24,239 results match your criteria yeasts associated

No Impact of Fluconazole to Echinocandins Replacement as First-Line Therapy on the Epidemiology of Yeast Fungemia (Hospital-Driven Active Surveillance, 2004-2017, Paris, France).

Front Med (Lausanne) 2021 20;8:641965. Epub 2021 Apr 20.

Institut Pasteur, CNRS, Unité de Mycologie Moléculaire, Centre National de Référence Mycoses Invasives et Antifongiques, Paris, France.

Replacement of fluconazole by echinocandins as the first-line therapy for yeast-related fungemia could have an impact on both the mortality rate and the epidemiology of yeast species responsible for candidemia. We analyzed the individual clinical and microbiological data collected through the active surveillance program on yeast fungemia (YEASTS program, 2004-2016, Paris area, France) within 14 University Hospitals. The cohort included 3,092 patients [male:female ratio: 1. Read More

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Fungaemia due to rare yeasts in paediatric intensive care units: a prospective study.

Mycoses 2021 May 3. Epub 2021 May 3.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Considering the emergence of fungaemia due to rare yeasts at our centre, we performed a systematic epidemiologic study on fungaemia due to rare yeast.

Objectives: We undertook the present prospective observational study to explore the epidemiological features, clinical characteristics, of fungaemia due to rare yeasts in paediatric ICUs at our centre.

Methods: The successive yeasts isolated from blood at our PICUs during December 2017 through March 2019 were identified by molecular methods. Read More

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Genomic analysis of novel Yarrowia-like yeast symbionts associated with the carrion-feeding burying beetle Nicrophorus vespilloides.

BMC Genomics 2021 May 3;22(1):323. Epub 2021 May 3.

Department of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology, Ohlebergsweg 12, 35392, Giessen, Germany.

Background: Mutualistic interactions with microbes can help insects adapt to extreme environments and unusual diets. An intriguing example is the burying beetle Nicrophorus vespilloides, which feeds and reproduces on small vertebrate carcasses. Its fungal microbiome is dominated by yeasts that potentially facilitate carcass utilization by producing digestive enzymes, eliminating cadaver-associated toxic volatiles (that would otherwise attract competitors), and releasing antimicrobials to sanitize the microenvironment. Read More

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Production of Biosurfactants by Ascomycetes.

Int J Microbiol 2021 14;2021:6669263. Epub 2021 Apr 14.

Mycology Laboratory, National Institute for Amazonian Research (INPA), Manaus, Brazil.

Surfactants are utilized to reduce surface tension in aqueous and nonaqueous systems. Currently, most synthetic surfactants are derived from petroleum. However, these surfactants are usually highly toxic and are poorly degraded by microorganisms. Read More

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Uncovering the hidden bacterial ghost communities of yeast and experimental evidences demonstrates yeast as thriving hub for bacteria.

Sci Rep 2021 Apr 30;11(1):9394. Epub 2021 Apr 30.

Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Hyderabad, India.

Our major concern was to address "yeast endobacteria" which was based on a few reports in the recent past where bacteria may find yeast as a niche for survival. In this study, we report the microbiota of twenty-nine axenic yeast cultures recovered from different habitats based on their 16S rRNA gene-amplicon metagenomes. Yeasts were identified based on D1/D2 or ITS gene sequences. Read More

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A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson's Disease Affects LRRK2 Protein Levels.

Int J Mol Sci 2021 Apr 2;22(7). Epub 2021 Apr 2.

Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.

() is a major causative gene of late-onset familial Parkinson's disease (PD). The suppression of kinase activity is believed to confer neuroprotection, as most pathogenic variants of associated with PD exhibit increased kinase activity. We herein report a novel variant-p. Read More

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pH-Dependent Expression, Stability, and Activity of MrLip5 Lipase.

Ann Dermatol 2020 Dec 11;32(6):473-480. Epub 2020 Nov 11.

Department of Dermatology, Konkuk University School of Medicine, Korea.

Background: The lipophilic yeasts spp. are normally resident on the surface of the human body, and often associated with various skin diseases. Of the 18 known spp. Read More

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December 2020

Whole genome sequencing of a clinical drug resistant isolate reveals known and novel mutations in genes involved in resistance acquisition mechanisms.

J Med Microbiol 2021 Apr;70(4)

Biomedical Center, Faculty of Medicine in Pilsen, Charles University, 32300 Pilsen, Czech Republic.

is an opportunistic pathogen accounting for the majority of cases of infections. Currently, are developing resistance towards different classes of antifungal drugs and this has become a global health burden that does not spare Lebanon. This study aims at determining point mutations in genes known to be involved in resistance acquisition and correlating resistance to virulence and ergosterol content in the azole resistant isolate CA77 from Lebanon. Read More

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Antimicrobial activity of bioactive compounds of and against human pathogenic microorganisms.

Iran J Microbiol 2021 Feb;13(1):98-103

Department of Microbiology, Faculty of Health Sciences, University of Talca, Talca, Chile.

Background And Objectives: and are medicinal shrubs native to Chile and are popularly known as "Bailahuén". Regularly, this plant is used for liver, digestive and renal affections, as well as colds and the cleaning of infected wounds. The aim of the study was to identify the responsible compounds for the antimicrobial activity of and

Materials And Methods: Infusions and ethanolic extracts of and were analysed by thin-layer chromatography bioautography (TLC-B) to determine the compounds responsible for the antimicrobial activity against Gram-positive and Gram-negative bacterial strains and yeasts of Bailahuén. Read More

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February 2021

Ambulatory induction phase treatment of cryptococcal meningitis in HIV integrated primary care clinics, Yangon, Myanmar.

BMC Infect Dis 2021 Apr 21;21(1):375. Epub 2021 Apr 21.

Medical Action Myanmar, Yangon, Myanmar.

Background: Cryptococcal meningitis (CM) is a common HIV-associated opportunistic-infection worldwide. Existing literature focusses on hospital-based outcomes of induction treatment. This paper reviews outpatient management in integrated primary care clinics in Yangon. Read More

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Human testis-expressed (TEX) genes: a review focused on spermatogenesis and male fertility.

Basic Clin Androl 2021 Apr 22;31(1). Epub 2021 Apr 22.

Département de Génétique, CHI de Poissy St Germain en Laye, Poissy, France.

Spermatogenesis is a complex process regulated by a multitude of genes. The identification and characterization of male-germ-cell-specific genes is crucial to understanding the mechanisms through which the cells develop. The term "TEX gene" was coined by Wang et al. Read More

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Intermediate thermoresistance in black yeast asexual cells variably increases with culture age, promoting survival and spoilage in thermally processed shelf-stable foods.

J Food Prot 2021 Apr 20. Epub 2021 Apr 20.

Cornell University College of Arts and Sciences 411 Tower Rd. UNITED STATES Ithaca 14853 (607) 255-2379.

Black yeasts are a functional group that has caused spoilage in cold-filled and hot-filled beverages as well as other water activity (a w )-controlled food products. We established quantitative thermoresistance parameters for the inactivation of 12 Aureobasidium and Exophiala isolates through isothermal experiments and a challenge study. Culture age (2-day vs. Read More

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Viruses in fermented foods: are they good or bad? Two sides of the same coin.

Food Microbiol 2021 Sep 25;98:103794. Epub 2021 Mar 25.

Department of Bioprocess Engineering and Biotechnology, Federal University of Paraná (UFPR), Curitiba, PR, Brazil.

The emergence of Coronavirus disease 2019 as a global pandemic has increased popular concerns about diseases caused by viruses. Fermented foods containing high loads of viable fungi and bacteria are potential sources for virus contamination. The most common include viruses that infect bacteria (bacteriophage) and yeasts reported in fermented milks, sausages, vegetables, wine, sourdough, and cocoa beans. Read More

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September 2021

Oral candidal carriage and its association with dental carious lesions in asymptomatic adults: a cross-sectional study from the UAE.

BMC Oral Health 2021 04 19;21(1):197. Epub 2021 Apr 19.

College of Dental Medicine, University of Sharjah, Room M28-130, PO Box 27272, Sharjah, UAE.

Background: Candida's potential association with dental caries has previously been reported in children. This research aimed at investigating the associations between Candida species in whole saliva and dental and periodontal health indices in a sample of adult patients.

Methods: A cross-sectional study involving 160 patients investigated the associations between Candida species collected by oral rinse technique, and Decayed, Missing, and Filled Surfaces (DMFS), and periodontal health indices. Read More

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Signatures of optimal codon usage in metabolic genes inform budding yeast ecology.

PLoS Biol 2021 Apr 19;19(4):e3001185. Epub 2021 Apr 19.

Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.

Reverse ecology is the inference of ecological information from patterns of genomic variation. One rich, heretofore underutilized, source of ecologically relevant genomic information is codon optimality or adaptation. Bias toward codons that match the tRNA pool is robustly associated with high gene expression in diverse organisms, suggesting that codon optimization could be used in a reverse ecology framework to identify highly expressed, ecologically relevant genes. Read More

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Telomere Replication: Solving Multiple End Replication Problems.

Front Cell Dev Biol 2021 1;9:668171. Epub 2021 Apr 1.

Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Cancer Research Pavilion, Université de Sherbrooke, Sherbrooke, QC, Canada.

Eukaryotic genomes are highly complex and divided into linear chromosomes that require end protection from unwarranted fusions, recombination, and degradation in order to maintain genomic stability. This is accomplished through the conserved specialized nucleoprotein structure of telomeres. Due to the repetitive nature of telomeric DNA, and the unusual terminal structure, namely a protruding single stranded 3' DNA end, completing telomeric DNA replication in a timely and efficient manner is a challenge. Read More

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Cottonseed Press Cake as a Potential Diet for Industrially Farmed Black Soldier Fly Larvae Triggers Adaptations of Their Bacterial and Fungal Gut Microbiota.

Front Microbiol 2021 29;12:634503. Epub 2021 Mar 29.

Department of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology, Giessen, Germany.

Black soldier fly larvae (, Diptera: Stratiomyidae) are used for the bioconversion of organic side products into valuable compounds such as proteins, lipids and chitin. However, the economic competitiveness of farmed insects compared to conventional protein production systems in agriculture and aquaculture depends on the availability of large quantities of inexpensive insect feed. Cottonseed press cake (CPC) is a side-stream of cotton production that is rich in proteins and lipids but unsuitable as feed for several farmed animals, except ruminants, due to the presence of the anti-nutritional sesquiterpenoid gossypol. Read More

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Survival of Salmonella and Shiga Toxin-producing Escherichia coli and Changes in Indigenous Microbiota During Fermentation of Kombucha Made from Home-brewing Kits.

J Food Prot 2021 Apr 14. Epub 2021 Apr 14.

University of Georgia Center for Food Safety 1109 Experiment St. UNITED STATES Griffin GA 30223-1797.

Survival and growth of Salmonella and Shiga toxin-producing Escherichia coli (STEC) in kombucha prepared from four brands of commercially available kombucha kits intended for use by home brewers were investigated. Changes in microbiota responsible for fermentation were also determined. An initial population of Salmonella (6. Read More

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Metabolic differences between a wild and a wine strain of Saccharomyces cerevisiae during fermentation unveiled by multi-omic analysis.

Environ Microbiol 2021 Apr 13. Epub 2021 Apr 13.

Instituto de Agroquímica y Tecnología de los Alimentos, IATA-CSIC, Paterna, E-46980, Spain.

Saccharomyces cerevisiae, a widespread yeast present both in the wild and in fermentative processes, like winemaking. During the colonization of these human-associated fermentative environments, certain strains of S. cerevisiae acquired differential adaptive traits that enhanced their physiological properties to cope with the challenges imposed by these new ecological niches. Read More

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Sapwood and heartwood affect differentially bacterial and fungal community structure and successional dynamics during Quercus petraea decomposition.

Environ Microbiol 2021 Apr 13. Epub 2021 Apr 13.

Université de Lorraine, INRAE, UMR IAM, Centre INRAE-Grand Est-Nancy, 54280 Champenoux, Nancy, F-54000, France.

In forests, bacteria and fungi are key players in wood degradation. Still, studies focusing on bacterial and fungal successions during the decomposition process depending on the wood types (i.e. Read More

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Keratinocyte IL-36 receptor/MyD88 signaling mediates Malassezia-induced IL-17-dependent skin inflammation.

J Infect Dis 2021 Apr 10. Epub 2021 Apr 10.

Department of Dermatology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Background: Among skin commensal fungi, lipophilic Malassezia species exist on nearly all human skin surfaces. The pathophysiology of Malassezia-associated skin diseases remains poorly understood due in part to the lack of appropriate animal models.

Objective: To investigate the mechanisms underlying Malassezia-induced skin inflammation using a novel murine model that physiologically recapitulates Malassezia skin infection. Read More

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Analysing indoor mycobiomes through a large-scale citizen science study in Norway.

Mol Ecol 2021 Apr 8. Epub 2021 Apr 8.

Section for Genetics and Evolutionary Biology (Evogene), Department of Biosciences, University of Oslo, Oslo, Norway.

In the built environment, fungi can cause important deterioration of building materials and have adverse health effects on occupants. Increased knowledge about indoor mycobiomes from different regions of the world, and their main environmental determinants, will enable improved indoor air quality management and identification of health risks. This is the first citizen science study of indoor mycobiomes at a large geographical scale in Europe, including 271 houses from Norway and 807 dust samples from three house compartments: outside of the building, living room and bathroom. Read More

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Bioethanolic yeasts from dung beetles: tapping the potential of extremophilic yeasts for improvement of lignocellulolytic feedstock fermentation.

Biotechnol Biofuels 2021 Apr 7;14(1):86. Epub 2021 Apr 7.

Department of Biological Sciences and Biotechnology, Botswana International University of Science and Technology, Private Bag 16, Palapye, Botswana.

Bioethanol from abundant and inexpensive agricultural and industrial wastes possesses the potential to reduce greenhouse gas emissions. Bioethanol as renewable fuel addresses elevated production costs, as well as food security concerns. Although technical advancements in simultaneous saccharification and fermentation have reduced the cost of production, one major drawback of this technology is that the pre-treatment process creates environmental stressors inhibitory to fermentative yeasts subsequently reducing bioethanol productivity. Read More

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Learning about microbial language: possible interactions mediated by microbial volatile organic compounds (VOCs) and relevance to understanding Malassezia spp. metabolism.

Metabolomics 2021 04 7;17(4):39. Epub 2021 Apr 7.

Cellular and Molecular of Pathogenic Microorganisms Research Group (CeMoP), Biological Sciences Department, Universidad de Los Andes, Cra 1 No. 18A-12, Bogotá, 111711, Cundinamarca, Colombia.

Background: Microorganisms synthesize and release a large diversity of small molecules like volatile compounds, which allow them to relate and interact with their environment. Volatile organic compounds (VOCs) are carbon-based compounds with low molecular weight and generally, high vapor pressure; because of their nature, they spread easily in the environment. Little is known about the role of VOCs in the interaction processes, and less is known about VOCs produced by Malassezia, a genus of yeasts that belongs to the human skin mycobiota. Read More

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The Vps13 Family of Lipid Transporters and Its Role at Membrane Contact Sites.

Int J Mol Sci 2021 Mar 12;22(6). Epub 2021 Mar 12.

Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

The conserved VPS13 proteins constitute a new family of lipid transporters at membrane contact sites. These large proteins are suspected to bridge membranes and form a direct channel for lipid transport between organelles. Mutations in the 4 human homologs () are associated with a number of neurological disorders, but little is known about their precise functions or the relevant contact sites affected in disease. Read More

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Biosurfactants from Filamentous Fungi-A Preliminary Study.

Biomolecules 2021 Mar 30;11(4). Epub 2021 Mar 30.

Department of Biotechnology and Food Microbiology, Wroclaw University of Environmental and Life Sciences, 37 Chelmonskiego Street, 51-630 Wroclaw, Poland.

Biosurfactants represent a structurally diverse group of secondary metabolites produced by bacteria, yeasts, and filamentous fungi. Their character is often associated with numerous additional properties. The observation of fungi of various species used as a source of bioinhibitors against pathogenic plants fungi focuses attention to the often quite specific behavior of preparations in contact with, among others, plant leaves, dependent on strain. Read More

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Antibiotics as a Stressing Factor Triggering the Harboring of J99 within ATCC10231.

Pathogens 2021 Mar 23;10(3). Epub 2021 Mar 23.

Laboratory of Bacterial Pathogenicity, Department of Microbiology, Faculty of Biological Sciences, Universidad de Concepción, Concepción 4070386, Chile.

First-line treatment for includes amoxicillin and clarithromycin or metronidazole plus a proton pump inhibitor. Treatment failure is associated with antibiotic resistance and possibly also with internalization of into eukaryotic cells, such as yeasts. Factors triggering the entry of into yeast are poorly understood. Read More

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Technological and Safety Attributes of Lactic Acid Bacteria and Yeasts Isolated from Spontaneously Fermented Greek Wheat Sourdoughs.

Microorganisms 2021 Mar 24;9(4). Epub 2021 Mar 24.

Laboratory of Food Quality Control and Hygiene, Department of Food Science and Human Nutrition, Agricultural University of Athens, 11855 Athens, Greece.

The aim of the present study was to assess the technological and safety potential of 207 lactic acid bacteria (LAB) and 195 yeast strains isolated from spontaneously fermented Greek wheat sourdoughs. More accurately, the amylolytic, proteolytic, lipolytic, phytase and amino acid decarboxylase activities, along with the production of exopolysaccharides and antimicrobial compounds by the LAB and yeast isolates, were assessed. A well diffusion assay revealed seven proteolytic LAB and eight yeast strains; hydrolysis of tributyrin was evident only in 11 LAB strains. Read More

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Addition of Grape Skin and Stems Extracts in Wines during the Storage to Reduce the Sulfur Dioxide: Impact on Red Wine Quality.

Int J Environ Res Public Health 2021 03 9;18(5). Epub 2021 Mar 9.

School of Agricultural Engineering, University of Extremadura, Avda, Adolfo Suárez s/n, 06071 Badajoz, Spain.

This study aimed to evaluate the usefulness of bioactive extracts obtained from red wine by-products, such as grape skins and stems, for reducing or eliminating the use of SO in red wine production. Special attention was focused on guaranteeing the microbiological stability of the red wines and protecting them against oxidation. Therefore, the antioxidant and antimicrobial activities of the extracts and red wines were studied. Read More

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Evaluation of Recombinant Kpkt Cytotoxicity on HaCaT Cells: Further Steps towards the Biotechnological Exploitation Yeast Killer Toxins.

Foods 2021 Mar 8;10(3). Epub 2021 Mar 8.

Department of Agricultural Sciences, University of Sassari, Viale Italia 39, 07100 Sassari, Italy.

The soil yeast secretes a killer toxin, named Kpkt, that shows β-glucanase activity and is lethal to wine spoilage yeasts belonging to , and . When expressed in , recombinant Kpkt displays a wider spectrum of action as compared to its native counterpart, being active on a vast array of wine yeasts and food-related bacteria. Here, to gather information on recombinant Kpkt cytotoxicity, lyophilized preparations of this toxin (LrKpkt) were obtained and tested on immortalized human keratinocyte HaCaT cells, a model for the stratified squamous epithelium of the oral cavity and esophagus. Read More

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