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Epidemiology of paediatric moderate and severe traumatic brain injury in the Netherlands.

Eur J Paediatr Neurol 2021 Oct 9;35:123-129. Epub 2021 Oct 9.

Department of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.

Introduction: Traumatic brain injury (TBI) is the main cause of death in children around the world. The last Dutch epidemiological study described the incidence over 10 years ago. Mechanism of injury seems to change with the age of the child, therefore it is important to appreciate different age groups. Read More

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October 2021

Long-term immunogenicity of BNT162b2 vaccination in older people and younger health-care workers.

Lancet Respir Med 2021 Oct 20. Epub 2021 Oct 20.

Institute of Virology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Centre for Infection Research, Partner Site Charité, Berlin, Germany.

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October 2021

The Effect of Delay Duration on Delay Discounting across Adulthood.

J Gerontol B Psychol Sci Soc Sci 2021 Oct 23. Epub 2021 Oct 23.

Center for Vital Longevity, The University of Texas at Dallas.

Objectives: Literature about the relationship between age and delay discounting, or the willingness to wait for delayed rewards, is mixed. We posit that some of this heterogeneity may be attributable to inconsistent delay durations across studies. Here we investigate how delay duration influences discounting across adulthood by systematically varying the duration of the delay between the smaller, sooner and the larger, later option. Read More

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October 2021

Holding on and letting go: Views about filial piety among adult children living in New Zealand.

J Clin Nurs 2021 Oct 22. Epub 2021 Oct 22.

School of Clinical Sciences, Nursing Department, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand.

Aims And Objectives: The study aimed to explore the perspectives of adult children about late-life living and care arrangements for their ageing immigrant parents living in New Zealand.

Background: Older immigrants' well-being is closely associated with filial relations and is often reliant on families as a main source of social, financial and emotional support. Research among migrant Asian adults has reported mixed findings regarding intergenerational perspectives of filial practices. Read More

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October 2021

Contrasting trends in heart failure incidence in younger and older New Zealanders, 2006-2018.

Heart 2021 Oct 22. Epub 2021 Oct 22.

Greenlane Cardiovascular Service, Auckland District Health Board, Auckland, New Zealand.

Objective: Studies indicate that age-standardised heart failure (HF) incidence has been decreasing internationally; however, contrasting trends in different age groups have been reported, with rates increasing in younger people and decreasing in the elderly. We aimed to describe age-specific trends in HF incidence in New Zealand (NZ).

Methods: In this nationwide data linkage study, we used routinely collected hospitalisation data to identify incident HF hospitalisations in NZ residents aged ≥20 years between 2006 and 2018. Read More

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October 2021

Survival benefit of chemotherapy in a contemporary cohort of metastatic urachal carcinoma.

Urol Oncol 2021 Oct 19. Epub 2021 Oct 19.

Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.

Background: We relied on the most contemporary Surveillance, Epidemiology, and End Results (SEER) database and tested the hypothesis that chemotherapy may improve survival in metastatic urachal carcinoma (m-UraC).

Material And Methods: Within the SEER database (2004-2016), we identified m-UraC patients aged ≥ 18 years. Propensity score matching (PSM: cystectomy status, age and sex), Kaplan-Meier plots, cumulative incidence plots, Cox regression models and competing risks regression (CRR) models addressed overall mortality (OM) and cancer-specific mortality (CSM). Read More

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October 2021

Photosynthetic Efficiency and Yield of Cucumber ( L.) Grown under HPS and LED Lighting in Autumn-Winter Cultivation.

Plants (Basel) 2021 Sep 28;10(10). Epub 2021 Sep 28.

Department of Vegetable and Medicinal Plants, Institute of Horticultural Sciences, Warsaw University of Life Sciences WULS-SGGW, Nowoursynowska 159, 02-776 Warszawa, Poland.

The objective of this study was to evaluate the effect of the supplemental lighting of cucumber with sodium pressure lamps (HPSs) and light-emitting diodes (LEDs) on photosynthetic efficiency and yield in autumn-winter cultivation. Cucumber plants of the 'Svyatogor' F1 midi-cucumber parthenocarpic type cultivar were grown on mineral wool mats in three compartments, differing only in the type of light, i.e. Read More

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September 2021

Determining the Influence of Habitual Dietary Protein Intake on Physiological Muscle Parameters in Youth and Older Age.

Nutrients 2021 Oct 12;13(10). Epub 2021 Oct 12.

Medical Research Council-Versus Arthritis Centre for Musculoskeletal Ageing and NIHR Nottingham Biomedical Research Centre, University of Nottingham, Derby DE22 3DT, UK.

Protein ingestion is a potent stimulator of skeletal muscle protein synthesis (MPS). However, older adults demonstrate resistance to anabolic stimuli. Some evidence has demonstrated that a larger acute protein dose is required in older compared to younger adults to elicit the same synthetic response, suggesting that older adults should be consuming higher habitual dietary protein to optimise muscle mass. Read More

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October 2021

Effects of Caffeine Ingestion on Human Standing Balance: A Systematic Review of Placebo-Controlled Trials.

Nutrients 2021 Oct 8;13(10). Epub 2021 Oct 8.

Human Sciences Research Centre, University of Derby, Kedleston Road, Derby DE22 1GB, UK.

Caffeine ingestion may influence balance control via numerous mechanisms. Although previously investigated using various study designs and methods, here we aimed to create the first evidence-based consensus regarding the effects of caffeine on the control of upright stance via systematic review (PROSPERO registration CRD42021226939). Embase, PubMed/MEDLINE, SPORTDiscus and Web of Science databases were searched on 27 January 2021 to identify placebo-controlled trials investigating caffeine-induced changes in human standing balance. Read More

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October 2021

Predictors of Mental Health Status among Quarantined COVID-19 Patients in Saudi Arabia.

Healthcare (Basel) 2021 Sep 26;9(10). Epub 2021 Sep 26.

College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.

Background: The negative psychological impact of COVID-19 in the general population has been well documented. Similar studies among those who were infected and who underwent quarantine remain scarce, particularly in the Arab region. The present study aims to fill this gap. Read More

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September 2021

Do Age and Sex Play a Role in the Intraocular Pressure Changes after Acrobatic Gymnastics?

J Clin Med 2021 Oct 13;10(20). Epub 2021 Oct 13.

Department of Optics, Optometry & Vision Science, University of Valencia, St. Dr Moliner 50, 46100 Burjassot, Spain.

To evaluate the effects of an acrobatic gymnastics (AG) training session on intraocular pressure (IOP), a familiarization session was employed to confirm the participant's suitability for the study. Forty-nine gymnasts (63.27% females, 18-40 years old) voluntarily agreed to participate. Read More

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October 2021

Gender Differences among Sardinians with Alcohol Use Disorder.

J Clin Med 2021 Oct 13;10(20). Epub 2021 Oct 13.

Laboratory of Sex-Gender Medicine, National Institute of Biostructures and Biosystems, I-07100 Sassari, SAR, Italy.

Sardinia is an Italian island in the Mediterranean characterized by secular isolation and the singular genetic characteristics of its inhabitants. Findings obtained in populations with diverse genetic make-up and cultural background indicate gender differences and/or similarities in drinking characteristics of patients with alcohol use disorder (AUD). Knowledge of these characteristics in AUD patients is useful to improve access to treatments. Read More

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October 2021

Occurrence, Trends, Management and Outcomes of Patients Hospitalized with Clinically Suspected Myocarditis-Ten-Year Perspectives from the MYO-PL Nationwide Database.

J Clin Med 2021 Oct 12;10(20). Epub 2021 Oct 12.

First Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland.

The epidemiology of myocarditis is unknown and based mainly on small single-centre studies. The study aimed to evaluate the current incidence, clinical characteristics, management and outcomes of patients hospitalized due to myocarditis in a general population. The study was registered in ClinicalTrials. Read More

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October 2021

Anemia among Men in Malaysia: A Population-Based Survey in 2019.

Int J Environ Res Public Health 2021 Oct 17;18(20). Epub 2021 Oct 17.

Director Office, Institute for Public Health, National Institutes of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia.

This study aimed to determine the prevalence of anemia and factors associated with anemia among men in Malaysia. The researchers used data from the 2019 National Health and Morbidity Survey (NHMS). The hemoglobin levels of men aged 15 years and above who gave their consent was measured using the HemoCue Hb 201+ System©. Read More

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October 2021

The Mediation Effect of Phobic Anxiety on the Treatment Outcome of Activity and Participation across Age: Comparison between Online and Face-to-Face Rehabilitation Aftercare of an RCT.

Int J Environ Res Public Health 2021 Oct 17;18(20). Epub 2021 Oct 17.

Department of Psychology & Methods, Jacobs University Bremen, 28759 Bremen, Germany.

The efficacy of internet and mobile-based interventions (IMIs) has been demonstrated with different mental health disorders, but little is known about the mediating effect of phobic anxiety on activity and participation and the differential effect of age. The current study tested a moderated mediation model with short-term change in phobic anxiety mediating between treatment (IMI vs. face-to-face, F2F) and long-term change in activity and participation, and age of patients moderating this mediation. Read More

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October 2021

Political Ideologies, Government Trust, and COVID-19 Vaccine Hesitancy in South Korea: A Cross-Sectional Survey.

Int J Environ Res Public Health 2021 Oct 12;18(20). Epub 2021 Oct 12.

Department of Public Health and Community Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Centre, Seoul 07061, Korea.

This study aimed to assess the correlation between political ideologies, government trust, and COVID-19 vaccine hesitancy in South Korea during the COVID-19 pandemic. A cross-sectional survey was conducted among South Korea's general population and 1000 respondents (aged 18 years and older) were included. We used multivariate logistic regression models to identify the factors associated with vaccine hesitancy. Read More

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October 2021

Factors Associated with Intention of Serbian Public Health Workers to Leave the Job: A Cross-Sectional, Population-Based Study.

Int J Environ Res Public Health 2021 Oct 11;18(20). Epub 2021 Oct 11.

Faculty of Medicine, Institute of Medical Statistics and Informatics, University of Belgrade, 11000 Belgrade, Serbia.

Recruitment and retention of public health workers (PHWs) is crucial for the optimal functioning of the public health system at a time of budget cuts and the threat of a pandemic. Individual and job-related variables were examined by univariate and multivariate logistic regression to identify predictors of the intention to leave a job during the COVID-19 outbreak among Serbian PHWs in 25 institutes of public health ( = 1663 respondents, of which 73.1% were female). Read More

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October 2021

Possibility of Venous Serum Cl Concentration ([Cl]) as a Marker for Human Metabolic Status: Correlation of [Cl] to Age, Fasting Blood Sugar (FBS), and Glycated Hemoglobin (HbA1c).

Int J Mol Sci 2021 Oct 15;22(20). Epub 2021 Oct 15.

Medical Research Institute, Kyoto Industrial Health Association, Kyoto 604-8472, Japan.

The HCO concentration in venous serum ([HCO]) is a factor commonly used for detecting the body pH and metabolic conditions. To exactly detect [HCO], the venous CO pressure should be kept as it is in the vein. The [HCO] measurement is technically complicated to apply for huge numbers of almost heathy persons taking only basic medical examinations. Read More

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October 2021

The Differential Impact of COVID-19 Lockdown on Sleep Quality, Insomnia, Depression, Stress, and Anxiety among Late Adolescents and Elderly in Italy.

Brain Sci 2021 Oct 11;11(10). Epub 2021 Oct 11.

Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

The restraining measures due to the COVID-19 outbreak deeply affected the general population's sleep health and psychological status. The current literature proposes young and older people as two particularly at-risk groups. However, the differential impact of the lockdown period in these specific age categories needs to be disentangled. Read More

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October 2021

Problematic Internet Use among University Students and Its Relationship with Social Skills.

Brain Sci 2021 Sep 30;11(10). Epub 2021 Sep 30.

Department of Evolutive and Educational Psychology, University of Granada, 18071 Granada, Spain.

Internet use has been steadily and unstoppably gaining ground in all areas of life, from recreational activities to the establishment of social relations. However, addictive use of the Internet is a problem that seriously affects some people. Factors that may influence the occurrence of inappropriate internet use include age and social skills. Read More

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September 2021

Impact of Donor Age on the Osteogenic Supportive Capacity of Mesenchymal Stromal Cell-Derived Extracellular Matrix.

Front Cell Dev Biol 2021 5;9:747521. Epub 2021 Oct 5.

Department of Bioengineering and IBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.

Mesenchymal stromal cells (MSC) have been proposed as an emerging cell-based therapeutic option for regenerative medicine applications as these cells can promote tissue and organ repair. In particular, MSC have been applied for the treatment of bone fractures. However, the healing capacity of these fractures is often compromised by patient's age. Read More

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October 2021

Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation Study.

Front Neurol 2021 4;12:741044. Epub 2021 Oct 4.

Department of Neurology, Yale University School of Medicine, New Haven, CT, United States.

Our objective was to identify characteristics associated with having an acute ischemic stroke (AIS) among hospitalized COVID-19 patients and the subset of these patients with a neurologic symptom. Our derivation cohort consisted of COVID-19 patients admitted to Yale-New Haven Health between January 3, 2020 and August 28, 2020 with and without AIS. We also studied a sub-cohort of hospitalized COVID-19 patients demonstrating a neurologic symptom with and without an AIS. Read More

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October 2021

Optimal Blood Pressure Keeps Our Brains Younger.

Front Aging Neurosci 2021 5;13:694982. Epub 2021 Oct 5.

Department of Neurology, Jena University Hospital, Jena, Germany.

: Elevated blood pressure (BP) is a major health risk factor and the leading global cause of premature death. Hypertension is also a risk factor for cognitive decline and dementia. However, when elevated blood pressure starts impacting cerebral health is less clear. Read More

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October 2021

Establishing risk of vision loss in Leber hereditary optic neuropathy.

Am J Hum Genet 2021 Oct 12. Epub 2021 Oct 12.

School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Hobart, 7005 TAS, Australia; Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, 2 Verdun Street, Nedlands, 6009 WA, Australia. Electronic address:

We conducted an updated epidemiological study of Leber hereditary optic neuropathy (LHON) in Australia by using registry data to establish the risk of vision loss among different LHON mutations, sex, age at onset, and mitochondrial haplogroup. We identified 96 genetically unrelated LHON pedigrees, including 56 unpublished pedigrees, and updated 40 previously known pedigrees, comprising 620 affected individuals and 4,948 asymptomatic carriers. The minimum prevalence of vision loss due to LHON in Australia in 2020 was one in 68,403 individuals. Read More

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October 2021

Combinations of BMI and cardiorespiratory fitness categories: trends between 1995 and 2020 and associations with CVD incidence and mortality and all-cause mortality in 471 216 adults.

Eur J Prev Cardiol 2021 Oct 20. Epub 2021 Oct 20.

Department of Physical Activity and Health, The Swedish School of Sport and Health Sciences, PO Box 5626, 114 86 Stockholm, Sweden.

Aims: To describe time trends in combinations of cardiorespiratory fitness (CRF) and body mass index (BMI) status, and to analyse their associations with cardiovascular disease (CVD) incidence and mortality and all-cause mortality.

Methods And Results: Prospective cohort study with data from occupational health screenings in Swedish employees, including n = 471 216 (aged 18-74 years) between 1995 and 2020, and n = 169 989 in risk analyses. Cardiorespiratory fitness was estimated from a submaximal cycle test. Read More

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October 2021

Adverse event profile and associated factors following surgical voluntary medical male circumcision in two regions of Namibia, 2015-2018.

PLoS One 2021 20;16(10):e0258611. Epub 2021 Oct 20.

Department of Global Health, International Training and Education Center for Health (I-TECH), University of Washington, Seattle, WA, United States of America.

Introduction: Monitoring clinical safety of voluntary medical male circumcision (VMMC) is critical to minimize risk as VMMC programs for HIV prevention are scaled. This cross-sectional analysis describes the adverse event (AE) profile of a large-scale, routine VMMC program and identifies factors associated with the development, severity, and timing of AEs to provide recommendations for program quality improvement.

Materials And Methods: From 2015-2018 there were 28,990 circumcisions performed in International Training and Education Center for Health (I-TECH) supported regions of Namibia in collaboration with the Ministry of Health and Social Services. Read More

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October 2021

Racial and Ethnic Disparities in Rates of Invasive Second Breast Cancer Among Women With Ductal Carcinoma In Situ in Hawai'i.

JAMA Netw Open 2021 Oct 1;4(10):e2128977. Epub 2021 Oct 1.

University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu.

Importance: Women with ductal carcinoma in situ (DCIS) may develop a subsequent invasive second breast cancer (SBC). Understanding the association of racial and ethnic factors with the development of invasive SBC may help reduce overtreatment and undertreatment of women from minority groups.

Objective: To evaluate risk factors associated with developing invasive ipsilateral SBC (iiSBC) and invasive contralateral SBC (icSBC) among women with an initial diagnosis of DCIS who are from racial and ethnic minority populations. Read More

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October 2021

Cost-Effectiveness of Follow-up Ultrasound for Incidental Thyroid Nodules on CT.

AJR Am J Roentgenol 2021 Oct 20. Epub 2021 Oct 20.

Icahn School of Medicine at Mount Sinai, New York, NY.

Thyroid nodules are common incidental findings on CT. Existing professional society recommendations, based primarily on expert opinion, advise follow-up ultrasound for nodules above size cut-offs in patients of all ages. To evaluate the cost-effectiveness of current recommendations as well as of other age- and size-based follow-up strategies for thyroid nodules incidentally detected on CT, using a simulation model. Read More

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October 2021

Younger age and early puberty are associated with cognitive function decline in children with Cushing disease.

Clin Endocrinol (Oxf) 2021 Oct 19. Epub 2021 Oct 19.

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland, USA.

Objective: To investigate the effect of hypercortisolism on the developing brain we performed clinical, cognitive, and psychological evaluation of children with Cushing disease (CD) at diagnosis and 1 year after remission.

Study Design: Prospective study of 41 children with CD. Children completed diverse sets of cognitive measures before and 1 year after remission. Read More

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October 2021