27,586 results match your criteria years interquartile


"Do I still have epilepsy?" Epilepsy identity 15-20 years after anterior temporal lobectomy.

Epilepsia 2021 Dec 4. Epub 2021 Dec 4.

Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Vic., Australia.

Objective: Identity is a multifaceted construct, comprising personal identity (sense of being a unique individual) and social identity (the sense-of-self derived from membership of social groups). Social identity involves explicit identification with a group ("I am …") and implicit behaviors or attitudes associated with group membership. Following successful treatment with surgery, patients with epilepsy can undergo a complex and lasting change in personal identity. Read More

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December 2021

Pediatric Parapneumonic Effusion/Pleural Empyema in Japan: A Nationwide Survey.

Pediatr Infect Dis J 2021 Nov 30. Epub 2021 Nov 30.

From the Division of Infectious Diseases, Chiba Children's Hospital, Chiba-city, Chiba, Japan Division of Allergy and Pulmonology, Fukuoka Children's Hospital, Kashiiteriha, Higashi-ku, Fukuoka, Japan, Department of Pediatrics, Tokai University Hospital, Isehara-city, Kanagawa, Japan Department of Pediatrics, St Luke's Hospital, Akashi-cho, Chuo-ku, Tokyo, Japan Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba-city, Chiba, Japan.

Background: Pediatric parapneumonic effusion/ pleural empyema (PPE/PE) is a severe infectious condition, and its management should be guided by local epidemiology and the patient's medical history. This survey aimed to determine the clinical and bacteriologic features of PPE/PE in Japan.

Methods: A nationwide retrospective questionnaire survey was conducted, targeting 159 pediatric specialist training medical facilities for inpatients ≤18 years of age who were admitted for PPE/PE between January 2007 and December 2016. Read More

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November 2021

The Suboptimal Pediatric HIV Viral Load Cascade: Multidistrict Cohort Study Among Children Taking Antiretroviral Therapy in Lesotho, Southern Africa.

Pediatr Infect Dis J 2021 Nov 30. Epub 2021 Nov 30.

From the SolidarMed, Partnerships for Health, Maseru, Lesotho Institute of Global Health, University of Geneva, Geneva, Switzerland Department of Medicine, Swiss Tropical & Public Health Institute, Basel, Switzerland Molecular Virology, Department of Biomedicine, University of Basel, Basel, Switzerland University of Basel, Basel, Switzerland Ministry of Health of Lesotho, Maseru, Lesotho Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland.

Background: Children living with HIV and taking antiretroviral therapy (ART) are a priority group for routine viral load (VL) monitoring. As per Lesotho guidelines, a VL ≥1000 copies/mL ("unsuppressed") should trigger adherence counseling and a follow-up VL; 2 consecutive unsuppressed VLs ("virologic failure") qualify for switching to second-line ART, with some exceptions. Here, we describe the pediatric VL cascade in Lesotho. Read More

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November 2021

Disorders of Consciousness Associated With COVID-19: A Prospective, Multimodal Study of Recovery and Brain Connectivity.

Neurology 2021 Dec 3. Epub 2021 Dec 3.

Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Background And Objectives: In patients with severe coronavirus disease 2019 (COVID-19), disorders of consciousness (COVID-DoC) have emerged as a serious complication. The prognosis and pathophysiology of COVID-DoC remain unclear, complicating decisions about continuing life-sustaining treatment. We describe the natural history of COVID-DoC and investigate its associated brain connectivity profile. Read More

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December 2021

Risk factors for COVID-19 progression and mortality in hospitalized patients without pre-existing comorbidities.

J Infect Public Health 2021 Nov 18;15(1):13-20. Epub 2021 Nov 18.

Huanggang Institute of Translational Medicine, Huanggang, China; Institute of Model Animal of Wuhan University, Wuhan, China; Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China. Electronic address:

Background: Coronavirus disease 2019 (COVID-19) pandemic continues to escalate intensively worldwide. Massive studies on general populations with SARS-CoV-2 infection have revealed that pre-existing comorbidities were a major risk factor for the poor prognosis of COVID-19. Notably, 49-75% of COVID-19 patients had no comorbidities, but this cohort would also progress to severe COVID-19 or even death. Read More

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November 2021

Development of a Prognostic Model for Predicting Multiple Sclerosis After Optic Neuritis: A Secondary Analysis of Data From the Optic Neuritis Treatment Trial.

J Neuroophthalmol 2021 Oct 22. Epub 2021 Oct 22.

Department of Neurology (WL), the First Affiliated Hospital of Guangxi Medical University, Nanning, China; Department of Environmental Health Sciences (XD), University at Albany, State University of New York, Rensselaer, New York; State Key Laboratory of Ophthalmology (XX), Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; Department of Ophthalmology (RS, ML, YD), the First Affiliated Hospital of Guangxi Medical University, Nanning, China; Byers Eye Institute (HEM), Stanford University, Palo Alto, California; and Department of Neurology and Neurological Sciences (HEM), Stanford University, Stanford, California.

Background: Optic neuritis can be the initial manifestation of multiple sclerosis (MS). The purpose of this study was to develop a prognostic model for predicting the risk of MS development among patients with optic neuritis.

Methods: The data from 388 patients with optic neuritis were retrieved from the Optic Neuritis Treatment Trial (ONTT). Read More

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October 2021

Urinary cadmium and incident heart failure: A case-cohort analysis among never-smokers in Denmark.

Epidemiology 2021 Dec 1. Epub 2021 Dec 1.

Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA Christina Lee Brown Envirome Institute, Division of Environmental Medicine, Department of Medicine, University of Louisville, Louisville, KY, USA Danish Cancer Society Research Center, Copenhagen, Denmark Department of Environmental Science, Aarhus University, Roskilde, Denmark Center for Analytical Science, Research Triangle Institute, Research Triangle Park, NC, USA Department of Family Medicine, University of Colorado Denver, Denver, CO, USA Department of Public Health, Aarhus University, Aarhus, Denmark Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark Department of Public Health, University of Copenhagen, Copenhagen, Denmark Program in Public Health, Department of Family, Population, & Preventive Medicine, Stony Brook University, NY, USA Department of Environmental Health, Boston University, Boston, MA, USA.

Background: Epidemiologic studies suggest cadmium exposure is associated with cardiovascular disease risk, including heart failure. However, prior findings may be influenced by tobacco smoking, a dominant source of cadmium exposure and risk factor for heart failure. The present study leverages up to 20 years of follow-up in the Danish Diet, Cancer and Health cohort to examine the relationship between urinary cadmium and incident heart failure among people who never smoked. Read More

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December 2021

Clinical and functional outcome of surgery for post-traumatic cloacal deformity.

Colorectal Dis 2021 Dec 3. Epub 2021 Dec 3.

Dept. of Emergency and Organ transplantation &Inter-Department Research Center for Pelvic Floor Disease (CIRPAP), University Aldo Moro of Bari, Italy.

Background: Cloacal deformity (CD) is a disabling condition that severely affects patients' quality of life.Surgery to repair CD remainsthe mainstay of treatment. The aim of this study is to assess the clinical and functional outcome of patients treated for traumaticCDby three different techniques. Read More

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December 2021

Both increased and decreased sleep duration over time are associated with subsequent cancer development.

Sleep Breath 2021 Dec 3. Epub 2021 Dec 3.

Department of General Medicine, Juntendo University Faculty of Medicine, Tokyo, Japan.

Purpose: Changes in sleep duration have been reported to correlate with lifestyle-related diseases in humans. However, equivalent studies regarding the effects of sleep on cancer progression are lacking. This study aimed to determine whether or not increase or decrease in sleep duration over time is associated with subsequent cancer development. Read More

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December 2021

Retrospective evaluation of an observational cohort by the Central and Eastern Europe Network Group shows a high frequency of potential drug-drug interactions among HIV-positive patients receiving treatment for coronavirus disease 2019 (COVID-19).

HIV Med 2021 Dec 3. Epub 2021 Dec 3.

Carol Davila University of Medicine and Pharmacy, Victor Babes Clinical Hospital for Infectious and Tropical Diseases, Bucharest, Romania.

Objectives: The aim of this international multicentre study was to review potential drug-drug interactions (DDIs) for real-life coadministration of combination antiretroviral therapy (cART) and coronavirus disease 2019 (COVID-19)-specific medications.

Methods: The Euroguidelines in Central and Eastern Europe Network Group initiated a retrospective, observational cohort study of HIV-positive patients diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Data were collected through a standardized questionnaire and DDIs were identified using the University of Liverpool's interaction checker. Read More

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December 2021

Presentation and Real-World Management of Giant Cell Arteritis (Artemis Study).

Front Med (Lausanne) 2021 11;8:732934. Epub 2021 Nov 11.

Rheumatology Department, University Hospital La Cavale Blanche, Brest, France.

Few studies of daily practice for patients with giant cell arteritis (GCA) are available. This French study aimed to describe the characteristics and management of GCA in a real-life setting. Cross-sectional, non-interventional, multicenter study of patients ≥50 years old who consulted hospital-based specialists for GCA and were under treatment. Read More

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November 2021

Do Anxiety and Depression Predict Persistent Physical Symptoms After a Severe COVID-19 Episode? A Prospective Study.

Front Psychiatry 2021 10;12:757685. Epub 2021 Nov 10.

Service de Microbiologie, Unité Mobile d'Infectiologie, Assistance Publique Hopitaux De Paris, Hôpital Européen Georges Pompidou, Université de Paris, Paris, France.

Persistent physical symptoms are common after a coronavirus disease 2019 (COVID-19) episode, but their pathophysiological mechanisms remain poorly understood. In this study, we aimed to explore the association between anxiety and depression at 1-month after acute infection and the presence of fatigue, dyspnea, and pain complaints at 3-month follow-up. We conducted a prospective study in patients previously hospitalized for COVID-19 followed up for 3 months. Read More

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November 2021

Celecoxib and Myrtol: A Novel Therapy for Recurrent Appendiceal Mucinous Neoplasms With Extensive Peritoneal Dissemination.

Am J Clin Oncol 2021 Nov 30. Epub 2021 Nov 30.

University of Chicago Pritzker School of Medicine Section of General Surgery and Surgical Oncology Department of Surgery Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine University of Chicago, Chicago, IL.

Background: Unresectable appendiceal mucinous neoplasms (AMNs) with extensive peritoneal dissemination cause significant morbidity and have limited treatment options. We evaluated a novel combination of Celecoxib and Myrtol in treating such AMNs.

Methods: Patients with recurrent AMNs with extensive peritoneal disease treated with a daily regimen of 200 mg Celecoxib and 1200 mg Myrtol Standardized were included. Read More

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November 2021

Extracellular water to total body water ratio may mediate the association between phase angle and mortality in patients with cancer cachexia: A single-center, retrospective study.

Clin Nutr ESPEN 2021 Dec 20;46:193-199. Epub 2021 Oct 20.

Innovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu University, 1-1 Yanagido, Gifu City, Gifu, 501-1194, Japan. Electronic address:

Background & Aims: Recently, prognostic factors for cancer cachexia patients have been reported. We hypothesized that phase angle (PhA), which is measured by bioelectrical impedance analysis (BIA), might be a promising marker for assessing the nutritional status and prognosis of cancer patients. This study aimed to evaluate the predictive utility of PhA, which is mediated by several BIA factors and other anthropometric parameters, such as calf circumference, for the prognosis of cancer cachexia patients. Read More

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December 2021

Preeclampsia Predicts Risk of Hospitalization for Heart Failure With Preserved Ejection Fraction.

J Am Coll Cardiol 2021 Dec;78(23):2281-2290

Cardiovascular Imaging and Clinical Research Core Laboratory, Cardiovascular Division, Washington University in St Louis, St Louis, Missouri, USA; Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Washington University in St Louis, St Louis, Missouri, USA. Electronic address:

Background: Preeclampsia is associated with increased risk of future heart failure (HF), but the relationship between preeclampsia and HF subtypes are not well-established.

Objectives: The objective of this analysis was to identify the risk of HF with preserved ejection fraction (HFpEF) following a delivery complicated by preeclampsia/eclampsia.

Methods: A retrospective cohort study using the New York and Florida state Healthcare Cost and Utilization Project State Inpatient Databases identified delivery hospitalizations between 2006 and 2014 for women with and without preeclampsia/eclampsia. Read More

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December 2021

Workforce demographics and unit structure in paediatric cardiac critical care in the United States.

Cardiol Young 2021 Dec 3:1-5. Epub 2021 Dec 3.

Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH, USA.

Objective: To assess current demographics and duties of physicians as well as the structure of paediatric cardiac critical care in the United States.

Design: REDCap surveys were sent by email from May till August 2019 to medical directors ("directors") of critical care units at the 120 United States centres submitting data to the Society of Thoracic Surgeons Congenital Heart Surgery Database and to associated faculty from centres that provided email lists. Faculty and directors were asked about personal attributes and clinical duties. Read More

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December 2021

The minimal clinically important change in the motor section of the Burke-Fahn-Marsden Dystonia Rating Scale for generalized dystonia: Results from deep brain stimulation.

Parkinsonism Relat Disord 2021 Nov 19;93:85-88. Epub 2021 Nov 19.

Department of Neurology, Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, USA.

Background: The minimal clinically important difference (MCID) describes the smallest change in an outcome that is considered clinically meaningful. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) is the most frequently rating scale assessing the efficacy of deep brain stimulation therapy (DBS) for dystonia. To expand our understanding, we evaluated the MCID thresholds for the BFMDRS motor subscale (MS) using physician-reported outcomes. Read More

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November 2021

Do the outcomes of hip arthroscopy for femoroacetabular impingement change over time?

Orthop Traumatol Surg Res 2021 Nov 29:103157. Epub 2021 Nov 29.

Edinburgh Orthopaedics, Royal Infirmary of Edinburgh, UK.

Background: The purpose of this study was to search for changes in functional outcomes of patients undergoing hip arthroscopy for femoroacetabular impingement (FAI) between short and medium-term follow-up. Secondary aims included reporting rates of revision surgery and total hip arthroplasty (THA) at medium-term follow-up.

Hypothesis: We hypothesised that patients' functional outcomes would improve between short and medium-term follow-up. Read More

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November 2021

Incorporating artificial intelligence in urology: Supervised machine learning algorithms demonstrate comparative advantage over nomograms in predicting biochemical recurrence after prostatectomy.

Prostate 2021 Dec 2. Epub 2021 Dec 2.

Department of Urology, Singapore General Hospital, Singapore, Singapore.

Objective: After radical prostatectomy (RP), one-third of patients will experience biochemical recurrence (BCR), which is associated with subsequent metastasis and cancer-specific mortality. We employed machine learning (ML) algorithms to predict BCR after RP, and compare them with traditional regression models and nomograms.

Methods: Utilizing a prospective Uro-oncology registry, 18 clinicopathological parameters of 1130 consecutive patients who underwent RP (2009-2018) were recorded, yielding over 20,000 data points for analysis. Read More

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December 2021

Rhythm- or rate-control strategies according to 4S-AF characterization scheme and long-term outcomes in atrial fibrillation patients: the FAMo (Fibrillazione Atriale in Modena) cohort.

Intern Emerg Med 2021 Dec 2. Epub 2021 Dec 2.

Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo, 71, 41124, Modena, Italy.

The 4S-AF scheme [Stroke risk, Symptom severity, Severity of atrial fibrillation (AF) burden, Substrate severity] was recently proposed to characterize AF patients. In this post hoc analysis we evaluated the agreement between the therapeutic strategy (rate or rhythm control, respectively), as suggested by the 4S-AF scheme, and the actual strategy followed in a patients cohort. Outcomes of interest were as follows: all-cause death, a composite of all-cause death/any thromboembolism/acute coronary syndrome, and a composite of all-cause death, any thrombotic/ischemic event, and major bleeding (net clinical outcome). Read More

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December 2021

Androgen Deprivation Therapy and the Risk of Dementia after Treatment for Prostate Cancer.

J Urol 2021 Dec 2:101097JU0000000000002335. Epub 2021 Dec 2.

Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.

Purpose: The association between androgen deprivation therapy (ADT) and dementia in men with prostate cancer remains inconclusive. We assessed the association between cumulative ADT exposure and the onset of dementia in a nationwide longitudinal registry of men with prostate cancer.

Materials And Methods: A retrospective analysis of men aged ≥50 years from the CaPSURE registry was performed. Read More

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December 2021

Determinants of survival after lung transplantation in telomerase-related gene mutation carriers: a retrospective cohort.

Am J Transplant 2021 Dec 1. Epub 2021 Dec 1.

Service de Pneumologie A, Centre de référence des maladies pulmonaires rares (site constitutif), APHP, Hôpital Bichat, Université de Paris and INSERM U1152, Paris, France.

Carriers of germline telomerase-related gene (TRG) mutations can show poor prognosis, with an increase in common hematological complications after lung transplantation (LT) for pulmonary fibrosis. The aim of this study was to describe the outcomes after LT in recipients carrying a germline TRG mutation and to identify predictors of survival. In a multicenter cohort of LT patients, we retrospectively reviewed those carrying pathogenic TRG variations (n=38; TERT, n=23, TERC, n=9, RTEL1, n=6) between 2009 and 2018. Read More

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December 2021

Health impacts of a scale-up of supervised injection services in a Canadian setting: an interrupted time series analysis.

Addiction 2021 Dec 2. Epub 2021 Dec 2.

British Columbia Centre on Substance Use, Vancouver, BC, Canada.

Background And Aims: In response to a dramatic rise in overdose deaths due to injection drug use, there was a rapid scale-up of low-threshold supervised injection services (SIS), termed 'overdose prevention sites' (OPS), in Vancouver, Canada in December 2016. We measured the potential impact of this intervention on SIS use and related health outcomes among people who inject drugs (PWID).

Design: Segmented regression analyses of interrupted time series data from two community-recruited prospective cohorts of PWID from January 2015 to November 2018 were used to measure the impact of the OPS scale-up on changes in SIS use, public injection, syringe sharing and addiction treatment participation, controlling for pre-existing secular trends. Read More

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December 2021

Streptococcus anginosus group infections in hospitalised children and young people.

J Paediatr Child Health 2021 Dec 1. Epub 2021 Dec 1.

Department of Paediatrics, Gold Coast Health, Gold Coast, Queensland, Australia.

Aim: The Streptococcus anginosus group (SAG) comprises three bacterial species colonising the mouth and gastrointestinal and genitourinary tracts and capable of serious pyogenic infections. Although well-described in adults, studies in children are limited. Here, we characterise paediatric SAG infections from a single Australian centre. Read More

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December 2021

Genetic variation of as a protective genotype for the development of colorectal cancer in men.

World J Gastrointest Oncol 2021 Nov;13(11):1766-1780

Department of Molecular Biology, Immunology and Medical Genetics, Medical Faculty, Trakia University, Stara Zagora 6000, Bulgaria.

Background: The role of transforming growth factor beta (TGF-β) signaling, including both the cytokine and their receptors, in the etiology of colorectal cancer (CRC) has been of particular interest lately.

Aim: To investigate the association between promoter polymorphism in TGF-β receptor 2 TGF-ΒR2GA with a CRC risk in a cohort of Bulgarian patients using a case-control gene association study approach, as well as the protein levels of TGF-β1 in the peripheral blood.

Methods: A cohort of 184 CRC patients and 307 sex and age-matched healthy subjects were recruited in the study. Read More

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November 2021

Dietary Potassium Intake and All-Cause Mortality in Adults Treated with Hemodialysis.

Clin J Am Soc Nephrol 2021 Dec 1. Epub 2021 Dec 1.

School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Background And Objectives: Dietary potassium restriction in people receiving maintenance hemodialysis is standard practice and is recommended in guidelines, despite a lack of evidence. We aimed to assess the association between dietary potassium intake and mortality and whether hyperkalemia mediates this association.

Design, Setting, Participants, & Measurements: A total of 8043 adults undergoing maintenance hemodialysis in Europe and South America were included in the DIETary intake, death and hospitalization in adults with end-stage kidney disease treated with HemoDialysis (DIET-HD) study. Read More

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December 2021

Financial incentives for smoking cessation in pregnancy: multicentre randomised controlled trial.

BMJ 2021 12 1;375:e065217. Epub 2021 Dec 1.

EDHEC Business School, Roubaix, France.

Objective: To evaluate the efficacy of financial incentives dependent on continuous smoking abstinence on smoking cessation and birth outcomes among pregnant smokers.

Design: Single blind, randomised controlled trial.

Setting: Financial Incentive for Smoking Cessation in Pregnancy (FISCP) trial in 18 maternity wards in France. Read More

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December 2021

The impact of hypo-attenuated leaflet thickening on haemodynamic valve deterioration following transcatheter aortic valve replacement.

J Cardiovasc Comput Tomogr 2021 Nov 26. Epub 2021 Nov 26.

Monash Heart, Monash Health and Monash Cardiovascular Research Centre, Monash University, Australia.

Background: Hypo-attenuated leaflet thickening (HALT) may occur following transcatheter aortic valve replacement (TAVR), however, it remains unclear if HALT is a predictor of haemodynamic valve deterioration (HVD).

Aim: To determine the impact of HALT on the occurrence of HVD.

Methods: We prospectively evaluated 186 patients for the presence of HALT at a median of 6 weeks following TAVR (Interquartile-range [IQR] 4-12 weeks). Read More

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November 2021

Comparative evaluation of pain perception with a new needle-free system and dental needle method in children: a randomized clinical trial.

BMC Anesthesiol 2021 Dec 1;21(1):301. Epub 2021 Dec 1.

Faculty of Medicine, Department of Biostatistics, Tokat Gaziosmanpaşa University, Tokat, Turkey.

Background: Pain control during dental procedures is one of the most important topics related to behavior management in children. This study aims to compare the pain perception associated with a needle-free system (Comfort-In™) and the dental needle method during filling and pulpotomy treatments in children.

Methods: The study included teeth that required treatment (pulpotomy or filling treatment) in 56 patients aged 4 to 11 years with no systemic problems or history of allergy. Read More

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December 2021

Early oral switch to combined cefixime therapy for management of osteoarticular infections in pediatric sickle cell disease patients: A descriptive analysis.

J Infect Public Health 2021 Nov 17;15(1):1-6. Epub 2021 Nov 17.

Center for Health Outcomes & PharmacoEconomic Research, University of Arizona, Tucson, AZ, USA; Department of Clinical Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.

Background: The treatment of osteoarticular infections in pediatric patients with sickle cell disease (SCD) is a challenging task for the practitioner. The aim of this study is to evaluate cefixime for the treatment of osteoarticular infections in pediatric SCD patients by retrospective design.

Methods: This study was done in the pediatric hospital of King Saud Medical City, Riyadh, Saudi Arabia. Read More

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November 2021