38,798 results match your criteria younger women

High Prevalence of Osteopathy in Chronic Pancreatitis: A Cross-sectional Analysis from the PROCEED Study.

Clin Gastroenterol Hepatol 2021 Sep 24. Epub 2021 Sep 24.

Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH. Electronic address:

Introduction: Chronic pancreatitis (CP) is associated with osteopathy (osteoporosis or osteopenia). However, existing literature is mostly limited to retrospective or administrative studies that have not clearly defined the prevalence and risk factors. Our aim was to identify patient- and disease-related associations with osteopathy in a prospective cohort study of CP. Read More

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September 2021

Trajectories of attitude toward own aging and subjective age from 2008 to 2020 among middle-aged and older adults: Partial evidence of a "COVID-19 effect".

Psychol Aging 2021 Sep 27. Epub 2021 Sep 27.

Heidelberg University.

As older adults have frequently been portrayed as one homogeneous and vulnerable risk group in public debates and in the media immediately after the outbreak of the Coronavirus disease (COVID-19) pandemic, a general shift toward less favorable attitude toward own aging (ATOA) might have resulted. In contrast, individuals may feel younger than before the pandemic, reflecting a psychological mechanism to avoid identifying themselves with the old age "risk group." We investigate 12-year trajectories of ATOA and subjective age among middle-aged and older German adults based on assessments between 2008 and Summer 2020 ( = 7,730; age in 2008: 40-93 years, = 62. Read More

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September 2021

"It just took something from me": A mixed-methods examination of intimate partner violence victimization and perpetration among U.S. Indigenous peoples.

Psychol Trauma 2021 Sep 27. Epub 2021 Sep 27.

Tulane University School of Social Work.

Objective: Indigenous peoples of the United States experience disproportionate rates of intimate partner violence (IPV). The framework of historical oppression, resilience, and transcendence (FHORT) was used to understand risk factors for IPV victimization and perpetration.

Method: In this exploratory sequential mixed-methods study, data were collected with 436 participants in the qualitative portion and 127 participants in the quantitative portion. Read More

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September 2021

Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial.

JAMA Neurol 2021 Sep 27. Epub 2021 Sep 27.

Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco.

Importance: Network hyperexcitability may contribute to cognitive dysfunction in patients with Alzheimer disease (AD).

Objective: To determine the ability of the antiseizure drug levetiracetam to improve cognition in persons with AD.

Design, Setting, And Participants: The Levetiracetam for Alzheimer's Disease-Associated Network Hyperexcitability (LEV-AD) study was a phase 2a randomized double-blinded placebo-controlled crossover clinical trial of 34 adults with AD that was conducted at the University of California, San Francisco, and the University of Minnesota, Twin Cities, between October 16, 2014, and July 21, 2020. Read More

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September 2021

Cutaneous Leiomyoma: A Clinical Study of 152 Patients.

Dermatology 2021 Sep 23:1-7. Epub 2021 Sep 23.

Department of Pathology, Hospital Universitari de Bellvitge, IDIBELL, University of Barcelona, Barcelona, Spain.

Background: Cutaneous leiomyoma (CL) is a benign smooth muscle tumour included in painful skin tumours. Multiple CLs are cutaneous markers of hereditary leiomyomatosis and renal cell cancer (HLRCC).

Objectives: To retrospectively review our series of patients with CLs to analyse their clinical features and the association with HLRCC. Read More

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September 2021

Racial Disparities and Sex Differences in Early- and Late-Onset Colorectal Cancer Incidence, 2001-2018.

Front Oncol 2021 9;11:734998. Epub 2021 Sep 9.

Slone Epidemiology Center at Boston University, Boston, MA, United States.

Background: Colorectal cancer (CRC) incidence rates have increased in younger individuals worldwide. We examined the most recent early- and late-onset CRC rates for the US.

Methods: Age-standardized incidence rates (ASIR, per 100,000) of CRC were calculated using the US Cancer Statistics Database's high-quality population-based cancer registry data from the entire US population. Read More

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September 2021

MRI-Based Radiomics Nomogram for Selecting Ovarian Preservation Treatment in Patients With Early-Stage Endometrial Cancer.

Front Oncol 2021 9;11:730281. Epub 2021 Sep 9.

Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, China.

Background: Ovarian preservation treatment (OPT) was recommended in young women with early-stage endometrial cancer [superficial myometrial invasion (MI) and grades (G) 1/2-endometrioid adenocarcinoma (EEC)]. A radiomics nomogram was developed to assist radiologists in assessing the depth of MI and in selecting eligible patients for OPT.

Methods: From February 2014 to May 2021, 209 G 1/2-EEC patients younger than 45 years (mean 39 ± 4. Read More

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September 2021

Predictors of Parental Coping During the Covid-19 Pandemic: A Survey in Germany.

Front Psychol 2021 10;12:715327. Epub 2021 Sep 10.

Hospital of Child and Adolescent Psychiatry/Psychotherapy, University of Ulm, Ulm, Germany.

The Covid-19 pandemic has been profoundly affecting nearly everybody, but families with minors have been hit particularly. Closure of schools and kindergartens, home schooling, and working from home have led to a profound upheaval in family life. Parental adverse childhood experiences (ACEs) are an important determinant for parenting behavior. Read More

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September 2021

Generalized Anxiety Disorder, Depressive Symptoms, and Sleep Problem During COVID-19 Outbreak in Ethiopia Among Police Officers: A Cross-Sectional Survey.

Front Psychol 2021 9;12:713954. Epub 2021 Sep 9.

Department of Psychiatry, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia.

Coronavirus disease 2019 (COVID-19) is an outbreak that caused serious threats to people worldwide. Police officers are one of those frontline fighters during pandemic. Our study is the first to examine psychological health response among police officers in Ethiopia during the COVID-19 outbreak. Read More

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September 2021

Predictive value of serum HCG concentrations for outcomes of vitrified-warmed blastocyst transfers in women of different ages.

Reprod Biomed Online 2021 Jul 21. Epub 2021 Jul 21.

Department of Reproductive Medicine, Xiamen Maternity and Child Health Hospital, Xiamen, China; Xiamen Key Laboratory of Reproduction and Genetics, Xiamen, China.

Research Question: Can serum human chorionic gonadotrophin (HCG) concentrations on day 10 after single-blastocyst transfer (SBT) in cryopreserved transfer cycles help to predict the cycle outcome in patients of different maternal ages?

Design: The study included 772 vitrified-warmed SBT cycles. The initial maternal serum HCG concentrations measured on day 10 after blastocyst transfer were evaluated using receiver operating characteristic (ROC) curves to predict clinical pregnancy and live birth. Threshold values for predicting a clinical pregnancy were established in three different age groups: group A (21-29 years old, n = 360), group B (30-34 years old, n = 290) and group C (35-47 years old, n = 122). Read More

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Risk reduction strategies for BRCA1/2 hereditary ovarian cancer syndromes: a clinical practice guideline.

Hered Cancer Clin Pract 2021 Sep 26;19(1):39. Epub 2021 Sep 26.

University of Toronto, Toronto, ON, Canada.

Objective: The purpose of this guideline is to make recommendations regarding the care of women who harbour a pathogenic or likely pathogenic variant in BRCA1 and BRCA2.

Methods: Draft recommendations were formulated based on evidence obtained through a systematic review of RCTs, comparative retrospective studies and guideline endorsement. The draft recommendations underwent an internal review by clinical and methodology experts, and an external review by clinical practitioners. Read More

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September 2021

Early combination therapy with hydroxychloroquine and azithromycin reduces mortality in 10,429 COVID-19 outpatients.

Rev Cardiovasc Med 2021 Sep;22(3):1063-1072

Service de Cardiologie, Centre Hospitalier Universitaire La Timone, Assistance Publique Hôpitaux de Marseille, Aix Marseille Univ, C2VN, 13005 Marseille, France.

We evaluated the age-specific mortality of unselected adult outpatients infected with SARS-CoV-2 treated early in a dedicated COVID-19 day hospital and we assessed whether the use of hydroxychloroquine (HCQ) + azithromycin (AZ) was associated with improved survival in this cohort. A retrospective monocentric cohort study was conducted in the day hospital of our center from March to December 2020 in adults with PCR-proven infection who were treated as outpatients with a standardized protocol. The primary endpoint was 6-week mortality, and secondary endpoints were transfer to the intensive care unit and hospitalization rate. Read More

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September 2021

Well-Being and Mental Health of Students during the COVID-19 Pandemic.

Psychopathology 2021 Sep 24:1-7. Epub 2021 Sep 24.

Department of General Psychiatry, Centre for Psychosocial Medicine at Heidelberg University Hospital, Heidelberg, Germany.

Background: During the COVID-19 pandemic, a decrease in well-being and an increase in mental health problems were registered in medical and psychotherapeutic practices, counseling centers, and clinics. According to previous studies, younger people and women seemed to be particularly affected. The aim of this study was to describe mental health problems of students and to draw consequences for the further handling of pandemics and other crises. Read More

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September 2021

Working conditions and antidepressant medication use: A prospective study among 18 to 39-year-old municipal employees.

Psychiatry Res 2021 Sep 20;305:114213. Epub 2021 Sep 20.

Faculty of Social Sciences, University of Helsinki, Helsinki, Finland; Administrative Data Research Centre (Northern Ireland), Queen's University Belfast, Belfast, United Kingdom.

This study aimed to examine the associations of perceived physical and mental working conditions with subsequent antidepressant medication purchases among 18-39-year-old municipal employees. Survey data collected in 2017 among employees of the City of Helsinki (n=5897, response rate 51.5%) were linked to register data on psychotropic medication purchases (82% gave permission to register linkage). Read More

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September 2021

The association of Lewy bodies with limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes and their role in cognition and Alzheimer's dementia in older persons.

Acta Neuropathol Commun 2021 Sep 25;9(1):156. Epub 2021 Sep 25.

Rush Alzheimer's Disease Center, Rush University Medical Center, 1750 W. Harrison street, Suite 1000, Chicago, IL, 60612, USA.

Lewy bodies (LBs) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) are common in older persons and associated with cognitive impairment. However, little is known about the relationship between LBs and LATE-NC and their combined roles in cognitive impairment and Alzheimer's dementia in community-dwelling participants. The study included 1670 community-based participants (mean age-at-death, 89. Read More

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September 2021

Diné (Navajo) female perspectives on mother-daughter communication and cultural assets around the transition to womanhood: a cross-sectional survey.

BMC Womens Health 2021 Sep 25;21(1):341. Epub 2021 Sep 25.

Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.

Background: The inclusion of protective factors ("assets") are increasingly supported in developing culturally grounded interventions for American Indian (AI) populations. This study sought to explore AI women's cultural assets, perspectives, and teachings to inform the development of a culturally grounded, intergenerational intervention to prevent substance abuse and teenage pregnancy among AI females.

Methods: Adult self-identified AI women (N = 201) who reside on the Navajo Nation completed a cross-sectional survey between May and October 2018. Read More

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September 2021

Survey on sodium and potassium intake in patients with hypertension in China.

J Clin Hypertens (Greenwich) 2021 Sep 25. Epub 2021 Sep 25.

Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Sodium and potassium intake in hypertensive patients in China is not clear. The authors aimed to investigate the distribution of sodium and potassium intake in hypertensive patients in China, and to analyze the relationship between sodium and potassium intake and blood pressure. The study was performed in 130 hospitals from 23 provinces across China from 2016 to 2019. Read More

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September 2021

Marijuana use and perinatal outcomes in obstetric patients at a safety net hospital.

Eur J Obstet Gynecol Reprod Biol 2021 Sep 16;266:36-41. Epub 2021 Sep 16.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Objective: To characterize the association between antepartum marijuana exposure and maternal and neonatal outcomes at our institution.

Study Design: Retrospective chart review identified an obstetric cohort of singleton gestations. Women with self-reported marijuana use were compared with non-users. Read More

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September 2021

[Surgery or not on an atypical breast lesion? Taking anxiety into account in shared decision support from a prospective cohort of 300 patients].

Gynecol Obstet Fertil Senol 2021 Sep 22. Epub 2021 Sep 22.

Université de Bordeaux, Bordeaux Population Health (U1219), Equipe Méthodes pour la Recherche Interventionnelle en Santé des Populations (MéRISP), France.

Introduction: Organized and individual breast screening have been accompanied by an increase in the detection of "atypical breast lesions "(ABL). Recently, the NOMAT multicenter study proposed a predictive model of the risk of developing breast cancer after detection of an ABL in order to avoid surgical removal of "low-risk" lesions. It also aimed to provide information on psychological experience, in particularly anxiety, to assist in the shared medical decision process. Read More

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September 2021

A multistate transition model for statin-induced myopathy and statin discontinuation.

CPT Pharmacometrics Syst Pharmacol 2021 Sep 25. Epub 2021 Sep 25.

Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA.

The overarching goal of this study was to simultaneously model the dynamic relationships among statin exposure, statin discontinuation, and potentially statin-related myopathic outcomes. We extracted data from the Indiana Network of Patient Care for 134,815 patients who received statin therapy between January 4, 2004, and December 31, 2008. All individuals began statin treatment, some discontinued statin use, and some experienced myopathy and/or rhabdomyolysis while taking the drug or after discontinuation. Read More

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September 2021

Time dependency in early major osteoporotic and hip re-fractures in women and men aged 50 years and older: a population-based observational study.

Osteoporos Int 2021 Sep 25. Epub 2021 Sep 25.

McGill University, Montreal, Canada.

We analyzed patterns in recurrent major osteoporotic fracture (MOF) following a first major osteoporotic fracture in a large population-based cohort. Re-fracture risk remained elevated over 10 years, with only modest and inconsistent attenuation in risk over time.

Introduction: Recurrent fracture risk remains elevated for up to 25 years, and is reportedly highest in the initial 2 years (imminent risk). Read More

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September 2021

Patterns of Mandibular Fractures in South Australia: Epidemiology, Treatment, and Clinical Outcomes.

J Craniofac Surg 2021 Sep 24. Epub 2021 Sep 24.

Australian Craniofacial Unit, Royal Adelaide Hospital, Women and Children's Hospital, University of Adelaide, Adelaide School of Medicine, University of Notre Dame, Sydney, Australia.

Introduction: The mandible is one of the most common facial bones to be injured with great clinical variability across countries caused by assaults, road traffic accidents, and falls.

Methods: A retrospective review was conducted for adult mandibular fractures from January 2012 to January 2017 at the Royal Adelaide Hospital, Adelaide. Our aim was to describe epidemiological trends of mandibular fractures, differences for sex and age, and clinical outcomes. Read More

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September 2021

Gender differences in prevalence and clinical correlates of anxiety symptoms in first-episode and drug-naïve patients with major depressive disorder.

Compr Psychiatry 2021 Sep 17;111:152275. Epub 2021 Sep 17.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address:

Aim: Gender differences in major depressive disorder (MDD) are commonly reported; however, gender differences in first-episode and drug-naïve (FEDN) patients with major depressive disorder remain unclear. This study aimed to examine potential gender differences in the prevalence and clinical correlates of comorbid anxiety in FEDN patients with MDD.

Methods: A cross-sectional study was conducted with1718 FEDN patients with MDD. Read More

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September 2021

Factors associated with severe maternal outcomes in patients with eclampsia in an obstetric intensive care unit: A cohort study.

Medicine (Baltimore) 2021 Sep;100(38):e27313

Instituto de Medicina Integral Professor Fernando Figueira, Recife, Pernambuco, Brazil.

Abstract: To describe the clinical profile, management, maternal outcomes and factors associated with severe maternal outcome (SMO) in patients admitted for eclampsia.A retrospective cohort study was carried out. All women admitted to the Obstetric Intensive Care Unit (ICU) at Instituto de Medicina Integral Prof. Read More

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September 2021

Outcomes of Elderly Patients Undergoing Left Atrial Appendage Closure.

J Am Heart Assoc 2021 Sep 24:e021973. Epub 2021 Sep 24.

Department of Epidemiology and Biostatistics Schulich School of Medicine & Dentistry Western University London Ontario Canada.

Background Elderly patients have a higher burden of comorbidities that influence clinical outcomes. We aimed to compare in-hospital outcomes in patients ≥80 years old to younger patients, and to determine the factors associated with increased risk of major adverse events (MAE) after left atrial appendage closure. Methods and Results The National Inpatient Sample was used to identify discharges after left atrial appendage closure between October 2015 and December 2018. Read More

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September 2021

Socioeconomic inequalities in the incidence of alcohol-related liver disease: A nationwide Danish study.

Lancet Reg Health Eur 2021 Sep 13;8:100172. Epub 2021 Jul 13.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

Background: There is socio-economic inequality in total alcohol-related harm, but knowledge of inequality in the incidence of specific alcohol-related diseases would be beneficial for prevention. Registry-based studies with nationwide coverage may reveal the full burden of socioeconomic inequality compared to what can be captured in questionnaire-based studies. We examined the incidence of alcohol-related liver disease (ALD) according to socioeconomic status and age. Read More

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September 2021

Data describing the poor outcome associated with a breast cancer diagnosis in the post-weaning period.

Data Brief 2021 Oct 10;38:107354. Epub 2021 Sep 10.

Department of Oncology, Laboratory of Gynecological Oncology, KU Leuven, Leuven, Belgium.

Postpartum breast cancer (PPBC) - which according to new data, can extend to 5-10 years after the birth - are estimated to represent 35-55% of all cases of breast cancer in women younger than 45 years. Increasing clinical evidence indicates that PPBC represents a high-risk form of breast cancer in young women with an approximately 2-fold increased risk for metastasis and death. Yet, the exact mechanisms that underlay this poor prognosis are incompletely understood and, hence, it is unknown why postpartum breast cancer has an enhanced risk for metastasis or how it should be effectively targeted for improved survival. Read More

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October 2021

Psychological Burden During the COVID-19 Pandemic in Germany.

Front Psychol 2021 7;12:640518. Epub 2021 Sep 7.

Department of Psychology, Private University of Applied Sciences, Göttingen, Germany.

After the first COVID-19 case was diagnosed in Germany, various measures limiting contact between people were introduced across the country. The implementation of these measures varied between jurisdictions and potentially had a negative impact on the psychological well-being of many people. However, the prevalence, severity, and type of symptoms of psychological burden has not been documented in detail. Read More

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September 2021

Common and Contrasting Characteristics of the Chronic Soft-Tissue Pain Conditions Fibromyalgia and Lipedema.

J Pain Res 2021 17;14:2931-2941. Epub 2021 Sep 17.

Department of Angiology, Rehaklinik Bad Zurzach, Bad Zurzach, Switzerland.

Objective: To examine the common and specific characteristics of fibromyalgia and lipedema, two chronic soft-tissue pain syndromes without curative therapy options.

Methods: Diseases' characteristics were compared using the findings of extensive literature and the empiric data from two cohorts, both fulfilling standardized diagnostic criteria. Outcome was measured by various socio-demographics, the generic Short Form 36 (SF-36), the Fibromyalgia Severity Questionnaire (FSQ), and the 6-minute walk distance (6MWD). Read More

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September 2021

Are we asking the right questions? Working with the LGBTQ+ community to prioritise healthcare research themes.

Res Involv Engagem 2021 Sep 24;7(1):64. Epub 2021 Sep 24.

Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, East Forvie Building, Forvie Site, Robinson Way, Cambridge, CB2 0SR, UK.

Background: Conversations about research priorities with members of the public are rarely designed specifically to include people who identify as Lesbian, Gay, Bisexual, Transgender and Queer (LGBTQ+) and are not researchers.

Methods: Generally, to address this gap, and specifically, to inform future research for CLS, we carried out a rapid review of published research priority sets covering LGBTQ+ topics, and an online workshop to prioritise identified themes.

Results: Rapid review: results. Read More

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September 2021