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Trends in risk factors of anastomotic leakage after colorectal cancer surgery (2011-2019), a Dutch population based study.

Colorectal Dis 2021 Sep 18. Epub 2021 Sep 18.

Radboud university medical centre, Radboud Institute for Health Sciences, Department of Surgery, Nijmegen, The Netherlands.

Aim: Anastomotic leakage (AL) after colon cancer (CC) and rectal cancer (RC) surgery often requires reintervention. Prevalence and morbidity may change over time with evolutions in treatment strategies and changes in patient characteristics. This nationwide study aimed to evaluate changes in the incidence, risk factors and mortality from AL during the past nine years. Read More

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September 2021

Identification of a Slovenian prewar elite couple killed in the Second World War.

Forensic Sci Int 2021 Sep 9;327:110994. Epub 2021 Sep 9.

Institute of Forensic Medicine, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia. Electronic address:

Genetic identification of a Slovenian prewar elite couple killed in 1944 was performed by typing autosomal and Y-chromosomal STRs, and phenotypic HIrisPlex SNPs for hair and eye color prediction were analyzed for the female skeleton using next-generation sequencing (NGS) technology. The clandestine grave containing the couple's skeletal remains was found in 2015 and only the partial remains were found. Living distant relatives could be found only for the male victim. Read More

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September 2021

Impacts of the respecting the circle of life teen pregnancy prevention program on risk and protective factors for early substance use among native American youth.

Drug Alcohol Depend 2021 Sep 4;228:109024. Epub 2021 Sep 4.

Johns Hopkins University, Bloomberg School of Public Health, Center for American Indian Health, 415 N. Washington St., Baltimore, MD, 21231, USA.

Background: Early substance use disproportionately impacts Native American (Native) youth and increases their risk for future abuse and dependence. The literature urges for interventions to move beyond focusing on single risk behaviors (e.g. Read More

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September 2021

Analysis of vascular involvement in 460 patients with Behçet's syndrome: Clinical characteristics and associated factors.

Joint Bone Spine 2021 Sep 15:105277. Epub 2021 Sep 15.

Ankara University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey.

Objectives: To describe demographic and clinical characteristics of vascular involvement in patients with Behçet's syndrome (BS) and to evaluate associations with such involvement.

Methods: We retrospectively evaluated records of 2118 BS patients. In total, 460 patients diagnosed with superficial thrombophlebitis (ST) and/or major vascular events (venous and/or arterial involvements) were included in current analysis. Read More

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September 2021

Surgical treatment of terrible triad of the elbow: retrospective continuous 50-patient series at 2 years' follow-up.

Orthop Traumatol Surg Res 2021 Sep 15:103057. Epub 2021 Sep 15.

Service Orthopédie et Traumatologie, CHU Grenoble Alpes, Boulevard de la Chantourne, 38700 La Tronche, France.

Introduction: Terrible triad (TT) of the elbow is an association at high risk of instability. Treatment aims to restore joint stability. Lateral collateral ligament (LCL) repair is systematic, whereas medial collateral ligament (MCL) repair is only exceptionally necessary. Read More

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September 2021

Juvenile-onset Open-angle Glaucoma - A Clinical and Genetic Update.

Surv Ophthalmol 2021 Sep 15. Epub 2021 Sep 15.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Juvenile-onset open-angle glaucoma (JOAG) is a subset of primary open-angle glaucoma that is diagnosed before 40 years of age. The disease may be familial or non-familial, with proportions varying among different populations. Myocilin mutations are the most commonly associated. Read More

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September 2021

Treadmill exercise sex-dependently alters susceptibility to depression-like behaviour, cytokines and BDNF in the hippocampus and prefrontal cortex of rats with sporadic Alzheimer-like disease.

Physiol Behav 2021 Sep 15:113595. Epub 2021 Sep 15.

Salari Institute of Cognitive and Behavioral Disorders (SICBD), Karaj, Alborz, Iran. Electronic address:

Alzheimer's disease (AD) is associated with increased depression-related behaviours. Previous studies have reported a greater risk of AD and depression in women. In recent years, we and others have provided evidence that exercise during life could be used as a therapeutic strategy for stress-related disorders such as depression. Read More

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September 2021

Suture granuloma with hydronephrosis caused by ileostomy closure after rectal cancer surgery: a case report.

Surg Case Rep 2021 Sep 18;7(1):210. Epub 2021 Sep 18.

Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

Background: Suture granuloma with hydronephrosis after abdominal surgery is extremely rare. We herein report a successfully treated case of suture granuloma with hydronephrosis caused by ileostomy closure after rectal cancer surgery.

Case Presentation: A 63-year-old male underwent laparoscopic low anterior resection with covering ileostomy. Read More

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September 2021

Epidemiologic trends in pediatric ocular injury in the USA from 2010 to 2019.

Graefes Arch Clin Exp Ophthalmol 2021 Sep 18. Epub 2021 Sep 18.

Depart, ment of Ophthalmology and Visual Sciences, Rutgers New Jersey Medical School, Newark, NJ, USA.

Purpose: Epidemiologic studies related to the demographics and trends of ocular injury in the pediatric cohort in the last decade are limited. This study describes epidemiologic trends in consumer product-related pediatric ocular injuries from 2010 to 2019.

Methods: This is a retrospective observational study utilizing data from the National Electronic Injury Surveillance System (NEISS). Read More

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September 2021

Biochemical characteristics and calcium and PTH levels of patients with high normal and elevated serum 25(OH)D levels in Turkey: DeVIT-TOX survey.

Arch Osteoporos 2021 Sep 18;16(1):138. Epub 2021 Sep 18.

Department of Endocrinology, School of Medicine, Dicle University, Diyarbakır, Turkey.

Vitamin D intake over the recommended dose is usually associated with high serum 25(OH)D levels and generally not associated with symptoms of hypercalcemia. High doses of cholecalciferol need to be avoided to protect against vitamin D toxicity and related complications. Strict adherence to the clinical guidelines for treating vitamin D deficiency can ensure safe and effective treatment. Read More

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September 2021

Longevity and subject-reported satisfaction after minimally invasive jawline contouring.

J Cosmet Dermatol 2021 Sep 18. Epub 2021 Sep 18.

Department for Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilian University Munich, Munich, Germany.

Background: Minimally invasive treatments as soft tissue filler injections can enhance the appearance of the jawline. This prospective, single-center study investigated aesthetic outcome, patient satisfaction, adverse events, and volume changes after jawline contouring using standardized reporting scales and objectifiable 3D surface analysis.

Methods: A total of 30 patients (1 male and 29 females, mean age: 57. Read More

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September 2021

Risk factors for prolonged air leak and need for intervention following lung resection.

Interact Cardiovasc Thorac Surg 2021 Sep 18. Epub 2021 Sep 18.

Division of Thoracic and Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Objectives: Prolonged air leak (PAL; >5 days) following lung resection is associated with postoperative morbidity. We investigated factors associated with PAL and PAL requiring intervention.

Methods: Retrospective review of all patients undergoing lobectomy, segmentectomy or wedge resection from 2016 to 2019 at our institution. Read More

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September 2021

Single-Sweep Pulmonary Vein Isolation using the new third-generation laser balloon - Evolution in ablation style using endoscopic ablation system.

J Cardiovasc Electrophysiol 2021 Sep 17. Epub 2021 Sep 17.

Cardioangiologisches Centrum Bethanien, Frankfurt, Germany.

Background: The endoscopic ablation system (EAS) is an established ablation device for pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF). The novel X3 EAS is now equipped with a contiguous circumferential ablation mode (RAPID mode).

Aim: To determine the feasibility of single-shot fashioned ablation using X3. Read More

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September 2021

The relationship between mortality and inflammatory markers and the systemic immune inflammatory index in patients in the intensive care unit with a pneumothorax as a complication of COVID-19 disease.

Ir J Med Sci 2021 Sep 18. Epub 2021 Sep 18.

Thoracic Surgery Clinic, Ankara City Hospital, Çankaya, Turkey.

Background: A pneumothorax is common in patients admitted to the intensive care unit (ICU) with coronavirus disease (COVID-19) when non-invasive or invasive mechanical ventilation is performed to maintain adequate oxygenation. The aim of the present study was to investigate the effects of elevated inflammatory markers and an elevated systemic immune inflammatory index (SII) on mortality in this patient population.

Materials And Methods: Between March 2020 and May 2021, 124 patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reacion positviity who were admitted to the ICU in our hospital and diagnosed with and treated for a pneumothorax were evaluated retrospectively. Read More

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September 2021

Prediction of Early Symptom Remission in Two Independent Samples of First-Episode Psychosis Patients Using Machine Learning.

Schizophr Bull 2021 Sep 18. Epub 2021 Sep 18.

Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia.

Background: Validated clinical prediction models of short-term remission in psychosis are lacking. Our aim was to develop a clinical prediction model aimed at predicting 4-6-week remission following a first episode of psychosis.

Method: Baseline clinical data from the Athens First Episode Research Study was used to develop a Support Vector Machine prediction model of 4-week symptom remission in first-episode psychosis patients using repeated nested cross-validation. Read More

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September 2021

A longitudinal cohort study of adolescent elite footballers and controls investigating the development of cam morphology.

Sci Rep 2021 Sep 17;11(1):18567. Epub 2021 Sep 17.

Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Cam morphology describes an asphericity of the femoral head that develops during adolescence, is highly prevalent in athletes, and predisposes individuals to future osteoarthritis. However, it's aetiology remains poorly understood. The aim of this study was to perform 3-year longitudinal follow-up of a control population and football club academy cohort to compare the change in hip and growth plate anatomy between athletes and controls. Read More

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September 2021

Associations of clinical, psychological, and socioeconomic characteristics with nicotine dependence in smokers.

Sci Rep 2021 Sep 17;11(1):18544. Epub 2021 Sep 17.

Respiratory Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Cigarette smoking is a risk factor of mortality and morbidity from various cancerous, respiratory, and myocardial diseases. Nicotine dependence is assessed based on the degree of physical dependence. We aimed to determine the clinical, socioeconomic and psychological factors associated with the smoking status and degree of nicotine dependence of smokers. Read More

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September 2021

Impact of genetic risk score on the association between male childlessness and cardiovascular disease and mortality.

Sci Rep 2021 Sep 17;11(1):18526. Epub 2021 Sep 17.

Reproductive Medicine Centre, Skåne University Hospital, Malmö, Sweden.

Childless men are reported to have a higher risk of cardiovascular disease (CVD) and mortality. Information on inherited genetic risk for CVD has improved the predictive models. Presuming that childlessness is a proxy of infertility we aimed to investigate if childless men inherit more often genetic traits for CVD and if combining genetic and parenthood information improves predictive models for CVD morbidity and mortality. Read More

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September 2021

Coronary Inflammation Assessed by Perivascular Fat Attenuation Index in Patients with Psoriasis: A Propensity Score-Matched Study.

Dermatology 2021 Sep 15:1-9. Epub 2021 Sep 15.

Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: This study aimed to evaluate coronary inflammation by measuring the perivascular fat attenuation index (FAI) and quantify the atherosclerosis burden in patients with psoriasis and control individuals without psoriasis based on coronary computed tomography angiography (CCTA) images.

Methods: A total of 98 consecutive patients with psoriasis (76 male [77.6%], aged 56. Read More

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September 2021

C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inflammatory Conditions.

J Am Board Fam Med 2021 Sep-Oct;34(5):974-983

From the Department of Internal Medicine, Complejo Hospitalario Universitario, University of Santiago de Compostela, Spain (VA-C, BS, AG-Q); Primary Care Center, A Estrada, Spain (CF-M, JS-C); Department of Clinical Epidemiology, Complejo Hospitalario Universitario, Santiago de Compostela, Spain (MA-S, FG).

Background: Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice.

Aim: To investigate the factors associated with discordances between CRP concentration and ESR in adults.

Methods: We conducted a cross-sectional study of 1472 adults with no known inflammatory disorders (44. Read More

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February 2021

Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study.

BMJ 2021 Sep 17;374:n2244. Epub 2021 Sep 17.

Division of Primary Care, School of Medicine, University of Nottingham, Nottingham, UK.

Objectives: To derive and validate risk prediction algorithms to estimate the risk of covid-19 related mortality and hospital admission in UK adults after one or two doses of covid-19 vaccination.

Design: Prospective, population based cohort study using the QResearch database linked to data on covid-19 vaccination, SARS-CoV-2 results, hospital admissions, systemic anticancer treatment, radiotherapy, and the national death and cancer registries.

Settings: Adults aged 19-100 years with one or two doses of covid-19 vaccination between 8 December 2020 and 15 June 2021. Read More

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September 2021

Ceftolozane/tazobactam for refractory P. aeruginosa endocarditis: A case report and pharmacokinetic analysis.

J Infect Chemother 2021 Sep 15. Epub 2021 Sep 15.

Antibiotic Management Program, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; XDR Pathogens Laboratory, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.

We describe a case of a 48 years old male with left sided endocarditis and septic emboli secondary to a Pseudomonas aeruginosa strain that developed resistance to other β-lactam antibiotics during therapy resulting in prolonged bacteremia. Blood cultures sterilized within 1 day of initiating ceftolozane/tazobactam 3 g every 8 hours in combination with ciprofloxacin. Steady state free ceftolozane plasma Cmax and Cmin concentrations were calculated to be 122. Read More

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September 2021

The Impact of Mental Health and Stress Concerns on Relationship and Sexuality Amidst the COVID-19 Lockdown.

J Sex Med 2021 Jun 28. Epub 2021 Jun 28.

Department of Health and Environmental Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, Jiangsu, China. Electronic address:

Background: Since January 23, 2020, the Chinese government has imposed restrictive measures including self-isolation, travel restrictions and lockdown of Wuhan city in order to prevent the incoming waves of COVID-19 outbreak in the country. However, the impact of mental health and stress concerns on relationship and sexuality amidst the COVID-19 lockdown was currently unclear.

Aim: The cross-sectional study was designed to determine the changes in health, relationship and sexuality among the Chinese couples who lived together amid the early stages of COVID-19 pandemic in China. Read More

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Male Genital Self-Image Scale (MGSIS): Cutoff Point, Cultural Adaptation and Validation of Measurement Properties in Brazilian Men.

J Sex Med 2021 Sep 14. Epub 2021 Sep 14.

Departamento de Fisioterapia e Reabilitação, Universidade Federal de Santa Maria, Santa Maria, Brasil.

Background: Concerns about genital self-image (GSI) can influence sexual function and quality of life, and instruments that assess male GSI, such as the Male Genital Self-Image Scale (MGSIS), need to be adapted and validated in different cultures.

Aims: To culturally adapt and validate the measurement properties of MGSIS in Brazilian men, according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) guideline, and to create a cutoff point for satisfaction with male GSI.

Methods: We assessed the validity of content through a committee of experts and cognitive interviews. Read More

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September 2021

Low COVID-19 vaccine hesitancy in Brazil.

Vaccine 2021 Sep 7. Epub 2021 Sep 7.

National Institute of Women, Children and Adolescents' Health Fernandes Figueira, FIOCRUZ, Avenue Rui Barbosa, 716, Flamengo, Rio de Janeio, RJ 22250-020, Brazil.

Background: The COVID-19 pandemic has affected the entire world, and the vaccine has emerged as a source of hope for return to normal life. Still, various countries have reported high vaccine hesitancy rates. It is important to know the vaccine hesitancy profile in Brazil to help design adequate communication strategies. Read More

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September 2021

Trichomonas Infection Rates in Males Presenting to the Emergency Department for Sexually Transmitted Infections.

J Emerg Med 2021 Sep 14. Epub 2021 Sep 14.

University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York; John R. Oishei Children's Hospital, Buffalo, New York; Erie County Department of Health, Buffalo, New York.

Background: Trichomonas vaginalis (TV) is one of the most common sexually transmitted infections (STIs). Overall prevalence is reported to be 3.1%, with rates approaching 12. Read More

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September 2021

Prescription Opioid Characteristics and Nonfatal Overdose Among Patients Discharged from Tennessee Emergency Departments.

J Emerg Med 2021 Sep 14. Epub 2021 Sep 14.

Department of Public Health, Grand Valley State University, Grand Rapids, Michigan. Electronic address:

Background: Despite increasing trends of nonfatal opioid overdoses in emergency departments (EDs), population-based studies comparing prescription opioid dosing patterns before and after nonfatal opioid overdoses are limited.

Objectives: To evaluate characteristics of prescribing behaviors before and after nonfatal overdoses, with a focus on opioid dosage.

Methods: Included were 5,395 adult residents of Tennessee discharged from hospital EDs after a first nonfatal opioid overdose (2016-2017). Read More

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September 2021

Early versus late awake prone positioning in non-intubated patients with COVID-19.

Crit Care 2021 Sep 17;25(1):340. Epub 2021 Sep 17.

Division of Respiratory Care, Department of Cardiopulmonary Sciences, Rush University Medical Center, 600 S Paulina St, Suite 765, Chicago, IL, USA.

Background: Awake prone positioning (APP) is widely used in the management of patients with coronavirus disease (COVID-19). The primary objective of this study was to compare the outcome of COVID-19 patients who received early versus late APP.

Methods: Post hoc analysis of data collected for a randomized controlled trial (ClinicalTrials. Read More

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September 2021

Risk factors for malaria in high incidence areas of Viet Nam: a case-control study.

Malar J 2021 Sep 17;20(1):373. Epub 2021 Sep 17.

Naval Medical Research Unit-2, Singapore, Singapore.

Background: A key step to advancing the goal of malaria elimination in Viet Nam by 2030 is focusing limited resources for treatment and prevention to groups most at risk for malaria transmission.

Methods: To better understand risk factors for malaria transmission in central Viet Nam, a survey of 1000 malaria positive cases and 1000 malaria negative controls was conducted. Cases and controls were matched for age and gender and self-presented at commune health stations (CHS) in Binh Phuoc, Dak Nong and Dak Lak Provinces. Read More

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September 2021

The prevalence and density of asymptomatic Plasmodium falciparum infections among children and adults in three communities of western Kenya.

Malar J 2021 Sep 17;20(1):371. Epub 2021 Sep 17.

Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Background: Further reductions in malaria incidence as more countries approach malaria elimination require the identification and treatment of asymptomatic individuals who carry mosquito-infective Plasmodium gametocytes that are responsible for furthering malaria transmission. Assessing the relationship between total parasitaemia and gametocytaemia in field surveys can provide insight as to whether detection of low-density, asymptomatic Plasmodium falciparum infections with sensitive molecular methods can adequately detect the majority of infected individuals who are potentially capable of onward transmission.

Methods: In a cross-sectional survey of 1354 healthy children and adults in three communities in western Kenya across a gradient of malaria transmission (Ajigo, Webuye, and Kapsisywa-Kipsamoite), asymptomatic P. Read More

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September 2021