373 results match your criteria zhoupu hospital


The treatment of posterolateral tibial plateau fracture with a newly designed anatomical plate via the trans-supra-fibular head approach: preliminary outcomes.

BMC Musculoskelet Disord 2021 Sep 18;22(1):804. Epub 2021 Sep 18.

Department of Orthopedics, Taizhou Hospital of Zhejiang Province, Affiliated to Wenzhou Medical University, No. 150 Ximen Street, Zhejiang, 317000, Linhai , China.

Background: There are no ideal plates or approaches for anatomical restoration and rigid fixation of posterolateral tibial plateau fractures. This study aimed to evaluate the short-term preliminary outcomes of our novel anatomical plate placed via the trans-supra-fibular approach to treat posterolateral tibial plateau fractures.

Methods: From May 2016 to May 2018, 23 consecutive patients with posterolateral tibial quadrant fractures underwent open reduction with internal fixation via the trans-supra-fibular-head approach with our newly developed plate. Read More

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September 2021

Pyroptosis inhibition improves the symptom of acute myocardial infarction.

Cell Death Dis 2021 Sep 16;12(10):852. Epub 2021 Sep 16.

Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, 200124, Shanghai, China.

Acute myocardial infarction (AMI), the leading cause of mortality worldwide, is a rapidly developing and irreversible disease. Therefore, proper prompt intervention at the early stage of AMI is crucial for its treatment. However, the molecular features in the early stage have not been clarified. Read More

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September 2021

Preoperative Short Physical Performance Battery as a predictor of prolonged hospitalization after coronary artery bypass grafting in older patients.

J Int Med Res 2021 Sep;49(9):3000605211044043

Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Objective: The study aimed to evaluate the predictive value of the Short Physical Performance Battery (SPPB) and its three components for identifying the requirement for a prolonged hospitalization for coronary artery bypass grafting (CABG) in older patients.

Methods: This prospective, observational study included 425 older patients who consecutively underwent selective CABG surgery. All patients were assessed for the SPPB. Read More

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September 2021

External validation and Comparison of two versions of simplified sequential organ failure assessment scores to predict prognosis of septic patients.

Int J Clin Pract 2021 Sep 14:e14865. Epub 2021 Sep 14.

Department of Emergency and Critical Care Medicine, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center.

Background: Evidence shows that simplified SOFA scoring system has better clinical practice.

Objective: This study aimed to validate and compare the scores acquired with simplified organ dysfunction criteria optimized for electronic health records (eSOFA), and simplified and accurate sequential organ failure assessment (sa-SOFA) for their accuracies in predicting the prognosis of septic patients.

Methods: This retrospective observational study was conducted at three major academic hospitals. Read More

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September 2021

LOXL2 Inhibitor Attenuates Angiotensin II-Induced Atrial Fibrosis and Vulnerability to Atrial Fibrillation through Inhibition of Transforming Growth Factor Beta-1 Smad2/3 Pathway.

Cerebrovasc Dis 2021 Sep 6:1-11. Epub 2021 Sep 6.

Department of Cardiology, Shanghai University of Medicine & Health Sciences affiliated Zhoupu Hospital, Shanghai, China.

Objectives: Angiotensin II (Ang II)-induced atrial fibrosis plays a vital role in the development of atrial fibrillation (AF). Lysyl oxidase-like 2 (LOXL2) plays an essential role in matrix remodeling and fibrogenesis, indicating it may involve fibrosis-associated diseases. This study aims to elucidate the role of LOXL2 in AF, and its specific inhibitor can suppress Ang II-induced inflammatory atrial fibrosis and attenuate the enhanced vulnerability to AF. Read More

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September 2021

The effectiveness and feasibility of fluid resuscitation directed by microcirculation monitoring in patients with septic shock: a randomized controlled trial.

Ann Palliat Med 2021 Aug;10(8):9069-9077

Department of Emergency and Critical Care, Shanghai Changzheng Hospital, Naval Military Medical University, Shanghai, China.

Background: This study sought to examine fluid resuscitation in septic shock patients by monitoring their sublabial point of care microcirculation score (POEM) scores (a 3.5 cut-off value was used as the end point of recovery). It also sought to explore the effectiveness and safety of using the POEM score in the fluid resuscitation of septic shock. Read More

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Kinetic changes in serum procalcitonin predict persistent acute kidney injury in critical patients.

Nephrology (Carlton) 2021 Sep 5. Epub 2021 Sep 5.

Department of Critical Care Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai.

Purpose: Persistentacute kidney injury (AKI) has been shown to be closely associated with poor prognosis in critical patients. Recent studies have shown that procalcitonin (PCT) is valuable for the early prediction of AKI in critically patients.. Read More

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September 2021

Combination of hepcidin with neutrophil gelatinase-associated lipocalin for prediction of the development of sepsis-induced acute kidney injury.

Clin Chim Acta 2021 Sep 2;523:38-44. Epub 2021 Sep 2.

Department of Emergency, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address:

Background And Aims: The early prediction of the development of acute kidney injury (AKI) in critically ill patients with sepsis would facilitate early effective intervention. Recently, interest has focused on the biomarkers for AKI-linked iron metabolism. This study aimed to assess the early predictive values of hepcidin, neutrophil gelatinase-associated lipocalin (NGAL), and their combination for secondary AKI in patients with sepsis. Read More

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September 2021

A Stepwise Approach to Inbound Passenger Management at a COVID-19 Temporary Medical Observation Site.

Risk Manag Healthc Policy 2021 26;14:3589-3596. Epub 2021 Aug 26.

Dean's Office, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, People's Republic of China.

Objective: To implement epidemic prevention among entry personnel, Shanghai has launched a number of Medical Observation Sites (Observation Site) for which high expectations are set. Ours is one such Observation Site.

Methods: As part of a novel project, we did not have any previous experience to use as reference. Read More

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LncRNA SOX2-OT regulates miR-192-5p/RAB2A axis and ERK pathway to promote glioblastoma cell growth.

Cell Cycle 2021 Sep 1:1-11. Epub 2021 Sep 1.

Department of Neurosurgery, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Glioblastoma (GBM) is the most frequent tumor in the central nervous system. Long non-coding RNAs (lncRNAs) have been widely accepted as essential participators in cancer progression. Nonetheless, the specific role and mechanism of lncRNA SRY-box transcription factor 2 overlapping transcript (SOX2-OT) in GBM have not been studied. Read More

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September 2021

Systemic Proteomic Analysis Reveals Distinct Exosomal Protein Profiles in Rheumatoid Arthritis.

J Immunol Res 2021 18;2021:9421720. Epub 2021 Aug 18.

Department of Endocrinology & Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China.

Objective: Rheumatoid arthritis (RA) is a complex disease with unknown pathogenesis. In recent years, fewer have paid attention to the broad spectrum of systemic markers of RA. The aim of this study was to identify exosomal candidate proteins in the pathogenesis of RA. Read More

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Inverse Association Between Iodine Status and Prevalence of Metabolic Syndrome: A Cross-Sectional Population-Based Study in a Chinese Moderate Iodine Intake Area.

Diabetes Metab Syndr Obes 2021 20;14:3691-3701. Epub 2021 Aug 20.

Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People's Republic of China.

Purpose: To investigate the relationship between iodine intake status and the prevalence of metabolic syndrome (MetS) through a population-based survey.

Patients And Methods: In total, 2691 Chinese adults participated in this cross-sectional study, and they were stratified by urinary iodine concentration (UIC) and sex. Fasting blood samples were used to assess biochemical parameters, including thyroid function and antibodies. Read More

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Response of extracellular polymeric substances and microbial community structures on resistance genes expression in wastewater treatment containing copper oxide nanoparticles and humic acid.

Bioresour Technol 2021 Nov 11;340:125741. Epub 2021 Aug 11.

Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China. Electronic address:

The extracellular polymeric substances (EPS) and microbial community structures were investigated in wastewater treatment containing copper oxide nanoparticles (CuO NPs) (reactor R1) and CuO NPs and humic acid (HA) (reactor R2) using both sequencing batch bioreactors (SBRs), and their response on resistance genes expression was analyzed. The removal of influent chemical oxygen demands (COD) and NH-N was moderately influenced under CuO NPs (5 mg/L) stress, while the function of HA (10 mg/L) was not reflected. However, the EPS production and microbial community were affected by the HA addition. Read More

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November 2021

ANGPTL4 Attenuates Ang II-Induced Atrial Fibrillation and Fibrosis in Mice via PPAR Pathway.

Cardiol Res Pract 2021 9;2021:9935310. Epub 2021 Aug 9.

Department of Cardiology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China.

Atrial fibrillation (AF) is the more significant portion of arrhythmia in clinical practice, with inflammation and fibrosis as its central pathological mechanisms. This study aimed to investigate angiopoietin-like 4 (ANGPTL4) effects on angiotensin II- (Ang II-) induced AF and its related pathophysiological mechanisms. C57BL/6J mice were randomized and divided into three groups: the control group, the Ang II group, and the ANGPTL4 group (Ang II with ANGPTL4 treatment). Read More

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Repair of long bone defects of large size using a tissue-engineered periosteum in a rabbit model.

J Mater Sci Mater Med 2021 Aug 21;32(9):105. Epub 2021 Aug 21.

Orthopaedic Department of Hanzhong Central Hospital, Shaanxi Province, People's Republic of China.

Tissue engineering is a promising approach for bone regeneration. In this study, we aimed to investigate whether tissue engineered periosteum (TEP), which was fabricated by combining osteogenically-induced mesenchymal stem cells (MSCs) with porcine small intestinal submucosa (SIS), could restore long bone defects of large size in rabbits. Twenty-four adult New Zealand white rabbits (NZWRs) were used in the experiments. Read More

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Mechanism of Endoplasmic Reticulum Stress in Cerebral Ischemia.

Front Cell Neurosci 2021 2;15:704334. Epub 2021 Aug 2.

Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Endoplasmic reticulum (ER) is the main organelle for protein synthesis, trafficking and maintaining intracellular Ca homeostasis. The stress response of ER results from the disruption of ER homeostasis in neurological disorders. Among these disorders, cerebral ischemia is a prevalent reason of death and disability in the world. Read More

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Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications.

Front Oncol 2021 26;11:654428. Epub 2021 Jul 26.

Department of Breast Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.

Breast cancer (BC) is the most frequent cancer among women worldwide and is the leading cause of cancer-related deaths in women. Cancer cells with stem cell-like features and tumor-initiating potential contribute to drug resistance, tumor recurrence, and metastasis. To achieve better clinical outcomes, it is crucial to eradicate both bulk BC cells and breast cancer stem cells (BCSCs). Read More

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The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65.

Endocrinol Metab (Seoul) 2021 Aug 10;36(4):778-789. Epub 2021 Aug 10.

Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure (BP) has been controversial. The aim of the study was to analyze the association between SCH and newly-diagnosed hypertension.

Methods: Based on data from the Thyroid disease, Iodine nutrition and Diabetes Epidemiology (TIDE) study, 49,433 euthyroid individuals and 7,719 SCH patients aged ≥18 years were enrolled. Read More

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Bibliometric Analysis Study on the Mechanisms of Brain Energy Metabolism Disorders in Alzheimer's Disease From 2000 to 2020.

Front Neurol 2021 21;12:670220. Epub 2021 Jul 21.

Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Alzheimer's disease (AD) is currently one of the main diseases afflicting the elderly in the world. In recent years, more and more studies have shown that brain energy metabolism disorders are the key pathogenic factors and main early pathological features of AD. Many risk factors such as insulin resistance, mitochondrial dysfunction, oxidative stress, Aβ-amyloid plaques, neurofibrillary tangles of hyperphosphorylated tau, aging, and neuroinflammation are involved in brain energy metabolism disorders. Read More

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Coronavirus Disease 2019 (COVID-19) Learning Online: A Flipped Classroom Based on Micro-Learning Combined with Case-Based Learning in Undergraduate Medical Students.

Adv Med Educ Pract 2021 28;12:835-842. Epub 2021 Jul 28.

Teaching & Training Department, Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, People's Republic of China.

Background: During the coronavirus disease 2019 (COVID-19) pandemic, medical colleges in China had to use online teaching. This study explored the effect of COVID-19 knowledge learning online in a flipped classroom based on micro-learning combined with case-based learning (CBL).

Methods: There were 74 undergraduate medical students who were randomly grouped to an observation group and a control group with 37 participants in each virtual classroom on the Network Teaching Platform. Read More

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Psoriasis Susceptibility 1 Candidate 1 () Polymorphism is Associated with Autoimmune Thyroid Disease in a Chinese Han Population.

Immunol Invest 2021 Jul 30:1-10. Epub 2021 Jul 30.

Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Background: Autoimmune thyroid disease (AITD) is an inherited, complex gene- and immune-related disorder that mainly includes Graves' disease (GD) and Hashimoto's thyroiditis (HT). Psoriasis susceptibility 1 candidate 1 () is a susceptibility gene associated with many autoimmune diseases, but its role in an individual's predisposition to AITD is unknown.

Methods: This study included 1065 Chinese Han patients with AITD and 943 matched healthy individuals. Read More

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Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases.

Biomed Res Int 2021 6;2021:6885897. Epub 2021 Jul 6.

Department of Orthopedics, Zhoupu Hospital, Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.

Osteosarcoma (OS) is a type of bone malignancy with a high rate of treatment failure. To date, few evident biomarkers for the prognostic significance of OS have been established. Oncomine was used to integrate RNA and DNA-seq data from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), and the published literature. Read More

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September 2021

Pain and Psychological Distress: Effect of Microvascular Decompression on Sleep Disorders and Obsessions in Trigeminal Neuralgia.

J Neurol Surg B Skull Base 2021 Jul 14;82(Suppl 3):e285-e294. Epub 2020 Jan 14.

Department of Neurosurgery, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, People's Republic of China.

 This study was aimed to investigate the effects of microvascular decompression (MVD) on sleep disorders and obsessions in trigeminal neuralgia.  Clinical data from 115 patients with trigeminal neuralgia treated with MVD from August 1, 2017 to May 31, 2018 at Jining First People's Hospital were analyzed retrospectively. The preoperative and postoperative risk factors for sleep disorders and obsessions, as well as the effects of MVD on sleep disorders and obsessions, were examined. Read More

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Inclusion of ALKBH5 as a candidate gene for the susceptibility of autoimmune thyroid disease.

Adv Med Sci 2021 Jul 22;66(2):351-358. Epub 2021 Jul 22.

Department of Endocrinology & Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China. Electronic address:

Purpose: RNA demethylase AlkB homolog 5 (ALKBH5) gene is pivotal in N6-methyladenosine (m6A) modification. Therefore, this study aimed to explore the potential relationship between polymorphisms of ALKBH5 gene and the development of autoimmune thyroid disease (AITD).

Material And Methods: A case-control study of 979 AITD patients, including 620 Graves' disease (GD) and 359 Hashimoto's thyroiditis (HT), and 732 normal controls of the Chinese Han population was performed using high-throughput sequencing (HiSeq) genotyping method for detecting 5 variants in ALKBH5 gene (rs12936694, rs2124370, rs4925144, rs8068517, and rs9913266). Read More

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Long Non-Coding RNA LINC00152 Regulates Self-Renewal of Leukemia Stem Cells and Induces Chemo-Resistance in Acute Myeloid Leukemia.

Front Oncol 2021 6;11:694021. Epub 2021 Jul 6.

Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Relapse of acute myeloid leukemia (AML) has a very poor prognosis and remains a common cause of treatment failure in patients with this disease. AML relapse is partially driven by the chemoresistant nature of leukemia stem cells (LSCs), which remains poorly understood, and our study aimed at elucidating the underlying mechanism. Accumulating evidences show that long noncoding RNAs (lncRNAs) play a crucial role in AML development. Read More

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The lncRNA OGFRP1/miR-149-5p/IL-6 axis regulates prostate cancer chemoresistance.

Pathol Res Pract 2021 Aug 22;224:153535. Epub 2021 Jun 22.

Department of Laboratory Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China. Electronic address:

Background: The long non-coding RNA (lncRNA) OGFRP1 has been found to promote malignancy in prostate cancer (PC) and other cancer types. How this lncRNA functions in the regulation of PC chemoresistance, however, is poorly defined.

Methods: qRT-PCR was employed to measure OGFRP1, miR-149-5p, and IL-6 expression in PC tissues and cells. Read More

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Circular RNA-DPP4 serves an oncogenic role in prostate cancer progression through regulating miR-195/cyclin D1 axis.

Cancer Cell Int 2021 Jul 16;21(1):379. Epub 2021 Jul 16.

Department of Laboratory Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, China.

Background: Recently, more and more studies have highlighted the critical regulatory roles of circular RNAs (circRNAs), a class of non-coding RNAs, in the progression of many human cancers, including prostate cancer (PCa). circRNA microarray analysis was performed to identify circRNAs that are differentially expressed in PCa tissues.

Methods: 104 pairs of PCa tissues and matched adjacent normal prostate tissues (at least 2 cm distal to the tumor margin) were obtained. Read More

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T cell receptor revision and immune repertoire changes in autoimmune diseases.

Int Rev Immunol 2021 Jul 9:1-17. Epub 2021 Jul 9.

Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.

Autoimmune disease (AID) is a condition in which the immune system breaks down and starts to attack the body. Some common AIDs include systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes mellitus and so forth. The changes in T-cell receptor (TCR) repertoire have been found in several autoimmune diseases, and may be responsible for the breakdown of peripheral immune tolerance. Read More

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Associations between CD160 polymorphisms and autoimmune thyroid disease: a case-control study.

BMC Endocr Disord 2021 Jul 8;21(1):148. Epub 2021 Jul 8.

Department of Endocrinology and Rheumatology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201508, China.

Background: Recent researches suggest that the CD160/HVEM/LIGHT/BTLA signaling pathway may contribute to the pathogeneses of autoimmune diseases, but the relationship between CD160 polymorphisms and autoimmune thyroid disease (AITD) has not been reported yet. This study aimed to evaluate the associations between CD160 polymorphisms and AITD.

Methods: A total of 1017 patients with AITD (634 Graves' disease and 383 Hashimoto's thyroiditis) and 856 unrelated healthy controls were recruited into our study. Read More

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Inhibition of Long Noncoding RNA Improves Angiotensin II-Induced Cardiac Fibrosis and Hypertrophy by Regulating the MicroRNA 335/ Axis.

Mol Cell Biol 2021 08 24;41(9):e0058020. Epub 2021 Aug 24.

Shanghai University of Medicine & Health Sciences, Zhoupu Hospital, Shanghai, China.

Cardiac fibrosis is a hallmark of various heart diseases and ultimately leads to heart failure. Although long noncoding RNA (lncRNA) has been reported to play important roles in various cancers, its function in cardiac fibrosis remains unclear. The expression of and microRNA 335 (miR-335) in heart tissues of angiotensin II-induced mice and angiotensin II-stimulated mouse cardiomyocyte cell line HL-1 were detected by quantitative real-time PCR (qRT-PCR). Read More

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