Adam Amsterdam

Adam Amsterdam

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Adam Amsterdam

Adam Amsterdam

Publications by authors named "Adam Amsterdam"

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41Publications

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Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology.

Pigment Cell Melanoma Res 2018 09 6;31(5):604-613. Epub 2018 Apr 6.

Department of Biology and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1111/pcmr.12700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151293PMC
September 2018

Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish.

FASEB J 2015 Dec 26;29(12):4989-5005. Epub 2015 Aug 26.

*Beijing Key Laboratory of Cardiometabolic Molecular Medicine and State Key Laboratory of Natural and Biomimetic Drugs, Institute of Molecular Medicine, Peking University, Beijing, China; Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Medical Pharmacology and Department of Physiology, School of Medicine, University of Missouri, Columbia, Missouri, USA; and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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http://www.fasebj.org/content/early/2015/08/26/fj.15-273409.
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http://www.fasebj.org/cgi/doi/10.1096/fj.15-273409
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http://dx.doi.org/10.1096/fj.15-273409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653057PMC
December 2015

Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome.

Dis Model Mech 2015 Aug 4;8(8):941-55. Epub 2015 Jun 4.

Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35294, USA

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http://dx.doi.org/10.1242/dmm.019059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527282PMC
August 2015

Zebrafish as a model to study live mucus physiology.

Sci Rep 2014 Oct 17;4:6653. Epub 2014 Oct 17.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.

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http://dx.doi.org/10.1038/srep06653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200417PMC
October 2014

Retroviral-mediated Insertional Mutagenesis in Zebrafish.

Methods Cell Biol 2011 ;104:59-82

Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1016/B978-0-12-374814-0.00004-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373308PMC
January 2012

Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish.

Hepatology 2011 Aug 2;54(2):452-62. Epub 2011 May 2.

Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh, and Childrens Hospital, Pittsburgh, PA 15260, USA.

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http://doi.wiley.com/10.1002/hep.24349
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http://dx.doi.org/10.1002/hep.24349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140628PMC
August 2011

Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers.

Proc Natl Acad Sci U S A 2010 Sep 13;107(39):16940-5. Epub 2010 Sep 13.

Department of Biology and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1011548107
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http://dx.doi.org/10.1073/pnas.1011548107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947874PMC
September 2010

Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development.

Neural Dev 2010 Apr 22;5:12. Epub 2010 Apr 22.

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509, USA.

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http://dx.doi.org/10.1186/1749-8104-5-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880287PMC
April 2010

A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.

Genes Dev 2010 Jan;24(2):183-94

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/gad.1860310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807353PMC
January 2010

A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergence.

Blood 2009 Jun 30;113(23):5776-82. Epub 2009 Mar 30.

Stem Cell Program and Division of Hematology/Oncology, Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2008-12-193607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700318PMC
June 2009

Zebrafish Hagoromo mutants up-regulate fgf8 postembryonically and develop neuroblastoma.

Mol Cancer Res 2009 Jun 16;7(6):841-50. Epub 2009 Jun 16.

David H. Koch Institute of Integrative Cancer Research, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-08-0555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744123PMC
June 2009

Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish.

Dev Dyn 2009 Jan;238(1):76-85

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1002/dvdy.21815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682537PMC
January 2009

The identification of zebrafish mutants showing alterations in senescence-associated biomarkers.

PLoS Genet 2008 Aug 15;4(8):e1000152. Epub 2008 Aug 15.

Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515337PMC
August 2008

Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations.

Proc Natl Acad Sci U S A 2008 Jul 18;105(30):10408-13. Epub 2008 Jul 18.

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.

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http://dx.doi.org/10.1073/pnas.0805036105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492501PMC
July 2008

Insertional mutagenesis strategies in zebrafish.

Genome Biol 2007 ;8 Suppl 1:S9

Institute of Genomics and Integrative Biology, Council for Scientific and Industrial Research, Mall Road, Delhi 110007, India.

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http://dx.doi.org/10.1186/gb-2007-8-s1-s9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2106850PMC
December 2007

Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis.

Development 2007 Oct 29;134(19):3461-71. Epub 2007 Aug 29.

Max-Planck-Institute of Immunobiology, Stuebeweg 51, D-79108 Freiburg, Germany.

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http://dx.doi.org/10.1242/dev.004556DOI Listing
October 2007

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.

Genes Dev 2006 Nov 3;20(22):3117-29. Epub 2006 Nov 3.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/gad.1482106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635147PMC
November 2006

Mutagenesis strategies in zebrafish for identifying genes involved in development and disease.

Trends Genet 2006 Sep 17;22(9):473-8. Epub 2006 Jul 17.

Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue E17-340, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.tig.2006.06.011DOI Listing
September 2006

A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression.

BMC Dev Biol 2006 Jun 7;6:28. Epub 2006 Jun 7.

Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1186/1471-213X-6-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523201PMC
June 2006

Insertional mutagenesis in zebrafish: genes for development, genes for disease.

Authors:
Adam Amsterdam

Brief Funct Genomic Proteomic 2006 Mar 22;5(1):19-23. Epub 2006 Feb 22.

Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue E17-340, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1093/bfgp/ell008DOI Listing
March 2006

Uses of GFP in transgenic vertebrates.

Methods Biochem Anal 2006 ;47:285-303

Beckman Institute of Biological Imaging, California Institute of Technology, Pasadena, CA 91125, USA.

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February 2006

Transgenes as screening tools to probe and manipulate the zebrafish genome.

Dev Dyn 2005 Oct;234(2):255-68

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1002/dvdy.20541DOI Listing
October 2005

A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease.

Development 2005 Aug 6;132(15):3561-72. Epub 2005 Jul 6.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge MA 02139, USA.

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http://dev.biologists.org/content/develop/132/15/3561.full.p
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http://dev.biologists.org/cgi/doi/10.1242/dev.01918
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http://dx.doi.org/10.1242/dev.01918DOI Listing
August 2005

TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.

Science 2005 Aug;309(5737):1074-8

Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E18-580, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/science.1110955DOI Listing
August 2005

Identification of zebrafish insertional mutants with defects in visual system development and function.

Genetics 2005 May 16;170(1):245-61. Epub 2005 Feb 16.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1534/genetics.104.039727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1444939PMC
May 2005

Retroviral-mediated insertional mutagenesis in zebrafish.

Methods Cell Biol 2004 ;77:3-20

Center for Cancer Research and Department of Biology, Massachusetts Institute for Technology, Cambridge, Massachusetts 01239, USA.

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http://dx.doi.org/10.1016/s0091-679x(04)77001-6DOI Listing
February 2005

Combined haploid and insertional mutation screen in the zebrafish.

Genesis 2004 Dec;40(4):231-40

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1002/gene.20090DOI Listing
December 2004

Identification of 315 genes essential for early zebrafish development.

Proc Natl Acad Sci U S A 2004 Aug 15;101(35):12792-7. Epub 2004 Jul 15.

Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0403929101
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http://dx.doi.org/10.1073/pnas.0403929101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC516474PMC
August 2004

A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney.

Development 2004 Aug 21;131(16):4085-93. Epub 2004 Jul 21.

MIT, Center for Cancer Research and Biology Department, Building E17 Room 340, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.01240
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http://dx.doi.org/10.1242/dev.01240DOI Listing
August 2004

Many ribosomal protein genes are cancer genes in zebrafish.

PLoS Biol 2004 May 11;2(5):E139. Epub 2004 May 11.

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1371/journal.pbio.0020139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC406397PMC
May 2004

Insertional mutagenesis in zebrafish.

Authors:
Adam Amsterdam

Dev Dyn 2003 Nov;228(3):523-34

Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1002/dvdy.10381DOI Listing
November 2003

Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning.

Development 2003 Jun;130(11):2543-54

Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1242/dev.00455DOI Listing
June 2003

Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development.

Nat Genet 2002 Jun 13;31(2):135-40. Epub 2002 May 13.

Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/ng896DOI Listing
June 2002