Publications by authors named "Aleksandr Ianevski"

24Publications

Identification and Tracking of Antiviral Drug Combinations.

Authors:
Aleksandr Ianevski Rouan Yao Svetlana Biza Eva Zusinaite Andres Mannik Gaily Kivi Anu Planken Kristiina Kurg Eva-Maria Tombak Mart Ustav Nastassia Shtaida Evgeny Kulesskiy Eunji Jo Jaewon Yang Hilde Lysvand Kirsti Løseth Valentyn Oksenych Per Arne Aas Tanel Tenson Astra Vitkauskienė Marc P Windisch Mona Høysæter Fenstad Svein Arne Nordbø Mart Ustav Magnar Bjørås Denis E Kainov

Viruses 2020 10 18;12(10). Epub 2020 Oct 18.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.

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October 2020

Non-canonical effector functions of the T-memory-like T-PLL cell are shaped by cooperative TCL1A and TCR signaling.

Authors:
Sebastian Oberbeck Alexandra Schrader Kathrin Warner Dennis Jungherz Giuliano Crispatzu Jana von Jan Markus Chmielewski Aleksandr Ianevski Hans H Diebner Petra Mayer Aichatou Kondo Ados Linus Wahnschaffe Till Braun Tony A Müller Prerana Wagle Alyssa Bouska Tom Neumann Sabine Pützer Lesley Varghese Natali Pflug Martin Thelen Jennifer Makalowski Nicole Riet Hedwig Julia Maria Göx Gunter Rappl Janine Altmüller Michaela Kotrova Thorsten Persigehl Georg Hopfinger Martin L Hansmann Hans Schlößer Stephan Stilgenbauer Jan Dürig Dimitrios Mougiakakos Michael von Bergwelt-Baildon Ingo Roeder Sylvia Hartmann Michael Hallek Richard H Moriggl Monika Brüggemann Tero Aittokallio Javeed Iqbal Sebastian Newrzela Hinrich Abken Marco Herling

Blood 2020 Sep 21. Epub 2020 Sep 21.

University of Cologne (UoC), Cologne, Germany.

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September 2020

RUNX1 mutations in blast-phase chronic myeloid leukemia associate with distinct phenotypes, transcriptional profiles, and drug responses.

Authors:
Shady Adnan Awad Olli Dufva Aleksandr Ianevski Bishwa Ghimire Jan Koski Pilvi Maliniemi Daniel Thomson Andreas Schreiber Caroline A Heckman Perttu Koskenvesa Matti Korhonen Kimmo Porkka Susan Branford Tero Aittokallio Matti Kankainen Satu Mustjoki

Leukemia 2020 Aug 11. Epub 2020 Aug 11.

Hematology Research Unit Helsinki, University of Helsinki and Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

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August 2020

Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis.

Authors:
Aleksandr Ianevski Evgeny Kulesskiy Klara Krpina Guofeng Lou Yahyah Aman Andrii Bugai Koit Aasumets Yevhen Akimov Daria Bulanova Kiira Gildemann Albert F Arutyunyan Olga Yu Susova Alexei L Zhuze Ping Ji Wei Wang Toril Holien Marit Bugge Eva Zusinaite Valentyn Oksenych Hilde Lysvand Joachim M Gerhold Magnar Bjørås Pål Johansen Anders Waage Caroline A Heckman Evandro F Fang Denis E Kainov

Cancers (Basel) 2020 Jun 25;12(6). Epub 2020 Jun 25.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.

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June 2020

Potential Antiviral Options against SARS-CoV-2 Infection.

Authors:
Aleksandr Ianevski Rouan Yao Mona Høysæter Fenstad Svetlana Biza Eva Zusinaite Tuuli Reisberg Hilde Lysvand Kirsti Løseth Veslemøy Malm Landsem Janne Fossum Malmring Valentyn Oksenych Sten Even Erlandsen Per Arne Aas Lars Hagen Caroline H Pettersen Tanel Tenson Jan Egil Afset Svein Arne Nordbø Magnar Bjørås Denis E Kainov

Viruses 2020 06 13;12(6). Epub 2020 Jun 13.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.

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June 2020

Prediction of drug combination effects with a minimal set of experiments.

Authors:
Aleksandr Ianevski Anil K Giri Prson Gautam Alexander Kononov Swapnil Potdar Jani Saarela Krister Wennerberg Tero Aittokallio

Nat Mach Intell 2019 Dec 9;1(12):568-577. Epub 2019 Dec 9.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00290 Helsinki, Finland.

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December 2019

SynergyFinder 2.0: visual analytics of multi-drug combination synergies.

Authors:
Aleksandr Ianevski Anil K Giri Tero Aittokallio

Nucleic Acids Res 2020 07;48(W1):W488-W493

Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, FI-00290 Helsinki, Finland.

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July 2020

Breeze: an integrated quality control and data analysis application for high-throughput drug screening.

Authors:
Swapnil Potdar Aleksandr Ianevski John-Patrick Mpindi Dmitrii Bychkov Clément Fiere Philipp Ianevski Bhagwan Yadav Krister Wennerberg Tero Aittokallio Olli Kallioniemi Jani Saarela Päivi Östling

Bioinformatics 2020 06;36(11):3602-3604

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00290 Helsinki, Finland.

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June 2020

SynergyFinder: a web application for analyzing drug combination dose-response matrix data.

Authors:
Aleksandr Ianevski Liye He Tero Aittokallio Jing Tang

Bioinformatics 2020 04;36(8):2645

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April 2020

Discovery and development of safe-in-man broad-spectrum antiviral agents.

Authors:
Petter I Andersen Aleksandr Ianevski Hilde Lysvand Astra Vitkauskiene Valentyn Oksenych Magnar Bjørås Kaidi Telling Irja Lutsar Uga Dumpis Yasuhiko Irie Tanel Tenson Anu Kantele Denis E Kainov

Int J Infect Dis 2020 Apr 17;93:268-276. Epub 2020 Feb 17.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7028 Trondheim, Norway; Institute of Technology, University of Tartu, 50090 Tartu, Estonia; Institute for Molecular Medicine Finland, FIMM, University of Helsinki, 00014 Helsinki, Finland. Electronic address:

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April 2020

SynToxProfiler: An interactive analysis of drug combination synergy, toxicity and efficacy.

Authors:
Aleksandr Ianevski Sanna Timonen Alexander Kononov Tero Aittokallio Anil K Giri

PLoS Comput Biol 2020 02 3;16(2):e1007604. Epub 2020 Feb 3.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.

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February 2020

Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity.

Authors:
Olli Dufva Jan Koski Pilvi Maliniemi Aleksandr Ianevski Jay Klievink Judith Leitner Petri Pölönen Helena Hohtari Khalid Saeed Tiina Hannunen Pekka Ellonen Peter Steinberger Matti Kankainen Tero Aittokallio Mikko A I Keränen Matti Korhonen Satu Mustjoki

Blood 2020 02;135(9):597-609

Hematology Research Unit Helsinki, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.

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February 2020

Common Nodes of Virus-Host Interaction Revealed Through an Integrated Network Analysis.

Authors:
Korbinian Bösl Aleksandr Ianevski Thoa T Than Petter I Andersen Suvi Kuivanen Mona Teppor Eva Zusinaite Uga Dumpis Astra Vitkauskiene Rebecca J Cox Hannimari Kallio-Kokko Anders Bergqvist Tanel Tenson Andres Merits Valentyn Oksenych Magnar Bjørås Marit W Anthonsen David Shum Mari Kaarbø Olli Vapalahti Marc P Windisch Giulio Superti-Furga Berend Snijder Denis Kainov Richard K Kandasamy

Front Immunol 2019 4;10:2186. Epub 2019 Oct 4.

Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway.

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November 2020

Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine.

Authors:
Petter I Andersen Klara Krpina Aleksandr Ianevski Nastassia Shtaida Eunji Jo Jaewon Yang Sandra Koit Tanel Tenson Veijo Hukkanen Marit W Anthonsen Magnar Bjoras Magnus Evander Marc P Windisch Eva Zusinaite Denis E Kainov

Viruses 2019 10 18;11(10). Epub 2019 Oct 18.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.

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October 2019

Genome-wide off-targets of drugs: risks and opportunities.

Authors:
Anil K Giri Aleksandr Ianevski Tero Aittokallio

Cell Biol Toxicol 2019 12 20;35(6):485-487. Epub 2019 Aug 20.

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00290, Helsinki, Finland.

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December 2019

Expanding the activity spectrum of antiviral agents.

Authors:
Aleksandr Ianevski Petter I Andersen Andres Merits Magnar Bjørås Denis Kainov

Drug Discov Today 2019 05 10;24(5):1224-1228. Epub 2019 Apr 10.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway; Institute of Technology, University of Tartu, Tartu 50090, Estonia. Electronic address:

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May 2019

Low Temperature and Low UV Indexes Correlated with Peaks of Influenza Virus Activity in Northern Europe during 2010⁻2018.

Authors:
Aleksandr Ianevski Eva Zusinaite Nastassia Shtaida Hannimari Kallio-Kokko Miia Valkonen Anu Kantele Kaidi Telling Irja Lutsar Pille Letjuka Natalja Metelitsa Valentyn Oksenych Uga Dumpis Astra Vitkauskiene Kestutis Stašaitis Christina Öhrmalm Kåre Bondeson Anders Bergqvist Rebecca J Cox Tanel Tenson Andres Merits Denis E Kainov

Viruses 2019 03 1;11(3). Epub 2019 Mar 1.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.

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March 2019

Interactive visual analysis of drug-target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing.

Authors:
Ziaurrehman Tanoli Zaid Alam Aleksandr Ianevski Krister Wennerberg Markus Vähä-Koskela Tero Aittokallio

Brief Bioinform 2018 Dec 18. Epub 2018 Dec 18.

Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.

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December 2018

A Systems Approach to Study Immuno- and Neuro-Modulatory Properties of Antiviral Agents.

Authors:
Eva Zusinaite Aleksandr Ianevski Diana Niukkanen Minna M Poranen Magnar Bjørås Jan Egil Afset Tanel Tenson Vidya Velagapudi Andres Merits Denis E Kainov

Viruses 2018 08 12;10(8). Epub 2018 Aug 12.

Institute of Technology, University of Tartu, 50090 Tartu, Estonia.

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August 2018

Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity.

Authors:
Simon Loevenich Aleksandr Ianevski Eneli Oitmaa Denis E Kainov Marit W Anthonsen

Genome Announc 2018 May 24;6(21). Epub 2018 May 24.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway

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May 2018

Novel activities of safe-in-human broad-spectrum antiviral agents.

Authors:
Aleksandr Ianevski Eva Zusinaite Suvi Kuivanen Mårten Strand Hilde Lysvand Mona Teppor Laura Kakkola Henrik Paavilainen Mira Laajala Hannimari Kallio-Kokko Miia Valkonen Anu Kantele Kaidi Telling Irja Lutsar Pille Letjuka Natalja Metelitsa Valentyn Oksenych Magnar Bjørås Svein Arne Nordbø Uga Dumpis Astra Vitkauskiene Christina Öhrmalm Kåre Bondeson Anders Bergqvist Tero Aittokallio Rebecca J Cox Magnus Evander Veijo Hukkanen Varpu Marjomaki Ilkka Julkunen Olli Vapalahti Tanel Tenson Andres Merits Denis Kainov

Antiviral Res 2018 06 23;154:174-182. Epub 2018 Apr 23.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim 7028, Norway; Institute of Technology, University of Tartu, Tartu 50090, Estonia. Electronic address:

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June 2018

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins.

Authors:
Daria Bulanova Aleksandr Ianevski Andrii Bugai Yevhen Akimov Suvi Kuivanen Henrik Paavilainen Laura Kakkola Jatin Nandania Laura Turunen Tiina Ohman Hanna Ala-Hongisto Hanna M Pesonen Marika S Kuisma Anni Honkimaa Emma L Walton Valentyn Oksenych Martina B Lorey Dmitry Guschin Jungmin Shim Jinhee Kim Thoa T Than So Young Chang Veijo Hukkanen Evgeny Kulesskiy Varpu S Marjomaki Ilkka Julkunen Tuula A Nyman Sampsa Matikainen Jani S Saarela Famara Sane Didier Hober Gülsah Gabriel Jef K De Brabander Miika Martikainen Marc P Windisch Ji-Young Min Roberto Bruzzone Tero Aittokallio Markus Vähä-Koskela Olli Vapalahti Arto Pulk Vidya Velagapudi Denis E Kainov

Viruses 2017 09 25;9(10). Epub 2017 Sep 25.

Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki 00290, Finland.

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September 2017

SynergyFinder: a web application for analyzing drug combination dose-response matrix data.

Authors:
Aleksandr Ianevski Liye He Tero Aittokallio Jing Tang

Bioinformatics 2017 Aug;33(15):2413-2415

Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00290 Helsinki, Finland.

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August 2017

Obatoclax, saliphenylhalamide and gemcitabine inhibit Zika virus infection in vitro and differentially affect cellular signaling, transcription and metabolism.

Authors:
Suvi Kuivanen Maxim M Bespalov Jatin Nandania Aleksandr Ianevski Vidya Velagapudi Jef K De Brabander Denis E Kainov Olli Vapalahti

Antiviral Res 2017 Mar 31;139:117-128. Epub 2016 Dec 31.

Department of Virology, Medicum, University of Helsinki, Finland; Department of Virology and Immunology, University of Helsinki and Helsinki University Hospital, Finland; Department of Veterinary Biosciences, University of Helsinki, Finland. Electronic address:

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March 2017