Publications by authors named "Adnane Aarab"

4 Publications

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invasive infection in a patient with Hirschsprung disease: A case report.

Ann Med Surg (Lond) 2021 Nov 9;71:102927. Epub 2021 Oct 9.

Department of Bacteriology, Mohammed V Teaching Military Hospital, Rabat, Morocco.

Introduction: is a ubiquitous aerobic, motile, gram-negative bacilli. The human gastro-intestinal tract is known to harbor this rarely opportunistic microorganism. We describe a rare case of invasive infection with a gastrointestinal starting point due to in a patient with Hirschsprung disease.

Case Report: It is about a newborn female who was admitted on the 3rd day of life to the neonatal intensive care unit for intestinal obstruction. On the 9th day of life, while managing the neonatal obstruction, the patient developed febrile peaks. Cytobacteriological examination of cerebrospinal fluid, blood cultures and culture of umbilical vein catheter allowed the exclusive isolation of . It was producing extended spectrum beta-lactamase and was treated with intravenous imipenem After favourable evolution, the patient was transferred to the pediatric surgery department. There, she was diagnosed with Hirschsprung disease.

Discussion: Knowledge of the route of transmission of is limited and the possible source of the infection is unclear. However, the authors describe three hypotheses of contamination of our propositus. In our patient, one or more of these routes of contamination would be possible. Indeed, bacteremia could occur as a result of a bacterial translocation across the mucosal barrier of the colon altered by Hirschsprung disease, antibiotic use and feeding practices.

Conclusion: Infection with revealed a wide range of infection. It has only recently been acknowledged as an emerging pathogen. Further studies of the pathogenesis and risk factors are required.
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http://dx.doi.org/10.1016/j.amsu.2021.102927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517714PMC
November 2021

[Transudative myelomatous pleurisy revealing pleural localization of primary plasma cell leukemia].

Ann Biol Clin (Paris) 2019 04;77(2):187-190

Laboratoire d'hématologie, CHU Mohammed VI, Oujda, Maroc, Faculté de médecine et de pharmacie, Université Mohammed Premier, Oujda, Maroc.

Primary plasma cell leukemia (PPCL) is an aggressive and rare variant of multiple myeloma (MM), with frequent extramedullary involvement, mainly liver and splenic lesions. Pleuropulmonary involvement has rarely been described in the literature. We report a case of primary plasma cell leukemia in a 46-year-old patient, whose first symptom was pleural effusion with mediastinal adenopathies simulating a pleural localization of a lymphomatous process. However, blood smear examination, electrophoresis as well as immunofixation of plasma proteins and immuno-histochemistry have helped to guide the diagnosis. Pleurisy is a rare mode of revelation of plasma cell leukemia and is a factor of poor prognosis.
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http://dx.doi.org/10.1684/abc.2019.1420DOI Listing
April 2019

A Rare Case of Non-Secretory Multiple Myeloma: A Case Report and Literature Review.

EJIFCC 2019 Mar 1;30(1):88-94. Epub 2019 Mar 1.

Hematology Laboratory, Mohammed VI University Hospital, Oujda, Morocco.

Non-secretory myeloma (NSM) is a rare form of myeloma. It is defined as monoclonal plasmocytic proliferation of the bone marrow with the same clinical and radiological manifestations of myeloma. However, plasma cells are unable to secrete immunoglobulin (serum and urinary electrophoresis are negative and free light chain measurement is unquantifiable). This variant of multiple myeloma (MM) usually poses a diagnostic challenge to the biologist and clinician. We report a rare case of non-secretory myeloma in a 76-year-old patient who was diagnosed at the Mohammed V University Hospital Center in Oujda, Morocco.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416810PMC
March 2019

Gaucher Disease: An Underdiagnosed Pathology in the Eastern Moroccan Population.

EJIFCC 2019 Mar 1;30(1):82-87. Epub 2019 Mar 1.

Laboratory of Hematology, Mohammed VI University Hospital, Oujda, Morocco.

Gaucher disease (GD) is a lysosomal storage disease. It corresponds to a congenital deficit in β-glucocerebrosidase. This pathology should be considered in the presence of unexplained splenomegaly, with or without signs of haemorrhage, skeletal manifestations or hepatomegaly. The diagnosis is based on the measurement of the β-glucocerebrosidase activity but the preanalytical process should be respected in order to avoid the under-diagnosis of this disorder and the delay of its management. We report two cases of Gaucher disease collected at Mohammed VI University Hospital and Al Farabi regional hospital in Oujda. We have emphasized the need for a reference center for overload diseases.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416808PMC
March 2019
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