum rechts der Isar, Technische Universität, Munich, Germany.

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http://dx.doi.org/10.1055/s-0039-1695009DOI Listing
November 2019

Subtype-specific Optical Action Potential Recordings in Human Induced Pluripotent Stem Cell-derived Ventricular Cardiomyocytes.

J Vis Exp 2018 09 27(139). Epub 2018 Sep 27.

Medical Department I, University Hospital Klinikum rechts der Isar, Technical University of Munich; German Centre for Cardiovascular Research (DZHK), Munich Heart Alliance;

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https://www.jove.com/video/58134/subtype-specific-optical-ac
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http://dx.doi.org/10.3791/58134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235334PMC
September 2018

Aberrant Deactivation-Induced Gain of Function in TRPM4 Mutant Is Associated with Human Cardiac Conduction Block.

Cell Rep 2018 07;24(3):724-731

Molecular Cell Biology, Centre for Molecular Signaling (PZMS), Medical Faculty, Saarland University, 66421 Homburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.034DOI Listing
July 2018

Perspectives and Challenges of Pluripotent Stem Cells in Cardiac Arrhythmia Research.

Curr Cardiol Rep 2017 03;19(3):23

Klinikum rechts der Isar, Technische Universität München, Klinik und Poliklinik Innere Medizin I - Kardiologie, Ismaningerstrasse 22, 81675, Munich, Germany.

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http://dx.doi.org/10.1007/s11886-017-0828-zDOI Listing
March 2017

Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium.

J Am Coll Cardiol 2017 Jan;69(2):131-143

I. Medizinische Klinik und Poliklinik, University Clinic Rechts der Isar, Technical University of Munich, Munich, Germany; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Walter-Brendel-Centre for Experimental Medicine, Ludwig Maximilian University of Munich, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.10.058DOI Listing
January 2017

[Diverticular disease: towards 2020. An evidence-based approach].

Recenti Prog Med 2016 Jun;107(6):309-19

Unità Complessa di Gastroenterologia ed Epatologia, Ospedale San Filippo Neri, Roma.

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http://dx.doi.org/10.1701/2296.24692DOI Listing
June 2016

Human Engineered Heart Tissue: Analysis of Contractile Force.

Stem Cell Reports 2016 07 19;7(1):29-42. Epub 2016 May 19.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2016.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944531PMC
July 2016

Genetically Encoded Voltage Indicators in Circulation Research.

Int J Mol Sci 2015 Sep 8;16(9):21626-42. Epub 2015 Sep 8.

Research Centre for Molecular Imaging and Screening, Institute for Molecular Cell Biology, Saarland University, Homburg/Saar 66421, Germany.

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http://dx.doi.org/10.3390/ijms160921626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613271PMC
September 2015

Functional comparison of induced pluripotent stem cell- and blood-derived GPIIbIIIa deficient platelets.

PLoS One 2015 21;10(1):e0115978. Epub 2015 Jan 21.

I. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany; DZHK (German Centre for Cardiovascular Research)-partner site Munich Heart Alliance, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115978PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301811PMC
January 2016

Extending human induced pluripotent stem cell technology to infectious diseases: new model for viral myocarditis.

Circ Res 2014 Aug;115(6):537-9

From the I. Medical Department, Cardiology, Klinikum rechts der Isar-Technische Universität München, Munich, Germany (D.S., K.-L.L., A.M.); and DZHK (German Centre for Cardiovascular Research)-Partner Site Munich Heart Alliance, Munich, Germany (K.-L.L., A.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.114.304786DOI Listing
August 2014

Induced pluripotent stem cell-derived cardiomyocytes for drug development and toxicity testing.

Pharmacol Ther 2014 Aug 19;143(2):246-52. Epub 2014 Mar 19.

Klinikum rechts der Isar - Technische Universität München, I. Medical Department - Cardiology, Ismaninger Strasse 22, 81675 Munich, Germany; DZHK (German Centre for Cardiovascular Research) - Partner Site, Munich Heart Alliance, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2014.03.004DOI Listing
August 2014

A case of hepatocellular carcinoma: spontaneous regression?

Dig Liver Dis 2014 Jul 13;46(7):659-60. Epub 2014 Mar 13.

Gastroenterology and Hepatology Unit, San Filippo Neri Hospital, Rome, Italy.

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http://dx.doi.org/10.1016/j.dld.2014.02.007DOI Listing
July 2014

Automated analysis of contractile force and Ca2+ transients in engineered heart tissue.

Am J Physiol Heart Circ Physiol 2014 May 28;306(9):H1353-63. Epub 2014 Feb 28.

Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Martinistraße, Hamburg, Germany;

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http://dx.doi.org/10.1152/ajpheart.00705.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116534PMC
May 2014

Pluripotent stem cell models of human heart disease.

Cold Spring Harb Perspect Med 2013 Nov 1;3(11). Epub 2013 Nov 1.

Klinikum rechts der Isar-Technische Universität München, I. Medical Department-Cardiology, 81675 Munich, Germany.

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http://dx.doi.org/10.1101/cshperspect.a014027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808770PMC
November 2013

Embryonic heart progenitors and cardiogenesis.

Cold Spring Harb Perspect Med 2013 Oct 1;3(10):a013847. Epub 2013 Oct 1.

Klinikum rechts der Isar, Technische Universität München, I. Medical Department, Cardiology, 81675 Munich, Germany.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a013847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784811PMC
October 2013

Negating the dominant-negative allele: a new treatment paradigm for arrhythmias explored in human induced pluripotent stem cell-derived cardiomyocytes.

Eur Heart J 2014 Apr 12;35(16):1019-21. Epub 2013 Apr 12.

Klinikum rechts der Isar-Technische Universität München, First Department of Medicine, Cardiology Division, Ismaninger Strasse 22, D-81675 Munich, Germany.

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http://dx.doi.org/10.1093/eurheartj/eht130DOI Listing
April 2014

Induced pluripotent stem cell-derived cardiomyocytes: a versatile tool for arrhythmia research.

Circ Res 2013 Mar;112(6):961-8

Klinikum rechts der Isar, Technische Universität München, I. Medizinische Klinik, Kardiologie, Munich, Germany.

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.112.26862
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http://dx.doi.org/10.1161/CIRCRESAHA.112.268623DOI Listing
March 2013

Low bioavailability and traditional systemic steroids in IBD: can the former take over the latter?

J Gastrointestin Liver Dis 2013 Mar;22(1):65-71

Gastroenterology and Hepatology Unit, San Filippo Neri Hospital, Rome, Italy.

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March 2013

Modeling long-QT syndromes with iPS cells.

J Cardiovasc Transl Res 2013 Feb 18;6(1):31-6. Epub 2012 Oct 18.

I. Medizinische Klinik Kardiologie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675, Munich, Germany.

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http://dx.doi.org/10.1007/s12265-012-9416-1DOI Listing
February 2013

Induced pluripotent stem cells in cardiovascular research.

Rev Physiol Biochem Pharmacol 2012 ;163:1-26

Klinikum rechts der Isar - Technische Universität München, I. Medizinische Klinik - Kardiologie, Ismaninger Strasse 22, 81675, Munich, Germany.

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http://dx.doi.org/10.1007/112_2012_6DOI Listing
March 2013

Recapitulating long-QT syndrome using induced pluripotent stem cell technology.

Pediatr Cardiol 2012 Aug 13;33(6):950-8. Epub 2012 Mar 13.

Medizinische Klinik-Kardiologie, Klinikum rechts der Isar-Technische Universität München, Ismaninger Straße 22, 81675, München, Germany.

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http://dx.doi.org/10.1007/s00246-012-0286-8DOI Listing
August 2012

MicroRNAs in a cardiac loop: progenitor or myocyte?

Dev Cell 2010 Dec;19(6):787-8

Department of Medicine, University of California San Diego, La Jolla, 92093, USA.

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http://dx.doi.org/10.1016/j.devcel.2010.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035161PMC
December 2010

Patient-specific induced pluripotent stem-cell models for long-QT syndrome.

N Engl J Med 2010 Oct 21;363(15):1397-409. Epub 2010 Jul 21.

Cardiology Division, First Department of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

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http://www.nejm.org/doi/abs/10.1056/NEJMoa0908679
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http://dx.doi.org/10.1056/NEJMoa0908679DOI Listing
October 2010

Neuropotent self-renewing neural stem (NS) cells derived from mouse induced pluripotent stem (iPS) cells.

Mol Cell Neurosci 2010 Mar 21;43(3):287-95. Epub 2009 Dec 21.

Università degli Studi di Milano, Department of Pharmacological Sciences and Centre for Stem Cell Research, 20133 Milano, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S104474310900263
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http://dx.doi.org/10.1016/j.mcn.2009.12.002DOI Listing
March 2010

Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors.

FASEB J 2010 Mar 22;24(3):700-11. Epub 2009 Oct 22.

Klinikum rechts der Isar and Deutsches Herzzentrum, Technical University of Munich, I. Medical Department, Molecular Cardiology, Ismaninger Strasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1096/fj.09-139477DOI Listing
March 2010

Multipotent progenitor cells in regenerative cardiovascular medicine.

Pediatr Cardiol 2009 Jul 5;30(5):690-8. Epub 2009 May 5.

Klinikum rechts der Isar and German Heart Center, Technical University of Munich, I. Medical Clinic, Molecular Cardiology, Ismaninger Strasse 22, 81675 Munich, Germany.

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http://dx.doi.org/10.1007/s00246-009-9450-1DOI Listing
July 2009

The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway.

Cell Stem Cell 2007 Aug 14;1(2):165-79. Epub 2007 Jun 14.

Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, MA 02114-2790, USA.

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http://dx.doi.org/10.1016/j.stem.2007.05.018DOI Listing
August 2007

Islet1 cardiovascular progenitors: a single source for heart lineages?

Development 2008 Jan;135(2):193-205

Massachusetts General Hospital - Cardiovascular Research Center, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1242/dev.001883DOI Listing
January 2008

Long-term outcome of Crohn's disease following corticosteroid-induced remission.

Am J Gastroenterol 2007 Apr 11;102(4):814-9. Epub 2007 Jan 11.

Gastroenterology Unit, S. Filippo Neri Hospital, Rome, Italy.

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http://dx.doi.org/10.1111/j.1572-0241.2007.01055.xDOI Listing
April 2007

Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification.

Cell 2006 Dec 22;127(6):1151-65. Epub 2006 Nov 22.

Massachusetts General Hospital - Cardiovascular Research Center, Charles River Plaza/CPZN 3208, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.cell.2006.10.029DOI Listing
December 2006

Gene transfer of the pancaspase inhibitor P35 reduces myocardial infarct size and improves cardiac function.

J Mol Med (Berl) 2005 Jul 21;83(7):526-34. Epub 2005 Jun 21.

1. Medizinische Klinik und Deutsches Herzzentrum München, Klinikum rechts der Isar, Technische Universität, Munich, Germany.

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http://dx.doi.org/10.1007/s00109-005-0683-zDOI Listing
July 2005

Development. ES cells to the rescue.

Science 2004 Oct;306(5694):239-40

Institute of Molecular Medicine, University of California San Diego, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/science.1104769DOI Listing
October 2004