782 results match your criteria yeasts moulds

Antimicrobial Activity of First-in-Class Antifungal, Manogepix, and Comparator Agents Testing against Contemporary Invasive Fungal Isolates from an International Surveillance Program (2018-2019): In Vitro Activity of Manogepix against Fungal Isolates.

J Glob Antimicrob Resist 2021 May 26. Epub 2021 May 26.

JMI Laboratories, North Liberty, IA, USA.

Objectives: Manogepix, the active moiety of the prodrug fosmanogepix, is a novel antifungal with activity against major fungal pathogens including Candida (except C. krusei), Aspergillus, and difficult-to-treat/rare moulds. We tested manogepix and comparators against 2,669 contemporary (2018-2019) fungal isolates collected from 82 medical centers located in North America (42. Read More

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Marine microbial L-glutaminase: from pharmaceutical to food industry.

Appl Microbiol Biotechnol 2021 Jun 27;105(11):4453-4466. Epub 2021 May 27.

Department of Fisheries, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.

Deamination of L-glutamine to glutamic acid with the concomitant release of ammonia by the activity of L-glutaminase (L-glutamine amidohydrolase EC 3.5.1. Read More

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Diversity of yeasts and moulds in dairy products from Umbria, central Italy.

J Dairy Res 2021 May 14;88(2):217-220. Epub 2021 May 14.

Medicina Veterinaria, Laboratorio di Ispezione degli Alimenti di Origine Animale, Università degli Studi di Perugia, 06126, Perugia, Italy.

In this research communication we report on the diversity of yeast and mould species in 69 samples of milk and different dairy products from three plants located in Umbria, central Italy. Isolates were characterised both macroscopically and microscopically and then identified by PCR and genome sequencing of the ITS region and the D1-D2 domain of the large-subunit rRNA gene for filamentous fungi and yeasts, respectively. Out of the 69 samples analysed, 51 (73. Read More

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The role of oxidative stress in onychomycosis: Thiol/disulphide homeostasis.

Mycoses 2021 May 8. Epub 2021 May 8.

Department of Dermatology, Guglielmo Marconi University, Rome, Italy.

Objectives: Onychomycosis is the general term to define fungal nail infections that arise from dermatophytes, non-dermatophytic moulds and yeasts. Thiol/disulphide homeostasis is a new indicator of oxidative stress. In this study, we aimed to investigate the role of thiol/disulphide balance in the pathogenesis of onychomycosis. Read More

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High-Pressure Processing and Ultrasonication of Minimally Processed Potatoes: Effect on the Colour, Microbial Counts, and Bioactive Compounds.

Molecules 2021 Apr 29;26(9). Epub 2021 Apr 29.

Department of Food BioSciences, Teagasc Food Research Centre Ashtown, D15 KN3K Dublin5, Ireland.

HPP at 600 MPa alone, and in combination with US at 20 kHz (200 W), was applied to minimally processed potatoes of two commonly grown cultivars in Ireland. Changes in colour and microbial load (, total aerobic count, , yeasts, and moulds) were monitored in vacuum-packaged potatoes during 14 days of storage at 4 °C. HPP and HPP/US significantly ( < 0. Read More

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Effect of storage time and the level of formic acid on fermentation characteristics, epiphytic microflora, carbohydrate components and in vitro digestibility of rice straw silage.

Anim Biosci 2021 Jun 22;34(6):1038-1048. Epub 2021 Apr 22.

Institute of Ensiling and Processing of Grass, College of Agro-grassland Science, Nanjing Agricultural University, Nanjing 210095, China.

Objective: The study aimed to evaluate the effect of storage time and formic acid (FA) on fermentation characteristics, epiphytic microflora, carbohydrate components and in vitro digestibility of rice straw silage.

Methods: Fresh rice straw was ensiled with four levels of FA (0%, 0.2%, 0. Read More

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Categorisation of culturable bioaerosols in a fruit juice manufacturing facility.

PLoS One 2021 21;16(4):e0242969. Epub 2021 Apr 21.

Centre for Applied Food Sustainability and Biotechnology (CAFSaB), Faculty of Health and Environmental Sciences, Central University of Technology, Free State, Bloemfontein, South Africa.

Bioaerosols are defined as aerosols that comprise particles of biological origin or activity that may affect living organisms through infectivity, allergenicity, toxicity, or through pharmacological or other processes. Interest in bioaerosol exposure has increased over the last few decades. Exposure to bioaerosols may cause three major problems in the food industry, namely: (i) contamination of food (spoilage); (ii) allergic reactions in individual consumers; or (iii) infection by means of pathogenic microorganisms present in the aerosol. Read More

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Analysing indoor mycobiomes through a large-scale citizen science study in Norway.

Mol Ecol 2021 06 7;30(11):2689-2705. Epub 2021 May 7.

Section for Genetics and Evolutionary Biology (Evogene), Department of Biosciences, University of Oslo, Oslo, Norway.

In the built environment, fungi can cause important deterioration of building materials and have adverse health effects on occupants. Increased knowledge about indoor mycobiomes from different regions of the world, and their main environmental determinants, will enable improved indoor air quality management and identification of health risks. This is the first citizen science study of indoor mycobiomes at a large geographical scale in Europe, including 271 houses from Norway and 807 dust samples from three house compartments: outside of the building, living room and bathroom. Read More

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Phosphonates enantiomers receiving with fungal enzymatic systems.

Microb Cell Fact 2021 Apr 7;20(1):81. Epub 2021 Apr 7.

Department of Biochemistry, Molecular Biology and Biotechnology, Laboratory of Biotechnology, Wrocław University of Science and Technology, Wrocław, Poland.

Background: Phosphonates derivatives are in the area of interests because of their unique chemical-physical features. These compounds manifest variety of biological interactions within the sensitive living cells, including impact on particular enzymes activities. Biological "cause and effect" interactions are based upon the specific matching between the structures and/or compounds and this is usually the result of proper optical configurations of particular chiral moieties. Read More

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Ibrexafungerp: A First-in-Class Oral Triterpenoid Glucan Synthase Inhibitor.

J Fungi (Basel) 2021 Feb 25;7(3). Epub 2021 Feb 25.

Centre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses (CHARM), National Institute for Communicable Diseases, a Division of the National Health Laboratory Service, Johannesburg 2131, South Africa.

Ibrexafungerp (formerly SCY-078 or MK-3118) is a first-in-class triterpenoid antifungal or "fungerp" that inhibits biosynthesis of β-(1,3)-D-glucan in the fungal cell wall, a mechanism of action similar to that of echinocandins. Distinguishing characteristics of ibrexafungerp include oral bioavailability, a favourable safety profile, few drug-drug interactions, good tissue penetration, increased activity at low pH and activity against multi-drug resistant isolates including and In vitro data has demonstrated broad and potent activity against and species. Importantly, ibrexafungerp also has potent activity against azole-resistant isolates, including biofilm-forming spp. Read More

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February 2021

Superficial mycoses, a matter of concern: Global and Indian scenario-an updated analysis.

Mycoses 2021 Mar 4. Epub 2021 Mar 4.

Department of Botany, University of Jammu, Jammu, Jammu and Kashmir, India.

Superficial mycoses of skin, nails and hair are among the common fungal infections. They are caused by dermatophytes, non-dermatophyte moulds, yeasts and yeast-like fungi. Such fungal infections are widespread all over the world and are predominant in tropical as well as subtropical regions. Read More

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Bacterial and fungal communities and their predictive functional profiles in kinema, a naturally fermented soybean food of India, Nepal and Bhutan.

Food Res Int 2021 02 24;140:110055. Epub 2020 Dec 24.

DAICENTER (DBT-AIST International Centre for Translational and Environmental Research) and Bioinformatics Centre, Department of Microbiology, School of Life Sciences, Sikkim University, Gangtok 737102, Sikkim, India. Electronic address:

Bacterial and fungal communities in kinema, a naturally fermented soybean food of the Eastern Himalayan regions of India, Nepal and Bhutan were profiled by high-throughout sequence analysis. Firmicutes (78.4%) was the most abundant phylum in kinema, followed by Proteobacteria (14. Read More

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February 2021

Evaluation of Rhodotorula spp. contamination in hospital environments.

Environ Monit Assess 2021 Mar 1;193(3):152. Epub 2021 Mar 1.

Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Microbiological monitoring of air and surfaces is a valuable tool for assessing the level of environmental contamination by bacteria and fungi in hospitals, especially in high-risk wards. The presence of these microorganisms requires strict control in view of their role as opportunistic pathogens. As regard yeasts, Candida albicans is one of the main opportunistic pathogens. Read More

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[Changing Trends in Isolation Frequencies and Species of Clinical Fungal Strains: What Do the 12-years (2008-2019) Mycology Laboratory Data Tell About?]

Mikrobiyol Bul 2021 Jan;55(1):53-66

Hacettepe University Faculty of Medicine, Department of Medical Microbiology, Ankara, Turkey.

The frequency and variety of infections caused by fungi are increasing. However, changes and intercenter and regional differences are observed in the distribution of fungal species over the years. It is important to update the epidemiological data in order to enable early and appropriate treatment. Read More

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January 2021

Optimizing the structure of (salicylideneamino)benzoic acids: Towards selective antifungal and anti-staphylococcal agents.

Eur J Pharm Sci 2021 Apr 22;159:105732. Epub 2021 Jan 22.

Department of Organic and Bioorganic Chemistry, Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 500 05 Hradec Králové, Czech Republic.

An increasing resistance of human pathogenic bacteria and fungi has become a global health problem. Based on previous reports of 4-(salicylideneamino)benzoic acids, we designed, synthesised and evaluated their me-too analogues as potential antimicrobial agents. Forty imines derived from substituted salicylaldehydes and aminobenzoic acids, 4-aminobenzoic acid esters and 4-amino-N-phenylbenzamide were designed using molecular hybridization and prodrug strategies. Read More

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Synthesis and Properties of Cleavable Quaternary Ammonium Compounds.

J Oleo Sci 2021 ;70(1):59-65

Universidad Nacional del Litoral, CONICET, Grupo de Medio Ambiente, Instituto de Desarrollo Tecnológico para la Industria Química (INTEC).

Quaternary ammonium compounds are widely used as antiseptic and disinfectant. It is been a concern that their widespread use will lead to an increase of environmental problems, therefore the development of biodegradable surfactants is necessary. The present research is aimed at the design of novel amphiphilic molecules with similar properties to those already known but more biodegradable. Read More

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Oral cysteamine as an adjunct treatment in cystic fibrosis pulmonary exacerbations: An exploratory randomized clinical trial.

PLoS One 2020 28;15(12):e0242945. Epub 2020 Dec 28.

NovaBiotics Ltd, Aberdeen, United Kingdom.

Background: Emerging data suggests a possible role for cysteamine as an adjunct treatment for pulmonary exacerbations of cystic fibrosis (CF) that continue to be a major clinical challenge. There are no studies investigating the use of cysteamine in pulmonary exacerbations of CF. This exploratory randomized clinical trial was conducted to answer the question: In future pivotal trials of cysteamine as an adjunct treatment in pulmonary exacerbations of CF, which candidate cysteamine dosing regimens should be tested and which are the most appropriate, clinically meaningful outcome measures to employ as endpoints?

Methods And Findings: Multicentre double-blind randomized clinical trial. Read More

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January 2021

Sphingolipid-enriched domains in fungi.

FEBS Lett 2020 11;594(22):3698-3718

Centro de Química Estrutural, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Portugal.

Plasma membrane carries out multiple physiological functions that require its dynamic and tightly regulated organization into specialized domains of different size, stability, and lipid/protein composition. Sphingolipids are a group of lipids in which the plasma membrane is particularly enriched, thus being crucial for its structure and function. A specific type of sphingolipid-enriched plasma membrane domains, where ergosterol is depleted and lipids are tightly packed in a rigid gel phase, has recently been found in several fungal species, including yeasts and moulds. Read More

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November 2020

Aetiology of superficial fungal infections of the foot in urban outpatients in mainland China: A multicentre, prospective case study.

Mycoses 2020 Nov 9;63(11):1235-1243. Epub 2020 Sep 9.

Department of Dermatology and Venerology, Peking University First Hospital, Beijing, China.

Background: In China, the prevalence of superficial fungal infections of the foot is high and recurrence is common. However, a prospective, large-scale and multicentre study on the aetiology of superficial fungal infections of the foot is still lacking.

Objectives: To study the epidemiology of aetiological agents of superficial fungal infections of the foot in urban outpatients in mainland China, as well as to understand the aetiology features of the pathogenic agent. Read More

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November 2020

Assessing the microbiological contamination along with environmental factors of old books in the 1490-founded Bistrița Monastery, Romania.

Environ Sci Pollut Res Int 2021 Feb 17;28(7):8743-8757. Epub 2020 Oct 17.

Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 29 N. Jiga St., 410028, Oradea, Romania.

Microbial contamination and damaging effects due to environmental factors (temperature, humidity) of old books is an extremely important issue in the heritage preserving field, being a great threat to this unique cultural and literary treasure. This paper analysed the indoor environmental conditions, the microbiological characteristics of the air and the condition itself of 27 clerical books (from eighteenth to nineteenth centuries), randomly chosen from the library of Bistrița Monastery, Romania. The analysis revealed that most of the books were contaminated and damaged by moulds and yeasts. Read More

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February 2021

Introduction of a bead beating step improves fungal DNA extraction from selected patient specimens.

Int J Med Microbiol 2020 Sep 5;310(6):151443. Epub 2020 Aug 5.

Department of Haematology, Oncology and Clinical Immunology, University of Duesseldorf, Medical Faculty, Duesseldorf, Germany.

In immunocompromised patients a colonisation with fungi carries the risk to develop serious invasive fungal infection. An early detection is therefore important, but not optimal hitherto. Fortunately, molecular genetic methods have increased the sensitivity of fungal detection and limited the time, until results are available. Read More

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September 2020

Effect of Different Method of Drying of Five Varieties Grapes (, L.) on the Bunch Stem on Physicochemical, Microbiological, and Sensory Quality.

Foods 2020 Aug 26;9(9). Epub 2020 Aug 26.

Department of Animal Science and Technology, Faculty of Agriculture, University of Zagreb, 10000 Zagreb, Croatia.

The influence of the drying technique on certain quality attributes of dried grapes was analysed. Five varieties of grape were used in this study (Bezsemenné, Perlette, Vrboska, Beauty seedless, and Jakubské). All the varieties were dried using four methods: drying at 40 °C, combined drying (70, 65, and 60 °C), drying at 70 °C, and lyophilisation. Read More

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Developing a Commercial Antimicrobial Active Packaging System of Ground Beef Based on "" Alcoholic Distillate.

Foods 2020 Aug 25;9(9). Epub 2020 Aug 25.

Laboratory of Food Quality Control and Hygiene, Department of Food Science & Human Nutrition, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece.

The present study aimed to develop a commercial active packaging system of ground beef, by exploiting the antimicrobial and antioxidant properties of a traditional Greek alcoholic distillate called "". Commercial packages (500 g) were used and 40 mL of "" was added in absorbent pads placed underneath the ground beef, while 10 mL was also mounted under the packaging film, facing the headspace. Samples were packaged in 80% O: 20% CO and stored at 0, 4, 8, and 12 °C. Read More

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Fungi in sands of Mediterranean Sea beaches of Israel-Potential relevance to human health and well-being.

Mycoses 2020 Aug 23. Epub 2020 Aug 23.

Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Sand of sea harbour bacteria that may cause enteric and other infections in humans, and are controlled by regulatory measures. Data on fungi in sea sand are scarce. Thus, an international group of mycologists was formed to explore fungal flora in sand of various waterbodies. Read More

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Nationwide surveillance of azole-resistant Aspergillus fumigatus environmental isolates in Greece: detection of pan-azole resistance associated with the TR46/Y121F/T289A cyp51A mutation.

J Antimicrob Chemother 2020 11;75(11):3181-3188

Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background: Acquired azole resistance (AR) in Aspergillus fumigatus emphasizes the importance of the One Health multisectorial approach. The prevalence of azole-resistant A. fumigatus in the environment of Greece is unknown. Read More

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November 2020

Biochemical characterisation of class III biotin protein ligases from Botrytis cinerea and Zymoseptoria tritici.

Arch Biochem Biophys 2020 09 25;691:108509. Epub 2020 Jul 25.

School of Biological Sciences, The University of Adelaide, South Australia, 5005, Australia; Institute for Photonics and Advanced Sensing (IPAS), The University of Adelaide, South Australia, 5005, Australia. Electronic address:

Biotin protein ligase (BPL) is an essential enzyme in all kingdoms of life, making it a potential target for novel anti-infective agents. Whilst bacteria and archaea have simple BPL structures (class I and II), the homologues from certain eukaryotes such as mammals, insects and yeast (class III) have evolved a more complex structure with a large extension on the N-terminus of the protein in addition to the conserved catalytic domain. The absence of atomic resolution structures of any class III BPL hinders structural and functional analysis of these enzymes. Read More

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September 2020

Silage making of maize stover and banana pseudostem under South Ethiopian conditions: evolution of pH, dry matter and microbiological profile.

Microb Biotechnol 2020 09 24;13(5):1477-1488. Epub 2020 Jul 24.

Department of Microbial and Molecular Systems, Lab4Food, KU Leuven, Geel Campus, Geel, Belgium.

The study was conducted to evaluate the microbial dynamics during silage of maize stover and banana pseudostem in the environmental conditions of southern Ethiopia. To meet this objective, microsilos containing either maize stover or banana pseudostem, both with and without molasses, were prepared. Subsequently, samples were analysed on day 0, 7, 14, 30, 60 and 90 of the fermentation process. Read More

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September 2020

Microbiological assessment of liquid feed for finisher pigs on commercial pig units.

J Appl Microbiol 2021 Feb 10;130(2):356-369. Epub 2020 Aug 10.

Teagasc, Pig Development Department, Animal and Grassland Research and Innovation Centre, Moorepark, Fermoy, County Cork, Ireland.

Aims: To investigate the microbiological and nutritional quality of liquid finisher pig feed on commercial production units and the factors influencing this.

Methods And Results: Microbiological and physio-chemical analyses were performed on liquid feed sampled from the mixing tank and troughs of the finisher section of eight commercial pig units. Lactic acid bacteria, yeast and Escherichia coli counts, as well as lactic acid, ethanol and acetate concentrations were higher in residual feed sampled from the troughs compared with mixing tank samples (P < 0·001). Read More

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February 2021

Use of ultrafiltrated cow's whey for the production of whey cheese with Kefir or probiotics.

J Sci Food Agric 2021 Jan 6;101(2):555-563. Epub 2020 Aug 6.

Polytechnic Institute of Coimbra, College of Agriculture, Coimbra, Portugal.

Background: In Southern European countries, whey cheeses are normally produced with ovine or caprine whey. Cow's cheese whey can also be used, although the whey cheese yield is low (2-3%, w/v) which discourages its use. In the present study, bovine cheese whey was concentrated by ultrafiltration for the production of four types of whey cheeses (Requeijão): conventional, without any addition (WC); with 10% (w/w) addition of cream (WCC); with cream fermented with Kefir culture (WCCK); and with cream fermented with Bifidobacterium sp. Read More

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January 2021

Study of the bioremediatory capacity of wild yeasts.

Sci Rep 2020 07 9;10(1):11265. Epub 2020 Jul 9.

Department of Analytical Chemistry and Food Technology, University of Castilla-La Mancha, Camilo José Cela Avenue, 13071, Ciudad Real, Spain.

Microbial detoxification has been proposed as a new alternative for removing toxins and pollutants. In this study, the biodetoxification activities of yeasts against aflatoxin B and zinc were evaluated by HPLC and voltammetric techniques. The strains with the best activity were also subjected to complementary assays, namely biocontrol capability and heavy-metal resistance. Read More

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