Publications by authors named "Abdolreza Sotoodeh Jahromi"

27 Publications

  • Page 1 of 1

Association of obesity and pulse pressure with hypertension in an Iranian urban population.

J Family Med Prim Care 2020 Sep 30;9(9):4705-4711. Epub 2020 Sep 30.

Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.

Objective: Nowadays, obesity is an important health problem and pulse pressure (PP) is a good predictor of cardiovascular events. The aim of study was to determine the association of obesity and PP with hypertension (HTN) in individuals aged 30 years or older in the urban population of Jahrom, Iran.

Materials And Methods: In this study, we used a multistage stratified sampling method to select participants among the urban population aged 30 years or older. Height, weight, and blood pressure were obtained by a trained physician. Obesity was defined according to the World Health Organization classification. Angina was assessed with reliable and validate Rose questionnaire. Data were record by SPSS-16. Categorical and continues variables analyzed by Chi-squared, independent -test, and one-way ANOVA test. Binary logistic regression analysis method was used for the association of PP and obesity with HTN and Rose angina that adjusted for age, gender, education class, marital status, smoking, total cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein. A < 0.05 was considered as statistical significance.

Results: The prevalence of obesity was 18.1% that was greater in women (24.8% vs. 9.9%, < 0.001). The prevalence of Rose angina and HTN in obese individuals were more than in normal weight individuals (24.8% vs. 16.4%, = 0.027) and (42.0% vs. 31.1%, < 0.001), respectively. Furthermore, patients in higher PP groups were older, were more possible to had HTN and had greater diastolic blood pressure (DBP), systolic blood pressure (SBP), and mean arterial pressure (MAP) in compared to individuals in the lower PP group. The individuals with HTN had greater DBP, SBP, MAP, PP, and body mass index (BMI) than individuals without HTN. However, individuals who had Rose angina, only had higher PP and BMI in compared to ones without Rose angina. The obese individuals had 1.97 (1.22-3.17, = 0.005) fold for HTN risk than individuals with normal weight. In addition, PP weakly increased the risk of HTN about 1.09 fold (1.07-1.10, < 0.001). However, Rose angina was associated only to overweight status (odds ratio = 1.51, confidence interval 95%: 1.03-2.20), = 0.035) than individuals in normal weight group.

Conclusion: Obesity and PP were higher in hypertensive individuals and overweight in individuals with Rose angina. It is time to pay more attention to abnormal BMI.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_723_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652129PMC
September 2020

Relation of health-related quality of life with abnormal weight: A cross-sectional study prior to the weight reduction intervention.

J Family Med Prim Care 2020 Sep 30;9(9):4662-4666. Epub 2020 Sep 30.

Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.

Objective: Obesity is a major health issue that is well-documented association with morbidity and mortality. The aim of this study was to investigate the associations between health-related quality of life (HRQOL) and abnormal body mass index (BMI) levels.

Materials And Methods: This descriptive study assessed 134 healthy individuals with abnormal BMI aged 18-39 years, clustered into three weight categories. The Short-form (SF)-36 Questionnaire was used for measuring of HRQOL.

Results: Linear-regression analyses discovered the negative correlation between BMI and the general health element of HRQL, however, a positive relation to role emotional dimension. But BMI was not associated with other six dimensions, and also with physical and mental component summary and with total health quality of life.

Conclusion: BMI was an important detriment factor for the general health dimension of HRQL with regression analysis. The higher grade of abnormal BMI had a negative influence on general health and positive effect on the role emotional dimension of HRQOL.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_667_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652151PMC
September 2020

Seroprevalence of toxoplasma gondii infection: An umbrella review of updated systematic reviews and meta-analyses.

J Family Med Prim Care 2020 Aug 25;9(8):3848-3855. Epub 2020 Aug 25.

Epidemiology and Zoonosis Division, Department of Food Hygiene, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Objectives: Toxoplasmosis is one of the neglected parasitic disease in humans and animals that produced via toxoplasma gondii. This study we implemented an umbrella review of all existing systematic reviews, meta-analyzing studies to apprise, and summarize seroprevalence of human toxoplasmosis in worldwide.

Methods: The search was carried out in databases including: Pub Med, Google Scholar, Science Direct, Scopus, Web of Science, Cochrane, and global health from their start dates until December 2018 in Persian and English language. A total of 21 systematics review and meta-analysis met the inclusion criteria of umbrella review. The Q test and the I statistic were used to evaluate heterogeneities. Quality assessment were performed and made use of the AMSTAR tool.

Results: The estimated pooled seroprevalence of T. gondii infection in blood donors, Immunocompromised patients, childbearing age women, general population, newborns and children, pregnant women and overall was 33% (95% CI, 29.0-38.0%), 42.0% (95 CI, 34.0-49.0%), 32.0% (CI, 26.0-38.0%), 42.0% (CI, 38.0-45.0%), 4.0% (CI, 2.0-5.0%), 40.0% (CI,37.0-44.0%), and 36% (CI, 24.0-48.0%), respectively.

Conclusion: The results of our umbrella review show a higher seroprevalence of T. gondii infection in immunocompromised patients, general population, pregnant women, blood donors, childbearing age women, and newborn groups, respectively. Routine serologic screening test and health education by primary care physicians for Toxoplasmosis is recommended to be conducted in high-risk groups in the endemic region.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_753_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586519PMC
August 2020

Toxicity of Saffron Extracts on Cancer and Normal Cells: A Review Article.

Asian Pac J Cancer Prev 2020 Jul 1;21(7):1867-1875. Epub 2020 Jul 1.

Department of Oncology-Pathology, Immune and Gene Therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute, Stockholm, Sweden.

Background And Aim: Medicinal plants have played an important role in human health since the Stone Age. According to WHO, 80% of Asian and African people rely on traditional medicine and medicinal plants to conserve their health. Saffron has received much attention among the herbal compounds related to cancer treatment.

Methods: This review aims to provide an overview of in-vitro and in-vivo evaluation molecule mechanism for anti-tumor activity, cancer preventing and protective effects of saffron extract. The review is based on the available data accessible in PubMed, Science Direct, Google Scholar, Magiran.ir, and SID.ir databases.

Results: Saffron has selective toxic and preventive effects on cancerous cells and without adverse effects on normal cells and prevents tumor formation. Saffron appears to reduce the toxic effects of anticancer drugs. Saffron has toxicity effects when used in high amounts, which are far greater than those  are used in human food culture.

Conclusions: Considering the observed effects of saffron on the removal of cancer cells, saffron extract can be used in the treatment and prevention of cancer after confirmation in human clinical trials. According to the high IC50 of saffron extracts in normal cells, its toxicity against non-cancerous cells is low and its use is safe. Besides, the studies suggested the cytotoxic effects of saffron on some of the  more cancers, including nervous system cancer and common cancers. Further studies are required to determine the effective dose and influence of mechanism of saffron in various animal type of cancers.
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http://dx.doi.org/10.31557/APJCP.2020.21.7.1867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573418PMC
July 2020

Application of Twitter and web news mining in infectious disease surveillance systems and prospects for public health.

GMS Hyg Infect Control 2019 2;14:Doc19. Epub 2019 Dec 2.

Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.

With the advancements of communication technology and growing access to social networks, these networks now play an important role in the dissemination of information and news without going through the time-consuming channels of official news networks. Analysis of social networking data is a new, interesting branch of text mining science. This study aimed to develop a text mining technique for extracting information about infectious diseases from tweets and news on social media. A method called "Fuzzy Algorithm for Extraction, Monitoring, and Classification of Infectious Diseases" (FAEMC-ID) was developed by the use of fuzzy modeling of the Takagi-Sugeno-Kang type. In addition to the real-time classification, the method is able to update its vocabulary for new keywords and visualize the classified data on the world map to mark the high risk areas. As an example, the monitoring was performed for measles-related news items over a 183-hour period from 01/03/2019 (01:00 am) to 08/03/2019 (12:00 pm), which were related to 2,870 tweets from 2,556 users. This monitoring showed that the number of tweets posted from each region ranged from 1 to 47, with the highest number, 47 tweets, belonging to Canada. The origins of most measles-related news were in the Americas and Europe, and they were mostly from the United States and Canada. The performance analysis of the developed method in comparison with other algorithms in the literature demonstrated the excellent precision of the method with a recall ratio of 88.41% and the high inter-correlation of data in each class. The proposed algorithm can also be used in the development of more effective monitoring and tracking systems for other human and even animal health hazards.
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http://dx.doi.org/10.3205/dgkh000334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997800PMC
December 2019

Prevalence and clinical characteristics of metabolically unhealthy obesity in an Iranian adult population.

Diabetes Metab Syndr Obes 2019 13;12:1387-1395. Epub 2019 Aug 13.

Research Center for Non-communicable Diseases, Internal Diseases Department, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

Purpose: The incidence of obesity is globally increasing and it is a predisposing factor for morbidity and mortality. This study assessed the prevalence of metabolically unhealthy (MU) individuals and its determinants according to body mass index (BMI).

Materials And Method: In our cross-sectional study, 891 persons aged 30 years or older participated. Participants were classified as obese (BMI ≥30 kg/m), overweight (BMI 25-<30 kg/m and normal weight (BMI <25 kg/m). Metabolic health status was defined using four existing cardio-metabolic abnormalities (elevated blood pressure, elevated serum concentrations of triglyceride and fasting glucose and a low serum concentration of high density lipoprotein cholesterol). Then, two phenotypes were defined: healthy (existence of 0-1 cardio-metabolic abnormalities) and unhealthy (presence of 2 or more cardio-metabolic abnormalities).

Result: Overall, 10.9% (95% confidence interval (CI): 8.8-13.0) and 7.2% (95% CI: 5.5-8.9) of participants were MU obese and metabolically healthy obese, respectively. The prevalence of MU was higher in overweight (55.6%; 95% CI: 50.6-60.6, <0.001) and obese (60.2%; 95% CI: 52.8-67.6, =0.001) subjects than in individuals with a normal weight (37.5%; 95% CI: 29.4-42.6). Multiple logistic regression analysis showed an association of a MU state with age and dyslipidaemia in the BMI subgroups and with female sex in the normal weight individuals.

Conclusion: The prevalence of a MU state increased with increasing BMI. Ageing and dyslipidaemia were associated with an unhealthy metabolic state in normal weight, overweight and obese subjects and with the female sex in normal weight subjects.
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http://dx.doi.org/10.2147/DMSO.S197476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698163PMC
August 2019

Data describing the association between rs266729 polymorphism inadiponectin promoter gene and Type 2 Diabetes Mellitus.

Data Brief 2016 Dec 21;9:1138-1140. Epub 2016 Nov 21.

Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.

This article investigates whether there is an association between the rs266729 polymorphism in adiponectin promoter gene with metabolic parameters and disease status in 300 type 2 diabetes patients and 300 healthy adults from Jahrom city, Iran. The variants (G/C) were tested by polymerase chain reaction-restriction fragment length polymorphism method (RFLP) and metabolic parameters (glucose, cholesterol, HDL and LDL cholesterol) were measured using biochemical methods. However, no differences were detected between the haplotypes investigated, and the data obtained from our lab shown association of the ADIPOQ promoter polymorphism neither with biochemical parameters, nor with disease status.
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http://dx.doi.org/10.1016/j.dib.2016.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133470PMC
December 2016

Sero-Epidemiological Study of Hepatitis E Virus among Thalassemia as High Risk Patients: A Cross-Sectional Survey in Jahrom, Southern, Iran.

Glob J Health Sci 2016 9 1;8(9):53885. Epub 2016 Sep 1.

Zonoses Research Center, Jahrom University of Medical Sciences, Jahrom,.

Hepatitis E virus (HEV) could be cause of viral hepatitis in the developing countries and cause severe epidemics. According to other studies, blood transfusion as a probable route of HEV infection has been suggested. An infection with hepatitis agents such as HEV causes active liver failure in multi-transfusion patients in particular thalassemia. The purpose of this study determines the seropositivity of anti-HEV antibodies in thalassemia individuals in Jahrom. In a cross-sectional study, sera from 110 thalassemia were collected between 2013 and 2014. Enzyme-linked immunosorbent assay (ELISA) method was performed to detection of anti-HEV antibodies. Individuals' data were collected such as, demographic and clinical, for statistical analysis. Our results show that 10% and 1.8% of the enrolled patients were HEV Ig-G and Ig-M positive antibodies respectively. In addition, there was statiscally significant difference in age groups for prevalence of anti-HEV Ig-G (P = 0.01). Also the serum levels of liver enzymes such as ALT and AST in the HEV Ig-G and Ig-M positive samples were significantly higher than anti-HEV negative samples. But there were no significant difference between sex and splenectomy with anti-HEV positive samples. The results indicate more study are needed to assess HEV screening of blood products to these patients that those have a probably risk of exposure to HEV especially in higher years old.
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http://dx.doi.org/10.5539/gjhs.v8n9p245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064080PMC
September 2016

Mechanisms of tumor cell resistance to the current targeted-therapy agents.

Tumour Biol 2016 Aug 7;37(8):10021-39. Epub 2016 May 7.

Department of Oncology-Pathology, Immune and Gene therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institutet, SE-171 76, Stockholm, Sweden.

Resistance to chemotherapy agents is a major challenge infront of cancer patient treatment and researchers. It is known that several factors, such as multidrug resistance proteins and ATP-binding cassette families, are cell membrane transporters that can efflux several substrates such as chemotherapy agents from the cell cytoplasm. To reduce the adverse effects of chemotherapy agents, various targeted-based cancer therapy (TBCT) agents have been developed. TBCT has revolutionized cancer treatment, and several agents have shown more specific effects on tumor cells than chemotherapies. Small molecule inhibitors and monoclonal antibodies are specific agents that mostly target tumor cells but have low side effects on normal cells. Although these agents have been very useful for cancer treatment, however, the presence of natural and acquired resistance has blunted the advantages of targeted therapies. Therefore, development of new options might be necessary. A better understanding of tumor cell resistance mechanisms to current treatment agents may provide an appropriate platform for developing and improving new treatment modalities. Therefore, in this review, different mechanisms of tumor cell resistance to chemotherapy drugs and current targeted therapies have been described.
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http://dx.doi.org/10.1007/s13277-016-5059-1DOI Listing
August 2016

Effects of Prepubertal Acute Immobilization Stress on Serum Kisspeptin Level and Testis Histology in Rats.

Pak J Biol Sci 2016 Jan;19(1):43-8

Stress has inhibitory effect on HPG axis through increasing cortisol serum level. In this study, the effect of acute prepubertal stress on kisspeptin, which plays essential role in puberty achievement is assessed. To do this experimental study thirty immature healthy male wistar rats of 4 weeks old and without any symptoms of puberty were selected randomly. These rats were divided into three groups, randomly. Two groups were chosen as control and pretest and one as stress (test) group. Immobilization stress was applied for 10 days and serum level of cortisol, testosterone and kisspeptin were measured. Primary and secondary spermatocyte and sertoli cell evaluated and compared among groups. Mean serum level of kisspeptin in pretest group, control group and stress (test) group were 0.0381 ± 0.0079, 91.0500 ± 4.87430 and 15.2156 ± 3.88135 pg mL(-1) respectively. Serum level of kisspeptin had significant differences between three groups (p < 0.001). Acute prepubertal immobilization stress led to decrease in serum level of kisspeptin and testosterone in stress (test) group compared to control groups. Also stress caused a significant decrease in the numbers of secondary spermatocytes of the test group.
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http://dx.doi.org/10.3923/pjbs.2016.43.48DOI Listing
January 2016

Lack of Association Between rs17568 Polymorphism in OX40 Gene and Myocardial Infarction, Southern of Iran.

Glob J Health Sci 2015 Sep 28;8(6):41-6. Epub 2015 Sep 28.

Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran.

Tumor necrosis factor (TNF) is one of the inflammatory cytokines which has an important role in inflammation and migration of other inflammatory cells to the atherosclerotic plaques. OX40 is a member of the TNF super family receptor protein. OX40 and OX40 ligand are co-stimulators for T-cells and can increase inflammatory response in atherosclerotic plaques. The aim of this study was to determine the association of rs17568 polymorphism in OX40 gene with premature myocardial infarction. This case control study was done on 100 patients with premature acute myocardial infarction (AMI) and a similar number of sex, age and some other cardiovascular risk factor matched healthy people. The OX40 rs17568 polymorphism was genotyped, using PCR-RFLP method. A-allele frequency of rs17568 SNP was lower non-significantly in Premature AMI, compared to healthy subjects (49% vs. 51%). The analysis of rs17568 (A/G) polymorphism showed an odds ratio of 1.127 (95% CI: 0.635-1.999; P= 0.686) for the GG genotype and 5.761 (95% CI: 1.200-27.655; P= 0.029) for the AG genotype, compared to the AA genotype. The results of this study indicate that the rs17568 SNP of OX40 gene is not associated with premature AMI in the evaluated population.
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http://dx.doi.org/10.5539/gjhs.v8n6p41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954911PMC
September 2015

Association of Tumor Growth Factor-β and Interferon-γ Serum Levels With Insulin Resistance in Normal Pregnancy.

Glob J Health Sci 2015 Sep 28;8(6):25-32. Epub 2015 Sep 28.

Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.

Pregnancy is related to change in glucose metabolism and insulin production. The aim of our study was to determine the association of serum IFN-γ and TGF- β levels with insulin resistance during normal pregnancy. This cross sectional study was carried out on 97 healthy pregnant (in different trimesters) and 28 healthy non-pregnant women. Serum TGF-β and IFN- γ level were measured by ELISA method. Pregnant women had high level TGF-β and low level IFN-γ as compared non-pregnant women. Maternal serum TGF-β concentration significantly increased in third trimester as compared first and second trimester of pregnancy. Maternal serum IFN-γ concentration significantly decreased in third trimester as compared first and second trimester of pregnancy. Pregnant women exhibited higher score of HOMA IR as compared non-pregnant women. There were association between gestational age with body mass index (r=0.28, P=0.005), TGF-β (r=0.45, P<0.001) and IFN-γ (r=-0.50, P<0.001). There was significant association between Insulin resistance and TGF-β (r=0.17, p=0.05). Our findings suggest that changes in maternal cytokine level in healthy pregnant women were anti-inflammatory. Furthermore, Tumor Growth Factor-β appears has a role in induction insulin resistance in healthy pregnant women. However, further studies needed to evaluate role of different cytokines on insulin resistance in normal pregnancy.
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http://dx.doi.org/10.5539/gjhs.v8n6p25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4954908PMC
September 2015

Non-Association between rs7903146 and rs12255372 Polymorphisms in Transcription Factor 7-Like 2 Gene and Type 2 Diabetes Mellitus in Jahrom City, Iran.

Diabetes Metab J 2015 Dec 13;39(6):512-7. Epub 2015 Nov 13.

Research Center for Non-Communicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: Transcription factor 7-like 2 (TCF7L2) is a transcription factor in the Wnt signaling pathway. High levels of TCF7L2 have been reported in most human tissues, including the heart, lung, brain, liver, kidney, placenta, adipose tissues, and pancreatic β-cells. The purpose of this study was to assess the association between TCF7L2 polymorphisms (rs12255372 and rs7903146) and type 2 diabetes mellitus in the city of Jahrom, Iran.

Methods: This case-control study was conducted with 200 patients referred to Diabetes Clinics and 200 healthy subjects in Jahrom City. Biochemical characteristics were first determined. TCF7L2 rs1255372 and rs7903146 polymorphisms were then genotyped using the polymerase chain reaction-restriction fragment length polymorphism method.

Results: T-allele frequencies of both single nucleotide polymorphisms (SNPs) were significantly higher in diabetic patients than in normal glucose-tolerant subjects (rs12255372: 20.3% vs. 14.5%; rs7903146: 28.5% vs. 22.25%). The rs12255372 (G/T) polymorphism analysis showed an odds ratio of 0.473 (95% confidence interval [CI], 0.170 to 1.314; P=0.151) for the TT genotype and 0.646 (95% CI, 0.410 to 1.019; P=0.060) for the TG genotype, compared with the GG genotype. The rs7903146 (C/T) polymorphism odds ratios for TT and TC genotypes were 0.564 (95% CI, 0.280 to 1.135; P=0.109) and 0.751 (95% CI, 0.487 to 1.157; P=0.194) compared with the CC genotype, respectively.

Conclusion: The rs12255372 and rs7903146 SNPs of the TCF7L2 gene were not associated with insulin resistance in the evaluated population.
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http://dx.doi.org/10.4093/dmj.2015.39.6.512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696988PMC
December 2015

The Association Between Pre-Diabetes With Body Mass Index and Marital Status in an Iranian Urban Population.

Glob J Health Sci 2015 Jul 31;8(4):95-101. Epub 2015 Jul 31.

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Pre-diabetes increased the development of diabetes mellitus (type 2). The aim of study was to determine the association of body weight, education and marital status with pre-diabetes in an Iranian urban population.A sample of 788 subjects (360 men and 428 women) between the ages 30-85 years participated in our study and anthropometric measurements, educational level and fasting blood sugar of participants were recorded. The t and Chi square tests were used for continuous and categorical variables. The association of age, BMI categories, educational level and marital status to pre-diabetes was assessed by estimating the odds ratio. A p-value ≤ 0.05 were considered significant. The analysis was done using SPSS version 11.5. Our study showed that pre-diabetic subjects were older and low educated than normoglycemic subjects. Mean BMI and educational level were associated to pre-diabetes only in women. The odds of being pre-diabetes also were higher in obese women than in normal BMI women. No relationship was found between education and marital status with pre-diabetes in both men and women. Based on our finding, it is possible that advancing age and obesity has increased in pre-diabetes. This highlights the importance of population based survey to monitor blood glucose for effective prevention and control.
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http://dx.doi.org/10.5539/gjhs.v8n4p95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873576PMC
July 2015

Effect of Palm Pollen on Sperm Parameters of Infertile Man.

Pak J Biol Sci 2015 Apr;18(4):196-9

There is a rapidly growing trend in the consumption of herbal remedies in the developing countries. The aim of this study was to determine the effects of orally administered Date Palm Pollen (DPP) on the results of semen analysis in adult infertile men. Forty infertile men participated in our study. They were treated by Pollen powder 120 mg kg(-1) in gelatinous capsules every other day, for two months. Before and at the end of therapy, the semen was collected after masturbation and sperm numbers, motility and morphology were determined. Our findings revealed that consumption of DPP improved the sperm count. The treatment was significantly increased sperm motility, morphology and forward progressive motility. Date palm pollen seems to cure male infertility by improving the quality of sperm parameters.
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http://dx.doi.org/10.3923/pjbs.2015.196.199DOI Listing
April 2015

Ibrutinib-A double-edge sword in cancer and autoimmune disorders.

J Drug Target 2016 11;24(5):373-85. Epub 2015 Sep 11.

b Department of Oncology-Pathology, Immune and Gene therapy Lab , Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute , Stockholm , Sweden .

Targeted therapies have appeared as new treatment options for several disease types, including cancer and autoimmune disorders. Of several targets, tyrosine kinases (TKs) are among the most promising. Overexpression of TKs provides a target for novel therapeutic agents, including small molecule inhibitors of tyrosine kinases (TKI). Ibrutinib (PCI-32765) is a TKI of Bruton's tyrosine kinase (Btk), a key kinase of the B-cell receptor signaling pathway that plays a significant role in the proliferation, differentiation and survival of B cells. In addition to inhibitory effects, recent studies have shown that ibrutinib has multiple immunomodulatory effects. It binds covalently to IL-2 inducible tyrosine kinase (Itk) in T lymphocytes and suppresses the survival of T-helper (Th) 2 cells. This changes the balance of Th1/Th2 cells toward Th1 subset, which are the main immune cells targeting tumor cells. The dual activity of ibrutinib has paid a great attention and several studies are evaluating the anti-tumor and immunomodulatory effects in cancer, autoimmune disorders and infectious diseases. In this article we review the inhibitory and immunomodulatory effects of ibrutinib in B-cell malignancies, autoimmune diseases and infections, as well as the communication between the Ror1 receptor tyrosine kinase and BCR and effects of ibrutinib on this crosstalk.
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http://dx.doi.org/10.3109/1061186X.2015.1086357DOI Listing
December 2016

Immunity to tetanus in major beta thalassemia patients.

Clin Exp Vaccine Res 2015 Jul 29;4(2):184-8. Epub 2015 Jul 29.

Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran.

Purpose: Patients with beta thalassemia major are at increased risk for bacterial infections specially splenectomized patients. The aim of this study was to determine the anti-tetanus antibody concentration among patients with beta thalassemia major.

Materials And Methods: The anti-tetanus antibody concentration was investigated in 224 patients with thalassemia major and 224 healthy subjects matched for age and gender. Tetanus antibody and ferritin serum level were determined by enzyme-linked immunosorbent assay method using commercial kits. Subjects who had antibody level ≥ 0.1 IU/mL was defined as complete protection, 0.01 to < 0.1 IU/mL as partial protection and < 0.01 IU/mL as no protection. For the analysis, we used SPSS version 11.5 software. A two-sided p-value less 0.05 was considered statistically significant.

Results: In patients with beta thalassemia major, antibody level against tetanus was inversely dependent about 29.3% to serum ferritin level. Thus, when serum ferritin increased 1 ng/mL, serum antibody against tetanus decreased 0.002 IU/mL. Mean anti-tetanus (IgG) antibody titers was lower in thalassemia patients compared to healthy subjects (1.53 ± 1.71 vs. 2.02 ± 2.05, p = 0.007) that was no significantly associated to age and gender in both study groups. All of participants had serum antibody level 0.01 IU/mL or greater. The complete protective level of anti-tetanus antibody was lower in thalassemia subjects in compare to healthy persons (71% vs. 87.9%, p < 0.001).

Conclusion: Patients with thalassemia had lower anti-tetanus antibody level than healthy subjects. Thus the vaccine recommendation seems essential for patients with beta thalassemia major.
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http://dx.doi.org/10.7774/cevr.2015.4.2.184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524903PMC
July 2015

Molecular Survey on Detection of Leishmania Infection in Rodent Reservoirs in Jahrom District, Southern Iran.

J Arthropod Borne Dis 2014 Dec 9;8(2):139-46. Epub 2014 Apr 9.

Department of Internal Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: Zoonotic Cutaneous Leishmaniasis (ZCL) is endemic in many parts of Iran. Recently its incidence is considerable in different parts of Jahrom district, in Fars Province, southern Iran. The aims of our study were to investigate the prevalence of leishmania infection, and identify and characterize the Leishmania species present, among the rodents by molecular methods in a new endemic focus of ZCL, in an urban and rural area of the Jahrom district, Fars Province, southern Iran.

Methods: From May to November 2010), 55 rodents in four regions of Jahrom focus were caught and checked for leishmania infection by the microscopical examination of liver, spleen, ears, and footpads' smears.

Results: Overall 18 Meriones persicus, 15 Tatera indica, 14 Mus musculus, and 8 Rattus rattus were caught. Totally, four (16.5%) and two (13.3%) of the Me. persicus and Ta. indica, but only one of Mu. musculus and Ra. rattus were found smear-positive for leishmania amastigotes, respectively. In the nested-PCR assay 8 (14.6%) smears were found positive for Leishmania major, none was found positive for any other Leishmania species. Sequencing based detection of Leishmania confirmed the microscopic and PCR findings. All positive specimens were shown 95-96% similarity with L. major Friedlin.

Conclusion: Tatera indica and Me. persicus are incriminated as the main 'reservoir' hosts of L. major in the rural area of Jahrom, moreover, Mu. musculus and Ra. rattus have the minor but remarkable role in the maintenance of the disease in the urban regions of Jahrom focus.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478425PMC
December 2014

Natural immunity against Haemophilus influenza type B in splenectomised Beta-thalassaemia children.

Pak J Biol Sci 2014 Nov;17(11):1190-4

Patients with beta-thalassaemia major and asplenia have an increased risk of encapsulated bacterial infections. The aim of this study was to determine the Haemophilus influenza type b (Hib) antibody concentrations in beta-thalassaemia patients with or without spleens. The Hib antibody concentrations were investigated in 850 patients with thalassaemia major, of whom 437 had undergone splenectomy. Hib antibody levels equal or greater than 1.0 μg mL(-1) were classified as long-term protection, those between 0.15 and less than 1.0 μg mL(-1) as short-term protection and those less than 0.15 μg mL(-1) as no protection. The mean Hib antibody level was lower in asplenic subjects than in non splenectomised subjects (0.39 ± 0.5 vs. 1.08 ± 0.55 μg mL(-1), p < 0.001). The protective antibody level prevalence in asplenic patients was significantly lower than that in patients with spleens (32.3% vs. 85.7%, p < 0.001). Protection against Hib decreased as the time interval after splenectomy increased from 57.2% at a less than 60 months interval to 10.8% at a greater than 120 months interval (p = 0.001). Nearly 30% of the 437 splenectomised subjects had long-term protection against Hib, whereas 64.4% of the 413 non splenectomised subjects had long-term protection (p < 0.001). Asplenic subjects had lower Hib antibody levels than non splenectomised subjects. Additionally, the antibody levels decreased as the time interval increased after splenectomy. A Hib vaccine recommendation for splenectomised thalassaemia major seems essential.
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http://dx.doi.org/10.3923/pjbs.2014.1190.1194DOI Listing
November 2014

Effects of Endurance Training on the Serum Levels of Tumour Necrosis Factor-α and Interferon-γ in Sedentary Men.

Immune Netw 2014 Oct 22;14(5):255-9. Epub 2014 Oct 22.

Department of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Physical activity could be considered one of the factors that affect the immune system status and function. To find the relation between exercise and cytokines, we examined the possible effects of an 8-week endurance training program on the serum levels of cytokines, including tumour necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in sedentary men. A total of 30 healthy young male volunteers were randomly divided into an endurance training group and a control group. The training group followed a specific exercise protocol (running on a treadmill for 15~30 min at 50~70% maximal heart rate) for 8 weeks and the control group did not participate in any exercise program. Venous blood samples were collected from both the groups 24 h before and 24 h and 48 h after the exercise. Repeated ANOVA was used for statistical purposes. The serum levels of TNF-α and IFN-γ were determined by ELISA. Significant (p<0.05) and non-significant (p>0.05) decreases were observed in the serum levels of IFN-γ and TNF-α, respectively, after the 8-week endurance training program. Our findings indicated that an 8-week endurance exercise may affect the serum levels of some inflammatory cytokines, suggesting the beneficial role of this training protocol in elderly population and people with certain conditions (inflammation of the vertebrae or other inflammatory diseases).
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http://dx.doi.org/10.4110/in.2014.14.5.255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212087PMC
October 2014

Insulin resistance and serum levels of interleukin-17 and interleukin-18 in normal pregnancy.

Immune Netw 2014 Jun 19;14(3):149-55. Epub 2014 Jun 19.

Department of Student Research Committee, Jahrom University of Medical Science, Jahrom, Iran.

We performed this study to evaluate the role of Interleukin-17 (IL-17) and Interleukin-18 (IL-18) in insulin resistance during normal pregnancy. This descriptive cross sectional study was carried out on 97 healthy pregnant women including 32, 25, and 40 individuals in the first, second, and third trimesters, respectively, and on 28 healthy non pregnant women between the autumn of 2012 and the spring of 2013. We analyzed the serum concentrations of IL-17 and IL-18 by using the enzyme linked immunosorbent assay (ELISA). Insulin resistance was measured by homeostasis model assessment of insulin resistance equation. No significant differences between the demographic data of the pregnant and non pregnant groups were observed. Insulin resistant in pregnant women was significantly higher than the controls (p=0.006). Serum IL-17 concentration was significantly different in non pregnant women and pregnant women in all gestational ages (p<0.05). Serum IL-18 level was significantly lower in subjects with first, second, and third trimesters of pregnancy in compared to non pregnant women (p<0.05). No significant correlations were found between serum IL-17 and IL-18 levels with insulin resistance (r=0.08, p=0.34 vs. r=0.01, p=0.91, respectively). Our data suggested that IL-17 and IL-18 do not appear to attribute greatly to pregnancy deduced insulin resistance during normal pregnancy.
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http://dx.doi.org/10.4110/in.2014.14.3.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079821PMC
June 2014

Hepatitis E virus and serum level aminotransferases in blood donors.

Rep Biochem Mol Biol 2013 Oct;2(1):48-51

Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran; Department of Internal Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: Hepatitis E virus (HEV) infection is a self-limiting viral infection that can lead to severe complications and death. In different regions the epidemiology of this infection varies. In this study we evaluated the seroepidemiology of hepatitis E infection in Jahrom, a city in southern Iran.

Methods: This was a cross-sectional descriptive study of serum samples from 477 subjects, including 30 females and 447 males. HEV immunoglobulin G (IgG) and immunoglobulin M (IgM) were measured by enzyme-linked immunosorbent assays (ELISA). Alanine transaminase (ALT) and aspartate transaminase (AST) levels were also determined. Four hundred forty-seven subjects were male and 30 were female. Subjects were classified by age and sex.

Results: One woman (3.3%) and 25 men (5.5%) were positive for HEV antibodies (IgG and/or IgM). There was found an association between serum level of aminotransferases and seropositivity for HEV.

Conclusion: The result of this study indicates that HEV is an etiological factor for hepatitis in this area of IRAN. The cost benefit of active immunization in endemic regions should be evaluated because an outbreak could have tragic consequences.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757067PMC
October 2013

Relation of type 2 diabetes mellitus with gender, education, and marital status in an Iranian urban population.

Rep Biochem Mol Biol 2013 Apr;1(2):64-8

Department of Immunology, Jahrom University of Medical Sciences, Jahrom, Iran.

Background: Type 2 diabetes mellitus is one of the most important cardiovascular risk factors.

Objectives: This study was performed to assess the relationship of diabetes with gender, education, and marital status in an Iranian urban population.

Methods: A total of 892 men and women aged 30-85 were recruited using a cluster-stratified sampling method from an urban population. Using a questionnaire, demographical data including gender, education, and marital status were collected. A blood sample after fasting for at least eight hours was collected from each subject. Associations of type 2 diabetes mellitus and studied variables were tested for significance.

Results: The prevalence of diabetes mellitus was 11.6%; 11.1% in men and 12.1% in women with no significant difference between them. Diabetes mellitus was most prevalent in the oldest age (age more than 60 years, 22.9%) and low education groups (17.9%, P < 0.001). Marital status was not significantly related to diabetes mellitus (P= 0.37).

Conclusion: The prevalence of diabetes mellitus is related to education within the Iranian population. Thus preventive strategies should be based on the affective factors.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757057PMC
April 2013

Natural immunity to hemophilus influenza type b in children, south of Iran: need for vaccination.

Pak J Biol Sci 2012 Feb;15(3):160-3

Department of Immunology, Jahrom University of Medical Sciences, Jahrom, Iran.

Hemophilus influenza type b (Hib) infection has a high morbidity and mortality rate especially in children less than 5 years of age. The incidence of Hib disease in Iran is not known and Hib vaccine is not included in the National Immunization Program. The aim of the present study was to investigate the level of antibody to Hib of children five years or younger living in Jahrom, Iran. Three hundred eighty six children 5 years or younger were selected by random sampling method. A blood samples were taken from those children. Anti-Hib IgG antibody (anti-PRP) level was determined in the serum by using anti-Hemophilus influenza IgG EIA kit (IBL, Germany). An anti-PRP antibody levels of 0.15 microg mL(-1) and over were accepted as the natural immunity. The mean concentration of Hib antibody was 0.94 +/- 0.480 microg mL(-1). Natural immunity was determined in three hundred and twenty six (84.5%) of the children. The proportion of natural immunity was increased from 64.9% among children = 12 month old to 95.2% in children aged 49-60 month (p < 0.001). The exposure rate of children with Hib was higher than expected, even in children who were just a few months old. Present data revealed need to be introducing Hib conjugate vaccine in the National Immunization Programs.
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http://dx.doi.org/10.3923/pjbs.2012.160.163DOI Listing
February 2012

Association of Insulin Resistance with Serum Interleukin-6 and TNF-α Levels During Normal Pregnancy.

Biomark Insights 2011 Jan 12;6:1-6. Epub 2011 Jan 12.

Department of Immunology, Jahrom University of Medical Sciences, Jahrom, Iran.

Overview: The purpose of this study was to evaluate the role of Tumor Necrosis Factor-α (TNF-α) in insulin resistance (IR) during normal pregnancy.

Approach: This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively, and in 21 healthy non pregnant women. Serum TNF-α concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method.

Results: There were significant differences between serum TNF-α and IL-6 levels in pregnant women as compared with maternal healthy controls. There was significant correlation between gestational age and Body Mass Index (BMI) (r = 0.28, P = 0.01). There was no significant correlation between gestational age and insulin resistance (IR). We also did not find correlations between IR and TNF-α and IR and IL-6 in pregnant women.

Conclusion: In conclusion, our findings suggest that TNF-α and IL-6 are not greatly contributed to pregnancy induced insulin resistance in normal pregnancy.
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http://dx.doi.org/10.4137/BMI.S6150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065372PMC
January 2011

Relationship between Selected Socio-Demographic Factors and Cancer of Oral Cavity - A Case Control Study.

Cancer Inform 2010 Aug 11;9:163-8. Epub 2010 Aug 11.

Department of Public Health, Hormozgan University of Medical Sciences, Bandarabbas, Hormozgan, Iran.

The aim of this study was to recognize factors associated with cancer of oral cavity considering socio-demographic characteristics. The cases were 350 with squamous-cell carcinoma of oral cavity diagnosed between 2005 and 2006 in Morbai, Narandia, Budharani Cancer Institute, Pune, India. Similar number of controls match for age and sex selected from the background population. Cases and controls were interviewed for tobacco related habits and general characteristics; age, gender, education and possible socio-demographic factors. Chi-square test in uni-variate analysis and estimate for risk showed that education, occupation and monthly household income were significantly different between cases and controls (P < 0.001). Irrespective to gender, relative risk, here odds ratio, (OR) of low level of education (OR = 5.3, CI 3.7-7.6), working in field as a farmer (OR = 2.5, CI 1.7-3.7), and monthly household income less than 5000 Indian Rupees currency (OR = 1.7, CI 1.2-2.3) were significant risk factors for oral cancer. While, there was no significant relationship between religious and or marital status either in males or females.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935817PMC
http://dx.doi.org/10.4137/cin.s4774DOI Listing
August 2010

Seropositivity for Listeria monocytogenes in women with spontaneous abortion: a case-control study in Iran.

Taiwan J Obstet Gynecol 2009 Mar;48(1):46-8

Infectious and Tropical Diseases Research Center, Hormozgan University of Medical Sciences, Banddar Abbas, Iran.

Objective: There are many studies supporting the role of certain asymptomatic infections such as Listeria monocytogenes (L. monocytogenes) in spontaneous abortion. In some cases, latent listeriosis may complicate the pregnancy, and serologic tests can, therefore, be used to detect the disease. This study was designed to assess the relationship between seropositivity for L. monocytogenes and spontaneous abortion.

Materials And Methods: A total of 250 women with previous spontaneous abortion and a control group of 200 women with normal full-term deliveries entered the study as case and control groups, respectively. Demographic characteristics were recorded for each subject, and serum samples were obtained from all participants. All serum samples were examined using the indirect immunofluorescence antibody test for L. monocytogenes antibody. Data was analyzed using Chi-squared and t tests.

Results: The average age of participants was 25.6 +/- 7.6 years in cases and 25.3 +/- 6.5 years in controls. Eighty-nine (35.6%) of the cases with abortion and 35 (17.5%) of the control group were positive for L. monocytogenes antibody (p = 0.001). No relationship was observed between the number of pregnancies and infection with L. monocytogenes (p = 0.4), or between the number of previous abortions and L. monocytogenes seropositivity (p = 0.2).

Conclusion: We suggest monitoring L. monocytogenes seroprevalence in pregnant women at high risk of threatened abortion, and further microbiological assessment of symptomatic women for detection of L. monocytogenes and insidious infection.
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http://dx.doi.org/10.1016/S1028-4559(09)60034-6DOI Listing
March 2009