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Racial/Ethnic differences in eligibility for asthma biologics among pediatric populations.

J Allergy Clin Immunol 2021 Sep 15. Epub 2021 Sep 15.

Department of Medicine, University of California San Francisco, San Francisco, CA, United States of America; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States of America.

Background: Asthma is a heterogenous disease. Clinical blood parameters differ by race/ethnicity and are used to distinguish asthma subtypes and inform therapies. Differences in subtypes may explain population-specific trends in asthma outcomes. Read More

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September 2021

Clinical Validation of p16/Ki-67 Dual-Stained Cytology Triage of HPV-Positive Women - Results from the IMPACT Trial.

Int J Cancer 2021 Sep 18. Epub 2021 Sep 18.

Ventana Medical Systems Inc./Roche Tissue Diagnostics, Tucson, AZ.

Triage strategies are needed for primary human papillomavirus (HPV)-based cervical cancer screening to identify women requiring colposcopy/biopsy. We assessed the performance of p16/Ki-67 dual-stained immunocytochemistry (DS) to triage HPV-positive women and compared it to cytology, with or without HPV16/18 genotyping. A prospective observational screening study enrolled 35,263 women aged 25-65 years at 32 U. Read More

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September 2021

The International EAACI/GA²LEN/EuroGuiDerm/APAAACI Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.

Allergy 2021 Sep 18. Epub 2021 Sep 18.

Centre Hospitalier Université Laval/Centre Hospitalier Universitaire de Québec, Service d'allergie, Québec, QC, Canada.

This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA²LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. Read More

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September 2021

The mutagenic effect of tobacco smoke on male fertility.

Environ Sci Pollut Res Int 2021 Sep 18. Epub 2021 Sep 18.

College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.

Despite the association between tobacco use and the harmful effects on general health as well as male fertility parameters, smoking remains globally prevalent. The main content of tobacco smoke is nicotine and its metabolite cotinine. These compounds can pass the blood-testis barrier, which subsequently causes harm of diverse degree to the germ cells. Read More

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September 2021

Survival Among New Yorkers with HIV from 1981 to 2017: Inequities by Race/Ethnicity and Transmission Risk Persist into the Post-HAART Era.

AIDS Behav 2021 Sep 18. Epub 2021 Sep 18.

New York City Department of Health and Mental Hygiene, Bureau of HIV, New York, NY, USA.

Data on long-term survival among people with HIV (PWH) can inform the development of services for this population. An estimated 90,000 PWH live in New York City (NYC). Using HIV surveillance data, we conducted survival analysis of PWH diagnosed in NYC before and after introduction of highly active antiretroviral therapy (HAART) (pre-HAART cohort: 1981-1994; post-HAART cohort: 1995-2016). Read More

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September 2021

What does gender affirmation mean to you? An exploratory study.

Nurs Forum 2021 Sep 17. Epub 2021 Sep 17.

Center for Innovations Advancement in Care (CIAC), NYU Langone Health, New York City, NY, USA.

Purpose: Gender affirmation lessens mental health disparities among transgender and gender nonbinary (TGNB) persons. However, the concept of what it means to be affirmed in one's gender has not been fully explored, nor has the impact of gender affirmation on other health indicators been determined. The purpose of this study was to explore the meaning of gender affirmation among a sample of TGNB persons. Read More

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September 2021

Fear is associated with attrition of first-time whole blood donors: A longitudinal examination of donor confidence and attitude as potential mediators.

Transfusion 2021 Sep 18. Epub 2021 Sep 18.

Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA.

Background: Elevated fear and anxiety regarding donation-related stimuli (e.g., needles, pain, blood, fainting) has been associated with reduced blood donor recruitment and retention. Read More

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September 2021

A matching procedure for sequential experiments that iteratively learns which covariates improve power.

Biometrics 2021 Sep 17. Epub 2021 Sep 17.

Department of Statistics, The Wharton School at the University of Pennsylvania, 3730 Walnut St, Philadelphia, PA, 19104.

We propose a dynamic allocation procedure that increases power and efficiency when measuring an average treatment effect in sequential randomized trials exploiting some subjects' previous assessed responses. Subjects arrive sequentially and are either randomized or paired to a previously randomized subject and administered the alternate treatment. The pairing is made via a dynamic matching criterion that iteratively learns which specific covariates are important to the response. Read More

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September 2021

Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa.

NPJ Precis Oncol 2021 Sep 17;5(1):83. Epub 2021 Sep 17.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Circulating tumor DNA (ctDNA) sequencing studies could provide novel insights into the molecular pathology of cancer in sub-Saharan Africa. In 15 patient plasma samples collected at the time of diagnosis as part of the Ghana Breast Health Study and unselected for tumor grade and subtype, ctDNA was detected in a majority of patients based on whole- genome sequencing at high (30×) and low (0.1×) depths. Read More

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September 2021

A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery.

Nat Commun 2021 Sep 17;12(1):5525. Epub 2021 Sep 17.

Liver Tumor Translational Research Program, Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Chronic liver disease and hepatocellular carcinoma (HCC) are life-threatening diseases with limited treatment options. The lack of clinically relevant/tractable experimental models hampers therapeutic discovery. Here, we develop a simple and robust human liver cell-based system modeling a clinical prognostic liver signature (PLS) predicting long-term liver disease progression toward HCC. Read More

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September 2021

Monitoring New Symptoms After COVID-19 Infection Among Primary Care Patients in New York City.

J Am Board Fam Med 2021 Sep-Oct;34(5):1014-1016

From the Department of Population Health, NYU Grossman School of Medicine, New York, NY (KT); Internal Medicine, NYU Langone Health, New York, NY (EK); Department of Child and Adolescent Psychiatry, New York University Grossman School of Medicine, New York, NY (YY).

Introduction: COVID-19 affects multiple organ systems causing substantial long-term morbidity. The implications of the Post-Acute Sequelae of SARS-CoV-2 infection, particularly for primary care, remain unknown. This cross-sectional study examines new symptoms reported at primary care encounters during three post-acute follow-up intervals after initial SARS-CoV-2 infection. Read More

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Evolution and Transformation of Uterine Transplantation: A Systematic Review of Surgical Techniques and Outcomes.

J Reconstr Microsurg 2021 Sep 17. Epub 2021 Sep 17.

Division of Plastic and Reconstructive Surgery, Strong Memorial Hospital, University of Rochester Medical Center, New York.

Background:  Uterine transplantation (UTx) is acknowledged to be on the second (2A) of five steps of development in accordance with the staging system for the evaluation of surgical innovations. Accordingly, we aimed to systematically review the available evidence of the surgical techniques and outcomes of UTx in terms of graft survival.

Methods:  A comprehensive search was conducted across PubMed Medline, Cochrane-EBMR, Scopus, Web of Science, and CENTRAL through November 2020. Read More

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September 2021

Does reduction of the Meyerding grade correlate with outcomes in patients undergoing decompression and fusion for grade I degenerative lumbar spondylolisthesis?

J Neurosurg Spine 2021 Sep 17:1-8. Epub 2021 Sep 17.

1Department of Neurological Surgery, University of California, San Francisco, San Francisco, California.

Objective: Reduction of Meyerding grade is often performed during fusion for spondylolisthesis. Although radiographic appearance may improve, correlation with patient-reported outcomes (PROs) is rarely reported. In this study, the authors' aim was to assess the impact of spondylolisthesis reduction on 24-month PRO measures after decompression and fusion surgery for Meyerding grade I degenerative lumbar spondylolisthesis. Read More

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September 2021

Cognitive and gait outcomes after primary endoscopic third ventriculostomy in adults with chronic obstructive hydrocephalus.

J Neurosurg 2021 Sep 17:1-8. Epub 2021 Sep 17.

12Department of Clinical Neurosciences, Division of Neurosurgery, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.

Objective: The object of this study was to determine the short- and long-term efficacy of primary endoscopic third ventriculostomy (ETV) on cognition and gait in adults with chronic obstructive hydrocephalus.

Methods: Patients were prospectively accrued through the Adult Hydrocephalus Clinical Research Network patient registry. Patients with previously untreated congenital or acquired obstructive hydrocephalus were included in this study. Read More

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September 2021

Biophysical matter in a marine estuary identified by the Sentinel-3B OLCI satellite and the presence of terrestrial iron (Fe) nanoparticles.

Mar Pollut Bull 2021 Sep 14;173(Pt A):112925. Epub 2021 Sep 14.

Department of Civil and Environmental, Universidad de la Costa, CUC, Calle 58 # 55-66, Barranquilla, Atlántico, Colombia. Electronic address:

The analysis of marine matter using the Sentinel-3B OLCI (Ocean Land Color Instrument) satellite is the most advanced technique for evaluating: the absorption of colored detrital and dissolved material (ADG_443_NN), total suspended matter concentration (TSM_NN) and of chlorophyll-a (CHL_NN) on a global scale. The objective is to analyze ADG_443_NN, TSM_NN and CHL_NN using the Sentinel-3B OLCI satellite and the presence of Fe-nanoparticles (NPs) + hazardous elements (HEs) in suspended sediments (SSs) in the maritime estuary of the Colombian city of Barranquilla. The study used the unpublished image of the Sentinel-3B OLCI satellite in the evaluation of ADG_443_NN, TSM_NN and CHL_NN in 72 sampled points. Read More

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September 2021

Eating disorder behaviors and treatment seeking in self-identified military personnel and veterans: Results of the National Eating Disorders Association online screening.

Eat Behav 2021 Sep 7;43:101562. Epub 2021 Sep 7.

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Objective: To characterize disordered eating behaviors, eating disorder (ED) risk and diagnosis, and treatment seeking behaviors in active-duty military personnel/veterans compared with civilians.

Method: Self-selecting participants (n = 113,388; 1744 were military personnel/veterans) 18+ years old completed the National Eating Disorders Association's online screen. Engagement in and frequencies of disordered eating behaviors were compared across military/veteran and civilian groups and were stratified by gender. Read More

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September 2021

Heavy episodic drinking and HIV disclosure by HIV treatment status among People with HIV in IeDEA Cameroon.

Int J Drug Policy 2021 Sep 14;98:103431. Epub 2021 Sep 14.

University of North Carolina at Chapel Hill, United States.

Background: Heavy alcohol use is common among people with HIV (PWH), leading to sub-optimal HIV care outcomes. Yet, heavy episodic drinking (HED) is not routinely addressed within most HIV clinics in sub-Saharan Africa. HIV disclosure may provide social support, potentially reducing HED to cope with HIV. Read More

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September 2021

The Relationship between Post Traumatic Stress Disorder and Self-management Behaviors in World Trade Center Workers with Asthma.

J Allergy Clin Immunol Pract 2021 Sep 14. Epub 2021 Sep 14.

Department of Psychiatry and Behavioral Health, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.

Background: Comorbid post-traumatic stress disorder (PTSD) is highly prevalent and associated with increased morbidity among World Trade Center (WTC) rescue and recovery workers with asthma. However, the potential behavioral pathways underlying this relationship remain unclear.

Objective: To evaluate if PTSD is associated with lower adherence to asthma self-management behaviors among WTC workers with asthma. Read More

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September 2021

Delayed Diagnosis of Autosomal Dominant Optic Atrophy Diagnosis until the Seventh Decade of Life.

Can J Ophthalmol 2021 Sep 14. Epub 2021 Sep 14.

Blanton Eye Institute, Houston Methodist Hospital, Houston, Tex.;; Weill Cornell Medicine, New York, NY;; University of Texas Medical Branch, Galveston, Tex.;; University of Texas MD Anderson Cancer Center, Houston, Tex.;; Texas A&M College of Medicine, Bryan, Tex.;; University of Iowa Hospitals and Clinics, Iowa City, Iowa;. Electronic address:

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September 2021

Ultrahigh-Resolution, Label-Free Hyperlens Imaging in the Mid-IR.

Nano Lett 2021 Sep 17. Epub 2021 Sep 17.

Department of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee 37212, United States.

The hyperbolic phonon polaritons supported in hexagonal boron nitride (hBN) with long scattering lifetimes are advantageous for applications such as super-resolution imaging via hyperlensing. Yet, hyperlens imaging is challenging for distinguishing individual and closely spaced objects and for correlating the complicated hyperlens fields with the structure of an unknown object underneath. Here, we make significant strides to overcome each of these challenges. Read More

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September 2021

Metabolomic Identification of Alpha-Ketoglutaric Acid Elevation in Pediatric Chronic Graft-versus-Host Disease.

Blood 2021 Sep 17. Epub 2021 Sep 17.

BC Children's Hospital, Vancouver, BC, Canada.

Chronic graft versus host disease (cGvHD) is the most common cause for non-relapse mortality post allogenic hematopoietic stem cell transplant (HSCT). However, there are no well-defined biomarkers for cGvHD or late acute GvHD (aGvHD). This study is a longitudinal evaluation of metabolomic patterns of cGvHD and late aGvHD in pediatric HSCT recipients. Read More

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September 2021

Ipsilateral internal carotid artery web and acute ischemic stroke: A cohort study, systematic review and meta-analysis.

PLoS One 2021 17;16(9):e0257697. Epub 2021 Sep 17.

Division of Vascular Neurology, Department of Neurology, Vidant Medical Center, Greenville, North Carolina, United States of America.

Introduction: The carotid web is a compelling potential mechanism of embolic ischemic stroke. In this study, we aim to determine the prevalence of ipsilateral carotid web in a cohort of ischemic stroke patients and to perform a systematic review and meta-analysis of similar cohorts.

Patients & Methods: We performed a retrospective, observational, cohort study of acute ischemic stroke patients admitted to a comprehensive stroke center from June 2012 to September 2017. Read More

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September 2021

Diagnosis Documentation of Critically Ill Children at Admission to a PICU.

Pediatr Crit Care Med 2021 Aug 23. Epub 2021 Aug 23.

University of Iowa Carver College of Medicine, Iowa City, IA. Department of Pediatrics, BronxCare Health System, New York, NY. Center for Access and Delivery Research and Evaluation, Iowa City Veterans Affairs Medical Center, Iowa City, IA. Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA. Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX. Institute for Clinical and Translational Science, University of Iowa, Iowa City, IA. Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA.

Objectives: Multidisciplinary PICU teams must effectively share information while caring for critically ill children. Clinical documentation helps clinicians develop a shared understanding of the patient's diagnosis, which informs decision-making. However, diagnosis-related documentation in the PICU is understudied, thus limiting insights into how pediatric intensivists convey their diagnostic reasoning. Read More

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Overview of Interventional Pulmonology for Radiologists.

Radiographics 2021 Sep 17:210046. Epub 2021 Sep 17.

From the Departments of Radiology (D.B.G., L.K.G., J.S.) and Cardiothoracic Surgery (E.S.), Weill Cornell Medicine, 525 E 68th St, Box 141, New York, NY 10065; Departments of Medicine (J.J.L.) and Radiology (D.V.), University of Colorado, Aurora, Colo; Department of Radiology, Hospital San Juan de Dios, Córdoba, Spain (J.B.); and Division of Pulmonary and Critical Care Medicine, University of Kansas Medical Center, Kansas City, Kan (M.C.).

Interventional pulmonology is a growing field specializing in minimally invasive procedures of the mediastinum, lungs, airways, and pleura. These procedures have both diagnostic and therapeutic indications and are performed for benign and malignant diseases. Endobronchial US has been combined with transbronchial needle aspiration to extend tissue sampling beyond the airways and into the lungs and mediastinum. Read More

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September 2021

Placental gene network modules are associated with maternal stress during pregnancy and infant temperament.

FASEB J 2021 Oct;35(10):e21922

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Maternal psychosocial stress during pregnancy (MPSP) is a known contributor to maladaptive neurobehavioral development of the offspring; however, the underlying molecular mechanisms linking MPSP with childhood outcome remain largely unknown. Transcriptome-wide gene expression data were generated using RNA-seq from placenta samples collected in a multi-ethnic urban birth cohort in New York City (n = 129). Weighted gene co-expression network analysis (WGCNA) was used to characterize placental co-expression modules, which were then evaluated for their associations with MPSP and infant temperament. Read More

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October 2021

The duration dilemma in opioid agonist therapy.

J Opioid Manag 2021 Jul-Aug;17(4):353-358

Division of Chemical Dependency, Mount Sinai Beth Israel, New York City, New York.

Objective: Studies dating back to 1964 consistently support the effectiveness of methadone as a maintenance treatment for opioid use disorder (OUD), and since 2003, the effectiveness of buprenorphine. Short-term detoxification has not proven to be an effective treatment, as it results in high relapse rates when compared with maintenance treatment with an opioid agonist therapy (OAT). The question about the duration of maintenance treatment for OUD has been debated with recommendations ranging from a minimum of 1 year, 2 years, to indefinitely. Read More

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September 2021

Pulmonary vasculitis in Hughes-Stovin syndrome (HSS): a reference atlas and computed tomography pulmonary angiography guide-a report by the HSS International Study Group.

Clin Rheumatol 2021 Sep 17. Epub 2021 Sep 17.

Serviço de Reumatologia, Hospital das Clínicas, Faculdade de Medicina, Universidade Federal de Goiás, Goiânia, GO, Brazil.

Introduction: Hughes-Stovin syndrome (HSS) is a systemic vasculitis characterized by widespread venous/arterial thrombosis and pulmonary artery aneurysms (PAAs), which is associated with serious morbidity and mortality. All fatalities reported in HSS resulted from unpredictable fatal suffocating hemoptysis. Therefore, it is necessary to recognize pulmonary complications at an early stage of the disease. Read More

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September 2021

Health Equity in Artificial Intelligence and Primary Care Research: Protocol for a Scoping Review.

JMIR Res Protoc 2021 Sep 17;10(9):e27799. Epub 2021 Sep 17.

Center for Vulnerable Populations at San Francisco General Hospital, University of California San Francisco, San Francisco, CA, United States.

Background: Though artificial intelligence (AI) has the potential to augment the patient-physician relationship in primary care, bias in intelligent health care systems has the potential to differentially impact vulnerable patient populations.

Objective: The purpose of this scoping review is to summarize the extent to which AI systems in primary care examine the inherent bias toward or against vulnerable populations and appraise how these systems have mitigated the impact of such biases during their development.

Methods: We will conduct a search update from an existing scoping review to identify studies on AI and primary care in the following databases: Medline-OVID, Embase, CINAHL, Cochrane Library, Web of Science, Scopus, IEEE Xplore, ACM Digital Library, MathSciNet, AAAI, and arXiv. Read More

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September 2021

Constraints on the Initial State of Pb-Pb Collisions via Measurements of Z-Boson Yields and Azimuthal Anisotropy at sqrt[s_{NN}]=5.02  TeV.

Phys Rev Lett 2021 Sep;127(10):102002

Universiteit Antwerpen, Antwerpen, Belgium.

The CMS experiment at the LHC has measured the differential cross sections of Z bosons decaying to pairs of leptons, as functions of transverse momentum and rapidity, in lead-lead collisions at a nucleon-nucleon center-of-mass energy of 5.02  TeV. The measured Z boson elliptic azimuthal anisotropy coefficient is compatible with zero, showing that Z bosons do not experience significant final-state interactions in the medium produced in the collision. Read More

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September 2021

Increased Blood Pressure Variability and the Risk of Probable Dementia or Mild Cognitive Impairment: A Post Hoc Analysis of the SPRINT MIND Trial.

J Am Heart Assoc 2021 Sep 17:e022206. Epub 2021 Sep 17.

Department of Neurology Harvard University Boston MA.

Background Increased systolic blood pressure variability (BPV) is associated with stroke, cardiovascular disease, and dementia and mild cognitive impairment. However, prior studies assessing the relationship between BPV and dementia or mild cognitive impairment had infrequent measurement of blood pressure or suboptimal blood pressure control. Methods and Results We performed a post hoc analysis of the SPRINT (Systolic Blood Pressure Intervention Trial) MIND (Memory and Cognition in Decreased Hypertension) trial. Read More

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September 2021