609,271 results match your criteria young middle-aged

Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland.

Proc Natl Acad Sci U S A 2021 Jun;118(25)

Laboratory of Tissue Plasticity in Health and Disease, Cluster of Stem Cell and Developmental Biology, Department of Development and Regeneration, Leuven Stem Cell Institute, Katholieke Universiteit Leuven, 3000 Leuven, Belgium;

Stem cells in the adult pituitary are quiescent yet show acute activation upon tissue injury. The molecular mechanisms underlying this reaction are completely unknown. We applied single-cell transcriptomics to start unraveling the acute pituitary stem cell activation process as occurring upon targeted endocrine cell-ablation damage. Read More

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The prognostic value of inflammation markers in postoperative gliomas with or without adjuvant treatments.

Medicine (Baltimore) 2021 Jun;100(25):e26437

Department of Radiation Oncology.

Abstract: Recent studies have shown that some inflammatory markers are associated with the prognosis of solid tumors. This study aims to evaluate the prognosis of glioma patients with or without adjuvant treatment using the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR).All patients who were diagnosed with gliomas at the first and second affiliated hospital of Guangxi Medical University between 2011 and 2020 were included in this study. Read More

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Efficacy of Brief Intervention for harmful and hazardous alcohol use: a systematic review and meta-analysis of studies from Low Middle-Income countries.

Addiction 2021 Jun 22. Epub 2021 Jun 22.

Department of Psychiatry and National Drug Dependence Treatment Centre, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, India, 110029.

Background And Aims: Low and middle-income countries (LMIC) have a disproportionately higher alcohol-attributable disease burden, in conjunction with a minimal focus on primary prevention. Screening and brief interventions can be a promising approach to address this problem. This systematic review aimed to perform a qualitative and quantitative synthesis of studies of brief interventions for harmful and hazardous alcohol use in LMIC. Read More

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Obesity Fact Sheet in Korea, 2020: Prevalence of Obesity by Obesity Class from 2009 to 2018.

J Obes Metab Syndr 2021 Jun 23. Epub 2021 Jun 23.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: We examined the prevalence of different obesity classes in South Korea based on the 2020 Obesity Fact Sheet.

Methods: Individuals ≥20 years who underwent a health examination provided by the Korean National Health Insurance System between 2009 and 2018 were included and the prevalence of class I, II, and III obesity was calculated for the total sample and age, sex, and region subgroups.

Results: From 2009 to 2018, the prevalence of obesity increased across all sex and age groups and all regions. Read More

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Caregivers' estimate of early childhood developmental status in rural Uganda: a cross-sectional study.

BMJ Open 2021 Jun 22;11(6):e044708. Epub 2021 Jun 22.

International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

Objective: To characterise developmental milestones among young children living in rural communities in Uganda.

Design: Cross-sectional study.

Setting: Iganga-Mayuge Health and Demographic Surveillance Site in rural eastern Uganda. Read More

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Wiad Lek 2021 ;74(4):902-905


Objective: The aim: the analysis of spectrum of causatively relevant aeroallergens of southern Ukraine which provoke allergic reaction in patients with pollinosis.

Patients And Methods: Materials and methods: ambulatory medical records data and skin prick-testing results of 477 patients afflicted with pollinosis in Kherson (250 women - 52,41 % and 227 men - 47,59 %) aged from 19 to 66 years old (38,05±0,45) have been analyzed retrospectively.

Results: Results: all patients revealed clinical implications mainly during the September-October period. Read More

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Revealing the time course of laser evoked potential habituation by high temporal resolution analysis.

Eur J Pain 2021 Jun 22. Epub 2021 Jun 22.

Division of Neurological Pain Research and Therapy, Department of Neurology, University Clinic Schleswig-Holstein, Campus Kiel, Arnold-Heller-Straße 3, 24105, Kiel, Germany.

Background And Objectives: Reduced laser evoked potential (LEP) habituation indicates abnormal central pain processing. But the paradigm (4 stimulation blocks a 25 stimuli) is time-consuming and potentially omits important information on the exact habituation time course. This study examined whether a high temporal resolution (HTR) analysis (dividing the 4 stimulation blocks into 12 analysis blocks) can answer the following questions: 1)After how many stimuli does LEP-habituation occur? 2)Is there a difference in LEP-habituation in younger versus older subjects? 3)Is HTR applicable on radiculopathy patients?

Methods: EEG data of 129 subjects were included. Read More

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Effect of Cigarette Smoking on Hearing Levels in Young and Middle-Aged Males.

Cureus 2021 May 18;13(5):e15093. Epub 2021 May 18.

Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Introduction: Smoking is a well-recognized risk factor for many health issues; however, its association with hearing loss has been a debate. Some studies have shown a positive association while others did not. In this study, we aim to identify the effect of cigarette smoking on hearing in our population. Read More

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Iris Melanocytoma in a Child: Clinical and Histopathological Findings.

Am J Case Rep 2021 Jun 21;22:e931385. Epub 2021 Jun 21.

King Fahad Medical City, Riyadh, Saudi Arabia.

BACKGROUND Melanocytoma is rare and can affect any part of the uveal tract. In rare cases, iris melanocytoma shows signs of growth, with extrascleral extension that mimics melanoma. This phenomenon makes clinical differentiation between the 2 pathologies particularly challenging. Read More

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HHLA2 deficiency inhibits non-small cell lung cancer progression and THP-1 macrophage M2 polarization.

Cancer Med 2021 Jun 21. Epub 2021 Jun 21.

Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Human endogenous retrovirus-H long terminal repeat-associating protein 2 (HHLA2) is a member of B7 family, which is upregulated in multiple tumors. However, its exact functions in non-small cell lung cancer (NSCLC) have not been fully understood. This study aimed to investigate the biological roles of HHLA2 in human NSCLC and the relevant mechanisms. Read More

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The transfer mechanism of pollution industry in China under multi-factor combination model-based on the perspective of industry, location, and environment.

Environ Sci Pollut Res Int 2021 Jun 21. Epub 2021 Jun 21.

Finance and Economics College, Jimei University, Xiamen, 361021, China.

With the development of industry transfer, the increasing attention of all government levels has been paid to the sustainable development of ecological environment. To highlight the effect of environmental factors on pollution industry transfer, a triangle model with various combination scenarios of industry, location, and environmental factors is adopted to empirically study the transfer mechanism of China's pollution industry according to the panel data of 30 provinces from 2000 to 2018. The obtained results indicate that (1) industrial advantage is the primary factor of improving the transfer of pollution industry in China; especially, the significance of location and environmental indicators is significantly lower than that of industrial indicators. Read More

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Knowledge, Attitude, and Self-Reported Practice Towards Measures for Prevention of the Spread of COVID-19 Among Australians: A Nationwide Online Longitudinal Representative Survey.

Front Public Health 2021;9:630189. Epub 2021 Jun 2.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, VIC, Australia.

To assess and share learnings on the motivators and behavioural adherence across sex and age to evolving strategies in public policy to prevent the spread of SARS-CoV-2 at the end of a first COVID-19 wave and the beginning of a second COVID-19 wave in Australia. A national longitudinal survey using a framework based on evidence-based behaviour change models. The survey was administered to a national sample representative across sex, age and location was undertaken at two time points: May 1st to 5th, 2020, and July 1st to 7th, 2020. Read More

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Severe Air Pollution and Psychological Distress in China: The Interactive Effects of Coping and Perceived Controllability.

Front Psychol 2021 2;12:601964. Epub 2021 Jun 2.

Department of Psychology, Wake Forest University, Winston-Salem, NC, United States.

The coping styles of focusing on a stressor (i.e., trauma focus), and moving beyond the emotional impact of a stressor (i. Read More

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Characteristics of high-resolution magnetic resonance vessel wall imaging of cervicocerebral artery dissection and the influential factors of vascular recanalization.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 May;46(5):467-474

Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objectives: Cervicocerebral artery dissection (CAD) is one of the important causes for ischemic stroke in young and middle-aged people. CAD is dangerous and untimely diagnosis and treatment are likely to result in severe disability. Early diagnosis and timely intervention can greatly improve the prognosis of patients. Read More

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[Economic burden and factors associated with Crohn's disease].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Jun;53(3):555-559

Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China.

Objective: To study the economic burden of Crohn's disease and its related factors, and to provide opinions for reducing personal burden and improving reimbursement policy.

Methods: Using a cross-sectional method, a self-created questionnaire based on the basic principles of health services research was used to survey Crohn's disease patients served by the Shanghai volunteer service foundation platform. Information collected included basic characteristics, therapy, and medical costs related to Crohn's disease in the past 12 months. Read More

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Prediction of venous thromboembolism with machine learning techniques in young-middle-aged inpatients.

Sci Rep 2021 Jun 18;11(1):12868. Epub 2021 Jun 18.

School of Nursing, Jilin University, Changchun, 130021, Jilin, People's Republic of China.

Accumulating studies appear to suggest that the risk factors for venous thromboembolism (VTE) among young-middle-aged inpatients are different from those among elderly people. Therefore, the current prediction models for VTE are not applicable to young-middle-aged inpatients. The aim of this study was to develop and externally validate a new prediction model for young-middle-aged people using machine learning methods. Read More

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Assessment of sagittal spinopelvic parameters in a Taiwanese population with spondylolysis by the EOS imaging system: a retrospective radiological analysis.

BMC Musculoskelet Disord 2021 Jun 18;22(1):553. Epub 2021 Jun 18.

Department of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Sheng-Li Road, 70428, Tainan, Taiwan.

Background: The impact of sagittal spinopelvic alignment on spondylolysis is well established in Caucasian populations. However, prior studies suggest that people from different ethnological backgrounds showed divergence, and a few studies that focused on Asian populations reported conflicting results. The aim of this study is to use the EOS imaging system to evaluate the spinopelvic parameters of spondylolysis patients, and their relationship with spondylolisthesis, disc degeneration, and age in a Taiwanese population. Read More

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Indications of Depressive Symptoms During the COVID-19 Pandemic in Germany: Comparison of National Survey and Twitter Data.

JMIR Ment Health 2021 Jun 18;8(6):e27140. Epub 2021 Jun 18.

Mental Health Research Unit, Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.

Background: The current COVID-19 pandemic is associated with extensive individual and societal challenges, including challenges to both physical and mental health. To date, the development of mental health problems such as depressive symptoms accompanying population-based federal distancing measures is largely unknown, and opportunities for rapid, effective, and valid monitoring are currently a relevant matter of investigation.

Objective: In this study, we aim to investigate, first, the temporal progression of depressive symptoms during the COVID-19 pandemic and, second, the consistency of the results from tweets and survey-based self-reports of depressive symptoms within the same time period. Read More

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[Clinical application of free peroneal artery perforator flap in soft tissue defect of foot and ankle].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jun;35(6):756-760

Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, P.R.China.

Objective: To investigate clinical application of the free peroneal artery perforator flap in soft tissue defect of foot and ankle.

Methods: The clinical data of 18 patients with soft tissue defects of foot and ankle who were repaired with free peroneal artery perforator flaps between March 2019 and March 2020 were retrospectively analyzed. Among them, there were 11 males and 7 females; the age ranged from 21 to 58 years, with an average age of 45 years. Read More

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[Three-dimensional printed drill guide template assisting percutaneous pedicle screw fixation for multiple-level thoracolumbar fractures].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jun;35(6):742-749

Department of Spine Surgery, Fushun People's Hospital, Fushun Sichuan, 643200, P.R.China.

Objective: To evaluate the feasibility and safety of three-dimensional (3D) printed drill guide template-assisted percutaneous pedicle screw fixation for multiple-level thoracolumbar fractures.

Methods: Clinical data of 19 patients with multilevel thoracolumbar fracture without nerve injury who underwent surgical treatment between May 2017 and January 2019 were retrospectively analyzed. There were 9 males and 10 females and their age ranged from 22 to 63 years, with an average age of 43. Read More

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[Digital study of the ideal position of lag screw internal fixation in the anterior column of the acetabulum].

Yazhi Bai Qiang Liu

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Jun;35(6):684-689

Department of Orthopedics, Shanxi Bethune Hospital, Taiyuan Shanxi, 030032, P.R.China.

Objective: To find the ideal position of lag screw internal fixation in the anterior column of acetabulum by digital technology, and measure its related parameters, so as to improve the accuracy of lag screw implantation.

Methods: The CT scan data of 266 semi-pelvic raw in 133 cases (78 males and 55 females, aged 18-65 years old with an average age of 42 years) were collected between January 2019 and January 2020 to compose three-dimensional models. According to the relationship between the peripheral bone cortex of the anatomical channel and the lag screw, a new standard for the ideal position of lag screw fixation in the anterior column of acetabulum was proposed to simulate the implantation of the screw. Read More

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A Case Report of Chondromyxoid Fibroma of the Neck of Femur, Intracapsular Location.

J Orthop Case Rep 2021 ;11(1):79-81

Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Chondromyxoid fibroma (CMF) is an uncommon benign tumor accounts for <2% of all benign and <1% all bone tumors. It is a cartilage tumor with myxoid and fibrous elements. Because of rarity and resemblance with other benign and malignant tumor, diagnosis of this tumor always remains challenging. Read More

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January 2021

SARS-CoV-2 RT-PCR test results across symptomatic COVID-19 cases in Auckland, New Zealand, February-June 2020.

Commun Dis Intell (2018) 2021 Jun 15;45. Epub 2021 Jun 15.

Abstract: During the first wave of COVID-19 transmission in New Zealand, a review of RT-PCR testing in all symptomatic cases reported in the Auckland Region found 74% of test results to have been positive. Detection rate was superior for nasopharyngeal swabs than for oropharyngeal samples, and highest one week after symptom onset. Certain symptom presentations may associate with these cases returning negative results, with dyspnoea reported by a greater proportion of cases who tested negative. Read More

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[Analysis of maternal mortality trend and age-period-cohort model in China from 1992 to 2017].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Jun;55(6):742-746

Department of Academic Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

To understand the trend of maternal mortality in China from 1992 to 2017, and to evaluate the effects of age, period and cohort of maternal mortality by using the age-period-cohort (APC) model. The data of maternal mortality in China from 1992 to 2017 were collected from the Global Burden of Disease project. The maternal mortality rate was adopted to describe the trend of death. Read More

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Mental Health Among Parents of Children Aged <18 Years and Unpaid Caregivers of Adults During the COVID-19 Pandemic - United States, December 2020 and February-⁠March 2021.

MMWR Morb Mortal Wkly Rep 2021 Jun 18;70(24):879-887. Epub 2021 Jun 18.

Early during the COVID-19 pandemic, nearly two thirds of unpaid caregivers of adults reported adverse mental or behavioral health symptoms, compared with approximately one third of noncaregivers (1). In addition, 27% of parents of children aged <18 years reported that their mental health had worsened during the pandemic (2). To examine mental health during the COVID-19 pandemic among U. Read More

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COVID-19 Vaccination Coverage Among Pregnant Women During Pregnancy - Eight Integrated Health Care Organizations, United States, December 14, 2020-May 8, 2021.

MMWR Morb Mortal Wkly Rep 2021 Jun 18;70(24):895-899. Epub 2021 Jun 18.

COVID-19 vaccines are critical for ending the COVID-19 pandemic; however, current data about vaccination coverage and safety in pregnant women are limited. Pregnant women are at increased risk for severe illness and death from COVID-19 compared with nonpregnant women of reproductive age, and are at risk for adverse pregnancy outcomes, such as preterm birth (1-4). Pregnant women are eligible for and can receive any of the three COVID-19 vaccines available in the United States via Emergency Use Authorization. Read More

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Hepatitis A Virus Infections Among Men Who Have Sex with Men - Eight U.S. States, 2017-2018.

MMWR Morb Mortal Wkly Rep 2021 Jun 18;70(24):875-878. Epub 2021 Jun 18.

During 1995-2011, the overall incidence of hepatitis A decreased by 95% in the United States from 12 cases per 100,000 population during 1995 to 0.4 cases per 100,000 population during 2011, and then plateaued during 2012─2015. The incidence increased by 294% during 2016-2018 compared with the incidence during 2013-2015, with most cases occurring among populations at high risk for hepatitis A infection, including persons who use illicit drugs (injection and noninjection), persons who experience homelessness, and men who have sex with men (MSM) (1-3). Read More

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[COVID-19 in adults with antibody deficiencies].

Medicina (B Aires) 2021 ;81(3):478-481

Unidad de Inmunología e Histocompatibilidad, Hospital Dr. Carlos G. Durand, Buenos Aires, Argentina.

COVID-19, caused by SARS-CoV-2, emerged in late 2019 in Wuhan, China. Its clinical course is variable, as well as the mortality rate, which is higher among people over 65 years of age and persons with underlying conditions. Immunodeficiencies are potential risk factors for severe forms of COVID-19. Read More

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Temporomandibular disorders in an adult population in northern Norway: A cross-sectional study.

Clin Exp Dent Res 2021 Jun 16. Epub 2021 Jun 16.

The Public Dental Health Service Competence Centre of Northern Norway, Tromsø, Norway.

Objectives: The aim of the study was to assess the prevalence of symptoms indicative of temporomandibular disorders (TMD) in an adult population in Troms County in Northern Norway, as well as the associations between TMD and socio-demographic factors, dental status, self-reported general, and oral health as well as oral health related quality of life (OHQoL).

Methods: Data were collected from a structured questionnaire and a clinical examination of a random sample of almost 2000 adults, 20-79-year-old, in Troms County in Northern Norway.

Results: Women had a higher prevalence of all self-reported and clinical signs of pain and dysfunction in the temporomandibular complex compared to men. Read More

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Predictors of complementary feeding practices among children aged 6-23 months in five countries in the Middle East and North Africa region.

Matern Child Nutr 2021 Jun 16:e13223. Epub 2021 Jun 16.

Center for Research on Population and Health, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon.

Ensuring diets of children aged 6-23 months meet recommended guidance is crucial for growth and development and for the prevention of malnutrition including stunting, wasting and micronutrient deficiencies. Despite some improvement, indicators related to undernutrition and overnutrition fall short of global targets in the Middle East and North Africa (MENA) region that consist of low- and middle-income countries witnessing political and social changes and a nutrition transition. This research aims at reviewing the situation related to the diets of children aged 6-23 months in five selected countries in the MENA region, examining factors affecting complementary feeding and providing recommendations for guiding effective strategies to improve it. Read More

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