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Differential auditory brain response abnormalities in two intellectual disability conditions: SYNGAP1 mutations and Down syndrome.

Clin Neurophysiol 2021 May 13;132(8):1802-1812. Epub 2021 May 13.

Department of Psychology, University of Montreal, Montreal, Québec, Canada; CHU Sainte-Justine Research Center, Montreal, Quebec, Canada. Electronic address:

Objective: Altered sensory processing is common in intellectual disability (ID). Here, we study electroencephalographic responses to auditory stimulation in human subjects presenting a rare condition (mutations in SYNGAP1) which causes ID, epilepsy and autism.

Methods: Auditory evoked potentials, time-frequency and inter-trial coherence analyses were used to compare subjects with SYNGAP1 mutations with Down syndrome (DS) and neurotypical (NT) participants (N = 61 ranging from three to 19 years of age). Read More

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Promoting cross-regional collaboration in antimicrobial stewardship: Findings of an infectious diseases working group survey in Arab countries of the Middle East.

J Infect Public Health 2021 Apr 24;14(7):978-984. Epub 2021 Apr 24.

American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Background: Antimicrobial resistance is a significant global issue that presents an increasing threat to patients' wellbeing. Although a global concern, the emergence of multi-drug resistant organisms is of particular significance in the Middle East. In recent years, this region has seen an alarming increase in antimicrobial resistance presenting a major challenge to physicians managing various infectious diseases. Read More

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Optimizing Order of Administration for Concussion Baseline Assessment Among NCAA Student-Athletes and Military Cadets.

Sports Med 2021 Jun 15. Epub 2021 Jun 15.

UGA Concussion Research Laboratory, Department of Kinesiology, University of Georgia, Ramsey Student Center, 330 River Rd., Athens, GA, 30606, USA.

Background: Concussion pre-injury (i.e., baseline) assessments serve as a benchmark comparison point in the event an individual sustains a concussion and allows clinicians to compare to post-injury measures. Read More

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Childhood adiposity associated with expanded effector memory CD8 + and Vδ2 +Vγ9 + T cells.

J Clin Endocrinol Metab 2021 Jun 15. Epub 2021 Jun 15.

Department of Pediatrics, Sophia Children's Hospital, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Context: Adult obesity is associated with chronic low-grade inflammation and may give rise to future chronic disease. However, it is unclear whether adiposity-related inflammation is already apparent at young age.

Objective: To study associations between child's adiposity measures with circulating monocytes and naive and memory subsets in CD4, CD8, and γδ T-cell lineages. Read More

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Developing a Framework for Pandemic COVID-19 Vaccine Allocation: a Modified Delphi Consensus Study in Korea.

J Korean Med Sci 2021 Jun 14;36(23):e166. Epub 2021 Jun 14.

Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: This study presents a framework for determining the allocation and distribution of the limited amount of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods: After analyzing the pandemic strategies of the major organizations and countries and with a literature review conducted by a core panel, a modified Delphi survey was administered to 13 experts in the fields of vaccination, infectious disease, and public health in the Republic of Korea. The following topics were discussed: 1) identifying the objectives of the vaccination strategy, 2) identifying allocation criteria, and 3) establishing a step-by-step vaccination framework and prioritization strategy based on the allocation criteria. Read More

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Perceived Discrimination, Nativity, and Cognitive Performance in a Multi-ethnic Study of Older Adults: Findings from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study.

J Gerontol A Biol Sci Med Sci 2021 Jun 14. Epub 2021 Jun 14.

Department of Public Health Sciences, University of California, Davis, Davis, CA.

Background: Despite growing research on the association between discrimination and disparities in cognitive aging, an evidence gap remains on how the association varies by racial/ethnic group. This study evaluates the associations of experiences of discrimination with cognitive function and whether these associations varied by race/ethnicity and nativity.

Methods: Using the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) cohort (N=1,712) with approximately equal groups of Black, White, Latino, and Asian community-dwelling older adults aged 65 years and older, we evaluated the associations between self-reported experiences of everyday and major lifetime discrimination with overall cognitive performance and domain-specific cognition (verbal episodic memory, semantic memory and executive functioning) across race/ethnicity and nativity. Read More

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A comparison of phenomenological, clinical and familial psychiatric features of pediatric OCD and trichotillomania.

Int J Psychiatry Clin Pract 2021 Jun 14:1-9. Epub 2021 Jun 14.

Public Health Professional, Osmaniye Community Health Center, Tuberculosis Dispensary, Osmaniye, Turkey.

Objectives: Although trichotillomania (TTM) is classified in the obsessive-compulsive disorders (OCD) chapter of the DSM-5, several studies showed that it has several differences. The aim of this study was to examine the phenomenology, comorbidity, and family psychiatric characteristisc of childhood TTM and OCD.

Methods: This study compared youth ages 6-17 years with a primary diagnosis of TTM ( = 63) to those with primary OCD ( = 65) on clinical and familial psychiatric characteristics. Read More

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Patient satisfaction with services at the Family Medicine Employee Clinic in a tertiary hospital in Riyadh.

J Family Med Prim Care 2021 Apr 29;10(4):1754-1758. Epub 2021 Apr 29.

Department of Family and Community Medicine, College of Medicine, King Saud University Medical City, Riyadh, Saudi Arabia.

Background: Patient satisfaction reflects the healthcare quality of the facility. Therefore, it is important to determine satisfaction level of the patient satisfaction in order to improve services'quality provided to patients.

Aim: to assess the satisfaction level of patients at the Family Medicine Employee Clinic at a tertiary hospital in Riyadh, Saudi Arabia. Read More

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Firmicutes Levels in the Mouth Reflect the Gut Condition With Respect to Obesity and Early Childhood Caries.

Front Cell Infect Microbiol 2021 27;11:593734. Epub 2021 May 27.

Laboratory of Clinical and Molecular Microbiology, University São Francisco, Bragança Paulista, Brazil.

The present cross-sectional study investigated whether Firmicutes (F) and Bacteroidetes (B) levels in the mouth reflected the gut condition in obesity and early childhood caries (ECC). Eighty preschoolers (3-5 years) were equally assigned into four groups: 1. obese + ECC, 2. Read More

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Treating Bladder Cancer: Engineering of Current and Next Generation Antibody-, Fusion Protein-, mRNA-, Cell- and Viral-Based Therapeutics.

Front Oncol 2021 27;11:672262. Epub 2021 May 27.

Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany.

Bladder cancer is a frequent malignancy and has a clinical need for new therapeutic approaches. Antibody and protein technologies came a long way in recent years and new engineering approaches were applied to generate innovative therapeutic entities with novel mechanisms of action. Furthermore, mRNA-based pharmaceuticals recently reached the market and CAR-T cells and viral-based gene therapy remain a major focus of biomedical research. Read More

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Intraword Variability in French-Speaking Monolingual and Bilingual Children.

J Speech Lang Hear Res 2021 Jun 12:1-19. Epub 2021 Jun 12.

Department of Psycholinguistics, Faculty of Psychology and Educational Sciences, University of Geneva, Switzerland.

Purpose This study examines intraword variability in 40 typically developing French-speaking monolingual and bilingual children, aged 2;6-4;8 (years;months). Specifically, it measures rate of intraword variability and investigates which factors best account for it. They include child-specific ones such as age, expressive vocabulary, gender, bilingual status, and speech sound production ability, and word-specific factors, such as phonological complexity (including number of syllables), phonological neighborhood density (PND), and word frequency. Read More

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Novel insights for the role of nitric oxide in placental vascular function during and beyond pregnancy.

J Cell Physiol 2021 Jun 14. Epub 2021 Jun 14.

Instituto de Ciencias de la Salud, Universidad de O'Higgins, Rancagua, Chile.

More than 30 years have passed since endothelial nitric oxide synthesis was described using the umbilical artery and vein endothelium. That seminal report set the cornerstone for unveiling the molecular aspects of endothelial function. In parallel, the understanding of placental physiology has gained growing interest, due to its crucial role in intrauterine development, with considerable long-term health consequences. Read More

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Superb microvascular imaging (SMI) detects increased vascularity of the torn anterior cruciate ligament.

Knee Surg Sports Traumatol Arthrosc 2021 Jun 13. Epub 2021 Jun 13.

Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Purpose: Ultrasound with superb microvascular imaging (SMI) is a novel microvascular imaging technology which may be useful to assess the vascularity of the torn anterior cruciate ligament (ACL) as a potential measure of healing potential following surgery. This study aimed to quantify the vascularity of the torn and intact ACL using ultrasound with SMI.

Methods: 23 patients (mean age ± standard deviation, 27. Read More

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Natural History of Growing Sporadic Vestibular Schwannomas During Observation: An International Multi-Institutional Study.

Otol Neurotol 2021 Jun 11. Epub 2021 Jun 11.

Department of Otolaryngology-Head and Neck Surgery, San Antonio Uniformed Services Health Education Consortium, San Antonio, Texas Department of Otolaryngology-Head and Neck Surgery Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota Department of Oto-rhinolaryngology-Head and Neck Surgery, and Audiology Copenhagen University Hospital Rigshospitalet Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Objective: Active treatment of small- or medium-sized vestibular schwannoma during wait-and-scan management is currently recommended at most centers globally once growth is detected. The primary aim of the current study was to characterize the natural history of growing sporadic vestibular schwannoma during observation.

Study Design: Cohort study. Read More

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Attenuation of antibody titer of measles and rubella virus among university students of department of healthcare providers during 2015-2018 in Japan.

Vaccine 2021 Jun 10. Epub 2021 Jun 10.

Center for Medical Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan.

Background: In Japan, measles elimination was confirmed in March 2015. Nevertheless, some outbreaks with cases imported from abroad were reported even after certification. A large rubella outbreak has been occurring since 2017. Read More

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Superiority of focused ion beam-scanning electron microscope tomography of cardiomyocytes over standard 2D analyses highlighted by unmasking mitochondrial heterogeneity.

J Cachexia Sarcopenia Muscle 2021 Jun 13. Epub 2021 Jun 13.

Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, Medical Faculty, University of Duisburg-Essen, Essen, Germany.

Background: Cardioprotection by preventing or repairing mitochondrial damage is an unmet therapeutic need. To understand the role of cardiomyocyte mitochondria in physiopathology, the reliable characterization of the mitochondrial morphology and compartment is pivotal. Previous studies mostly relied on two-dimensional (2D) routine transmission electron microscopy (TEM), thereby neglecting the real three-dimensional (3D) mitochondrial organization. Read More

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The use of simple muscle strength tests to reflect body compositions among individuals with spinal cord injury.

Spinal Cord 2021 Jun 12. Epub 2021 Jun 12.

School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.

Study Design: A cross-sectional study.

Objectives: To investigate the correlation between simple muscle strength tests (including handgrip test and upper limb loading during a seated push-up test [ULL-SPUT]) and body compositions among individuals with spinal cord injury (SCI).

Setting: A tertiary rehabilitation center. Read More

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Dynamic Serial Cytokine Measurements During Intravenous Ca-DTPA Chelation in Gadolinium Deposition Disease and Gadolinium Storage Condition: A Pilot Study.

Invest Radiol 2021 Jun 11. Epub 2021 Jun 11.

From the Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA CytoAnalytics, Denver, CO Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA Department of Radiology, Hospital Garcia de Orta, Almada Department of Radiology, Hospital da Luz, Lisbon, Portugal Richard Semelka Consulting, PLLC, Chapel Hill, NC.

Purpose: The aim of this study was to investigate the feasibility of measuring early changes in serum cytokine levels after intravenous diethylenetriaminepentaacetic acid (Ca-DTPA) chelation in patients manifesting either gadolinium deposition disease (GDD) or gadolinium storage condition (GSC) and the possible usefulness of this method in further research.

Methods: Four patients with recent-onset GDD (≤1 year) and 2 patients with long-standing GSC (4 and 9 years) underwent chelation with intravenous bolus administration of Ca-DTPA. Multiple blood draws were performed to measure serum cytokines: at T = 0 (before Ca-DTPA injection) and 1, 5, 10, 30, 60 minutes, and 24 hours after Ca-DTPA injection. Read More

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Are clinical trial eligibility criteria representative of older patients with lung cancer? A population-based data linkage study.

J Geriatr Oncol 2021 Jun 9. Epub 2021 Jun 9.

NHMRC Clinical Trials Centre, University of Sydney,Levels 4-6 Medical Foundation Building, 92-94 Parramatta Rd, Camperdown, NSW 2050, Australia.

Objectives: Older adults constitute the majority of patients with lung cancer. However, they are under-represented in clinical trials as eligibility criteria often restrict enrolment based on comorbidities that are common with aging. We aimed to describe comorbidities relating to trial exclusion criteria in older adults with lung cancer, determine the proportion that would typically be excluded from trials, and examine the impact on treatment uptake. Read More

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Does Cost-Effectiveness Analysis Overvalue Potential Cures? Exploring Alternative Methods for Applying a "Shared Savings" Approach to Cost Offsets.

Value Health 2021 Jun 10;24(6):839-845. Epub 2021 May 10.

The Institute for Clinical and Economic Review, Boston, MA, USA. Electronic address:

Objectives: To evaluate alternative methods to calculate and/or attribute economic surplus in the cost-effectiveness analysis of single or short-term therapies.

Methods: We performed a systematic literature review of articles describing alternative methods for cost-effectiveness analysis of potentially curative therapies whose assessment using traditional methods may suggest unaffordable valuations owing to the magnitude of estimated long-term quality-adjusted life-year (QALY) gains or cost offsets. Through internal deliberation and discussion with staff at the Health Technology Assessment bodies in England and Canada, we developed the following 3 alternative methods for further evaluation: (1) capping annual costs in the comparator arm at $150 000 per year; (2) "sharing" the economic surplus with the health sector by apportioning only 50% of cost offsets or 50% of cost offsets and QALY gains to the value of the therapy; and (3) crediting the therapy with only 12 years of the average annual cost offsets or cost offsets and QALY gains over the lifetime horizon. Read More

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Measuring recovery after open lower limb fractures: combined objective functional tests and global perceived recovery outperform narrower metrics and a standard generic patient reported outcome measure.

BMC Musculoskelet Disord 2021 Jun 12;22(1):539. Epub 2021 Jun 12.

Department of Wales Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea, UK.

Background: Open lower limb fractures are serious injuries requiring combined ortho-plastic surgery and have significantly worse outcomes than similar closed fractures. There is little objective published data to determine which functional outcome measures best reflect progress or completeness of physical recovery. Our hypothesis was that objective measures combining strength, mobility and balance would better reflect recovery than isolated parameters (e. Read More

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Change of physical activity parameters of hip and pelvic fracture patients during inpatient rehabilitation and after discharge: analysis of global and in-depth parameters.

Eur Rev Aging Phys Act 2021 Jun 12;18(1). Epub 2021 Jun 12.

Department of Clinical Gerontology, Robert-Bosch-Hospital, Auerbachstr. 110, 70376, Stuttgart, Germany.

Background: A growing number of older adults suffer hip and pelvic fractures leading to hospital admission. They often result in reduced physical activity (PA) and impaired mobility. PA can be objectively measured with body-worn sensors. Read More

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HATs off to clot blockers - A potential new role for statins post-transplant.

Liver Transpl 2021 Jun 12. Epub 2021 Jun 12.

Division of Gastroenterology and Hepatology, University of Colorado Denver - Anschutz Medical Campus, United States.

For years after the approval of statins in 1987 for reduction of cardiovascular events, concerns of hepatotoxicity created a barrier to access for patients - especially for those with chronic liver disease. Fortunately, there has since been extensive research showing that the mild, often temporary rise in liver enzymes often seen with statins do not reflect a risk for significant liver damage and that statins are generally safe for the liver. Read More

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Adipokines, Weight Gain and Metabolic and Inflammatory Markers after Antiretroviral Therapy Initiation: ACTG A5260s.

Clin Infect Dis 2021 Jun 12. Epub 2021 Jun 12.

Case Western Reserve University, Cleveland, Ohio, USA.

Background: The adipokines leptin and adiponectin, produced primarily by adipose tissue, have diverse endocrine and immunologic effects, and circulating levels reflect adipocyte lipid content, local inflammation, and tissue composition. We assessed relationships between changes in regional fat depots, leptin and adiponectin levels, and metabolic and inflammatory markers over 96 weeks in the ACTG A5260s metabolic substudy of the A5257 randomized trial of tenofovir disoproxil fumarate-emtricitabine plus atazanavir-ritonavir, darunavir-ritonavir, or raltegravir among treatment-naïve persons with HIV (PWH).

Methods: Fat depots were measured using dual-energy absorptiometry and abdominal CT imaging at treatment initiation and 96 weeks later. Read More

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Risk factors analysis according to regional distribution of white matter hyperintensities in a stroke cohort.

Eur Radiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Neurology, Hospital del Mar; Neurovascular Research Group, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Universitat Autònoma de Barcelona (UAB)/DCEXS-Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Objectives: The spectrum of distribution of white matter hyperintensities (WMH) may reflect different functional, histopathological, and etiological features. We examined the relationships between cerebrovascular risk factors (CVRF) and different patterns of WMH in MRI using a qualitative visual scale in ischemic stroke (IS) patients.

Methods: We assembled clinical data and imaging findings from patients of two independent cohorts with recent IS. Read More

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Can flowers affect land surface albedo and soil microclimates?

Int J Biometeorol 2021 Jun 12. Epub 2021 Jun 12.

Aarhus Institute of Advanced Studies, Aarhus University, Aarhus, Denmark.

The phenology of vegetation, namely leaf-out and senescence, can influence the Earth's climate over regional spatial scales and long time periods (e.g., over 30 years or more), in addition to microclimates over local spatial scales and shorter time periods (weeks to months). Read More

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Psychometric Testing of the Self-care of Hypertension Inventory Version 3.0.

J Cardiovasc Nurs 2021 Jun 9. Epub 2021 Jun 9.

Victoria Vaughan Dickson, PhD, RN, CRNP, FAHA, FHFSA, FAAN Associate Professor, New York University Rory Meyers College of Nursing. Jason Fletcher, PhD Senior Biostatistician, New York University Rory Meyers College of Nursing. Barbara Riegel, PhD, RN, FAHA, FHFSA, FAAN Edith Clemmer Steinbright Professor of Gerontology, University of Pennsylvania School of Nursing, Philadelphia and Professorial Fellow, Australian Catholic University.

In this updated Self-care of Hypertension Inventory Version 3.0 (SC-HI v3.0), items were added to better reflect the Theory of Self-care of Chronic Illness and revised based on recent research. Read More

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Systematic review and meta-analysis: the incidence and prevalence of paediatric coeliac disease across Europe.

Aliment Pharmacol Ther 2021 Jun 11. Epub 2021 Jun 11.

Swansea, UK.

Background: Coeliac disease is one of the most prevalent immune-mediated gastrointestinal disorders in children.

Aim: To review the incidence and prevalence of paediatric coeliac disease, and their trends, regionally across Europe, overall and according to age at diagnosis.

Methods: Systematic review and meta-analysis from January 1, 1950 to December 31, 2019, based on PubMed, CINAHL and the Cochrane Library, searches of grey literature and websites and hand searching of reference lists. Read More

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Gait Adaptations at 8 Years After Reconstruction of Unilateral Isolated and Combined Posterior Cruciate Ligament Injuries.

Am J Sports Med 2021 Jun 11:3635465211017147. Epub 2021 Jun 11.

Julius Wolff Institute, Berlin Institute of Health and Charité-Universitätsmedizin Berlin, Berlin, Germany.

Background: It remains unclear how posterior cruciate ligament (PCL) reconstruction influences long-term lower extremity joint biomechanics.

Purpose: To determine whether patients who underwent PCL reconstruction exhibited long-term alterations in lower limb gait mechanics.

Study Design: Controlled laboratory study. Read More

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Quality of Life and Functioning of People With Mental Disorders Who Underwent Deinstitutionalization Using Assisted Living Facilities: A Cross-Sectional Study.

Front Psychol 2021 25;12:622973. Epub 2021 May 25.

Graduate Program in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, Brazil.

Context: People with mental disorders can acquire long-term disabilities, which could impair their functioning and quality of life (QoL), requiring permanent care and social support. Systematic data on QoL and functioning, which could support a better management of these people, were not available.

Objective: To analyze the QoL, level of functioning and their association with sociodemographic and clinical factors of people with mental disorders who underwent deinstitutionalization using assisted living facilities. Read More

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