Publications by authors named "Abbas Moradi"

22 Publications

  • Page 1 of 1

Prevalence of Shiga Toxin-Producing O157 and Non-O157 Serogroups Isolated from Fresh Raw Beef Meat Samples in an Industrial Slaughterhouse.

Int J Microbiol 2021 15;2021:1978952. Epub 2021 Dec 15.

Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: The aims of the current study are the identification of O157 and non-O157 Shiga Toxin-Producing (STEC) serogroups isolated from fresh raw beef meat samples in an industrial slaughterhouse, determination of antimicrobial resistance patterns, and genetic linkage of STEC isolates.

Materials And Methods: A total of 110 beef samples were collected from the depth of the rump of cattle slaughtered at Hamadan industrial slaughterhouse. After detection of isolates, STEC strains were identified according to PCR for , , and virulence genes, and STEC serogroups (O157 and non-O157) were identified by PCR. The genetic linkage of STEC isolates was analyzed by the ERIC- (Enterobacterial Repetitive Intergenic Consensus-) PCR method. The antimicrobial susceptibility of STEC isolates was detected by the disk diffusion method according to CLSI guidelines.

Results: Among 110 collected beef samples, 77 (70%) were positive for . The prevalence of STEC in isolates was 8 (10.4%). The overall prevalence of O157 and non-O157 STEC isolates was 12.5% (one isolate) and 87.5% (7 isolates), respectively. The hemolysin gene was detected in 25% (2 isolates) of STEC strains. Evaluation of antibiotic resistance indicated that 100% of STEC isolates were resistant to ampicillin, ampicillin-sulbactam, amoxicillin-clavulanic acid, and cefazolin. Resistance to tetracycline and ciprofloxacin was detected in 62.5% and 12.5% of isolates, respectively. The analysis of the ERIC-PCR results showed five different ERIC types among the STEC isolates.

Conclusion: The isolation of different clones STECs from beef and the presence of antibiotic-resistant isolates indicate that more attention should be paid to the hygiene of slaughterhouses.
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http://dx.doi.org/10.1155/2021/1978952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695030PMC
December 2021

MIF and MMP-9 Serum Changes in Type II Diabetes and Non-Diabetic Subjects: A Short Communication.

Iran J Pathol 2021 6;16(4):444-447. Epub 2021 Jul 6.

Department of Community Medicine. Hamedan University of Medical science. Iran.

Background & Objective: Diabetes is a metabolic disease and is associated with failure of various organs. Macrophage migration factor (MIF) and matrix metalloproteinase (MMP-9) are two of the most important factors in the pathogenesis of diabetes.

Methods: In this descriptive-analytical study, 30 patients with type 2 diabetes mellitus from Hamadan Diabetes Center were selected by convenience sampling. Moreover, 30 healthy first-degree relatives and 30 unrelated non-diabetics, were examined for MMF and MMP-9 and their variations based on age, gender, body mass index (BMI) and hemoglobin A1C.

Results & Conclusion: The mean and standard deviation of MIF in diabetic patients, and relatives and non-relatives of diabetic patients were 592.87±78.19, 131.82±88.27 and 94.63±23.88, respectively (<0.001). The mean and standard deviation of the MMP-9 in diabetic patients, and relatives and non-relatives of diabetic patients were 2570.64±2220.03, 918.57±650.08 and 629.09±288.32, respectively (<0.001). MIF and MMP-9 did not have a significant relationship with age, sex, duration of disease and BMI. However, we observed a direct and significant correlation between hemoglobin A1C and the level of MIF and MMP-9 (<0.001). In patients with type 2 diabetes, serum levels of MMP-9 and MIF, consistent with HbA1c, increase with no significant association with age, sex, BMI and duration of diabetes.
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http://dx.doi.org/10.30699/IJP.2021.131429.2456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8463755PMC
July 2021

The Effects of Intravenous Nitroglycerin Bolus Doses in Reducing Hemodynamic Responses to Laryngoscopy and Endotracheal Intubation.

Biomed Res Int 2021 3;2021:6694150. Epub 2021 Aug 3.

Department of Community Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Hemodynamic responses to laryngoscopy and endotracheal intubation are transient in most patients. However, in some patients with a history of heart disease, systemic hypertension, or cerebrovascular disease, these may lead to dangerous complications. This study is aimed at determining the effectiveness of intravenous nitroglycerin bolus doses in reducing hemodynamic responses to laryngoscopy and endotracheal intubation. In this double-blind randomized controlled trial, 78 patients aged 18 to 65 years were randomly divided into three groups: 1 g/kg dose of nitroglycerin (first group), 2 g/kg dose of nitroglycerin (second group), and normal saline or placebo (third group). 26 samples were allocated for each group. Patients' hemodynamic responses to laryngoscopy and endotracheal intubation were measured at different times. Data were analyzed using SPSS V 16.

Results: Patients in the three study groups were similar in terms of age, sex, and weight. There was no significant difference between the mean saturation of peripheral oxygen (SPO) and the mean heart rate between the three groups before endotracheal intubation and 1 to 10 minutes after intubation ( > 0.05). The difference of mean arterial blood pressure between study groups was only significant in the first and fifth minutes after intubation. Mean systolic and diastolic blood pressure in the first, third, and fifth minutes after intubation was significantly lower in the intervention groups than the control group ( < 0.05). However, no significant difference was observed between the intervention groups. The frequency of systolic blood pressure decrease was significantly different in the first and fifth minutes after intubation in the three study groups ( < 0.05).

Conclusion: Bolus doses of 1 and 2 g/kg nitroglycerin in noncardiac elective surgery prevents the increase of mean systolic, diastolic, and arterial blood pressure but has no significant effect on heart rate after intubation.
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http://dx.doi.org/10.1155/2021/6694150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355956PMC
September 2021

Comparative Study of Effect of Spinal Anesthesia in Sitting and Lateral Positions on the Onset Time of Sensory Block and Hemodynamic Condition in Cesarean Section: A Randomized Clinical Trial.

Anesth Pain Med 2021 Feb 27;11(1):e111483. Epub 2021 Feb 27.

Medical Sciences Faculty, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Spinal anesthesia is the method of choice for the cesarean section. Hypotension is a common complication of this method.

Objectives: This study aimed to compare the effect of spinal anesthesia in the sitting and lateral positions on the onset time of sensory block and hemodynamic condition in cesarean sections.

Methods: In this clinical trial, 106 elective cesarean section candidates under spinal anesthesia were selected and randomly divided into two groups: spinal anesthesia in the sitting position (group S) and the lateral position (group L). The onset time of the sensory block, quality of sensory and motor block, hemodynamic condition, frequency of hypotension, nausea, and vomiting, and the doses of ephedrine and atropine were compared between both groups. Data were analyzed with SPSS version 16 software at a 95% confidence level.

Results: There was no statistically significant difference between the two groups in terms of age. The frequency of hypotension in L and S groups was 24.5% and 57.7%, respectively (P = 0.001), in minute 6 after spinal anesthesia and 5.7% and 36.5%, respectively (P < 0.001), in minute 8 after spinal anesthesia. The mean time to reach the sensory level of T6 was 1.30 ± 0.43 min versus 4.54 ± 2.12 min (P < 0.001), motor block score in minute 5 was 2.98 ± 0.14 versus 2.82 (P = 0.044), and ephedrine dose was 11.5 mg and 16.92 mg in the L and S groups, respectively (P = 0.010). The maximum sensory-motor block and satisfaction of women with spinal anesthesia were significantly higher in the lateral position than in the sitting position (P < 0.05).

Conclusions: Cesarean sections under spinal anesthesia in the lateral position than in the sitting position lead to a more rapid sensory and motor block, reduced ephedrine consumption, and enhanced satisfaction of women.
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http://dx.doi.org/10.5812/aapm.111483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241818PMC
February 2021

The Effects of Ondansetron on the Analgesic Action of Intravenous Acetaminophen after Tonsillectomy in Children: A Triple-Blind Randomized Controlled Trial.

Oxid Med Cell Longev 2021 23;2021:6611740. Epub 2021 Apr 23.

Department of Community Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: Severe pain, nausea, and vomiting after tonsillectomy surgery are among the issues that not only affect patient satisfaction but also may result in complications and delay patient discharge. This study was conducted to assess the effect of intravenous administration of ondansetron on the analgesic action of intravenous acetaminophen after tonsillectomy in children. . This randomized controlled trial was conducted on 53 children between the age of 3 and 12 years old who were referred to Besat Hospital Hamadan, Iran, for tonsillectomy. Patients were randomly assigned to two groups. The intervention group (I) received intravenous acetaminophen plus 0.1 mg/kg ondansetron intravenously while the control group (C) received intravenous acetaminophen plus 2 ml of normal saline intravenously. Postoperative pain severity was assessed using the Children's Hospital Eastern Ontario Pain Scale (CHEOPS). Frequency of nausea, vomiting, and need for analgesic was assessed and recorded four times, at recovery unit, after 6, 12, and 24 hours postsurgery. Data analysis was performed at 95% confidence level using the statistical package for social sciences (SPSS) software version 21.

Results: The number of patients in groups I and C was 27 and 26 patients, respectively. Mean pain score in I and C groups was 4.48 and 2.88 at recovery unit, 2.74 and 2.04 after 6 hours, 1.67 and 0.81 after 12 hours, and 0.67 and 0.20 after 24 hours postsurgery, respectively. Frequency of nausea at recovery unit was 23.1% in I group and 0.0% in group C ( = 0.010) while the mean number of analgesic requirements in I and C groups was 1.07 and 0.56 times, respectively ( = 0.027).

Conclusions: Intravenous administration of 0.1 mg/kg ondansetron reduces the analgesic action of intravenous acetaminophen after tonsillectomy in 3 to 12-year-old children.
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http://dx.doi.org/10.1155/2021/6611740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088369PMC
May 2021

A Randomized, Controlled, Parallel-Group, Trial on the Effects of Melatonin on Fatigue Associated with Breast Cancer and Its Adjuvant Treatments.

Integr Cancer Ther 2021 Jan-Dec;20:1534735420988343

Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: Fatigue associated with malignant conditions and their treatments is a disabling condition. This trial assessed the anti-fatigue effects of melatonin coadministration during adjuvant treatment of patients with the breast cancer.

Material And Methods: Patients with breast cancer were randomly assigned to receive melatonin or placebo during adjuvant chemotherapy and radiotherapy. Thirty-seven patients were randomly enrolled in each group. The mean ages of patients in the intervention and control groups were 50.47 ± 10.79 and 46.05 ± 10.55 years, respectively ( = .223). The intervention group received oral melatonin (18 mg/day) from 1 week before until 1 month after the adjuvant radiotherapy. The level of fatigue was assessed before and after intervention using Brief Fatigue Inventory (BFI) in both groups. To analyze data, the Student's -test and the Chi-square test were used at a significance level of  ≤ .05.

Results: The BFI score was similar before the intervention in both groups, however, after the intervention, it was significantly lower in the melatonin group ( < .001). Moreover, the frequency of severe fatigue in the melatonin group was significantly lower than in the placebo group after intervention (42.1% vs 83.3%,  < .001).

Conclusion: Coadministration of melatonin during adjuvant chemotherapy and radiotherapy of women with breast cancer decreased the levels of fatigue associated with the malignant condition and its treatments.
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http://dx.doi.org/10.1177/1534735420988343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868453PMC
October 2021

Comparison of Intrathecal Injection of Fentanyl and Sufentanil on the Onset, Duration, and Quality of Analgesia in Labor: A Randomized, Double-Blind Clinical Trial.

Anesth Pain Med 2020 Jun 28;10(3):e99843. Epub 2020 Jun 28.

Medical Sciences Faculty, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Labor pain is a severe pain, and intrathecal opioid injection is one of the analgesia methods to reduce it.

Objectives: We assessed the effects of intrathecal Fentanyl and Sufentanil on the onset, duration, and quality of analgesia for labor analgesia.

Methods: In this double-blind, randomized clinical trial, 54 healthy nulliparous women 18 - 45 years in the active phase of labor who were requesting labor analgesia were enrolled in two groups fentanyl (F) and sufentanil (S). Patients received 75 µg fentanyl or 7.5 µg sufentanil intrathecally in the fentanyl group (n = 27) and the sufentanil group (n = 27), respectively. Pain relief, onset, duration of analgesia, hemodynamic parameters, patients' satisfaction, and neonatal Apgar score were assessed in this study. Data were analyzed by using SPSS16.

Results: There were no significant differences between the groups in terms of demographic and hemodynamic parameters. The onset time of analgesia was 5.6 ± 4.3 and 3.6 ± 2.1 minutes, in the sufentanil and fentanyl groups, respectively (P = 0.037). The duration of analgesia was higher in patients who received sufentanil than those who received fentanyl (113 ± 45 vs. 103 ± 22 minutes (P = 0.629)). The pain score in the Fentanyl group was significantly lower at 5, 10, and 15 minutes after spinal analgesia (P < 0.05). The sedation score at 1 and 5 minutes was significantly higher in the fentanyl group than the sufentanil group (P < 0.05). The frequency and severity of pruritus and satisfaction rate in the fentanyl group were significantly higher than the sufentanil group.

Conclusions: Intrathecal fentanyl and sufentanil have a similar analgesic effect on labor. Fentanyl is associated with a faster onset of analgesia and more satisfaction, while sufentanil has longer analgesia.
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http://dx.doi.org/10.5812/aapm.99843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472646PMC
June 2020

Applying Wells score to inconclusive perfusion only modified PIOPED II (Prospective Investigation of Pulmonary Embolism Diagnosis II) readings in order to optimize the lung scintigraphy diagnostic yield in acute pulmonary embolism detection.

Ann Nucl Med 2020 Aug 23;34(8):521-526. Epub 2020 May 23.

School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: When using perfusion only modified PIOPED II criteria for PE detection, generated non-diagnostic scans are found to be the main diagnostic restriction. The objective of current study is to identify the role of Wells criteria added to inconclusive readings with the intent of enhancing the lung scintigraphy diagnostic yield.

Methods: CTPA was performed in 34 suspected PE patients with inconclusive lung scintigraphy. They also were evaluated by Wells score and classified as low, intermediate and high probability. Overall prevalence and the rate of PE for each probability were calculated. Furthermore, NPV for scores < 2 and PPV for scores > 6 were computed.

Results: Having a mean age of 59.75 ± 17.38 years, 7 (20.6%), 23 (67.6%) and 4 (11.8%) of cases had total criteria point count < 2, 2-6 and > 6, respectively. Using CTPA, 5 patients (14.7%) were diagnosed with PE. None of the patients with scores < 2 had PE with an associated NVP of 100%. Patients with scores 2-6 had a PE rate of 4.3% and 100% of patients with scores > 6 were diagnosed with PE, implying that the PPV of scores > 6 was 100%.

Conclusion: Adding Wells score to non-diagnostic scans allowed identification of PE to be done reliably, and provided further insight into how lung scintigraphy in conjunction with clinical assessment is a practical strategy not only for the patients unfit for performing CTPA but also in all the patients referred for PE evaluation.
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http://dx.doi.org/10.1007/s12149-020-01478-3DOI Listing
August 2020

The Prevalence of Human Immunodeficiency Virus Infection in Patients with Sexually Transmitted Diseases.

Adv Biomed Res 2020 16;9:11. Epub 2020 Mar 16.

Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Human immunodeficiency virus (HIV) transmission pattern in Iran has been changed from injection drug to sexual contact. Lack of accurate assessment of HIV in people with sexually transmitted diseases (STDs) in Iran prompted us to conduct this study to determine the frequency of HIV infection in these patients.

Materials And Methods: In this cross-sectional study which conducted in 2016-2017, overall, 190 patients with STDs referring to two hospitals of Hamadan were enrolled in the study. All of the patients were examined for HIV in the first visit by rapid test and then 1 and 4 months later by the 4 generation ELISA. A questionnaire including demographic data, clinical manifestations, and high-risk behaviors was completed for all of the referring people. The collected data were analyzed using appropriate statistical tests.

Results: Of 190 patients, 126 (66.3%) were female with a mean age of 34.1 ± 10.1 years and 64 (33.7%) were male with a mean age of 30.8 ± 7.8 years. One hundred twenty-eight (67.4%) got married, 73 (38.4%) and 76 (40%) had a diploma and postgraduate education, respectively, 32 (16.8%) mentioned the history of unsafe sex, and 23 (12.1%) had used condoms continuously during sexual contacts. The most common STDs were reported genital warts, 107 patients (56.3%), vaginal discharge (28, 14.7%), and genital ulcer (33, 17.4%). Two (1%) patients were positive for HIV at the first visit.

Conclusion: Patients with STDs should be considered as an important source of HIV transmission, so clinicians should pay more attention to screening these patients for HIV infection.
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http://dx.doi.org/10.4103/abr.abr_233_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147514PMC
March 2020

Evaluation of cinnamon extract effects on clbB gene expression and biofilm formation in Escherichia coli strains isolated from colon cancer patients.

BMC Cancer 2020 Mar 30;20(1):267. Epub 2020 Mar 30.

Microbiology Department, Faculty of Medicine, Hamadan University of Medical Sciences, P.O box: 6517838678, Hamadan, Iran.

Background: Colon cancer is one of the most common malignancies and the fourth leading cause of cancer-related mortality in the world. Colibactin, which is synthesized by the pks genomic island of E. coli interfere with the eukaryotic cell cycle. Cinnamon has an antimicrobial effect and considered as a colon cancer-preventing agent. The aim of the study was to evaluate the effects of cinnamon extract and cinnamaldehyde on clbB gene expression and biofilm formation in clinical isolates of E. coli.

Methods: Thirty E. coli carrying pks gene were isolated from the colon cancer patients, inflammatory bowel disease and healthy subjects. Antibiotic susceptibility was evaluated by disk diffusion method and the minimum inhibitory concentration of cinnamon essential oil and cinnamaldehyde by microdilution broth method. In vitro biofilm formation of E.coli isolates was monitored using a microtiter plate method. The presence of clbB, clbA and clbQ genes in E.coli isolates were evaluated by PCR. The effect of cinnamaldehyde and cinnamon essential oil on clbB gene expression was evaluated by Real-Time PCR.

Results: The highest antibiotic resistance was obtained with 94.4% for ticarcillin-clavulanic acid, azithromycin, amoxicillin, and amikacin. The MIC for all clinical isolates was 32 μl/ml of cinnamon essential oil and the MIC of cinnamaldehyde was between 0.00002 to 0.03 μl/ml. After exposure of isolates to cinnamon extract and cinnamaldehyde, 40 and 13.3% were weakly biofilm producers, respectively. The frequencies of clbB, clbA, and clbQ genes were 23.3, 23.3, and 26.7%, respectively. The expression of clbB gene in the presence of the Sub-MIC concentration of cinnamon essential oil and cinnamaldehyde was decreased in 8 isolates compared to untreated isolates (p-value < 0.05).

Conclusions: The antibacterial activity of cinnamaldehyde and cinnamon essential oil allows the use of these herbal compounds for treatment or supplements in infections caused by E. coli and in patients with suspected colorectal cancer.
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http://dx.doi.org/10.1186/s12885-020-06736-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106621PMC
March 2020

Comparison of the serum level of interleukin-4 in patients with brucellosis and healthy controls.

J Clin Lab Anal 2020 Jul 26;34(7):e23267. Epub 2020 Feb 26.

Department of Community Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: Evaluation of cytokines such as interleukin-4 (IL-4) can be an important tool in examining immune responses to brucellosis. Also, determining the response rate to treatment is necessary for controlling and eradicating of disease. The review of previous studies reveals contradictory results that require further research in this regard. The aim of this study was to compare the serum level of IL-4 in patients with brucellosis and healthy controls.

Material And Methods: In this descriptive-analytical study for comparison of two groups, a total of 165 participants, including 83 patients with brucellosis and 82 non-infected people, were evaluated after matching of sex and age in Hamadan (northwest of Iran) in 2017 and the serum level of IL-4 was compared by ELISA method. The collected data were analyzed by SPSS software version 21 at 95% significant level.

Results: Mean of age in the case and control groups were 50.25 ± 16.01 and 43.26 ± 15.6 years, respectively. The serum levels of IL-4 in the case and control groups were 1.42 ± 0.51 pg/mL and 1.31 ± 1.02 pg/mL, respectively. Based on the non-parametric Mann-Whitney test, the IL-4 level was significantly higher in the case group, compared with the control (P < .001), but no statistically significant relationship was found between serum levels of IL-4 with age, sex, and serologic titers of Wright and 2ME.

Conclusion: In patients with brucellosis, the level of IL-4 increases independently of the duration and severity of the disease, which indicates the role of this cytokine of immune system in this infectious disease.
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http://dx.doi.org/10.1002/jcla.23267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370742PMC
July 2020

The effect of working in an auto factory on functional constipation and bowel habits.

Gastroenterol Hepatol Bed Bench 2019 ;12(Suppl1):S101-S107

Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: The aim of the present study was to evaluate the factors associated with functional constipation (FC) and to determine a normal range of bowel movement (BM) in an Iranian Auto factory's workers.

Background: The digestive system may be affected by workplace conditions. Some occupational conditions can affect the bowel habit and FC.

Methods: In this cross-sectional study, 3590 workers who worked in Tehran suburb in 2017 were evaluated. The workers worked in morning or rotatory shifts and in the official and non-official sections. In addition to demographic and stool frequency questions, workers were asked to complete the Rome IV Questionnaire.

Results: The normal range of BM frequency was determined between one and three per day. The BM frequency had a significant association with age (P=0.002), marital status (P=0.024), education (P=0.011), exposure to chemical materials (P<0.001), and work section (P<0.001). The total prevalence of FC was 9.7% which was greater among rotatory shift working than among only morning shift workers (10% vs 6%; P=0.02). Independent factors associated with FC were found as age (for 30- 40 years old: OR=1.88; 95% CI (1.20, 3.03) and for ≥41 years old: OR=1.91; 95% CI (1.12,3.17)), smoking (OR=1.52; 95% CI (1.20,1.93)) and work section (for Paint section: OR=0.33; 95% CI (0.12,0.87), for montage section: OR=0.44; 95% CI (0.18,1.10), for press & platform section: OR=0.12; 95% CI (0.05,0.37)).

Conclusion: Occupational condition may make a difference in bowel habit. Rotatory shift, official working, and smoking may increase the risk of constipation.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011070PMC
January 2019

Genotyping and characterization of prophage patterns in clinical isolates of Staphylococcus aureus.

BMC Res Notes 2019 Oct 21;12(1):669. Epub 2019 Oct 21.

Department of Microbiology, Faculty of Medicine, School of Medicine, University of Hamadan, Hamadan, Iran.

Objective: Staphylococcus aureus is considered an important pathogen with a variety of virulence factors in communities and hospitals all around the world. Prophage typing is a practical technique for categorizing this bacterium. In this study, we focused on the detection of prophage patterns in methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) strains based on their virulence factors, antimicrobial resistance patterns, and molecular typing by rep-PCR.

Results: Out of 126 S. aureus isolates, 45 (35.7%) were identified as MRSA. In total, 17 different prophage types were detected and 112 strains out of 126 strains contained at least one prophage. There was a statistically significant relationship between hld, hlg, eta and SGA, SGA, and SGFb, respectively. The results of the rep-PCR analysis revealed 14 different patterns among the MRSA and MSSA isolates. In conclusion, the presence of different prophage-encoded virulence factors and antibiotic-resistant genes among MRSA strains enables them to produce a broad range of diseases. Thus, diverse MRSA strains which have these prophages can be considered as a potential threat to the patient's health in either the hospital or the community.
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http://dx.doi.org/10.1186/s13104-019-4711-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805666PMC
October 2019

Local Anesthetic Effect of Amitriptyline versus Lidocaine in Isolated Lesion of the Limb Requiring Primary Suturing; Assessing a Novel Therapeutic Agent.

Bull Emerg Trauma 2019 Jul;7(3):240-244

Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: To compare the anesthetic effects of topical amitriptyline 2% with lidocaine 2% in isolated limb wound repair with suturing.

Methods: In a randomized clinical trial, 90 patients with a complaint of isolated ulcer and require a preliminary repair by suturing were selected from patients referred to emergency department of Beast Hospital in Hamadan. First, the scars were washed and anesthetized with lidocaine 2%. If after the peak period effect of lidocaine, the pain score of patients did not decrease, they randomly assigned to two groups, Lidocaine or Amitriptyline gel. After the intervention and during the suturing, the patient's pain score was measured at the intervals specified time by the visual analogous scale (VAS) and results recorded on the checklist. Finally, the collected data were analyzed by SPSS software version 20 at 95% confidence level.

Results: In the lidocaine and amitriptyline group, the mean age of the patients was 29.08 and 27.34 years, and male gender frequency was 71.1% and 80% respectively. Both groups were matched for age and sex. Mean score of pain in both groups decreased from the score of 10 before the intervention to 7.33 in the lidocaine group and 0.53 in amitriptyline group. Based on the results of the ANOVA repeated measure test, there was a statistically significant difference between the mean score of pain in the two groups (<0.001).

Conclusion: In patients with isolated limbs ulcers, requiring initial repair with suturing, numbness and analgesia effect of amitriptyline 2% gel, with dose 2 mg/kg is better than lidocaine 2%.
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http://dx.doi.org/10.29252/beat-070305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681890PMC
July 2019

Preparation of porous biomass-derived hydrothermal carbon modified with terminal amino hyperbranched polymer for prominent Cr(VI) removal from water.

Bioresour Technol 2019 Sep 24;288:121545. Epub 2019 May 24.

Department of Polymer Engineering & Color Technology, Amirkabir University of Technology, Tehran, Iran.

Herein, a series of functionalized hydrochars with high density of nitrogen-containing functional groups were engineered by co-processing of terminal amino hyperbranched polymer and walnut shell biomass in the hydrothermal carbonization media. Hydrothermal Carbonization with optimized key parameters was implemented to determine the impact of added polymer to the biomass on the properties of the obtained hydrochars. Consequently, the optimum hydrochar which was achieved with the values of 250 °C, 60 min, and 50% (w/w) for temperature, time, and polymer/biomass weight ratio, demonstrated a highly improved surface area of 544 m.g and the highest adsorption capacity for Cr(VI) removal which was obtained from Freundlich isotherm model and described by the pseudo-second-order kinetic model to be 363.22 mg.g (at pH = 2.0). This work suggests that the co-hydrothermal carbonization promotes the uniform incorporation of polymers into the hydrochar matrix and provides adsorbents for the effective removal of Cr(VI) from water.
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http://dx.doi.org/10.1016/j.biortech.2019.121545DOI Listing
September 2019

Influence of working in auto factory on gastroesophageal reflux disease.

Gastroenterol Hepatol Bed Bench 2018 ;11(Suppl 1):S1-S7

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: Present study aimed to evaluate association between job -related factors and gastroesophageal reflux disease (GERD) among Iranian auto factory's workers.

Background: Many of the gastrointestinal disorders may be caused as the result of stress-related occupations and biorhythm disruption.

Methods: We performed a cross-sectional study on 3590 Iranian Auto factory employees. GERD symptoms, demographic information, work shift, work section and history of some gastrointestinal disease were asked from all employees by physician. Logistic regression was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) for GERD symptoms according to the potential risk factors.

Results: The prevalence of GERD was 25.57%, which was higher in rotatory shift (91.6%) than the fixed shift (8.4%) (P-value = 0.009). Smoking (OR: 1.31; 95% CI: (1.09, 1.57)), working in official section (P-value < 0.001), history of GERD (OR: 8.63; 95 % CI (6.53, 11.40)), history of peptic ulcer (OR: 2.96; 95 % CI (2.08, 4.20)), family history of gastrointestinal cancers (OR: 1.47; 95 % CI (1.19, 1.81)) were the factors associated with GERD symptoms.

Conclusion: The prevalence of GERD in the rotatory shift was more than the fixed shift. Smoking, family history of gastrointestinal cancers and peptic ulcer could be associated with GERD symptoms. Working in the special job with high activity, may probably lead to decrease in the risk of reflux.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347988PMC
January 2018

Microbiological study of dacryocystitis in northwest of Iran.

Clin Ophthalmol 2018 25;12:1859-1864. Epub 2018 Sep 25.

School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: The prevalence of bacterial pathogens isolated from patients with acute and chronic dacryocystitis and the pattern of antibiotic susceptibility tests are varied in each region. Moreover, the management of dacryocystitis is only based on clinical observations without microbiological evaluation. The present study aimed to identify epidemiologic and etiologic factors of dacryocystitis in our geographical area.

Materials And Methods: This cross-sectional and analytical study was carried out in the ophthalmology department of Hamadan University of Medical Sciences (northwest of Iran) during 2016-2017. Nasolacrimal duct discharges were inoculated to culture media including blood agar, eosin methylene blue, chocolate agar, and Sabouraud agar for the determination of microbial agents. Disc diffusion method with MAST antibiogram discs was used for antibiotic susceptibility tests, according to the Clinical and Laboratory Standards Institute, 2017.

Results: Of the total 129 patients enrolled in the study, 34.1% had acute dacryocystitis and 65.9% showed chronic type. The result of culture was positive in 75.2% of patients. , , , spp., and were the most prevalent microorganisms. The most sensitive antibiotics used against prevalent bacteria were ciprofloxacin (75.9%), ceftriaxone (73.6%), vancomycin (67.8%), and chloramphenicol (60.9%), respectively.

Conclusion: The present study is useful for determining the appropriate antibiotic for systemic treatment of dacryocystitis in our region. Ciprofloxacin and vancomycin are the most sensitive antibiotics against the most common isolated microorganisms in both age groups (under and above 10 years) that can be used for empirical therapy of dacryocystitis in both acute and chronic type.
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http://dx.doi.org/10.2147/OPTH.S175463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165732PMC
September 2018

Visual Impairment Was Related to Educational Level but Not to Cognitive Performance Among Adults in Their 60s.

Psychol Rep 2019 Dec 9;122(6):2266-2281. Epub 2018 Oct 9.

Center for Affective, Stress and Sleep Disorders, University of Basel, Psychiatric Clinics, Switzerland; Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Iran; Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Iran; Division of Sport Sciences and Psychosocial Health, Department of Sport, Exercise and Health, University of Basel, Switzerland.

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http://dx.doi.org/10.1177/0033294118800984DOI Listing
December 2019

A comparative study on the effect of "black cohosh" and "evening primrose oil" on menopausal hot flashes.

J Educ Health Promot 2018 1;7:36. Epub 2018 Mar 1.

MSc. of Midwifery consulting, Department of Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran.

Introduction: Hot flashes are considered to be a common experience for menopausal women and they can compromise the quality of life. The objective of this study is to assess the efficacy of in comparison with evening primrose oil (EPO) in postmenopausal women with menopause-related symptoms.

Materials And Methods: This study was performed on 80 postmenopausal women with hot flashes. The participants were randomly divided into two groups by blocked randomization. The participants of one group received black cohosh and the other group received EPO for 8 weeks. The severity and number of hot flashes and quality of life were measured by four-point scale, and the Menopause-Specific Quality of Life (MENQOL) questionnaire at pre-intervention, 1, 4, and 8 weeks after treatment. Data were analyzed in SPSS Version 16 using independent -test, Chi-square, and Fisher's exact test.

Results: Average severity of hot flashes in both groups and number of hot flashes in black cohosh group in 8 week were significantly lower than 1 week ( < 0.001), but number of hot flashes in primrose oil group in 8 week showed no significant differences ( = 0.32). The number of hot flashes and quality of life score in black cohosh arm compared to EPO showed a significant decrease in the 8 week ( < 0.05). All MENQOL scores were significantly improved in two groups ( < 0.05), but the percentage of improvement in black cohosh arm was significantly superior to EPO group.

Conclusion: Both herbs were effective in reduction of severity of hot flashes and improvement of the quality of life, but it seems that black cohosh is more effective than primrose oil because it was able to reduce the number of hot flashes too.
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http://dx.doi.org/10.4103/jehp.jehp_81_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868221PMC
March 2018

The relationship between mitotic rate and depth of invasion in biopsies of malignant melanoma.

Clin Cosmet Investig Dermatol 2018 16;11:125-130. Epub 2018 Mar 16.

School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Malignant melanoma of the skin is a potentially lethal neoplasm that generally originates from atypical melanocytes in the dermal-epidermal junction. When the neoplasm penetrates into the dermis, several variables can affect the extent of its spread, among which depth of invasion has the most important prognostic value. Mitotic rate is another prognostic factor that reflects the biological behavior of the neoplasm.

Objective: This study was designed to evaluate the probable relationship between the depth of invasion of malignant melanoma and its mitotic rate.

Materials And Methods: This study was performed on 50 excisional biopsy specimens that had received the diagnosis of malignant melanoma histopathologically. Tumor characteristics including Breslow thickness, Clark level, T-stage, and tumor mitotic rate were recorded.

Results: We observed that at higher Clark levels and higher T-stages, and the mean mitotic rate was significantly increased. Moreover, there was a positive and significant correlation between Breslow thickness and mitotic rate. We demonstrated that one unit increase in mitotic rate was correlated with 0.8 mm increase in Breslow thickness of the tumor.

Conclusion: In malignant melanoma, mitotic activity may probably indicate the depth of tumor invasion. Therefore, in incisional biopsies where depth of invasion cannot be accurately determined, the mitotic activity may be used to estimate Breslow thickness, which is necessary for planning surgical management.
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http://dx.doi.org/10.2147/CCID.S158043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858543PMC
March 2018

An Evaluation of the Numbers and Locations of Coronary Artery Disease with Some of the Major Atherosclerotic Risk Factors in Patients with Coronary Artery Disease.

J Clin Diagn Res 2017 Aug 1;11(8):OC21-OC24. Epub 2017 Aug 1.

Community Medicine Specialist, Department of Community Medicine, Education Development Office, Hamadan University of Medical Science, Hamadan, Iran.

Introduction: Despite definite recognition of major atherosclerotic risk factors, the relationship between the pattern of coronary artery disease and these risk factors is unknown.

Aim: The aim of this study was to identify the relationship between some of the major atherosclerotic risk factors and the number and pattern of coronary artery disease in patients with coronary artery disease who presented to Farshchian Heart University Hospital, Hamadan, Iran.

Materials And Methods: In this descriptive cross-sectional study, we investigated some of the major atherosclerotic risk factors and their relationships with the type of coronary artery disease in terms of number and location of disease. A total of 1100 patients were enrolled with coronary artery disease confirmed by selective coronary angiography from 2010-2014. A p-value<0.05 was considered statistically significant.

Results: A total of 1100 patients enrolled in this study. The patient population consisted of 743 (67.5%) males and 357 (32.5%) females. A meaningful relationship existed between ageing, diabetes mellitus, hypertension and 3-Vessel Disease (3VD, p<0.001) as well as between hyperlipidemia and Single Vessel Disease (SVD, p<0.001). Patients diagnosed with diabetes mellitus, hypertension, and hyperlipidemia showed greater potential to develop coronary artery disease at the proximal section of the coronary arteries.

Conclusion: Based on the relationship between some of the major risk factors and the pattern of coronary artery disease in the current study, prospective studies should investigate other risk factors. We recommend that a plan should be developed to reduce adjustable risk factors such as diabetes mellitus, hypertension and hyperlipidemia in order to decrease coronary artery disease.
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http://dx.doi.org/10.7860/JCDR/2017/29104.10460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620820PMC
August 2017

Evaluating a diabetes screening program in older than age 30 rural populations, Hamedan District, Iran.

Soc Work Public Health 2013 ;28(6):591-5

Department of Community Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.

This study was conducted to assess validity (sensitivity and specificity) of a diabetes screening program in Hamedan, Iran district health centers. Eight hundred and thirty-five persons older than age 30 in Hamedan rural areas who had no diabetes risk factors were tested for fasting glucose, then the results of the national diabetes program in the area were added to these results. Finally, sensitivity, specificity, and positive and negative predictive values (PPV and NPV, respectively) of type 2 diabetes were calculated. Nineteen persons (2.28%) had impaired fasting glucose (110-126 mg/dl), and three (0.36%) had diabetes (fasting glucose ≥ 126 mg/dl) according to standard diagnostic criteria. Prevalence and incidence rates of diabetes were 2.97% and 7.53 per 1,000. Sensitivity, specificity, PPV, and NPV of the diabetes screening test were 80.23%, 61.67%, 2.2%, and 99.65%, respectively. The study revealed that the primary screening program in district health centers had an acceptable sensitivity (80.23%) and a low specificity (61.67%).
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http://dx.doi.org/10.1080/19371918.2011.593450DOI Listing
April 2014
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