Invest Radiol 2021 Jun 11. Epub 2021 Jun 11.
From the Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA CytoAnalytics, Denver, CO Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA Department of Radiology, Hospital Garcia de Orta, Almada Department of Radiology, Hospital da Luz, Lisbon, Portugal Richard Semelka Consulting, PLLC, Chapel Hill, NC.
Purpose: The aim of this study was to investigate the feasibility of measuring early changes in serum cytokine levels after intravenous diethylenetriaminepentaacetic acid (Ca-DTPA) chelation in patients manifesting either gadolinium deposition disease (GDD) or gadolinium storage condition (GSC) and the possible usefulness of this method in further research.
Methods: Four patients with recent-onset GDD (≤1 year) and 2 patients with long-standing GSC (4 and 9 years) underwent chelation with intravenous bolus administration of Ca-DTPA. Multiple blood draws were performed to measure serum cytokines: at T = 0 (before Ca-DTPA injection) and 1, 5, 10, 30, 60 minutes, and 24 hours after Ca-DTPA injection. Read More