Akhil B Vaidya

Akhil B Vaidya

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Akhil B Vaidya

Publications by authors named "Akhil B Vaidya"

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Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages.

PLoS One 2019 9;14(4):e0214023. Epub 2019 Apr 9.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214023PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456166PMC
December 2019

Diverse Chemical Compounds Target Plasmodium falciparum Plasma Membrane Lipid Homeostasis.

ACS Infect Dis 2019 04 28;5(4):550-558. Epub 2019 Jan 28.

Center for Molecular Parasitology, Department of Microbiology and Immunology , Drexel University College of Medicine , 2900 Queen Lane , Philadelphia , Pennsylvania 19129 , United States of America.

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http://dx.doi.org/10.1021/acsinfecdis.8b00277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461493PMC
April 2019

Reflections on an inflection: From virology to parasitology guided by POLARIS.

Authors:
Akhil B Vaidya

PLoS Pathog 2018 06 14;14(6):e1006941. Epub 2018 Jun 14.

Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America.

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https://dx.plos.org/10.1371/journal.ppat.1006941
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http://dx.doi.org/10.1371/journal.ppat.1006941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002024PMC
June 2018

The mitochondrial ribosomal protein L13 is critical for the structural and functional integrity of the mitochondrion in .

J Biol Chem 2018 05 6;293(21):8128-8137. Epub 2018 Apr 6.

From the Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129.

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http://dx.doi.org/10.1074/jbc.RA118.002552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971461PMC
May 2018

Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity.

Antimicrob Agents Chemother 2017 01 27;61(1). Epub 2016 Dec 27.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/AAC.01220-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192125PMC
January 2017

Antiparasitic and disease-modifying activity of Nyctanthes arbor-tristis Linn. in malaria: An exploratory clinical study.

J Ayurveda Integr Med 2016 Oct - Dec;7(4):238-248. Epub 2016 Nov 30.

ICMR Advanced Centre of Reverse Pharmacology in Traditional Medicine, Medical Research Centre, Kasturba Health Society, Vile Parle (West), Mumbai 400056, India.

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http://dx.doi.org/10.1016/j.jaim.2016.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5192257PMC
November 2016

Characterization of a Plasmodium falciparum Orthologue of the Yeast Ubiquinone-Binding Protein, Coq10p.

PLoS One 2016 25;11(3):e0152197. Epub 2016 Mar 25.

Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152197PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807763PMC
August 2016

Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria.

Antimicrob Agents Chemother 2016 08 22;60(8):4853-9. Epub 2016 Jul 22.

Departments of Physiology and Pharmacology, Molecular Microbiology and Immunology, and Emergency Medicine, Oregon Health & Science University, Portland, Oregon, USA VA Medical Center, Portland, Oregon, USA

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http://dx.doi.org/10.1128/AAC.00791-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958223PMC
August 2016

Na+ Influx Induced by New Antimalarials Causes Rapid Alterations in the Cholesterol Content and Morphology of Plasmodium falciparum.

PLoS Pathog 2016 05 26;12(5):e1005647. Epub 2016 May 26.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881962PMC
May 2016

ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.

Antimicrob Agents Chemother 2015 Sep 29;59(9):5555-60. Epub 2015 Jun 29.

VA Medical Center, Experimental Chemotherapy Laboratory, Portland, Oregon, USA Oregon Health & Science University, Department of Molecular Microbiology and Immunology, Portland, Oregon, USA

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http://dx.doi.org/10.1128/AAC.01183-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538462PMC
September 2015

Inhibition of cytochrome bc1 as a strategy for single-dose, multi-stage antimalarial therapy.

Am J Trop Med Hyg 2015 Jun 27;92(6):1195-201. Epub 2015 Apr 27.

Departments of Physiology and Pharmacology, Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon; Departments of Medicine, Pathology, and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania; VA Medical Center, Portland, Oregon

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http://dx.doi.org/10.4269/ajtmh.14-0553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458825PMC
June 2015

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.

Antimicrob Agents Chemother 2015 Apr 20;59(4):1977-82. Epub 2015 Jan 20.

Departments of Physiology and Pharmacology, Molecular Microbiology, and Immunology, Oregon Health & Science University, Portland, Oregon, USA VA Medical Center, Portland, Oregon, USA

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http://dx.doi.org/10.1128/AAC.04149-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356778PMC
April 2015

Genetic investigation of tricarboxylic acid metabolism during the Plasmodium falciparum life cycle.

Cell Rep 2015 Apr 2;11(1):164-74. Epub 2015 Apr 2.

Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394047PMC
April 2015

The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages.

J Biol Chem 2014 Dec 28;289(50):34827-37. Epub 2014 Oct 28.

From the Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129,

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http://dx.doi.org/10.1074/jbc.M114.615831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263882PMC
December 2014

The metabolic roles of the endosymbiotic organelles of Toxoplasma and Plasmodium spp.

Curr Opin Microbiol 2013 Aug 5;16(4):452-8. Epub 2013 Aug 5.

Center for Tropical and Emerging Global Diseases & Department of Cellular Biology, University of Georgia, 500 D.W. Brooks Drive, Athens, GA 30602, USA.

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http://dx.doi.org/10.1016/j.mib.2013.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767399PMC
August 2013

Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum.

Mol Biochem Parasitol 2012 Sep 26;185(1):48-51. Epub 2012 May 26.

Center for Molecular Parasitology and Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2012.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433233PMC
September 2012

Remarkable stability in patterns of blood-stage gene expression during episodes of non-lethal Plasmodium yoelii malaria.

Malar J 2012 Aug 6;11:265. Epub 2012 Aug 6.

Centre for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA.

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http://malariajournal.biomedcentral.com/articles/10.1186/147
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http://dx.doi.org/10.1186/1475-2875-11-265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489522PMC
August 2012

ATP synthase complex of Plasmodium falciparum: dimeric assembly in mitochondrial membranes and resistance to genetic disruption.

J Biol Chem 2011 Dec 7;286(48):41312-22. Epub 2011 Oct 7.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA.

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http://dx.doi.org/10.1074/jbc.M111.290973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308843PMC
December 2011

A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor.

ACS Chem Biol 2011 Nov 8;6(11):1214-22. Epub 2011 Sep 8.

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/cb200105dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220786PMC
November 2011

Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function.

Eukaryot Cell 2011 Aug 17;10(8):1053-61. Epub 2011 Jun 17.

Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA.

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http://ec.asm.org/content/early/2011/06/17/EC.05049-11.full.
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http://ec.asm.org/cgi/doi/10.1128/EC.05049-11
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http://dx.doi.org/10.1128/EC.05049-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165440PMC
August 2011

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

Mol Biochem Parasitol 2011 May 18;177(1):29-34. Epub 2011 Jan 18.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 W. Queen Lane, Philadelphia, PA 19129, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2011.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057331PMC
May 2011

Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies.

Mol Biochem Parasitol 2010 Dec 30;174(2):150-3. Epub 2010 Jul 30.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2010.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950219PMC
December 2010

Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum.

Antimicrob Agents Chemother 2010 Dec 20;54(12):5281-7. Epub 2010 Sep 20.

Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA.

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http://dx.doi.org/10.1128/AAC.00937-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981233PMC
December 2010

Branched tricarboxylic acid metabolism in Plasmodium falciparum.

Nature 2010 Aug;466(7307):774-8

Department of Molecular Biology and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA.

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http://dx.doi.org/10.1038/nature09301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917841PMC
August 2010

Highly divergent mitochondrial ATP synthase complexes in Tetrahymena thermophila.

PLoS Biol 2010 Jul 13;8(7):e1000418. Epub 2010 Jul 13.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America.

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https://dx.plos.org/10.1371/journal.pbio.1000418
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http://dx.doi.org/10.1371/journal.pbio.1000418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903591PMC
July 2010

Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum.

J Chem Inf Model 2010 May;50(5):840-9

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1021/ci100039kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881581PMC
May 2010

Mitochondrial evolution and functions in malaria parasites.

Annu Rev Microbiol 2009 ;63:249-67

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA.

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http://dx.doi.org/10.1146/annurev.micro.091208.073424DOI Listing
October 2009

Complex inheritance of the plasmodial surface anion channel in a Plasmodium falciparum genetic cross.

Mol Microbiol 2009 Apr 6;72(2):459-69. Epub 2009 Mar 6.

The Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2009.06661.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702155PMC
April 2009

Host-parasite interactions revealed by Plasmodium falciparum metabolomics.

Cell Host Microbe 2009 Feb;5(2):191-9

Department of Molecular Biology, 2Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

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http://dx.doi.org/10.1016/j.chom.2009.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737466PMC
February 2009

Mitochondria in malaria and related parasites: ancient, diverse and streamlined.

J Bioenerg Biomembr 2008 Oct 24;40(5):425-33. Epub 2008 Sep 24.

Department of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129, USA.

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http://dx.doi.org/10.1007/s10863-008-9176-4DOI Listing
October 2008

The validity of mitochondrial dehydrogenases as antimalarial drug targets.

Trends Parasitol 2008 Jan 26;24(1):8-9. Epub 2007 Nov 26.

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http://dx.doi.org/10.1016/j.pt.2007.10.005DOI Listing
January 2008

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum.

Nature 2007 Mar;446(7131):88-91

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA.

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http://dx.doi.org/10.1038/nature05572DOI Listing
March 2007

Mitochondrial drug targets in apicomplexan parasites.

Curr Drug Targets 2007 Jan;8(1):49-60

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USA.

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http://dx.doi.org/10.2174/138945007779315632DOI Listing
January 2007

Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor.

Proc Natl Acad Sci U S A 2006 Mar 17;103(13):4852-7. Epub 2006 Mar 17.

Department of Biochemistry and Biological Structure, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1073/pnas.0510907103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458759PMC
March 2006

Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis.

Proc Natl Acad Sci U S A 2005 Nov 7;102(46):16813-8. Epub 2005 Nov 7.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8132, USA.

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http://dx.doi.org/10.1073/pnas.0501858102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1277966PMC
November 2005

Alteration in host cell tropism limits the efficacy of immunization with a surface protein of malaria merozoites.

Infect Immun 2005 Oct;73(10):6363-71

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA.

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http://dx.doi.org/10.1128/IAI.73.10.6363-6371.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1230925PMC
October 2005

Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system.

J Biol Chem 2005 Jul 24;280(29):27458-65. Epub 2005 May 24.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA.

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http://dx.doi.org/10.1074/jbc.M502319200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421511PMC
July 2005

Plasmodium vivax malaria in spite of atovaquone/proguanil (malarone) prophylaxis.

J Travel Med 2003 Nov-Dec;10(6):353-5

Division of Communicable Disease, Wisconsin State Laboratory of Hygiene, Madison, WI, USA.

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http://dx.doi.org/10.2310/7060.2003.9318DOI Listing
March 2004

Mitochondrial and plastid functions as antimalarial drug targets.

Authors:
Akhil B Vaidya

Curr Drug Targets Infect Disord 2004 Mar;4(1):11-23

Division of Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA.

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http://dx.doi.org/10.2174/1568005043480907DOI Listing
March 2004

A member of a conserved Plasmodium protein family with membrane-attack complex/perforin (MACPF)-like domains localizes to the micronemes of sporozoites.

Mol Biochem Parasitol 2004 Jan;133(1):15-26

Department of Pathology, Michael Heidelberger Division, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2003.08.009DOI Listing
January 2004

A multigene family that interacts with the amino terminus of plasmodium MSP-1 identified using the yeast two-hybrid system.

Eukaryot Cell 2002 Dec;1(6):915-25

Division of Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC138761PMC
http://dx.doi.org/10.1128/ec.1.6.915-925.2002DOI Listing
December 2002

Vacuolar type H+ pumping pyrophosphatases of parasitic protozoa.

Int J Parasitol 2002 Jan;32(1):1-14

Department of Microbiology and Immunology, MCP Hahnemann School of Medicine, Philadelphia, PA 19129, USA.

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http://dx.doi.org/10.1016/s0020-7519(01)00325-3DOI Listing
January 2002

Atovaquone resistance in malaria parasites.

Drug Resist Updat 2000 Oct;3(5):283-287

Department of Microbiology and Immunology, MCP Hahnemann University, Philadelphia, USA

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http://dx.doi.org/10.1054/drup.2000.0157DOI Listing
October 2000