Alberto Mantovani

Alberto Mantovani

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Alberto Mantovani

Publications by authors named "Alberto Mantovani"

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Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor-conditioned macrophages.

Eur J Immunol 2019 May 28;49(5):801-811. Epub 2019 Feb 28.

Humanitas Clinical and Research Center IRCCS, Department of Innate Immunity and Inflammation, via Manzoni 56, 20089, Rozzano, Milan, Italy.

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http://dx.doi.org/10.1002/eji.201847888DOI Listing
May 2019

One Clever Macrophage Checkpoint.

Clin Cancer Res 2019 Apr 1. Epub 2019 Apr 1.

Humanitas Clinical and Research Center-IRCCS, Rozzano (Milan), Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0483DOI Listing
April 2019

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity.

Immunity 2019 Apr;50(4):778-795

IRCCS Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano Milan, Italy; Humanitas University, via Rita Levi Montalcini, 20090 Pieve Emanuele Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.03.012DOI Listing
April 2019

Complementing the Cancer-Immunity Cycle.

Front Immunol 2019 12;10:774. Epub 2019 Apr 12.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.00774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473060PMC
April 2019

Pentraxin 3 in Cardiovascular Disease.

Front Immunol 2019 17;10:823. Epub 2019 Apr 17.

Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy.

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00823
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http://dx.doi.org/10.3389/fimmu.2019.00823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481278PMC
April 2019

The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals.

J Immunol 2019 Mar 4;202(6):1807-1814. Epub 2019 Feb 4.

Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1701531
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http://dx.doi.org/10.4049/jimmunol.1701531DOI Listing
March 2019

Characterization and Management of Uncertainties in Toxicological Risk Assessment: Examples from the Opinions of the European Food Safety Authority.

Methods Mol Biol 2018 ;1800:219-229

Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità (ISS) viale Regina Elena, Rome, Italy.

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http://dx.doi.org/10.1007/978-1-4939-7899-1_10DOI Listing
February 2019

Vaccines: An achievement of civilization, a human right, our health insurance for the future.

J Exp Med 2019 Jan 3;216(1):7-9. Epub 2018 Dec 3.

Humanitas Clinical and Research Center, Milan, Italy

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http://dx.doi.org/10.1084/jem.20182160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314523PMC
January 2019

Scientists on the Spot: the Guide to Immunopharmacology as a new resource for the cardiovascular community.

Cardiovasc Res 2019 Jan;115(1):e5-e6

Spedding Research Solutions SAS, 6 Rue Ampere, Le Vesinet, France.

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http://dx.doi.org/10.1093/cvr/cvy296DOI Listing
January 2019

Aging, inflammation and cancer.

Semin Immunol 2018 12 6;40:74-82. Epub 2018 Nov 6.

Humanitas Clinical and Research Center, via Manzoni 56, 20089, Rozzano, Milan, Italy; Humanitas University, via Rita Levi Montalcini, 20090, Pieve Emanuele, Milan, Italy; The William Harvey Research Institute, Queen Mary University of London, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10445323183008
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http://dx.doi.org/10.1016/j.smim.2018.10.011DOI Listing
December 2018

Editorial: The Environment-Animal-Human Web: A "One Health" View of Toxicological Risk Analysis.

Front Public Health 2018 3;6:353. Epub 2018 Dec 3.

Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.

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https://www.frontiersin.org/article/10.3389/fpubh.2018.00353
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http://dx.doi.org/10.3389/fpubh.2018.00353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287105PMC
December 2018

Macrophage Checkpoint Blockade in Cancer - Back to the Future.

N Engl J Med 2018 11;379(18):1777-1779

From the Humanitas Clinical and Research Center and Humanitas University, Milan (A.M.); and the William Harvey Research Institute, Queen Mary University of London, London (A.M.).

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http://www.nejm.org/doi/10.1056/NEJMe1811699
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http://dx.doi.org/10.1056/NEJMe1811699DOI Listing
November 2018

Why research on Endocrine Disrupting Chemicals is still worthwhile. Editorial.

Ann Ist Super Sanita 2017 Jan-Mar;53(1):1-2

Dipartimento di Sanità Pubblica Veterinaria e Sicurezza Alimentare, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.4415/ANN_17_01_01DOI Listing
October 2018

Regulation of hematopoiesis by the chemokine system.

Cytokine 2018 Sep;109:76-80

Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano (MI), Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, 20090 Pieve Emanuele (MI), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2018.01.021DOI Listing
September 2018

Cancer Inflammation and Cytokines.

Cold Spring Harb Perspect Biol 2018 Aug 1;10(8). Epub 2018 Aug 1.

Istituto di Ricovero e Cura a Carattere Scientifo (IRCCS), Istituto Clinico Humanitas, Rozzano, Milan, Italy.

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http://dx.doi.org/10.1101/cshperspect.a028662DOI Listing
August 2018

The atypical chemokine receptor ACKR2 drives pulmonary fibrosis by tuning influx of CCR2 and CCR5 IFNγ-producing γδT cells in mice.

Am J Physiol Lung Cell Mol Physiol 2018 Jun 22;314(6):L1010-L1025. Epub 2018 Feb 22.

Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.

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https://www.physiology.org/doi/10.1152/ajplung.00233.2017
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http://dx.doi.org/10.1152/ajplung.00233.2017DOI Listing
June 2018

Protective effect of Nigella sativa oil against acetamiprid induced reproductive toxicity in male rats.

Drug Chem Toxicol 2018 Apr 3;41(2):206-212. Epub 2017 Jul 3.

e Department of Food Safety and Veterinary Public Health , Istituto Superiore di Sanità , Rome , Italy.

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http://dx.doi.org/10.1080/01480545.2017.1337127DOI Listing
April 2018

Redundancy and robustness versus division of labour and specialization in innate immunity.

Semin Immunol 2018 04 19;36:28-30. Epub 2017 Dec 19.

Humanitas Clinical and Research Center, via Manzoni 56, 20089, Rozzano, Milan, Italy; Humanitas University, via Rita Levi Montalcini, 20090, Pieve Emanuele, Milan, Italy; The William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, EC1 M 6BQ, United Kingdom.

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http://dx.doi.org/10.1016/j.smim.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923876PMC
April 2018

PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer.

Physiol Rev 2018 04;98(2):623-639

Humanitas Clinical and Research Center, Rozzano, Milan , Italy ; Humanitas University, Rozzano, Milan , Italy ; Department of Medical Biotechnologies and Translational Medicine, University of Milan , Milan , Italy ; and The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1152/physrev.00016.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985957PMC
April 2018

Alessandro Moretta 1953-2018.

Nat Immunol 2018 04;19(4):315

Istituto Clinico Humanitas, Humanitas University, Milan, Italy.

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http://dx.doi.org/10.1038/s41590-018-0075-5DOI Listing
April 2018

Roles of neutrophils in cancer growth and progression.

J Leukoc Biol 2018 03 15;103(3):457-464. Epub 2017 Dec 15.

Department of Translational Medical Sciences (DiSMeT), University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1002/JLB.3MR0717-292RDOI Listing
March 2018

The inflammation - cancer connection.

FEBS J 2018 02;285(4):638-640

Humanitas Clinical and Research Center, Milan, Italy.

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http://dx.doi.org/10.1111/febs.14395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935239PMC
February 2018

Complement in cancer: untangling an intricate relationship.

Nat Rev Immunol 2018 Jan 18;18(1):5-18. Epub 2017 Sep 18.

Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania 19104, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/nri.2017.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816344PMC
January 2018

Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8.

Immunol Rev 2018 01;281(1):233-247

Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano, Italy.

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http://dx.doi.org/10.1111/imr.12609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922415PMC
January 2018

IL-1 and IL-1 regulatory pathways in cancer progression and therapy.

Immunol Rev 2018 01;281(1):57-61

Humanitas Clinical and Research Center, Milan, Italy.

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http://dx.doi.org/10.1111/imr.12614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922413PMC
January 2018

Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice.

Intensive Care Med Exp 2017 Dec 6;5(1):13. Epub 2017 Mar 6.

Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122, Milan, Italy.

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http://dx.doi.org/10.1186/s40635-017-0126-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339261PMC
December 2017

Targeting tumor associated macrophages: The new challenge for nanomedicine.

Semin Immunol 2017 12 21;34:103-113. Epub 2017 Sep 21.

Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Via A. Manzoni 113, 20089 Rozzano, Milan, Italy.

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http://dx.doi.org/10.1016/j.smim.2017.09.004DOI Listing
December 2017

Wandering pathways in the regulation of innate immunity and inflammation.

J Autoimmun 2017 Dec 25;85:1-5. Epub 2017 Oct 25.

Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, Milan, Italy; Humanitas University, Via Rita Levi Montalcini, 20090, Pieve Emanuele, Milan, Italy; The William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923875PMC
December 2017

The long pentraxin PTX3: A prototypical sensor of tissue injury and a regulator of homeostasis.

Immunol Rev 2017 11;280(1):112-125

Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1111/imr.12570DOI Listing
November 2017

From Invention to Innovation: Risk Analysis to Integrate One Health Technology in the Dairy Farm.

Front Public Health 2017 23;5:302. Epub 2017 Nov 23.

Istituto Zooprofilattico Sperimentale del Lazio e della Toscana "M. Aleandri", Section of Florence, Florence, Italy.

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http://dx.doi.org/10.3389/fpubh.2017.00302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703835PMC
November 2017

The juvenile toxicity study as a tool for a science-based risk assessment in the children population group.

Reprod Toxicol 2017 09 4;72:136-141. Epub 2017 Jul 4.

Center for Gender-Specific Medicine, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.reprotox.2017.06.188DOI Listing
September 2017

Editorial.

Reprod Toxicol 2017 Sep;72:12

Istituto Superiore di Sanità, Italy.

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http://dx.doi.org/10.1016/j.reprotox.2017.07.018DOI Listing
September 2017

Heme-oxygenase-1 Production by Intestinal CX3CR1 Macrophages Helps to Resolve Inflammation and Prevents Carcinogenesis.

Cancer Res 2017 08 15;77(16):4472-4485. Epub 2017 Jun 15.

Departement of Immunology and Inflammation, IRCCS-Humanitas Clinical and Research Center, Via Manzoni, Rozzano, Milano, Italy.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-16-2501DOI Listing
August 2017

Tumour-associated macrophages as treatment targets in oncology.

Nat Rev Clin Oncol 2017 Jul 24;14(7):399-416. Epub 2017 Jan 24.

Istituto Clinico Humanitas, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Via A. Manzoni 113, 20089 Rozzano, Milan, Italy.

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http://dx.doi.org/10.1038/nrclinonc.2016.217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480600PMC
July 2017

Atypical matters in myeloid differentiation.

Nat Immunol 2017 06;18(7):711-712

Humanitas Clinical and Research Center and the Department of Biomedical Sciences, Humanitas University, Rozzano, Italy.

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http://dx.doi.org/10.1038/ni.3776DOI Listing
June 2017

Immune checkpoint inhibitors in malignant pleural mesothelioma.

Lancet Oncol 2017 05;18(5):559-561

Humanitas University, Istituto Clinico Humanitas IRCCS, Milan, Italy.

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http://dx.doi.org/10.1016/S1470-2045(17)30191-2DOI Listing
May 2017

Iodine nutritional status and thyroid effects of exposure to ethylenebisdithiocarbamates.

Environ Res 2017 04 7;154:152-159. Epub 2017 Jan 7.

Department of Cell Biology and Neuroscience, Italian National Institute of Health, Viale Regina Elena 299, 00161 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.envres.2016.12.019DOI Listing
April 2017

Editorial: Regulation of Inflammation, Its Resolution and Therapeutic Targeting.

Front Immunol 2017 18;8:415. Epub 2017 Apr 18.

Humanitas Clinical and Research Center, Rozzano, Italy.

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http://dx.doi.org/10.3389/fimmu.2017.00415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394768PMC
April 2017

Humoral innate immunity at the crossroad between microbe and matrix recognition: The role of PTX3 in tissue damage.

Semin Cell Dev Biol 2017 01 29;61:31-40. Epub 2016 Jul 29.

Humanitas Clinical and Research Center, Rozzano, Milan 20089, Italy.

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http://dx.doi.org/10.1016/j.semcdb.2016.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419421PMC
January 2017

Pentraxin 3 in patients with severe sepsis or shock: the ALBIOS trial.

Eur J Clin Invest 2017 Jan 14;47(1):73-83. Epub 2016 Dec 14.

Department of Cardiovascular Research, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.

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http://dx.doi.org/10.1111/eci.12704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414835PMC
January 2017

Analysis of Food Safety and Security Challenges in Emerging African Food Producing Areas through a One Health Lens: The Dairy Chains in Mali.

J Food Prot 2017 Jan;80(1):57-67

External Relations Office, Istituto Superiore di Sanità, via Giano della Bella 34, 00162 Rome, Italy.

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http://dx.doi.org/10.4315/0362-028X.JFP-15-561DOI Listing
January 2017

Human semen as an early, sensitive biomarker of highly polluted living environment in healthy men: A pilot biomonitoring study on trace elements in blood and semen and their relationship with sperm quality and RedOx status.

Reprod Toxicol 2016 12 1;66:1-9. Epub 2016 Sep 1.

Andrology Unit of the "San Francesco d'Assisi" Hospital, Local Health Authority (ASL) Salerno, EcoFoodFertility Project Coordination Unit, via M. Clemente, 84020 Oliveto Citra (SA), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.reprotox.2016.07.018DOI Listing
December 2016

Dietary exposure of the Italian population to inorganic arsenic: The 2012-2014 Total Diet Study.

Food Chem Toxicol 2016 Dec 15;98(Pt B):148-158. Epub 2016 Oct 15.

Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità-Italian National Institute of Health, Rome, Italy.

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http://dx.doi.org/10.1016/j.fct.2016.10.015DOI Listing
December 2016

Innate immunity, hemostasis and matrix remodeling: PTX3 as a link.

Semin Immunol 2016 12 20;28(6):570-577. Epub 2016 Nov 20.

Istituto Clinico Humanitas IRCCS, via Manzoni 113, 20089 Rozzano, Italy; Humanitas University, via Manzoni 113, 20089 Rozzano, Italy.

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http://dx.doi.org/10.1016/j.smim.2016.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414833PMC
December 2016

Macrophage Metabolism Shapes Angiogenesis in Tumors.

Cell Metab 2016 12;24(6):887-888

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http://dx.doi.org/10.1016/j.cmet.2016.11.007DOI Listing
December 2016

Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation.

Cytokine 2016 11 4;87:37-45. Epub 2016 Aug 4.

Department of Animal Pathology, Faculty of Veterinary Medicine, University of Milan, Italy.

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http://dx.doi.org/10.1016/j.cyto.2016.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414836PMC
November 2016

Pentraxins in the activation and regulation of innate immunity.

Immunol Rev 2016 11;274(1):202-217

Department of Inflammation and Immunology, Humanitas Clinical and Research Center, Rozzano (Milan), Italy.

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http://dx.doi.org/10.1111/imr.12476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412954PMC
November 2016

Macrophage Metabolism Shapes Angiogenesis in Tumors.

Cell Metab 2016 11;24(5):653-654

Istituto Clinico Humanitas IRCCS, via Manzoni 56, 20089 Rozzano, Italy; Department of Medical Biotechnology and Translational Medicine, University of Milan, 20122 Milan, Italy.

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http://dx.doi.org/10.1016/j.cmet.2016.10.016DOI Listing
November 2016

Health risks from lost awareness of cultural behaviours rooted in traditional medicine: An insight in geophagy and mineral intake.

Sci Total Environ 2016 Oct 21;566-567:1465-1471. Epub 2016 Jun 21.

University of Port Harcourt, Rivers State, Nigeria. Electronic address:

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http://dx.doi.org/10.1016/j.scitotenv.2016.06.028DOI Listing
October 2016

The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.

J Exp Med 2016 09 12;213(10):2167-85. Epub 2016 Sep 12.

Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029 Program for Inflammatory and Cardiovascular Disorders, Institut Hospital del Mar d'Investigacions Mèdiques, 08003 Barcelona, Spain Catalan Institute for Research and Advanced Studies, 08003 Barcelona, Spain

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http://dx.doi.org/10.1084/jem.20150282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030794PMC
September 2016

Carcinogenetic mechanisms of endocrine disruptors in female cancers (Review).

Oncol Rep 2016 Aug 21;36(2):603-12. Epub 2016 Jun 21.

Department of Medical Oncology, CRO Aviano, National Cancer Institute, I-33081 Aviano, Italy.

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http://dx.doi.org/10.3892/or.2016.4886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933552PMC
August 2016

Macrophage heterogeneity in the context of rheumatoid arthritis.

Nat Rev Rheumatol 2016 08 7;12(8):472-85. Epub 2016 Jul 7.

Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford OX3 7LF, UK.

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http://dx.doi.org/10.1038/nrrheum.2016.91DOI Listing
August 2016

The Dual Complexity of PTX3 in Health and Disease: A Balancing Act?

Trends Mol Med 2016 06 11;22(6):497-510. Epub 2016 May 11.

Humanitas Clinical and Research Center, Rozzano, Milan 20089, Italy.

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http://dx.doi.org/10.1016/j.molmed.2016.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414840PMC
June 2016