Molecules 2021 Apr 19;26(8). Epub 2021 Apr 19.
Department of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy.
In this work, we have analysed the binding of the Pt(II) complexes ([PtCl(4'-phenyl-2,2':6',2″-terpyridine)](CFSO) (), [PtI(4'-phenyl-2,2':6',2″-terpyridine)](CFSO) () and [PtCl(1,3-di(2-pyridyl)benzene) ()] with selected model proteins (hen egg-white lysozyme, HEWL, and ribonuclease A, RNase A). Platinum coordination compounds are intensively studied to develop improved anticancer agents. In this regard, a critical issue is the possible role of Pt-protein interactions in their mechanisms of action. Read More