479,578 results match your criteria years months


Frequency of measuring body weight in (sub)populations of patients with cancer treated with chemotherapy.

Eur J Hosp Pharm 2022 May 23. Epub 2022 May 23.

Clinical Pharmacology and Pharmacy, Amsterdam UMC Location Vrije Universiteit, Amsterdam, The Netherlands

Objectives: Most cytostatics used in cancer treatment are dosed on body surface area (BSA). To administer an appropriate dose it is therefore necessary to know the patient's correct body weight. However, evidence is lacking on how often, after initiation of treatment, body weight should be measured to recalculate BSA. Read More

View Article and Full-Text PDF

The genomic landscape of low-grade serous ovarian/peritoneal carcinoma and its impact on clinical outcomes.

Gynecol Oncol 2022 Jun 30;165(3):560-567. Epub 2022 Mar 30.

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, PO Box 301439, Houston, TX 77230-1429, USA. Electronic address:

Objective: Low-grade serous carcinoma (LGSOC) is a rare epithelial ovarian/peritoneal cancer characterized by younger age at diagnosis, relative chemoresistance, prolonged overall survival (OS), and mutations in the mitogen activated protein kinase (MAPK) pathway compared to high-grade serous carcinoma. We describe the genomic profile of LGSOC by next generation sequencing (NGS) and evaluated its potential relationship to clinical outcomes.

Methods: The study included 215 women with LGSOC with: 1) pathologically confirmed LGSOC, 2) availability of NGS data, and 3) adequate clinical data. Read More

View Article and Full-Text PDF

Anlotinib in recurrent or metastatic endometrial cancer.

Int J Gynecol Cancer 2022 May 23. Epub 2022 May 23.

Department of Integrated Traditional Chinese and Western Medicine, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China

Objective: For recurrent or metastatic endometrial cancer after second-line treatment, therapeutic options are limited. Anlotinib is a new multi-targeted tyrosine kinase inhibitor of tumor angiogenesis and growth. The aim of this study was to explore the efficacy and safety of anlotinib in patients with recurrent or metastatic endometrial cancer. Read More

View Article and Full-Text PDF

Tongue graft-versus-host disease: remission with ruxolitinib.

BMJ Case Rep 2022 May 23;15(5). Epub 2022 May 23.

Bone Marrow Transplantation Unit, Department of Internal Medicine, University Hospital of Patras, Rion, Greece.

Graft-versus-host disease (GvHD) is a potentially life-threatening and commonly encountered event of allogeneic haematopoietic stem cell transplantation. Here, we present a young adult male with primary refractory Hodgkin's lymphoma who received a transplant and developed cutaneous GvHD after donor lymphocyte infusion, which was managed with cyclosporine and steroids. However, while the patient was under immunosuppressive treatment, diffuse confluent whitish patches on the patient's tongue were observed. Read More

View Article and Full-Text PDF

Multi-staged management of a mangled, exploded hand crush injury with long-term outcome: the critical link between surgery and therapy.

BMJ Case Rep 2022 May 20;15(5). Epub 2022 May 20.

Plastic and Reconstructive Surgery, Wright State University Boonshoft School of Medicine, Dayton, Ohio, USA.

A 38-year-old right-hand dominant man sustained a severe, work-related left-hand crushing injury. A multi-staged approach to salvage was employed in conjunction with aggressive hand therapy involvement for a successful, functional outcome. Now at approximately 5 years postinjury, the patient can perform daily activities, coaches sports and has returned to and maintained his full-time work position. Read More

View Article and Full-Text PDF

Risk factors of disease flares in a Chinese lupus cohort with low-grade disease activity.

Lupus Sci Med 2022 May;9(1)

Department of Rheumatology, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China

Objective: Recurrent disease flare is one of the key problems in lupus patients. A Chinese Flare-Prevention Lupus Initiative Cohort (FLIC) was established. Risk factors of disease flare were evaluated accordingly. Read More

View Article and Full-Text PDF

Fagerstrom score predicts smoking status six months after hospitalization for acute myocardial infarction: a prospective study.

Hellenic J Cardiol 2022 May 20. Epub 2022 May 20.

Emergency Medicine Department, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Background: Fagerstrom score is a validated marker of nicotine addiction in smokers.

Methods: In a prospective study, we investigated a) the predictive value of Fagerstrom score for the smoking status in patients early after acute myocardial infarction (AMI) and b) the effectiveness of medically-assisted smoking cessation programs in the prevention of relapsing to smoking post-discharge . In 103 smokers (58±12 years, 79. Read More

View Article and Full-Text PDF

Spinal meningioma in adults: Imaging characteristics, surgical outcomes, and risk factors for recurrence.

World Neurosurg 2022 May 20. Epub 2022 May 20.

Department of Neurosurgery, University of Iowa Hospitals & Clinics, Iowa City, IA, USA. Electronic address:

Objectives: Spinal meningiomas (SM) are associated with overall long tumor-free survival. Nevertheless, recurrences following surgery for SM do occur. This study analyzed the factors associated with complications, misdiagnosis, and recurrence of SM. Read More

View Article and Full-Text PDF

Long-term outcomes of allogeneic hematopoietic cell transplantation in patients with newly diagnosed multiple myeloma.

Transplant Cell Ther 2022 May 19. Epub 2022 May 19.

Department of Stem Cell Transplantation & Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Despite remarkable progress in survival with the availability of novel agents, an overwhelming majority of patients with multiple myeloma (MM) have disease that relapses. Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative option for a subgroup of patients with high- risk disease.

Objective: This study assesses the long-term outcome of MM patients who received allo-HCT at the first remission as consolidation treatment. Read More

View Article and Full-Text PDF

Lebanese SARS-CoV-2 genomics: 24 months of the pandemic.

Virus Res 2022 May 20:198824. Epub 2022 May 20.

Multi-Omics Laboratory, School of Pharmacy, Lebanese American University, P.O. Box 36, 1401 Byblos, Lebanon. Electronic address:

The COVID-19 pandemic continues to pose a global health concern, despite the ongoing vaccination campaigns, due to the emergence and rapid spread of new variants of the causative agent SARS-CoV-2. These variants are identified and tracked via the marker mutations they carry, and the classification system put in place following tremendous sequencing efforts. In this study, the genomes of 1,230 Lebanese SARS-CoV-2 strains collected throughout 2 years of the outbreak in Lebanon were analyzed, 115 of which sequenced within this project. Read More

View Article and Full-Text PDF

Cefepime population pharmacokinetics and dosing regimen optimization in critically ill children with different renal function.

Clin Microbiol Infect 2022 May 20. Epub 2022 May 20.

Department of Pediatric Intensive Care Unit, Necker Enfants Malades Hospital, Université de Paris, AP-HP, France; Pharmacology and Drug Evaluation in Children and Pregnant Women EA7323, Université de Paris, France.

Objective: Cefepime is commonly used in pediatric intensive care units (PICUs), where unpredictable variations in the patients' pharmacokinetic (PK) variables may require drug dose adjustments. The objectives of the present study were to build a population PK model for cefepime in critically ill children and to optimize individual initial dosing regimens.

Methods: Children (aged from 1 month to 18 years; bodyweight >3 kg) receiving cefepime were included. Read More

View Article and Full-Text PDF

Health risk assessment of polychlorinated biphenyls (PCBs) in baby clothes. A preliminary study.

Environ Pollut 2022 May 20:119506. Epub 2022 May 20.

Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Sant Llorenç 21, 43201, Reus, Catalonia, Spain.

Clothes may contain a large range of chemical additives and other toxic substances, which may eventually pose a significant risk to human health. Since they are associated with pigments, polychlorinated biphenyls (PCBs) may be especially relevant. On the other hand, infants are very sensitive to chemical exposure and they may wear some contact and colored textiles for a prolonged time. Read More

View Article and Full-Text PDF

Central Nervous System Infections in Solid Organ Transplant Recipients: Results from the Swiss Transplant Cohort Study.

J Infect 2022 May 20. Epub 2022 May 20.

Service of Infectious Diseases and Transplantation Center, Lausanne University Hospital, Lausanne, Switzerland.

Objectives: To describe the epidemiology and clinical presentation of central nervous system (CNS) infections in solid organ transplant (SOT) recipients in the current era of transplantation.

Methods: Patients from the Swiss Transplant Cohort Study (STCS) transplanted between 2008 and 2018 were included with a median follow-up of 3.8 years. Read More

View Article and Full-Text PDF

Duplex Ultrasound and Clinical Outcomes of Medical Management of Pediatric Lower Extremity Arterial Thrombosis.

J Vasc Surg 2022 May 20. Epub 2022 May 20.

Division of Vascular Surgery, Oregon Health & Science University.

Objectives: Natural history and duplex ultrasound (DU) findings of pediatric lower extremity arterial thrombosis (PLEAT) are not well defined. We describe acute and short-term DU findings of PLEAT to aid duplex interpretation and patient management.

Methods: From 8/2018 to 4/2021 children with suspected PLEAT were prospectively identified. Read More

View Article and Full-Text PDF

Post-discharge morbidity and mortality in children admitted with severe anaemia and other health conditions in malaria-endemic settings in Africa: a systematic review and meta-analysis.

Lancet Child Adolesc Health 2022 May 20. Epub 2022 May 20.

Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. Electronic address:

Background: Severe anaemia is associated with high in-hospital mortality among young children. In malaria-endemic areas, surviving children also remain at increased risk of mortality for several months after hospital discharge. We aimed to compare the risks of morbidity and mortality among children discharged from hospital after recovery from severe anaemia versus other health conditions in malaria-endemic settings in Africa. Read More

View Article and Full-Text PDF

Lymph Node Tuberculosis in Otolaryngological Practice: A Study of 68 Cases at the Sourô Sanou University Hospital of Bobo Dioulasso, Burkina Faso.

ORL J Otorhinolaryngol Relat Spec 2022 May 23:1-5. Epub 2022 May 23.

Higher Institute of Health Sciences, Nazi Boni University, Bobo-Dioulasso, Burkina Faso.

Introduction: Lymph node tuberculosis (LNTB) frequently affects peripheral cervical lymph node body sites. We aimed to study epidemiology and diagnostic and therapeutic characteristics of LNTB patients in ENT routine practice.

Methods: We conducted a cross-sectional prospective study in the ENT and cervicofacial surgery department at the Sourô Sanou University Hospital of Bobo Dioulasso, Burkina Faso, for a period of 36 months. Read More

View Article and Full-Text PDF

A systematic review of economic models for cost effectiveness of physiotherapy interventions following total knee and hip replacement.

Physiotherapy 2022 Jan 31;116:90-96. Epub 2022 Jan 31.

Department of Medical Rehabilitation, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.

Background: Osteoarthritis is a primary cause of pain and disability, and it places a considerable economic burden on individuals and the society. In the management of total knee or hip replacement (TKHR), the long-term effectiveness of physiotherapy interventions may slowly accumulate over a period.

Objectives: To evaluate all the model-based cost-effectiveness (CE) of physiotherapy interventions for patients with (TKHR). Read More

View Article and Full-Text PDF
January 2022

SARS-CoV-2 infection in patients with neuroimmunological disorders in a tertiary referral centre from the north of Portugal.

Mult Scler Relat Disord 2022 May 16;63:103893. Epub 2022 May 16.

Department of Neurology, Hospital de Santo António (HSA), Centro Hospitalar Universitário do Porto (CHUP), Porto, Portugal; Multidisciplinary Unit for Biomedical Research, Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto.

Introduction: The impact of COVID-19 in patients with neuroimmunological disorders is not fully established. There is some evidence suggesting an increased risk of more severe infection associated with the use of immunosuppressors in this population.

Objective: To characterize SARS-CoV-2 infection in patients followed in the neuroimmunology outpatient clinic of a tertiary centre from the north of Portugal. Read More

View Article and Full-Text PDF

Predictive validity of ESSENCE Q screening tool for early detection of neurodevelopmental disorder in children.

Asian J Psychiatr 2022 May 13;73:103162. Epub 2022 May 13.

Department of Radiodiagnosis, All India Institute of Medical Sciences(AIIMS), Bhopal, India. Electronic address:

Introduction: Neurodevelopmental disorders (NDD) are a group of conditions that typically manifest early during the child's development with lifelong consequences. Early identification using efficient screening tools can positively modify the natural history of the disorder. ESSENCE Q is a simple questionnaire to detect ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations to reflect the co-existence of NDDs in children less than five years). Read More

View Article and Full-Text PDF

Efficacy of cenobamate by focal seizure subtypes: Post-hoc analysis of a phase 3, multicenter, open-label study.

Epilepsy Res 2022 May 5;183:106940. Epub 2022 May 5.

SK Life Science, Inc, Paramus, NJ, USA.

Purpose: To report post-hoc efficacy data by focal seizure subtypes from 10 US study sites from a large, global, open-label, phase 3 study of adjunctive cenobamate.

Methods: Patients 18-70 years old with uncontrolled focal seizures taking stable doses of 1-3 antiseizure medications were administered increasing daily doses of cenobamate (12.5, 25, 50, 100, 150, 200 mg/day) at 2-week intervals (target dose 200 mg/day). Read More

View Article and Full-Text PDF

More efficient formation of longer-term representations for word forms at birth can be linked to better language skills at 2 years.

Dev Cogn Neurosci 2022 May 13;55:101113. Epub 2022 May 13.

Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Logopedics, Welfare Sciences, Faculty of Social Sciences, Tampere University, Finland.

Infants are able to extract words from speech early in life. Here we show that the quality of forming longer-term representations for word forms at birth predicts expressive language ability at the age of two years. Seventy-five neonates were familiarized with two spoken disyllabic pseudowords. Read More

View Article and Full-Text PDF

Safety of inactivated COVID-19 vaccine in tuberous sclerosis complex patients with epilepsy treated with rapamycin.

Seizure 2022 May 16;99:71-74. Epub 2022 May 16.

Senior Department of Pediatrics, Chinese PLA General Hospital, Department of Pediatrics, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China; Center for Brain Disorders Research, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China. Electronic address:

Purpose: To assess the safety of inactivated coronavirus 2019 disease (COVID-19) vaccine in tuberous sclerosis complex (TSC) patients with epilepsy.

Methods: All patients with epilepsy were selected from Efficacy and Safety of Sirolimus in Pediatric Patients with Tuberous Sclerosis (ESOSPIT) project and younger than 17 years old. The patients were treated with mTOR inhibitors (rapamycin). Read More

View Article and Full-Text PDF

Gastrointestinal perforations by ingested foreign bodies: A preoperative diagnostic flowchart-based experience. A case series report.

Int J Surg Case Rep 2022 May 18;95:107216. Epub 2022 May 18.

Department of General Surgery, Jendouba Hospital, Tunisia; Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.

Background: Gastrointestinal tract perforation is the most harmful complication of Foreign Body (FB) ingestion, besides diagnostic delay adversely affects the outcome. This paper aims to present our preoperative diagnostic flowchart and describe the surgical management in a Tunisian center.

Methods: A retrospective review of 48 patients with gastrointestinal perforation by ingested FB treated in the surgery department of Jendouba Hospital. Read More

View Article and Full-Text PDF

Evolution of teriflunomide use in multiple sclerosis: A real-world experience.

J Neurol Sci 2022 May 18;438:120292. Epub 2022 May 18.

Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Dpt of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Objectives: The present study aims to describe the evolution of teriflunomide use for multiple sclerosis (MS) in the clinical setting, in particular for naïve patients and young women. Predictors of treatment response were also investigated.

Methods: This was an independent, retrospective, real-world monocentric study. Read More

View Article and Full-Text PDF

Cardiovascular Outcomes in Patients Initiating First-Line Treatment of Type 2 Diabetes With Sodium-Glucose Cotransporter-2 Inhibitors Versus Metformin : A Cohort Study.

Ann Intern Med 2022 May 24. Epub 2022 May 24.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (H.S., R.J.G., E.P.).

Background: Evidence on the risk for cardiovascular events associated with use of first-line sodium-glucose cotransporter-2 inhibitors (SGLT-2i) compared with metformin is limited.

Objective: To assess cardiovascular outcomes among adults with type 2 diabetes (T2D) who initiated first-line treatment with SGLT-2i versus metformin.

Design: Population-based cohort study. Read More

View Article and Full-Text PDF

Enduring undetectable MRD and updated outcomes in relapsed/refractory CLL after fixed-duration venetoclax-rituximab.

Blood 2022 May 23. Epub 2022 May 23.

Department of Hematology, Cancer Center Amsterdam and Lymphoma and Myeloma Center Amsterdam, The Netherlands, Amsterdam, Netherlands.

The MURANO trial (ClinicalTrials.gov identifier, NCT02005471) demonstrated superior progression-free survival (PFS) and overall survival (OS) with venetoclax-rituximab treatment vs bendamustine-rituximab in relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL). Patients were randomized to 2 years venetoclax-rituximab (n = 194; rituximab for the first 6 months) or 6 months bendamustine-rituximab (n = 195). Read More

View Article and Full-Text PDF

Prospective Characterization of Pain And Function in Patients With Unstable Pelvic Fractures Treated With Posterior Screw Fixation.

J Orthop Trauma 2022 May 23. Epub 2022 May 23.

Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD.

Objectives: Describe patient-reported pain and function within 24 months of a pelvic fracture treated with posterior screw fixation and identify factors associated with increased pain.

Design: Prospective case series.

Setting: Academic trauma center. Read More

View Article and Full-Text PDF

What the snake leaves in its wake: Functional limitations and disabilities among snakebite victims in Ghanaian communities.

PLoS Negl Trop Dis 2022 May 23;16(5):e0010322. Epub 2022 May 23.

University of Groningen, Department of Internal Medicine/Infectious Diseases, University Medical Centre Groningen, Groningen, The Netherlands.

Background: The estimated five million snakebites per year are an important health problem that mainly affect rural poor populations. The global goal is to halve both mortality and morbidity from this neglected tropical disease by 2030. Data on snakebite morbidity are sparse and mainly obtained from hospital records. Read More

View Article and Full-Text PDF

Feasibility indicators of telemedicine for patients with dementia in a public hospital in Northeast Brazil during the COVID-19 pandemic.

PLoS One 2022 23;17(5):e0268647. Epub 2022 May 23.

Division of Neurology, Department of Clinical Medicine, Universidade Federal do Ceará, Fortaleza, Brazil.

Background: The use of telemedicine has become a fundamental tool in healthcare in recent years, especially at times of Covid-19 pandemic. Currently, there are several telemedicine tools that are simple, inexpensive, and effective means of communication. This article aims to describe indicators of feasibility including patient recruitment, attendance, discomfort (internet connection issues and/or noncompliant patient behavior), satisfaction, and travel time and cost savings of virtual telemedicine consultations for patients with dementia. Read More

View Article and Full-Text PDF