Alberto Bardelli

Alberto Bardelli

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Alberto Bardelli

Publications by authors named "Alberto Bardelli"

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A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology.

Clin Colorectal Cancer 2019 Jun 7;18(2):91-101.e3. Epub 2019 Mar 7.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Italy; University of Turin, Department of Oncology, Candiolo (TO), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2019.02.008DOI Listing
June 2019

Corrigendum to Preclinical models for precision oncology. BBACAN 1870/2 (2018) 239-246.

Biochim Biophys Acta Rev Cancer 2019 May 25. Epub 2019 May 25.

Candiolo Cancer Institute-FPO, IRCCS, Candiolo, TO, Italy; Department of Oncology, University of Torino, SP 142 km 3.95, Candiolo, TO, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2019.05.002DOI Listing
May 2019

Exploiting DNA repair defects in colorectal cancer.

Mol Oncol 2019 04 2;13(4):681-700. Epub 2019 Mar 2.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Italy.

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http://doi.wiley.com/10.1002/1878-0261.12467
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http://dx.doi.org/10.1002/1878-0261.12467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441925PMC
April 2019

Early-onset colorectal cancer in young individuals.

Mol Oncol 2019 02 22;13(2):109-131. Epub 2018 Dec 22.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano (La Statale), Milan, Italy.

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http://dx.doi.org/10.1002/1878-0261.12417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360363PMC
February 2019

Retreatment with anti-EGFR monoclonal antibodies in metastatic colorectal cancer: Systematic review of different strategies.

Cancer Treat Rev 2019 Feb 27;73:41-53. Epub 2018 Dec 27.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy; Università degli Studi di Milano, Dipartimento di Oncologia ed Emato-Oncologia, Milano, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03057372183021
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http://dx.doi.org/10.1016/j.ctrv.2018.12.006DOI Listing
February 2019

Preclinical models for precision oncology.

Biochim Biophys Acta Rev Cancer 2018 12 28;1870(2):239-246. Epub 2018 Jun 28.

Candiolo Cancer Institute-FPO, IRCCS, Candiolo, TO, Italy; Department of Oncology, University of Torino, SP 142 km 3.95, Candiolo, TO, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2018.06.004DOI Listing
December 2018

The Clinical Impact of the Genomic Landscape of Mismatch Repair-Deficient Cancers.

Cancer Discov 2018 12 15;8(12):1518-1528. Epub 2018 Nov 15.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Torino, Italy.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-0150DOI Listing
December 2018

Inactivation of DNA repair-prospects for boosting cancer immune surveillance.

Genome Med 2018 11 28;10(1):91. Epub 2018 Nov 28.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, TO, Italy.

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http://dx.doi.org/10.1186/s13073-018-0603-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260742PMC
November 2018

SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.

Nat Med 2018 07 28;24(7):961-967. Epub 2018 May 28.

Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41591-018-0023-9DOI Listing
July 2018

Exploring the links between cancer and placenta development.

Open Biol 2018 06;8(6)

INGM, Istituto Nazionale Genetica Molecolare "Romeo ed Enrica Invernizzi", Milan, Italy.

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http://rsob.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rsob.180081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030113PMC
June 2018

Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer.

Clin Colorectal Cancer 2018 03 1;17(1):80-83. Epub 2017 Nov 1.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2017.10.017DOI Listing
March 2018

Integrating liquid biopsies into the management of cancer.

Nat Rev Clin Oncol 2017 Sep 2;14(9):531-548. Epub 2017 Mar 2.

Candiolo Cancer Institute - Fondazione del Piemonte per l'Oncologia (FPO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Strada Provinciale 142, Km 3.95, 10060 Candiolo, Torino, Italy.

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http://dx.doi.org/10.1038/nrclinonc.2017.14DOI Listing
September 2017

Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges.

Nat Rev Clin Oncol 2017 09 4;14(9):562-576. Epub 2017 Apr 4.

Drug Resistance Group, Centre for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.

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http://dx.doi.org/10.1038/nrclinonc.2017.40DOI Listing
September 2017

Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients.

Clin Cancer Res 2017 Aug 15;23(15):4312-4322. Epub 2017 Mar 15.

Digestive Molecular Clinical Oncology Research Unit, Department of Medicine, Università degli studi di Verona, Verona, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-3153DOI Listing
August 2017

Tumor Evolution as a Therapeutic Target.

Cancer Discov 2017 Jul 20. Epub 2017 Jul 20.

Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia (FPO), IRCCS, Candiolo, Torino, Italy.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0343DOI Listing
July 2017

Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance.

Nat Commun 2017 06 8;8:15617. Epub 2017 Jun 8.

Department of Pharmacology and Cancer Biology, Duke University, Durham, North California 27710, USA.

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http://dx.doi.org/10.1038/ncomms15617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472712PMC
June 2017

Medical research: Personalized test tracks cancer relapse.

Authors:
Alberto Bardelli

Nature 2017 05;545(7655):417-418

Department of Oncology, University of Torino, 10060 Candiolo, Italy, and at the Candiolo Cancer Institute-FPO, IRCCS.

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http://dx.doi.org/10.1038/545417aDOI Listing
May 2017

Lemur tyrosine kinase 2 (LMTK2) is a determinant of cell sensitivity to apoptosis by regulating the levels of the BCL2 family members.

Cancer Lett 2017 03 29;389:59-69. Epub 2016 Dec 29.

Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.12.025DOI Listing
March 2017

Lesion-Directed Therapies and Monitoring Tumor Evolution Using Liquid Biopsies.

Cold Spring Harb Perspect Med 2017 Feb 1;7(2). Epub 2017 Feb 1.

Department of Oncology, University of Torino, 10060 Candiolo (TO), Italy.

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http://dx.doi.org/10.1101/cshperspect.a029587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287059PMC
February 2017

Liquid Biopsies, What We Do Not Know (Yet).

Cancer Cell 2017 02;31(2):172-179

Department of Tumor Biology, Center of Experimental Medicine, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraβe 52, 20246 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.01.002DOI Listing
February 2017

Overcoming dynamic molecular heterogeneity in metastatic colorectal cancer: Multikinase inhibition with regorafenib and the case of rechallenge with anti-EGFR.

Cancer Treat Rev 2016 Dec 29;51:54-62. Epub 2016 Oct 29.

Department of Medical Oncology, Campus Bio-Medico University of Rome, 00128 Rome, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03057372163010
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http://dx.doi.org/10.1016/j.ctrv.2016.10.006DOI Listing
December 2016

Clonal evolution and - coamplification during secondary resistance to EGFR-targeted therapy in metastatic colorectal cancer.

ESMO Open 2016 4;1(4):e000079. Epub 2016 Aug 4.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milano, Italy; Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano, Milano, Italy.

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http://esmoopen.bmj.com/lookup/doi/10.1136/esmoopen-2016-000
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http://dx.doi.org/10.1136/esmoopen-2016-000079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070243PMC
August 2016

Blood circulating tumor DNA for non-invasive genotyping of colon cancer patients.

Mol Oncol 2016 Mar 17;10(3):475-80. Epub 2015 Dec 17.

University of Torino, Department of Oncology, SP 142, KM 3.95, 10060 Candiolo, Torino, Italy; Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528968PMC
March 2016

Sensitivity to Entrectinib Associated With a Novel LMNA-NTRK1 Gene Fusion in Metastatic Colorectal Cancer.

J Natl Cancer Inst 2016 Jan 12;108(1). Epub 2015 Nov 12.

Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy (ASB, AA, EV, LP, EB, GM, SV, AV, SS); Nerviano Medical Sciences S.r.l Nerviano, Milan, Italy (EA, RB, AS, LR, PB, AL, RA, AG, AI); Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy (SM, AB); University of Torino, Department of Oncology, Candiolo, Torino, Italy (AB); FIRC Institute of Molecular Oncology (IFOM), Milano, Italy (SM); Ignyta, Inc., San Diego, CA (DL, ZH, JL); Clioss S.r.l. Nerviano, Milan, Italy (MM, CD); Università degli Studi di Milano, Milan, Italy (SS).

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http://dx.doi.org/10.1093/jnci/djv306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712682PMC
January 2016

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs.

Cell Rep 2015 Sep 10;12(12):1978-85. Epub 2015 Sep 10.

Cancer Genomics Centre Netherlands, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.037DOI Listing
September 2015

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

Nat Commun 2015 Sep 22;6:8305. Epub 2015 Sep 22.

Candiolo Cancer Institute - Fondazione Piemontese per l'Oncologia (FPO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Torino, 10060, Italy.

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http://dx.doi.org/10.1038/ncomms9305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595628PMC
September 2015

Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model.

FASEB J 2015 Feb 30;29(2):464-76. Epub 2014 Oct 30.

Oncogenesis and Antitumor Drug Group, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina, Barcelona, Spain;

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http://dx.doi.org/10.1096/fj.14-262303DOI Listing
February 2015

TGFα and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells.

Clin Cancer Res 2014 Dec 10;20(24):6429-38. Epub 2014 Jun 10.

Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Torino. University of Torino, Department of Oncology, Candiolo, Torino, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0774DOI Listing
December 2014

Circulating pEGFR is a candidate response biomarker of cetuximab therapy in colorectal cancer.

Clin Cancer Res 2014 Dec 16;20(24):6346-56. Epub 2014 Oct 16.

Vall d'Hebron Institute of Oncology (VHIO), Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0361DOI Listing
December 2014

Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution.

Cancer Discov 2014 Nov 7;4(11):1269-80. Epub 2014 Oct 7.

Department of Oncology, University of Torino, Candiolo, Torino, Italy. Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy. FIRC Institute of Molecular Oncology (IFOM), Milano, Italy.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0462DOI Listing
November 2014

The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone.

Neuro Oncol 2014 Sep 6;16(9):1263-73. Epub 2014 Feb 6.

Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (R.J.M., C.J.F.v.N.); Neurosurgical Center Amsterdam, Academic Medical Center, Amsterdam, The Netherlands (F.E.B., D.V., W.P.V.); Laboratory of Molecular Genetics, The Oncogenomics Center, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy (S.La., C.Z., A.B., F.E.B.); Department of Pathology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands (J.W.M.J., S.H.E.B.-S., P.W.); Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands (P.W.); Department of Neurogenetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (T.J.M.H.); Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (D.T., A.A.v.T.); Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands (W.P.V.); Department of Neurosurgery, St. Elisabeth Hospital Tilburg, The Netherlands (S.Le.); Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands (S.Le.); FIRC Institute of Molecular Oncology, Milan, Italy (A.B.)Present affiliation: Department of Clinical Genetics, Academic Medical Center and University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands (F.E.B.); Department of Pathology, Radboud University Medical Center Nijmegen, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands (A.A.v.T.); Department of Neurology, Radboud University Medical Centre Nijmegen, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands (S.H.E.B.-S.); Department of Pathology, Stichting PAMM, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands (J.W.M.J.).

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https://academic.oup.com/neuro-oncology/article-lookup/doi/1
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http://dx.doi.org/10.1093/neuonc/nou005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136888PMC
September 2014

Acquired resistance to EGFR-targeted therapies in colorectal cancer.

Mol Oncol 2014 Sep 14;8(6):1084-94. Epub 2014 May 14.

Candiolo Cancer Institute - FPO, IRCCS, Str prov 142 Km 3.95, 10060 Candiolo, Torino, Italy; University of Torino, Department of Oncology, Strada Provinciale, 142 km 3.95, 10060 Candiolo, Torino, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2014.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528615PMC
September 2014

RAF suppression synergizes with MEK inhibition in KRAS mutant cancer cells.

Cell Rep 2014 Sep 4;8(5):1475-83. Epub 2014 Sep 4.

Department of Oncology, University of Torino, Str prov 142 Km 3.95, Candiolo, 10060 Torino, Italy; Candiolo Cancer Institute-FPO, IRCCS, Str prov 142 Km 3.95, Candiolo, 10060 Torino, Italy. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(14)00617-2.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471400617
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http://dx.doi.org/10.1016/j.celrep.2014.07.033DOI Listing
September 2014

Mutational profiling of kinases in glioblastoma.

BMC Cancer 2014 Sep 26;14:718. Epub 2014 Sep 26.

Department of Oncology, University of Torino, SP 142, Km 3,95, Candiolo, Torino, 10060, Italy; Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy.

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http://dx.doi.org/10.1186/1471-2407-14-718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192443PMC
September 2014

Monitoring tumor-derived cell-free DNA in patients with solid tumors: clinical perspectives and research opportunities.

Cancer Treat Rev 2014 Jun 23;40(5):648-55. Epub 2013 Oct 23.

Division of Early Drug Development for Innovative Therapies, Istituto Europeo di Oncologia, Via Ripamonti 435, 20133 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ctrv.2013.10.003DOI Listing
June 2014

Minimal residual disease in breast cancer: in blood veritas.

Clin Cancer Res 2014 May 21;20(10):2505-7. Epub 2014 Mar 21.

Authors' Affiliations: Department of Oncology, University of Turin; Candiolo Cancer Institute-FPO, IRCCS, Turin; and FIRC Institute of Molecular Oncology (IFOM), Milan, ItalyAuthors' Affiliations: Department of Oncology, University of Turin; Candiolo Cancer Institute-FPO, IRCCS, Turin; and FIRC Institute of Molecular Oncology (IFOM), Milan, ItalyAuthors' Affiliations: Department of Oncology, University of Turin; Candiolo Cancer Institute-FPO, IRCCS, Turin; and FIRC Institute of Molecular Oncology (IFOM), Milan, Italy

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0370DOI Listing
May 2014

Targeted knock-in of the polymorphism rs61764370 does not affect KRAS expression but reduces let-7 levels.

Hum Mutat 2014 Feb 27;35(2):208-14. Epub 2013 Dec 27.

IRCC, Institute for Cancer Research at Candiolo, SP142 Km 3.95, Torino, Italy.

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http://dx.doi.org/10.1002/humu.22487DOI Listing
February 2014

Liquid biopsies: genotyping circulating tumor DNA.

J Clin Oncol 2014 Feb 21;32(6):579-86. Epub 2014 Jan 21.

Luis A. Diaz Jr, Swim Across America Laboratory and Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD; and Alberto Bardelli, Institute for Cancer Research and Treatment at Candiolo, University of Torino, Candiolo, and the Fondazione Italiana per la Ricerca sul Cancro Institute of Molecular Oncology, Milan, Italy.

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http://dx.doi.org/10.1200/JCO.2012.45.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820760PMC
February 2014

Somatic alterations as the basis for resistance to targeted therapies.

J Pathol 2014 Jan;232(2):244-54

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/path.4278DOI Listing
January 2014

Climbing RAS, the everest of oncogenes.

Cancer Discov 2014 Jan;4(1):19-21

1University of Turin, Department of Oncology, Candiolo (TO); 2IRCC, Institute for Cancer Research and Treatment at Candiolo, Candiolo (TO); 3FIRC Institute of Molecular Oncology (IFOM), Milan, Italy.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0906DOI Listing
January 2014

BRAF V600E is a determinant of sensitivity to proteasome inhibitors.

Mol Cancer Ther 2013 Dec 9;12(12):2950-61. Epub 2013 Oct 9.

Corresponding Authors: Federica Di Nicolantonio, Department of Oncology, University of Torino, Institute for Cancer Research and Treatment at Candiolo, Strada Provinciale 142 Km 3.95, Candiolo, I-10060, Turin, Italy.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0243DOI Listing
December 2013

Oncogenes and angiogenesis: a way to personalize anti-angiogenic therapy?

Cell Mol Life Sci 2013 Nov 18;70(21):4131-40. Epub 2013 May 18.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, PO Box 2543, 4058, Basel, Switzerland,

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http://dx.doi.org/10.1007/s00018-013-1331-3DOI Listing
November 2013

Liquid biopsy: monitoring cancer-genetics in the blood.

Nat Rev Clin Oncol 2013 Aug 9;10(8):472-84. Epub 2013 Jul 9.

Department of Oncology, University of Turin, Institute for Cancer Research and Treatment, Strada Provinciale 142 Km 3.95, 10060 Candiolo, Turin, Italy.

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http://dx.doi.org/10.1038/nrclinonc.2013.110DOI Listing
August 2013

Mouse models of Kras-mutant colorectal cancer: valuable GEMMs for drug testing?

Clin Cancer Res 2013 Jun 23;19(11):2794-6. Epub 2013 Apr 23.

Department of Oncology, University of Torino, Torino, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0339DOI Listing
June 2013

Tivantinib (ARQ197) displays cytotoxic activity that is independent of its ability to bind MET.

Clin Cancer Res 2013 May 26;19(9):2381-92. Epub 2013 Mar 26.

Laboratory of Experimental Therapy, Institute for Cancer Research and Treatment (IRCC), Candiolo, Turin, Italy.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-3459DOI Listing
May 2013