3,571 results match your criteria years posttransplant

Cumulative Deficits Frailty Index Predicts Outcomes for Solid Organ Transplant Candidates.

Transplant Direct 2021 Mar 22;7(3):e677. Epub 2021 Feb 22.

Ajmera Transplant Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

Despite comprehensive multidisciplinary candidacy assessments to determine appropriateness for solid organ transplantation, limitations persist in identifying candidates at risk of adverse outcomes. Frailty measures may help inform candidacy evaluation. Our main objective was to create a solid organ transplant frailty index (FI), using the cumulative deficits model, from data routinely collected during candidacy assessments. Read More

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Deep Learning-Based Quantification of Visceral Fat Volumes Predicts Posttransplant Diabetes Mellitus in Kidney Transplant Recipients.

Front Med (Lausanne) 2021 25;8:632097. Epub 2021 May 25.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Because obesity is associated with the risk of posttransplant diabetes mellitus (PTDM), the precise estimation of visceral fat mass before transplantation may be helpful. Herein, we addressed whether a deep-learning based volumetric fat quantification on pretransplant computed tomographic images predicted the risk of PTDM more precisely than body mass index (BMI). We retrospectively included a total of 718 nondiabetic kidney recipients who underwent pretransplant abdominal computed tomography. Read More

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Use of high-dose mesna and hyperhydration leads to lower incidence of hemorrhagic cystitis after posttransplant cyclophosphamide-based allogeneic transplantation.

Bone Marrow Transplant 2021 Jun 9. Epub 2021 Jun 9.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA, USA.

Currently, there is no consensus on best practices to prevent hemorrhagic cystitis (HC) in patients receiving posttransplant cyclophosphamide (PTCy). We retrospectively reviewed 194 patients undergoing their first hematopoietic cell transplant (HCT) who received PTCy from 2014 to 2018 to describe the incidence and severity of HC, identify potential risk factors, and impact of HC on HCT outcomes. Standard HC prophylaxis was hyperhydration with forced diuresis and mesna at 320% the daily dose of PTCy. Read More

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Non-HDL cholesterol is an independent predictor of long-term cardiovascular outcomes in patients with dyslipidemia after renal transplantation.

Int J Clin Pract 2021 Jun 9:e14465. Epub 2021 Jun 9.

Acıbadem International Hospital, Department of Nephrology and Transplantation, İstanbul, Turkey.

Background: Posttransplant dyslipidemia is a common condition in renal transplantation recipients (RTR) and is related to poor cardiac outcomes. We aimed to demonstrate the value of non-high-density lipoprotein cholesterol (non-HDL-C) in predicting long-term major cardiovascular and cerebrovascular events (MACCE) in RTR with dyslipidemia.

Methods: Patients who had undergone renal transplantation between 2011 and 2019 were retrospectively analyzed and were classified as normal non-HDL-C and high non-HDL-C groups based on first year levels. Read More

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Post-allogeneic hematopoietic stem cell transplantation viral reactivations and viremias: a focused review on human herpesvirus-6, BK virus and adenovirus.

Ther Adv Infect Dis 2021 Jan-Dec;8:20499361211018027. Epub 2021 May 24.

Division of Hematology and Oncology, Department of Medicine, UMass Memorial Medical Center, 55 Lake Avenue North, Worcester, MA, 01655, USA.

Human cytomegalovirus and Epstein-Barr virus have been recognized as potential drivers of morbidity and mortality of patients undergoing allogeneic stem cell transplantation for years. Specific protocols for monitoring, prophylaxis and pre-emptive therapy are in place in many transplant settings. In this review, we focus on the next three most frequent viruses, human herpesvirus-6, BK virus and adenovirus, causing reactivation and/or viremia after allogeneic transplant, which are increasingly detected in patients in the post-transplant period owing to emerging techniques of molecular biology, recipients' characteristics, treatment modalities used for conditioning and factors related donors or stem cell source. Read More

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Evaluation of Clinical Neuropathy After Living Donor Liver Transplant.

Exp Clin Transplant 2021 Jun 3. Epub 2021 Jun 3.

From the Department of Pharmacy, Changhua Christian Hospital, Changhua, Taiwan.

Objectives: Neurologic complications are more common in liver transplants than in other solid-organ transplants. One such neurologic complication, peripheral neuropathy, may cause functional limitations for recipients and have a negative effect on posttransplant quality of life. We aimed to examine the risk factors associated with the occurrence of clinical neuropathy after liver transplant and to investigate the frequency of sensory deficits. Read More

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Posttransplant Diabetes Mellitus Incidence and Risk Factors in Adult Liver Transplantation Recipients.

Acta Endocrinol (Buchar) 2020 Oct-Dec;16(4):449-453

Baskent University, Faculty of Medicine - General Surgery, Ankara, Turkey.

Aim: Posttransplant diabetes mellitus (PTDM) is a metabolic complication that usually occurs after liver transplantation (LT) due to immunosuppression. In this study, our aim was to identify PTDM incidence after LT in our center and the potential risk factors.

Materials And Methods: In this study, 238 adult LT patients were evaluated in terms of PTDM development. Read More

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Third retransplantation using a whole liver graft for late graft failure from hepatic vein stent stenosis in a pediatric patient who underwent split liver retransplantation.

Ann Hepatobiliary Pancreat Surg 2021 May;25(2):299-306

Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

We present a case of third retransplantation using a whole liver graft in a 13-year-old girl who suffered graft failure and hepatopulmonary syndrome following split liver retransplantation with endovascular stenting of the hepatic and portal veins as an infant. She was diagnosed with biliary atresia-polysplenia syndrome, and thus underwent living donor liver transplantation from her mother at 9 months of age. The first liver graft failed due to stenosis of the portal vein. Read More

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Clinical Effects of COVID-19 on Hematopoietic Stem Cell Transplant Outcomes in Pediatric Patients.

Exp Clin Transplant 2021 05;19(5):501-507

From the Pediatric Cell and Gene Therapy Research Center, Tehran University of Medical Sciences, Tehran, Iran; and the Pediatric Hematopoietic Stem Cell Transplant Department, Children's Hospital, Damascus University, Damascus, Syria.

Coronavirus disease 2019 is the third zoonotic acute respiratory disease after SARS virus and Middle East respiratory syndrome. Most cases are mild in healthy children. In contrast, the infection is more severe in patients with underlying health conditions. Read More

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High-Intensity Training for 6 Months Safely, but Only Temporarily, Improves Exercise Capacity in Selected Solid Organ Transplant Recipients.

Transplant Proc 2021 May 25. Epub 2021 May 25.

Department of Microbiology, Immunology, and Transplantation, Laboratory of Abdominal Transplantation, KU Leuven, Leuven, Belgium; Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Background: Organ transplantation is a life-saving intervention that improves quality of life of patients with irreversible organ failure. Although exercise training immediately after transplantation has been suggested to be beneficial, such interventions remain rare in stable transplant recipients, whereas effects of high-intensity training (HIT) are even less frequently investigated. Moreover, sustainability of such interventions has not yet been reported. Read More

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The 2020 Facial Transplantation Update: A 15-Year Compendium.

Plast Reconstr Surg Glob Open 2021 May 21;9(5):e3586. Epub 2021 May 21.

Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, N.Y.

Over the past 15 years, landmark achievements have established facial transplantation (FT) as a feasible reconstructive option for otherwise irreparable craniofacial defects. However, as the field matures and long-term outcomes begin to emerge, FT teams around the world are now facing new challenges. Data for this review were identified by searches of the PubMed/MEDLINE database from inception through August 2020. Read More

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Efficacy of Distraction for Reducing Pain and Distress Associated With Venipuncture in the Pediatric Posttransplant Population: A Randomized Controlled Trial.

Pediatr Emerg Care 2021 May 18. Epub 2021 May 18.

From the Division of Pediatric Emergency Medicine, Department of Emergency Medicine Department of Pediatrics Division of Cardiology, Department of Pediatrics Division of Nephrology, Department of Pediatrics Division of Hepatology and Gastroenterology, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY.

Objective: Distraction can reduce pain and distress associated with painful procedures but has never been studied in children with solid organ transplants. We aimed to determine whether there is a difference in pain and distress associated with venipuncture in pediatric posttransplant patients who receive distraction compared with those who do not.

Methods: Randomized controlled trial of children aged 4 to 17 years with solid organ transplants undergoing venipuncture in the outpatient setting. Read More

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Treatment of posttransplant lymphoproliferative disorder with poor prognostic features in children and young adults: Short-course EPOCH regimens are safe and effective.

Pediatr Blood Cancer 2021 May 21:e29126. Epub 2021 May 21.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

No guidelines exist for which intensive chemotherapy regimen is best in pediatric or young adult patients with high-risk posttransplant lymphoproliferative disorder (PTLD). We retrospectively reviewed patients with PTLD who received interval-compressed short-course etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin (SC-EPOCH) regimens at our institution. Eight patients were included with median age of 12 years. Read More

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Autonomic Nervous System Profiling In Response to Liver Transplantation: Prognostic Evaluation and Preliminary Study.

Transplant Proc 2021 May 13. Epub 2021 May 13.

University of Louisville, Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Louisville, Kentucky. Electronic address:

Background: Liver cirrhosis leads to autonomic dysfunction (AD). We present a pilot study and review of published literature to investigate the long-term changes in the Autonomic Nervous System (ANS) of patients who underwent liver transplant. We propose Autonomic Function Tests (AFT) can be used as a predictor of liver transplant outcome. Read More

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Paradigm Shift in Utilization of Livers from Hepatitis C-Viremic Donors into Hepatitis C Virus-Negative Patients.

Eric F Martin

Clin Liver Dis 2021 Feb 5;25(1):195-207. Epub 2020 Nov 5.

Division of Digestive Health and Liver Disease, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Suite 1112, Miami, FL 33136, USA. Electronic address:

Despite record-breaking numbers of liver transplants (LTs) performed in the United States in each of the last 7 years, many patients remain on the wait list as the demand for LT continues to exceed the supply of available donors. The emergence of highly effective and well-tolerated direct-acting antiviral therapy has transformed the clinical course and management of hepatitis C virus (HCV) in both the pretransplant and posttransplant setting. Historically, donor livers infected with HCV were either transplanted into patients already infected with HCV or discarded. Read More

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February 2021

Utility of Framingham Score for Optimizing Preoperative Evaluation Among Patients Undergoing Liver Transplant Evaluation.

Transplant Proc 2021 May 5. Epub 2021 May 5.

Divisions of Cardiology and Liver Transplant, Loma Linda University Medical Center, Loma Linda, California, United States. Electronic address:

Background: Cardiac testing of candidates for liver transplant (LT) requires balancing risks and benefits of cardiac procedures. The goal of this study was to evaluate the utility of the Framingham score (FS) for optimizing preoperative risk stratification for coronary artery disease (CAD).

Methods: In this single-center retrospective study of 615 adults undergoing LT evaluation from 2016 to 2019, data of preoperative evaluation, post-LT 1-year mortality, and post-LT cardiac events were reviewed. Read More

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An Unusual Cause of Acute Pancreatitis in a Liver Transplant Recipient.

Transplant Direct 2021 May 27;7(5):e694. Epub 2021 Apr 27.

Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, IL.

Posttransplant lymphoproliferative disorder (PTLD) in liver transplant recipients is relatively uncommon, with an estimated incidence of 1%-3%. Retrospective reviews of liver transplant recipients have mainly reported posttransplant lymphoproliferative disorder affecting the liver, gastrointestinal tract, or lymph nodes. In this case report, we describe a 45-y-old female with a history of deceased donor liver transplantation for autoimmune hepatitis who had recurrent hospital admissions for acute pancreatitis. Read More

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Risk Prediction Model for Basal Cell Carcinoma in Cardiac Allograft Recipients.

Transplant Proc 2021 Apr 27. Epub 2021 Apr 27.

Department of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, Alabama.

Background: Basal cell carcinoma (BCC) is the second most common skin cancers in posttransplant patients. Long-term immunosuppression predisposes the patients to higher risk. This study was undertaken to develop a risk prediction model using the United Network for Organ Sharing (UNOS) database. Read More

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Low-Dose Antithymocyte Globulin Has No Disadvantages to Standard Higher Dose in Pediatric Kidney Transplant Recipients: Report From the Pediatric Nephrology Research Consortium.

Kidney Int Rep 2021 Apr 17;6(4):995-1002. Epub 2021 Jan 17.

Division of Pediatric Nephrology, Hypertension and Pheresis, Washington University and St. Louis Children's Hospital, St. Louis, Missouri, USA.

Introduction: Rabbit antithymocyte globulin (rATG) dosing strategies for induction in pediatric kidney transplantation vary between centers. It is not known whether a lower rATG induction dose provides safe and effective immunosuppression compared with a "standard" higher dose.

Methods: We performed a retrospective multicenter study of all isolated first-time kidney transplant recipients <21 years old who received rATG induction between 1 January 2010 and 31 December 2014 at 9 pediatric centers. Read More

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Arq Gastroenterol 2021 Jan-Mar;58(1):10-16

Serviço de Transplante Hepático, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil.

Background: Receptors of living donor liver transplantation (LDLT) have higher rate of postoperative biliary and vascular complications that may reduce posttransplant quality of life (QOL) due to the need of invasive and repetitive treatments.

Objective: The purpose of our study is to assess the various aspects of QOL of receptors undergoing LDLT after 10 years of transplantation and to identify potential factors that might be associated with impaired QOL.

Methods: Data of all patients with more than 10 years of LDLT were retrospectively evaluated. Read More

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Postrecurrence Survival After Liver Transplantation for Liver Metastases From Neuroendocrine Tumors.

Transplantation 2021 Apr 27. Epub 2021 Apr 27.

HPB Surgery, Hepatology and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy Pathology Unit 1, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy.

Background: Liver metastases from neuroendocrine tumors (NETs) is an accepted indication for liver transplantation (LT). Despite strict patient selection, post-LT recurrence is observed in 30-50% of cases. Postrecurrence survival is poorly investigated as well as factors influencing postrecurrence outcomes. Read More

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Solid Organ Transplantation From Deceased Donors With Infective Endocarditis: The UK Experience.

Transplantation 2021 Apr 21. Epub 2021 Apr 21.

Department of Statistics and Clinical Studies, NHS Blood and Transplant, UK School of Immunology and Microbial Sciences, King's College London, London, UK Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK Department of Nephrology and Transplantation, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK Department of Surgery, University of Cambridge, Cambridge, UK The Cambridge NIHR Biomedical Research Centre, Cambridge, UK NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Cambridge Biomedical Campus, Cambridge, UK.

Background: There is little evidence regarding the use of organs from deceased donors with infective endocarditis. We performed a retrospective analysis of the utilization, safety, and long-term survival of transplants from donors with infective endocarditis in the UK.

Methods: We studied deceased donor transplants over an 18-year period (2001 to 2018) using data from the UK Transplant Registry. Read More

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Living-Related Donor Kidney Transplant in a Patient With Single Ventricle and Fontan Circulation.

World J Pediatr Congenit Heart Surg 2021 Apr 25:2150135120978959. Epub 2021 Apr 25.

Division of Cardiology, The Cardiac Center at The Children's Hospital of Philadelphia, PA, USA.

The hemodynamic profile of the Fontan circulation presents challenges that raise questions about candidacy for organ transplantation. We report a case of a 24-year-old male with double-inlet right ventricle and aortic atresia, who suffered bilateral renal cortical necrosis due to neonatal cardiovascular shock, received a live-donor kidney transplant from his mother at age 17, and has diminished yet stable renal function seven years posttransplant. Read More

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Overcoming Mismatch Concerns for Adult Recipients of Small Pediatric Deceased Donor Kidneys.

Transplant Proc 2021 Apr 20. Epub 2021 Apr 20.

Division of Transplant Surgery, Mayo Clinic, Phoenix, Arizona. Electronic address:

Background: Kidneys from very young pediatric donors continue to be underutilized. To reduce discard, the Organ Procurement and Transplantation Network (OPTN) policy was recently updated to allow kidneys from donors weighing <18 kg to be recovered en bloc.

Methods: We reviewed our center's experience with kidney transplantation in adult recipients of <18 kg pediatric donor kidneys to assess renal function outcomes specific to solitary vs en bloc usage. Read More

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The impact of donor-specific anti-human leukocyte antigen antibodies in salvage haploidentical hematopoietic cell transplantation with posttransplant cyclophosphamide in patients with nonmalignant disorders.

HLA 2021 Jun 2;97(6):493-504. Epub 2021 May 2.

Bone Marrow Transplantation Unit, Complexo Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil.

The presence of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) has been recognized as a major risk factor for graft failure (GF) after haploidentical hematopoietic cell transplantation with posttransplant cyclophosphamide (haplo-PTCy). However, the role of DSAs in salvage haplo-PTCy for rescuing patients with nonmalignant disorders (NMDs) has not yet been reported. The present study retrospectively analyzed 22 patients with NMDs who underwent salvage haplo-PTCy from January 2008 to December 2017. Read More

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De Novo Human Leukocyte Antigen Allosensitization in Heartmate 3 Versus Heartmate II Left Ventricular Assist Device Recipients.

ASAIO J 2021 Apr 19. Epub 2021 Apr 19.

From the Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, New York Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, New York Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Irving Medical Center, New York, New York.

Left ventricular assist devices (LVADs) are associated with the development of antihuman leukocyte antigen (HLA) antibodies, which can create a challenge for future transplantation in these patients. The differential effects of Heartmate 3 (HM3) versus Heartmate II (HMII) on de novo HLA allosensitization remain unknown. Patients who underwent HMII or HM3 implantation and had no prior HLA antibodies by solid-phase assay (Luminex) testing were included in this study. Read More

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Donation After Circulatory Death Yields Survival Rates Similar to Donation After Brain Death Liver Transplant, Which Effectively Expands the Donor Pool.

Exp Clin Transplant 2021 Apr 16. Epub 2021 Apr 16.

From the Division of Transplantation, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Objectives: Liver allograft shortage has necessitated greater use of donations after circulatory death. Limited data are available to compare recipients' health care utilization for donation after circulatory death versus brain death.

Materials And Methods: Liver transplant data for our center from November 2016 until May 2019 were obtained (208 donations after brain death and 39 after circulatory death). Read More

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Safe Use of Erythromycin For Refractory Gastroparesis After Small Bowel Transplantation.

Exp Clin Transplant 2021 Apr 16. Epub 2021 Apr 16.

From the the Intestinal Rehabilitation and Transplant Center, Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Current therapeutic options with prokinetic agents for posttransplant gastroparesis are limited. Erythromycin is associated with adverse reactions, including corrected QT interval prolongation and cytochrome P450 3A4 isoenzyme inhibition. The use of erythromycin has been avoided in patients undergoing treatment with cyclosporine or tacrolimus because of significant fluctuations in therapeutic immunosuppression levels. Read More

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Recipient Obesity and Kidney Transplant Outcomes: A Mate-Kidney Analysis.

Am J Kidney Dis 2021 Apr 16. Epub 2021 Apr 16.

Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL. Electronic address:

Rationale & Objective: The impact of extreme recipient obesity on long-term kidney transplant outcomes has been controversial. This study sought to evaluate the association of various levels of recipient obesity on kidney transplantation outcomes by comparing mate-kidney recipient pairs to address possible confounding effects of donor characteristics on posttransplant outcomes.

Study Design: Nationwide observational cohort study using mate-kidney models. Read More

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Posttransplant nephrotic syndrome resulting from NELL1-positive membranous nephropathy.

Am J Transplant 2021 Apr 18. Epub 2021 Apr 18.

Division of Nephrology, Department of Internal Medicine, University of Leipzig Medical Center, Leipzig, Germany.

Membranous nephropathy (MN) constitutes a major cause of nephrotic syndrome (NS) in adults. After kidney transplantation (KTx), both recurrent and de novo MN has been reported. In addition to PLA2R and THSD7A, recent identification of neural EGFL-like-1 protein, NELL1, as a potential disease antigen has enriched our understanding of MN pathogenesis. Read More

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