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Social and sexual health of thyroid cancer survivors 2 and 5 years after diagnosis: the VICAN survey.

Support Care Cancer 2021 Nov 27. Epub 2021 Nov 27.

Cancer & Cognition Platform, Ligue Contre Le Cancer, Caen, France.

Purpose: Thyroid cancer (TC) incidence is increasing. With its good prognosis and the young population concerned, the number of survivors is rising. However, their quality of life appears worse than expected. Read More

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November 2021

Evaluating vagus nerve stimulation treatment with heart rate monitoring in pediatric patients with intractable epilepsy.

Childs Nerv Syst 2021 Nov 27. Epub 2021 Nov 27.

Division of Pediatric Neurosurgery, Cohen Children's Medical Center, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, New Hyde Park, NY, USA.

Purpose: Vagus nerve stimulators (VNS) have emerged as an effective treatment modality for pediatric patients suffering from intractable, drug-resistant epilepsy. Newer devices, AspireSR™ Model 106 and the SenTiva™ Model 1000 (VNS TherapyⓇ, LivaNova™), contain an "auto-stimulation" feature that detects ictal tachycardia and transmits pulsations to attenuate seizures. However, the exact benefits of auto-stimulation compared to its risks still merit further exploration. Read More

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November 2021

Demographics and long-term outcomes of children with end-stage kidney disease: a 20-year territory-wide study.

Nephrology (Carlton) 2021 Nov 26. Epub 2021 Nov 26.

Paediatric Nephrology Centre, Hong Kong Children's Hospital, Hong Kong.

Aim: To evaluate the demographics and long-term patient outcomes of children with end-stage kidney disease in Hong Kong.

Methods: We conducted a cohort study at the Paediatric Nephrology Centre, the designated site providing kidney replacement therapy (KRT) for children in Hong Kong. The clinical characteristics and outcomes of all children who initiated chronic KRT before 19 years, between 2001-2020, were analyzed. Read More

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November 2021

Young Women with Breast Cancer: Chemotherapy or Surgery First? An Evaluation of Time to Treatment for Invasive Breast Cancer.

Ann Surg Oncol 2021 Nov 26. Epub 2021 Nov 26.

Department of Surgery, University of Toronto, Toronto, ON, Canada.

Background: Breast cancer in young women (ages 18-40 years) is rare, yet remains a leading cause of cancer-related death. Time to treatment (TTT) is an increasingly important factor in breast cancer outcomes, specifically time to systemic therapy. Our objective was to review patterns of care for young women presenting with invasive breast cancer and compare TTT for surgery first versus neoadjuvant chemotherapy (NAC). Read More

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November 2021

Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma.

Lab Invest 2021 Nov 26. Epub 2021 Nov 26.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY, 11724, USA.

Mesenchymal chondrosarcoma (MCS) is a high-grade malignancy that represents 2-9% of chondrosarcomas and mostly affects children and young adults. HEY1-NCoA2 gene fusion is considered to be a driver of tumorigenesis and it has been identified in 80% of MCS tumors. The shortage of MCS samples and biological models creates a challenge for the development of effective therapeutic strategies to improve the low survival rate of MCS patients. Read More

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November 2021

Impact of COVID-19 Mitigation Measures on Inner-City Female Youth in New York City.

J Adolesc Health 2021 Oct 16. Epub 2021 Oct 16.

Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York; Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.

Purpose: New York City (NYC) was the global epicenter of the COVID-19 pandemic in spring 2020. A "shelter in place" mandate was issued in March 2020. The effect on vulnerable populations of adolescent and young adult females has not been well documented. Read More

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October 2021

Open repair versus thoracic endovascular aortic repair for treating traumatic aortic injury.

Asian J Surg 2021 Nov 23. Epub 2021 Nov 23.

Department of Emergency Medicine, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

Background/objective: Blunt traumatic aortic injury (BTAI) is rare and fatal. Treatment has evolved with advances in imaging and the emergence of thoracic endovascular aortic repair (TEVAR). This study reports a single-center, 5-year experience of TEVAR and open repair for BTAI. Read More

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November 2021

Pediatric Pulmonary Embolism: Imaging Guidelines and Recommendations.

Radiol Clin North Am 2022 Jan;60(1):69-82

Department of Radiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

In contrast with the algorithms and screening criteria available for adults with suspected pulmonary embolism, there is a paucity of guidance on the diagnostic approach for children. The incidence of pulmonary embolism in the pediatric population and young adults is higher than thought, and there is an urgent need for updated guidelines for the imaging approach to diagnosis in the pediatric population. This article presents an up-to-date review of imaging techniques, characteristic radiologic findings, and an evidence-based algorithm for the detection of pediatric pulmonary embolism to improve the care of pediatric patients with suspected pulmonary embolism. Read More

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January 2022

Testing positive pressure delivered from commercial and WHO-style pediatric bubble CPAP devices.

BMC Pediatr 2021 Nov 27;21(1):524. Epub 2021 Nov 27.

Division of Emergency Medicine, Department of Pediatrics, Baylor College of Medicine/Texas Children's Hospital, Houston, TX, USA.

Background/aim: Low-cost commercial bCPAP devices have been deployed in resource-limited settings to treat neonatal respiratory failure. The use of these devices has increased access to pediatric respiratory support for infants. However, constrained resources may result in substitution of recommended consumables and/or use in older age groups. Read More

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November 2021

Increasing trend in rhegmatogenous retinal detachment in Korea from 2004 to 2015.

BMC Ophthalmol 2021 Nov 26;21(1):406. Epub 2021 Nov 26.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, South Korea.

Background: To determine the 12-year incidence of and trends in rhegmatogenous retinal detachment (RRD) requiring surgery in Korea.

Methods: This was a nationwide, population-based, retrospective study. We identified 53,179 patients with incident RRD requiring surgery using the Korean National Health Claims Database from 2004 to 2015. Read More

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November 2021

A machine learning based two-stage clinical decision support system for predicting patients' discontinuation from opioid use disorder treatment: retrospective observational study.

BMC Med Inform Decis Mak 2021 Nov 26;21(1):331. Epub 2021 Nov 26.

Department of Mechanical and Industrial Engineering, College of Engineering, Center for Health Policy and Healthcare Research, Northeastern University, 360 Huntington Avenue, Boston, MA, 02135, USA.

Background: Buprenorphine is a widely used treatment option for patients with opioid use disorder (OUD). Premature discontinuation from this treatment has many negative health and societal consequences.

Objective: To develop and evaluate a machine learning based two-stage clinical decision-making framework for predicting which patients will discontinue OUD treatment within less than a year. Read More

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November 2021

Identification of transcriptomics biomarkers for the early prediction of the prognosis of septic shock from pneumopathies.

BMC Infect Dis 2021 Nov 26;21(1):1190. Epub 2021 Nov 26.

Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No.134 East Street, Gulou District, Fuzhou, 350001, Fujian, People's Republic of China.

Background: Identifying the biological subclasses of septic shock might provide specific targeted therapies for the treatment and prognosis of septic shock. It might be possible to find biological markers for the early prediction of septic shock prognosis.

Methods: The data were obtained from the Gene Expression Omnibus databases (GEO) in NCBI. Read More

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November 2021

Dysregulated Arginine Metabolism in Young Patients with Chronic Persistent Asthma and in Human Bronchial Epithelial Cells.

Nutrients 2021 Nov 17;13(11). Epub 2021 Nov 17.

Cardiovascular Department, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 W. Yanta Road, Xi'an 710061, China.

Background: Recent metabolomics studies have found circulatory metabolism alterations in patients with asthma, indicating that altered metabolites played a significant role in asthma. However, the regulatory mechanisms in asthma, especially in young chronic persistent asthma remain underexplored.

Methods: In this study, a prospective cohort of 162 patients diagnosed of asthma admitted to the First Affiliated Hospital of Xi'an Jiaotong University from January 2018 to December 2019 was used to perform a nested case-control study. Read More

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November 2021

Effect of Nutritional Habits on the Glycemic Response to Different Carbohydrate Diet in Children with Type 1 Diabetes Mellitus.

Nutrients 2021 Oct 27;13(11). Epub 2021 Oct 27.

Department of Paediatrics, Diabetology and Endocrinology, Medical University of Gdańsk, 80-210 Gdańsk, Poland.

Unhealthy eating habits are associated with obesity, metabolic syndrome, and increased insulin resistance in young patients with type 1 diabetes mellitus (T1DM), and may impact the possible benefit from dietary interventions on glycaemic control. This study determines how nutritional patterns influence the quality of dietary intervention with a 30% or 50% carbohydrate diet in terms of glycaemic control measured with continuous glucose monitoring (CGM). Eating habits were obtained with a frequency-of-consumption questionnaire (FFQ-6) before the diet assessment. Read More

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October 2021

Improved Healing after Non-Surgical Periodontal Therapy Is Associated with Higher Protein Intake in Patients Who Are Non-Smokers.

Nutrients 2021 Oct 22;13(11). Epub 2021 Oct 22.

Department of Kinesiology, Faculty of Applied Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.

The aim of this study was to determine whether a relationship between periodontal healing and protein intake exists in patients undergoing non-surgical treatment for periodontitis. Dietary protein intake was assessed using the 2005 Block food frequency questionnaire in patients with chronic generalized periodontitis undergoing scaling and root planing ( = 63 for non-smokers, = 22 for smokers). Protein intake was correlated to post-treatment probing depth using multiple linear regression. Read More

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October 2021

Parotid Space, a Different Space from Other Deep Neck Infection Spaces.

Microorganisms 2021 Nov 15;9(11). Epub 2021 Nov 15.

Department of Otorhinolaryngology & Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou 333, Taiwan.

Deep neck infections (DNIs) such as parotid abscesses are medical emergencies with a seemingly different etiology and treatment course from other DNIs. We sought to confirm this in the present retrospective population-based cohort study. Between August 2016 and January 2020, 412 patients with DNIs seen at a tertiary medical center were enrolled in this study. Read More

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November 2021

Abnormal Blood Coagulation and Kidney Damage in Aged Hamsters Infected with Severe Acute Respiratory Syndrome Coronavirus 2.

Viruses 2021 Oct 22;13(11). Epub 2021 Oct 22.

Laboratory for Biologics Development, International Institute for Zoonosis Control, Hokkaido University, Sapporo 001-0020, Japan.

Systemic symptoms have often been observed in patients with coronavirus disease 2019 (COVID-19) in addition to pneumonia, however, the details are still unclear due to the lack of an appropriate animal model. In this study, we investigated and compared blood coagulation abnormalities and tissue damage between male Syrian hamsters of 9 (young) and over 36 (aged) weeks old after intranasal infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite similar levels of viral replication and inflammatory responses in the lungs of both age groups, aged but not young hamsters showed significant prolongation of prothrombin time and prominent acute kidney damage. Read More

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October 2021

Developing an Algorithm for Discriminating Oral Cancerous and Normal Tissues Using Raman Spectroscopy.

J Pers Med 2021 Nov 9;11(11). Epub 2021 Nov 9.

Department of Electronic Engineering, Chang Gung University, Taoyuan 333, Taiwan.

The aim of this study was to investigate the clinical potential of Raman spectroscopy (RS) in detecting oral squamous cell carcinoma (OSCC) in tumor and healthy tissues in surgical resection specimens during surgery. Raman experiments were performed on cryopreserved specimens from patients with OSCC. Univariate and multivariate analysis was performed based on the fingerprint region (700-1800 cm-1) of the Raman spectra. Read More

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November 2021

Machine Learning Consensus Clustering Approach for Patients with Lactic Acidosis in Intensive Care Units.

J Pers Med 2021 Nov 2;11(11). Epub 2021 Nov 2.

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Background: Lactic acidosis is a heterogeneous condition with multiple underlying causes and associated outcomes. The use of multi-dimensional patient data to subtype lactic acidosis can personalize patient care. Machine learning consensus clustering may identify lactic acidosis subgroups with unique clinical profiles and outcomes. Read More

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November 2021

Benefits of Combining Physical Therapy with Occupational Therapy in Hip Arthroplasty.

J Pers Med 2021 Nov 2;11(11). Epub 2021 Nov 2.

Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania.

(1) Background: Hip arthroplasty (HA) is a surgery that replaces the damaged hip joint with an artificial implant called a hip prosthesis. The increase in life expectancy correlated with the population aging level, to which the increase in the number of prosthetic interventions among the young population is added, translates to the imperative need to analyze the quality of life beyond the immediate postoperative period. Strict adherence to an individualized rehabilitation program (IRP), and adapted to each patient, is followed by an improved quality of life. Read More

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November 2021

Vital Pulp Therapy in Permanent Teeth with Irreversible Pulpitis Caused by Caries: A Prospective Cohort Study.

J Pers Med 2021 Nov 1;11(11). Epub 2021 Nov 1.

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310006, China.

Background: When a tooth is diagnosed with irreversible pulpitis, root canal therapy (RCT) is generally performed to completely remove pulp tissue, which might lead to a higher risk of loss of vascularity, and teeth being more prone to fracture. Vital pulp therapy (VPT) is a personalized method of treating irreversible pulpitis, which conforms to the trend of minimally invasive endodontics. The remaining vital pulp could promote the physiological development of the roots of young permanent teeth with incomplete apical foramen. Read More

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November 2021

Myocarditis and Pericarditis following COVID-19 Vaccination: Inequalities in Age and Vaccine Types.

J Pers Med 2021 Oct 28;11(11). Epub 2021 Oct 28.

College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.

An increasing number of myocarditis/pericarditis incidences has been reported after coronavirus disease-19 (COVID-19) vaccination in adolescents and young adults. This study was designed to investigate the incidence rate of-and risk for-myocarditis and pericarditis following COVID-19 vaccination in the United States according to age and vaccine type. This study used the Vaccine Adverse Events Reporting System (VAERS) from 11 December 2020 to 13 August 2021. Read More

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October 2021

Individualized Assessment of Exercise Capacity in Response to Acute and Long-Term Enzyme Replacement Therapy in Pediatric Pompe Disease.

J Pers Med 2021 Oct 28;11(11). Epub 2021 Oct 28.

Technion Faculty of Medicine, Haifa 3109601, Israel.

Background: Enzyme replacement therapy (ERT) with alglucosidase alfa improves the prospect of patients with infantile-onset Pompe disease (IOPD). However, a progressive decline has been reported. Objective quantification of the response to ERT when assessing newer strategies is warranted. Read More

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October 2021

The Feasibility and Efficiency of Remote Spirometry System on the Pulmonary Function for Multiple Ribs Fracture Patients.

J Pers Med 2021 Oct 23;11(11). Epub 2021 Oct 23.

Department of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Chang Gung University, 5, Fu-Hsing Street, Kwei Shan Township, Taoyuan 33328, Taiwan.

Background: Multiple rib fractures is a common chest trauma with a significant and sustained impact on pulmonary function and quality of life. Continuous monitoring of the pulmonary function parameter was necessary to adjust the therapeutic goals in these patients. We developed an internet-based remote system for lung function monitoring with a remote spirometry and smart device application to follow up these patients consecutively. Read More

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October 2021

A Sneak-Peek into the Physician's Brain: A Retrospective Machine Learning-Driven Investigation of Decision-Making in TAVR versus SAVR for Young High-Risk Patients with Severe Symptomatic Aortic Stenosis.

J Pers Med 2021 Oct 22;11(11). Epub 2021 Oct 22.

Division of Cardiac Surgery, Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.

Transcatheter aortic valve replacement (TAVR) has rapidly become a viable alternative to the conventional isolated surgical aortic valve replacement (iSAVR) for treating severe symptomatic aortic stenosis. However, data on younger patients is scarce and a gap exists between data-based recommendations and the clinical use of TAVR. In our study, we utilized a machine learning (ML) driven approach to model the complex decision-making process of Heart Teams when treating young patients with severe symptomatic aortic stenosis with either TAVR or iSAVR and to identify the relevant considerations. Read More

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October 2021

Genetic Polymorphisms Affecting Ranibizumab Response in High Myopia Patients.

Pharmaceutics 2021 Nov 20;13(11). Epub 2021 Nov 20.

Pharmacy Department, Instituto de Investigación Biosanitaria de Granada (ibs.Granada), Hospital Universitario Virgen de las Nieves, 18016 Granada, Spain.

High myopia is an ophthalmic pathology that affects half of the young adults in the United States and Europe and it is predicted that a third of the world's population could be nearsighted at the end of this decade. It is characterized by at least 6 diopters or axial length > 26 mm and, choroidal neovascularization (CNV) in 5 to 11% of cases. Ranibizumab is a recombinant humanized monoclonal antibody fragment. Read More

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November 2021

Ceragenin-Coated Non-Spherical Gold Nanoparticles as Novel Candidacidal Agents.

Pharmaceutics 2021 Nov 16;13(11). Epub 2021 Nov 16.

Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, 15-222 Bialystok, Poland.

Background: Infections caused by spp. have become one of the major causes of morbidity and mortality in immunocompromised patients. Therefore, new effective fungicides are urgently needed, especially due to an escalating resistance crisis. Read More

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November 2021

Machine Learning Techniques for Differential Diagnosis of Vertigo and Dizziness: A Review.

Sensors (Basel) 2021 Nov 14;21(22). Epub 2021 Nov 14.

School of Computer Science, Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney 2007, Australia.

Vertigo is a sensation of movement that results from disorders of the inner ear balance organs and their central connections, with aetiologies that are often benign and sometimes serious. An individual who develops vertigo can be effectively treated only after a correct diagnosis of the underlying vestibular disorder is reached. Recent advances in artificial intelligence promise novel strategies for the diagnosis and treatment of patients with this common symptom. Read More

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November 2021

Predictors of Clinical Course and Outcomes of Acute Diverticulitis: The Role of Age and Ethnicity.

Medicina (Kaunas) 2021 Nov 19;57(11). Epub 2021 Nov 19.

Department of Gastroenterology and Hepatology, Hillel Yaffe Medical Center, Affiliated to the Technion Faculty of Medicine, Haifa 38100, Israel.

: Acute diverticulitis (AD) is the leading and most burdensome complication of colonic diverticulosis. However, risk factors for its development and predictors of its course are still poorly defined. In this regard, the association of a young age with a complicated course and worse outcome are still controversial. Read More

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November 2021