12 results match your criteria yemenite ethiopian

  • Page 1 of 1

The genetics of benign neutropenia.

Isr Med Assoc J 2011 Oct;13(10):625-9

Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel.

In Israel, Yemenite Jews and other populations including Ethiopian Jews and Bedouins have a low neutrophil count. This phenomenon has been called "benign neutropenia" since it has not been associated with any increased risk of infection and has also been described in other populations around the world including Africans, African Americans and Afro-Carribeans. Here we describe the recent success in mapping the gene that underlies benign neutropenia in African American populations. Read More

View Article and Full-Text PDF
October 2011

Mitochondrial DNA reveals distinct evolutionary histories for Jewish populations in Yemen and Ethiopia.

Am J Phys Anthropol 2011 Jan;144(1):1-10

Department of Anthropology, University of Florida, Gainesville, FL 32611, USA.

Southern Arabia and the Horn of Africa are important geographic centers for the study of human population history because a great deal of migration has characterized these regions since the first emergence of humans out of Africa. Analysis of Jewish groups provides a unique opportunity to investigate more recent population histories in this area. Mitochondrial DNA is used to investigate the maternal evolutionary history and can be combined with historical and linguistic data to test various population histories. Read More

View Article and Full-Text PDF
January 2011

Ethiopia: between Sub-Saharan Africa and western Eurasia.

Ann Hum Genet 2005 May;69(Pt 3):275-87

Centre de Recherche, Hôpital Sainte-Justine, Montréal, Québec, Canada.

Ethiopia is central to population genetic studies investigating the out of Africa expansion of modern humans, as shown by Y chromosome and mtDNA studies. To address the level of genetic differentiation within Ethiopia, and its relationship to Sub-Saharan Africa and Eurasia, we studied an 8 kb segment of the X-chromosome from 72 chromosomes from the Amhara, Oromo and Ethiopian Jews, and compared these results with 804 chromosomes from Middle Eastern, African, Asian and European populations, and 22 newly typed Saharawi. Within Ethiopia the two largest ethnic groups, the Amhara and Oromo, were not found to be statistically distinct, based on an exact test of haplotype frequencies. Read More

View Article and Full-Text PDF

Polymorphisms of CYP2C19 and CYP2D6 in Israeli ethnic groups.

Am J Pharmacogenomics 2004 ;4(6):395-401

Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160-7417, USA.

Background: The cytochrome P450 isoenzymes CYP2C19 and CYP2D6 catalyze reactions involved in the metabolism of many widely used drugs. Their polymorphisms give rise to important interindividual and interethnic variability in the metabolism and disposition of several therapeutic agents and may cause differences in clinical response to some drugs. Individuals who carry two null alleles of either gene are known as poor metabolizers (PMs), while those who carry more than two copies of the functional CYP2D6 gene are ultrarapid metabolizers (UMs). Read More

View Article and Full-Text PDF
February 2005

Reconstruction of patrilineages and matrilineages of Samaritans and other Israeli populations from Y-chromosome and mitochondrial DNA sequence variation.

Hum Mutat 2004 Sep;24(3):248-60

Stanford Genome Technology Center, Palo Alto, California 94305-5020, USA.

The Samaritan community, which numbered more than a million in late Roman times and only 146 in 1917, numbers today about 640 people representing four large families. They are culturally different from both Jewish and non-Jewish populations in the Middle East and their origin remains a question of great interest. Genetic differences between the Samaritans and neighboring Jewish and non-Jewish populations are corroborated in the present study of 7,280 bp of nonrecombining Y-chromosome and 5,622 bp of coding and hypervariable segment I (HVS-I) mitochondrial DNA (mtDNA) sequences. Read More

View Article and Full-Text PDF
September 2004

Distinctive genetic signatures in the Libyan Jews.

Proc Natl Acad Sci U S A 2001 Jan;98(3):858-63

Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.

Unlinked autosomal microsatellites in six Jewish and two non-Jewish populations were genotyped, and the relationships among these populations were explored. Based on considerations of clustering, pairwise population differentiation, and genetic distance, we found that the Libyan Jewish group retains genetic signatures distinguishable from those of the other populations, in agreement with some historical records on the relative isolation of this community. Our methods also identified evidence of some similarity between Ethiopian and Yemenite Jews, reflecting possible migration in the Red Sea region. Read More

View Article and Full-Text PDF
January 2001

Genetic polymorphism of CYP2D6 and CYP2C19 metabolism determined by phenotyping Israeli ethnic groups.

Ther Drug Monit 2000 Oct;22(5):510-6

Kimron Veterinary Institute, Beit Dagan, Israel .

Genetic polymorphism of the cytochrome P450 isoenzymes CYP2D6 and CYP2C19 was determined by phenotyping four ethnic groups of the Israeli population. The groups consisted of Ethiopian subjects, Yemenite subjects, and Russian subjects representing first-generation new immigrants and an Israeli Arab group. Dextromethorphan was used as the probe for CYP2D6 activity and mephenytoin was used for CYP2C19 activity. Read More

View Article and Full-Text PDF
October 2000

Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes.

Proc Natl Acad Sci U S A 2000 Jun;97(12):6769-74

Laboratory of Molecular Systematics and Evolution, University of Arizona, Tucson, AZ 85721, USA.

Haplotypes constructed from Y-chromosome markers were used to trace the paternal origins of the Jewish Diaspora. A set of 18 biallelic polymorphisms was genotyped in 1,371 males from 29 populations, including 7 Jewish (Ashkenazi, Roman, North African, Kurdish, Near Eastern, Yemenite, and Ethiopian) and 16 non-Jewish groups from similar geographic locations. The Jewish populations were characterized by a diverse set of 13 haplotypes that were also present in non-Jewish populations from Africa, Asia, and Europe. Read More

View Article and Full-Text PDF

Genetic variation of three tetrameric tandem repeats in four distinct Israeli ethnic groups.

J Forensic Sci 1999 Sep;44(5):983-6

Tissue Typing Unit, Hadasah Medical Organization, Jerusalem, Israel.

The allele frequency distributions of three STR loci amplified by PCR have been studied in four Israeli communities: Ashkenazi Jews and three non-Ashkenazi groups, namely Moroccan, Yemenite, and Ethiopian Jews. The loci analyzed were CSF1PO, TPOX, and HUMTHO1. The typing was performed in sequencing polyacrylamide gels under denaturing conditions that could separate alleles with differences of a single base. Read More

View Article and Full-Text PDF
September 1999

Health risks of immigration: the Yemenite and Ethiopian cases in Israel.

N Trostler

Biomed Pharmacother 1997 ;51(8):352-9

Institute of Biochemistry, Food Science and Nutritional Science, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel.

Immigration almost always involves major cultural changes in dietary, social and health-related beliefs and behaviour. Two years after the arrival of the earliest Yemenite immigration wave to Israel, about 30 years ago, the prevalence rate of diabetes in that population was almost nonexistent (approximately 0.06%), increasing to approximately 12% 25 years later. Read More

View Article and Full-Text PDF
February 1998

The differences among Jewish communities--maternal and paternal contributions.

J Mol Evol 1993 Oct;37(4):435-40

Department of Genetics, Hebrew University of Jerusalem, Israel.

The haplotypes of Y chromosome (paternally inherited) and mtDNA (maternally inherited) were analyzed in representatives of six Jewish communities (Ashkenazic, North African, Near Eastern, Yemenite, Minor Asian/Balkanian, and Ethiopian). For both elements, the Ethiopian community has a mixture of typically African and typically Caucasian haplotypes and is significantly different from all others. The other communities, whose haplotypes are mostly Caucasian, are more closely related; significant differences that were found among some of them possibly indicate the effects of admixture with neighboring communities of non-Jews. Read More

View Article and Full-Text PDF
October 1993
  • Page 1 of 1