1,163,925 results match your criteria young adults

Lifestyle and the aging brain: interactive effects of modifiable lifestyle behaviors and cognitive ability in men from midlife to old age.

Neurobiol Aging 2021 Aug 19;108:80-89. Epub 2021 Aug 19.

Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA.

We examined the influence of lifestyle on brain aging after nearly 30 years, and tested the hypothesis that young adult general cognitive ability (GCA) would moderate these effects. In the community-dwelling Vietnam Era Twin Study of Aging (VETSA), 431 largely non-Hispanic white men completed a test of GCA at mean age 20. We created a modifiable lifestyle behavior composite from data collected at mean age 40. Read More

View Article and Full-Text PDF

A two-generation study: The transmission of attachment and young adults' depression, anxiety, and social media addiction.

Addict Behav 2021 Sep 3;124:107109. Epub 2021 Sep 3.

Bahcesehir University, Department of Psychology, Istanbul, Turkey.

Social media use is on the rise among young adults (YA) and evidence suggests a positive association between social media addiction (SMA) and the psychological symptoms of depression and anxiety globally. However, the contribution of attachment and its transgenerational influence on YAs' SMA and psychological symptoms have not been widely explored. Thus, we examined how parental reports of attachment (anxiety and avoidance) can directly and through YAs' attachment predict YAs' SMA, depression and anxiety symptoms. Read More

View Article and Full-Text PDF
September 2021

Only one fifth of young Australian adults have beliefs about medical imaging for low back pain that align with current evidence: A cross-sectional study.

Musculoskelet Sci Pract 2021 Sep 14;56:102460. Epub 2021 Sep 14.

Curtin EnAble Institute and Curtin School of Allied Health, Curtin University, Perth, Australia. Electronic address:

Background: Patients' perceptions/expectations may be a factor behind medical imaging referral rates. Few studies have investigated the beliefs that might drive expectations of medical imaging.

Objectives: This study examined whether beliefs of young Australian adults with and without impactful low back pain (LBP) concerning medical scans for LBP align with current evidence. Read More

View Article and Full-Text PDF
September 2021

Effects of anterior load carriage on gait parameters: A systematic review with meta-analysis.

Appl Ergon 2021 Sep 18;98:103587. Epub 2021 Sep 18.

Department of Kinesiology & Health, Georgia State University, Atlanta, GA, USA. Electronic address:

Anterior load carriage is common in occupational work and daily activities. Our primary purpose was to systematically review previous work concerning the biomechanics of walking with anterior load carriage. A secondary goal was to conduct a meta-analysis on common gait parameters relevant to front load carriage. Read More

View Article and Full-Text PDF
September 2021

A Survey of Healthcare Providers About Reproductive Healthcare for Adolescent Women with Epilepsy.

J Pediatr Adolesc Gynecol 2021 Sep 18. Epub 2021 Sep 18.

Division of General Academic Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:

Study Objective: Evaluate knowledge, attitudes, and practices about sexual and reproductive health (SRH) for adolescent and young adult (AYA) women with epilepsy among general pediatricians, adolescent medicine specialists, and pediatric gynecologists.

Design: Survey comprising previously validated and novel items that underwent content validity testing, distributed through specialty listservs. Categorical variables analyzed with Chi-Square or Fisher's exact tests, and continuous variables with Kruskal-Wallis tests. Read More

View Article and Full-Text PDF
September 2021

Do Alcohol Consequences Serve as Teachable Moments? A Test of Between- and Within-Person Reciprocal Effects From College Age to Adulthood.

J Stud Alcohol Drugs 2021 Sep;82(5):647-658

Department of Psychology, Arizona State University, Tempe, Arizona.

Objective: Several studies find between-person reciprocal relations between adolescent/college drinking and positive expectancies. However, drinking and expectancies from college into adulthood are largely unstudied, as are within-person associations. During these age periods, negative alcohol consequences may represent "teachable moments" via expectancy change. Read More

View Article and Full-Text PDF
September 2021

Alcohol Advertising Regulation for the Adult Population: An Analysis of Distilled Spirits Radio Endorsements in Spain.

J Stud Alcohol Drugs 2021 Sep;82(5):610-614

Department of Communication Sciences and Sociology, Universidad Rey Juan Carlos, Camino del Molino s/n, Fuenlabrada (Madrid), Spain.

Objective: Restrictions on advertising of high-alcohol-content beverages aims to prevent consumption in young people and alcohol misuse in adults. The main objective of this research was to analyze the presence of distilled spirits mentions and its compliance with legislation in relation to the minor protection time slot, the factors associated with drinking, and the promotion of excessive consumption.

Method: We conducted a content analysis of all advertising mentioning spirits broadcast throughout 2017 on news/talk radio stations targeting an adult audience in Spain. Read More

View Article and Full-Text PDF
September 2021

Social Role, Behavior, and Belief Changes Associated With Driving After Using Marijuana Among U.S. Young Adults, and Comparisons With Driving After 5+ Drinking.

J Stud Alcohol Drugs 2021 Sep;82(5):584-594

Institute for Social Research, University of Michigan, Ann Arbor, Michigan.

Objective: This study examined past-2-week driving after marijuana use (DMU) and driving after having five or more drinks (D5D) during young adulthood, specifically focusing on associations between within-person change in social roles (living situation, marriage, parenthood, education, employment) and mediators (perceived risk, evenings out, and religiosity) from modal ages 19 to 30.

Method: Multilevel analyses were conducted using survey data collected from 2013 to 2019 from 1,873 adults (1,060 women; total number of data collection waves = 7,037) participating in the longitudinal Monitoring the Future study.

Results: Change across waves from not being married to married was associated with lower DMU likelihood at any particular wave both directly and via mediation through wave-level change in evenings out. Read More

View Article and Full-Text PDF
September 2021

Peripheral Auditory Function in Young HIV-Positive Adults With Clinically Normal Hearing.

Otolaryngol Head Neck Surg 2021 Sep 21:1945998211047147. Epub 2021 Sep 21.

Space Medicine Innovations Lab, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

Objective: Little is known about peripheral auditory function in young adults with HIV, who might be expected to show early evidence of hearing loss if HIV infection or treatment does affect peripheral function. The goal of this study was to compare peripheral auditory function in 2 age- and gender-matched groups of young adults with clinically normal hearing with and without HIV.

Study Design: Matched cohort study with repeated measures. Read More

View Article and Full-Text PDF
September 2021

Reinforcement sensitivity and bulimia symptoms: the role of emotion regulation.

Eat Weight Disord 2021 Sep 21. Epub 2021 Sep 21.

Department of Psychology, University of South Dakota, Vermillion, SD, USA.

Objective: Reinforcement Sensitivity Theory (RST) provides a theoretical foundation associated with various approach and avoidance behaviors and individual personality differences. Sensitivity to reward and punishment, two neural systems within the RST have been significantly associated with bingeing and purging behaviors. However, inconsistent findings are observed and specific factors mediating these relationships are not well understood. Read More

View Article and Full-Text PDF
September 2021

The cancer-related transcription factor Runx2 combined with osteopontin: a novel prognostic biomarker in resected osteosarcoma.

Int J Clin Oncol 2021 Sep 21. Epub 2021 Sep 21.

Department of Bone Disease, The Second Hospital of Tangshan, No.21, Jianshe North Road, Tangshan, 063000, China.

Purpose: Osteosarcoma is the most common primary bone cancer in children and young adults. Recent experimental evidence has indicated that Runx2/OPN axis play important roles in the metastasis of osteosarcoma cells. The present study aimed to explore their relationship and prognostic significance in surgically resected osteosarcoma. Read More

View Article and Full-Text PDF
September 2021

Characterizing the PrEP Continuum for Black and Latinx Sexual and Gender Minority Youth.

AIDS Behav 2021 Sep 21. Epub 2021 Sep 21.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD, 21205, USA.

Pre-exposure prophylaxis (PrEP) rollout efforts thus far have inadequately reached young people from underrepresented backgrounds. This study explores PrEP engagement among young Black and Latinx men who have sex with men, transgender women, and gender diverse individuals in three U.S. Read More

View Article and Full-Text PDF
September 2021

Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial.

JAMA 2021 Sep;326(11):1024-1033

Université de Sherbrooke, Sherbrooke, Canada.

Importance: Growing interest in microbial dysbiosis during critical illness has raised questions about the therapeutic potential of microbiome modification with probiotics. Prior randomized trials in this population suggest that probiotics reduce infection, particularly ventilator-associated pneumonia (VAP), although probiotic-associated infections have also been reported.

Objective: To evaluate the effect of Lactobacillus rhamnosus GG on preventing VAP, additional infections, and other clinically important outcomes in the intensive care unit (ICU). Read More

View Article and Full-Text PDF
September 2021

Acute Radiation Effects, the H-ARS in the Non-human Primate: A Review and New Data for the Cynomolgus Macaque with Reference to the Rhesus Macaque.

Health Phys 2021 Oct;121(4):304-330

University of Maryland, School of Medicine, Department of Radiation Oncology, Baltimore.

Abstract: Medical countermeasure development under the US Food and Drug Administration animal rule requires validated animal models of acute radiation effects. The key large animal model is the non-human primate, rhesus macaque. To date, only the rhesus macaque has been used for both critical supportive data and pivotal efficacy trials seeking US Food and Drug Administration approval. Read More

View Article and Full-Text PDF
October 2021

Transition outcomes for young people discharged from adolescent medium secure services in England: A qualitative study exploring adolescents' and carers' experiences.

Clin Child Psychol Psychiatry 2021 Sep 21:13591045211026048. Epub 2021 Sep 21.

Division of Health Sciences, Mental Health and Wellbeing, Warwick Medical School, Coventry, UK.

Background: Young people in secure services present with multiple vulnerabilities; therefore, transition periods are especially challenging for this group. In this study, we followed up young people discharged from adolescent medium secure services to adult and community settings with the aim to explore transition experiences and outcomes.

Methods: Participants were recruited from 15 child and adult mental health services in England. Read More

View Article and Full-Text PDF
September 2021

Genomic Stability and Genetic Defense Systems in , a Candidate Beneficial Bacterium from the Human Microbiome.

mSystems 2021 Sep 21:e0042521. Epub 2021 Sep 21.

The Forsyth Institute (Microbiology), Cambridge, Massachusetts, USA.

Dolosigranulum pigrum is positively associated with indicators of health in multiple epidemiological studies of human nasal microbiota. Knowledge of the basic biology of is a prerequisite for evaluating its potential for future therapeutic use; however, such data are very limited. To gain insight into 's chromosomal structure, pangenome, and genomic stability, we compared the genomes of 28 strains that were collected across 20 years. Read More

View Article and Full-Text PDF
September 2021

Shame in younger adults with a type 2 diabetes diagnosis: where might this be leading?

Jackie Sturt

Diabet Med 2021 Sep 21:e14693. Epub 2021 Sep 21.

Behavioural Medicine in Nursing.

I recently enjoyed a Russell T Davies fictional biographical TV drama about a group of young friends exposed to the growing AIDS epidemic in 1980s London . Whilst the joy of their lives together was palpable and infectious, the undercurrent of shame was equally so. Shame for being homosexual, shame about some of their behaviours and shame for their HIV+ diagnosis. Read More

View Article and Full-Text PDF
September 2021

Human or Chimeric Monoclonal Anti-CD20 Antibodies for Children with Nephrotic Syndrome: A Superiority Randomized Trial.

J Am Soc Nephrol 2021 Sep 20. Epub 2021 Sep 20.

Laboratory on Molecular Nephrology, Division of Nephrology, Dialysis, Transplantation, Istituto Giannina Gaslini Istituto di Ricovero e Cura a Carattere Scientifico, Genoa, Italy

Background: The chimeric anti-CD20 monoclonal antibody rituximab is effective in steroid-dependent and calcineurin inhibitor-dependent forms of nephrotic syndrome, but many patients relapse at 1 year. Because ofatumumab, a fully human anti-CD20 monoclonal antibody, has a more extended binding site and higher affinity to CD20 compared with rituximab, it might offer superior efficacy in these patients.

Methods: We designed a single-center randomized clinical trial to compare the long-term efficacy of ofatumumab versus rituximab in children and young adults with nephrotic syndrome maintained in remission with prednisone and calcineurin inhibitors. Read More

View Article and Full-Text PDF
September 2021

Inconsistencies in fertility preservation for young people with cancer in the UK.

Arch Dis Child 2021 Sep 20. Epub 2021 Sep 20.

Leeds Institute of Medical Research, University of Leeds, Leeds, UK

Objective: To assess the utilisation of and funding structure for fertility preservation for children diagnosed with cancer in the UK.

Design: Survey of paediatric oncologists/haematologists. Questionnaires were sent electronically with reminder notifications to non-responders. Read More

View Article and Full-Text PDF
September 2021

Effects of contingency management and use of reminders for drug use treatment on readmission and criminality among young people: A linkage study of a randomized trial.

J Subst Abuse Treat 2021 Aug 31:108617. Epub 2021 Aug 31.

Centre for Alcohol and Drug Research, Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, Denmark.

Introduction: An increasing number of adolescents and emerging adults are entering treatment for drug use disorders in high-income countries. This fact points not only to a need to evaluate treatment outcomes related to drug use reduction, but also to evaluate other indicators of treatment success. The aim of this study was to examine treatment effects on predicting readmission to drug use treatment and being convicted for a criminal offence among youth. Read More

View Article and Full-Text PDF

Needs of young adults with type 1 diabetes during life transitions - An Australian-Danish experience.

Patient Educ Couns 2021 Sep 9. Epub 2021 Sep 9.

Steno Diabetes Center Odense, Odense University Hospital, Denmark; Department of Endocrinology, Odense University Hospital, Denmark; Department of Clinical Research, University of Southern Denmark, Denmark; School of Nursing and Midwifery, Faculty of Health, Deakin University, Australia.

Objective: To explore the similarities and differences in the needs of young adults with T1D during life transitions.

Methods: Data obtained for this paper was based on three qualitative studies carried out in Denmark and Australia. In total, 33 Individual interviews and two focus groups (n = 46) were conducted. Read More

View Article and Full-Text PDF
September 2021

The pattern of romantic and sexual related experiences among Chinese young adolescents: an exploration with multi-group latent class analysis.

Reprod Health 2021 Sep 20;18(1):184. Epub 2021 Sep 20.

NHC Key Lab. of Reproductive Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, 779 Old Hu Min Road, 200237, Shanghai, People's Republic of China.

Background: Studies on very young adolescents' romantic and sexual experiences would help inform the context in which early sex arises. However, such studies are scant in China due to sparse data and cultural issues.

Method: This study used the GEAS baseline data conducted among1776 adolescents in Shanghai. Read More

View Article and Full-Text PDF
September 2021

The clinical-epidemiological profile of malaria patients from Southern Venezuela, a critical hotspot in Latin America.

Malar J 2021 Sep 20;20(1):375. Epub 2021 Sep 20.

Biology Department/Institute of Genomics and Evolutionary Medicine (iGEM), Temple University, Philadelphia, PA, 19122-1801, USA.

Background: Venezuela accounted for 55% of the cases and 73% of the malaria deaths in the Americas in 2019. Bolivar state, in the southeast, contributes > 60% of the country's Plasmodium vivax and Plasmodium falciparum cases every year. This study describes the clinical-epidemiological characteristics of clinical malaria patients in this high-transmission area. Read More

View Article and Full-Text PDF
September 2021

An individually randomized controlled trial of a mother-daughter HIV/STI prevention program for adolescent girls and young women in South Africa: IMARA-SA study protocol.

BMC Public Health 2021 Sep 20;21(1):1708. Epub 2021 Sep 20.

Desmond Tutu HIV Center, Cape Town, South Africa.

Background: South Africa has the world's largest HIV epidemic, but South African adolescent girls and young women (AGYW) acquire HIV at twice the rate of and seroconvert on average 5-7 years earlier than their male peers. Female caregivers (FC) are an untapped resource for HIV/STI prevention in South Africa and offer a novel opportunity to strengthen AGYW prevention efforts. This study will evaluate the effectiveness and cost-effectiveness of an evidence-based mother-daughter HIV/STI prevention program tested in the United States and adapted for South Africa, Informed Motivated Aware and Responsible Adolescents and Adults (IMARA), to decrease STI incident infections and increase HIV testing and counseling (HTC) and PrEP uptake in AGYW. Read More

View Article and Full-Text PDF
September 2021

I Will Get Myself Vaccinated for Others: The Interplay of Message Frame, Reference Point, and Perceived Risk on Intention for COVID-19 Vaccine.

Health Commun 2021 Sep 20:1-11. Epub 2021 Sep 20.

Department of Communication and Journalism, MSC 03 2240, University of New Mexico, Albuquerque,NM, 87131, USA.

The purpose of this study is to seek an effective strategy to promote COVID-19 vaccination among young adults. Given that COVID-19 is less deadly for young adults, this study explores whether highlighting potential benefits or disadvantages that others may experience as a result of one's vaccination increases young adults' intention to get vaccinated, particularly for those who have low perceived risk of COVID-19. To test this idea, we conducted an experiment and analyzed the effect of interaction between message frame (gain vs. Read More

View Article and Full-Text PDF
September 2021

Seroepidemiology of TORCH Infections among 1.7 Million Women of Childbearing Age in Rural China: A Population-Based Cross-Sectional Study.

Am J Trop Med Hyg 2021 Sep 20. Epub 2021 Sep 20.

Department of Clinical Laboratory Medicine, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, China.

We conducted a national seroepidemiological study of the TORCH (Toxoplasma gondii [TOX], Rubella [RV], Cytomegalovirus [CMV], and Herpes Simplex Virus) in rural women to provided updated baseline data on TORCH prevalence. A total of 1,541,329 women of childbearing age were gathered from 2010 to 2012 in China. Of these, 858,072 women were tested positive for anti-RV IgG antibodies, 602,251 women were tested positive for anti-CMV antibodies, and 40,055 women were tested positive for anti-TOX antibodies. Read More

View Article and Full-Text PDF
September 2021

Multigeneration toxicity of Geunsami® (a glyphosate-based herbicide) to Allonychiurus kimi (Lee) (Collembola) from sub-individual to population levels.

Environ Pollut 2021 Sep 13;291:118172. Epub 2021 Sep 13.

Department of Environmental Science and Ecological Engineering, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

Glyphosate-based herbicide (GBH) is the most widely used herbicide worldwide and has long been considered to have significantly low toxicity to non-target soil invertebrates based on short-term toxicity tests (<56 d). However, long-term GBH toxicity assessment is necessary as GBH is repeatedly applied in the same field annually because of the advent of glyphosate-resistant crops. In this study, a multigeneration test was conducted where Allonychiurus kimi (Collembola) was exposed to GBH for three generations (referred to as F, F, and F) to evaluate the long-term toxic effect. Read More

View Article and Full-Text PDF
September 2021

First-in-child phase I/II study of the dual mTORC1/2 inhibitor vistusertib (AZD2014) as monotherapy and in combination with topotecan-temozolomide in children with advanced malignancies: arms E and F of the AcSé-ESMART trial.

Eur J Cancer 2021 Sep 17;157:268-277. Epub 2021 Sep 17.

Gustave Roussy Cancer Campus, Department of Paediatric and Adolescent Oncology, Villejuif, France; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. Electronic address:

Aim: Arms E and F of the AcSé-ESMART phase I/II platform trial aimed to define the recommended dose and preliminary activity of the dual mTORC1/2 inhibitor vistusertib as monotherapy and with topotecan-temozolomide in a molecularly enriched population of paediatric patients with relapsed/refractory malignancies. In addition, we evaluated genetic phosphatidylinositol 3-kinase (PI3K)/AKT/ mammalian (or mechanistic) target of rapamycin (mTOR) pathway alterations across the Molecular Profiling for Paediatric and Young Adult Cancer Treatment Stratification (MAPPYACTS) trial (NCT02613962).

Experimental Design And Results: Four patients were treated in arm E and 10 in arm F with a median age of 14. Read More

View Article and Full-Text PDF
September 2021

Migration and Diabetes Incidence Among Chinese Adults in Canada, China, Hong Kong, and Taiwan: An International Population-Based Comparative Study from 2000 to 2017.

Diabetes Res Clin Pract 2021 Sep 17:109062. Epub 2021 Sep 17.

Department of Medicine, University of Toronto, Toronto, Canada; ICES, Toronto, Canada; Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada.

Aims: We conducted an international population-based study comparing the incidence of young- (age 20-39 years) and usual- (age≥40 years) onset diabetes among Chinese-Canadian immigrants; their source populations (mainland China, Hong Kong, Taiwan); and other Canadians.

Methods: Using population-based data (2000-17; n=3.4 million cases), we calculated incidence rates and incidence rate ratios comparing the average incidence for each cohort. Read More

View Article and Full-Text PDF
September 2021