2,755,672 results match your criteria years hyperthyroidism


Lifestyle Changes that Impact Personal Quality of Life in the COVID-19 Pandemic in South Korea.

Psychiatry Investig 2021 Jul 22;18(7):701-707. Epub 2021 Jul 22.

Department of Psychiatry, Dong-A University Hospital, Busan, Republic of Korea.

Objective: We investigated which factors in psychological changes positively or negatively affect the quality of life to suggest desirable directions in the period of the COVID-19 pandemic.

Methods: Online survey was conducted with 1,011 adults more than 19 years old in Busan, South Korea. Quality of life was measured using the World Health Organization Quality of Life-BREF. Read More

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Cortical Morphometric Abnormality and Its Association with Working Memory in Children with Attention-Deficit/Hyperactivity Disorder.

Psychiatry Investig 2021 Jul 22;18(7):679-687. Epub 2021 Jul 22.

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.

Objective: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. The present study investigated the cortical morphology features and their relationship with working memory (WM).

Methods: In the present study, a total of 36 medication naïve children with ADHD (aged from 8 to 15 years) and 36 age- and gendermatched healthy control (HC) children were included. Read More

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The promise and role of point of care testing to reduce the global burden of sickle cell disease through early diagnosis and linkage to care.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Division of Hematology and Global Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Sickle cell disease (SCD) is a devastating and under-recognised global child health issue affecting over 300,000 infants annually, with the highest prevalence in India and sub-Saharan Africa. Most affected infants born in low- and middle-income countries (LMIC) lack access to SCD testing and die from complications in the first years of life without a formal diagnosis. The majority of deaths are preventable with early diagnosis and provision of inexpensive interventions. Read More

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Structural connectivity predicts sequential processing differences in music perception ability.

Eur J Neurosci 2021 Aug 2. Epub 2021 Aug 2.

Language Literacy and Music Laboratory, National Brain Research Centre (Deemed University), Manesar, India.

To relate individual differences in music perception ability with whole brain white matter connectivity, we scanned a group of twenty-seven individuals with varying degrees of musical training and assessed musical ability in sensory and sequential music perception domains using the Profile of Music Perception Skills-Short version (PROMS-S). Sequential processing ability was estimated by combining performance on tasks for Melody, Standard Rhythm, Embedded Rhythm, and Accent sub-scores while sensory processing ability was ascertained via tasks of Tempo, Pitch, Timbre and Tuning. Controlling for musical training, gender and years of training, Network Based Statistics revealed positive linear associations between total PROMS-S scores and increased inter-hemispheric fronto-temporal and parieto-frontal white matter connectivity, suggesting a distinct segregated structural network for music perception. Read More

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Disease outcomes and biomarkers of progression in smouldering Waldenström macroglobulinaemia.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Patients with asymptomatic/smouldering Waldenström macroglobulinaemia (SWM) have a variable risk of progression to active WM. Our study evaluated 143 patients with SWM consecutively seen between January 1996 and December 2013. With a median [95% confidence interval (CI)] follow-up of 9·5 [8·1-11·5] years, the cumulative rate of progression was 11% at 1 year, 38% at 3 years and 55% at 5 years. Read More

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Recurrent bacterial infections, but not fungal infections, characterise patients with ELANE-related neutropenia: a French Severe Chronic Neutropenia Registry study.

Br J Haematol 2021 Aug 2. Epub 2021 Aug 2.

Registre des Neutropénies Chroniques, Centre de Référence des Neutropénies Chroniques, Hôpital Trousseau, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.

Among 143 patients with elastase, neutrophil-expressed (ELANE)-related neutropenia enrolled in the French Severe Chronic Neutropenia Registry, 94 were classified as having severe chronic neutropenia (SCN) and 49 with cyclic neutropenia (CyN). Their infectious episodes were classified as severe, mild or oral, and analysed according to their natural occurrence without granulocyte-colony stimulating factor (G-CSF), on G-CSF, after myelodysplasia/acute leukaemia or after haematopoietic stem-cell transplantation. During the disease's natural history period (without G-CSF; 1913 person-years), 302, 957 and 754 severe, mild and oral infectious events, respectively, occurred. Read More

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The Association between Sarcopenia as a Comorbid Disease and Incidence of Institutionalisation and Mortality in Geriatric Rehabilitation Inpatients: REStORing health of acutely unwell adulTs (RESORT).

Gerontology 2021 Aug 2:1-11. Epub 2021 Aug 2.

Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, Victoria, Australia.

Introduction: Sarcopenia is associated with poor health outcomes and highly prevalent in individuals with age-related diseases. This study aimed to determine whether sarcopenia as a comorbid disease is associated with the incidence of institutionalisation and mortality in geriatric rehabilitation inpatients.

Methods: REStORing health of acutely unwell adulTs (RESORT) includes geriatric rehabilitation patients assessed for sarcopenia (the European Working Group on Sarcopenia in Older People [EWGSOP, 2010], EWGSOP2 [2018], and the Asian Working Group for Sarcopenia [AWGS 2019]), multimorbidity, disease severity, and specific diseases (Charlson Comorbidity Index and Cumulative Illness Rating Scale) at admission. Read More

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Elementary Laboratory Assays as Biomarkers of Ageing: Support for Treatment of COVID-19?

Gerontology 2021 Aug 2:1-14. Epub 2021 Aug 2.

Kantonsspital Graubünden, Chur, Switzerland.

Youth, working age and the elderly: On a timeline, chronological age (CA) and biological age (BA) may dissociate; nosological entities manifest themselves at different BAs. In determining which disease corresponds to a given age decade, statistical registries of causes of death are unreliable and this does not change with SARS CoV-2 infection. Beyond adolescence, ageing metrics involve estimations of changes in fitness, including prediction models to estimate the number of remaining years left to live. Read More

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Recent Advances in Anticancer and Antimicrobial Activity of Silver Nanoparticles Synthesized Using Phytochemicals and Organic Polymers.

Nanotechnology 2021 Aug 2. Epub 2021 Aug 2.

Department of Mechanical Systems Engineering, Yamagata University, Faculty of Engineering, Yamagata University, Yonezawa, Yamagata, Yamagata, Yamagata, 992-8510, JAPAN.

Development of eco-friendly synthetic methods has resulted in the production of biocompatible Ag NPs for applications in medical sector. To overcome the prevailing antibiotic resistance in bacteria, Ag NPs are being extensively researched over the past few years due to their broad spectrum & robust antimicrobial properties. Silver nanoparticles are also being studied widely in advanced anticancer therapy as an alternative anticancer agent to combat cancer in an effective manner. Read More

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Chemotherapy-Induced Peripheral Neurotoxicity in Cancer Survivors: Predictors of Long-Term Patient Outcomes.

J Natl Compr Canc Netw 2021 Jul 28;19(7):821-828. Epub 2021 Jul 28.

5Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.

Background: Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major adverse effect of cancer treatment. However, its impact remains poorly understood. This study aimed to investigate the impact associated with CIPN on the lives of cancer survivors. Read More

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Patients characteristics related to screening mammography cancellation and rescheduling rates during the COVID-19 pandemic.

Clin Imaging 2021 Jul 29;80:205-210. Epub 2021 Jul 29.

Center for Evidence-Based Imaging, Brigham and Women's Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, United States of America. Electronic address:

Purpose: To identify patient characteristics associated with screening mammography cancellations and rescheduling during the COVID-19 pandemic.

Methods: Scheduled screening mammograms during three time periods were retrospectively reviewed: state-mandated shutdown (3/17/2020-6/16/2020) during which screening mammography was cancelled, a period of 2 months immediately after screening mammography resumed (6/17/2020-8/16/2020), and a representative period prior to COVID-19 (6/17/2019-8/16/2019). Relative risk of cancellation before COVID-19 and after reopening was compared for age, race/ethnicity, insurance, history of chronic disease, and exam location, controlling for other collected variables. Read More

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Parents' experiences of their child's assessment on an epilepsy surgery pathway: A qualitative study.

Seizure 2021 Jul 17;91:456-461. Epub 2021 Jul 17.

Institute of Population Health, Department of Public Health, Policy and Systems, University of Liverpool, Liverpool L69 3G, United Kingdom. Electronic address:

Purpose: Children's epilepsy surgery services (CESS) in the UK aim to improve outcomes for young children by increasing access to surgery. Consideration for surgery is complex and time consuming, yet there is lack of research exploring how this process might impact on families. This study aimed to explore parents' experiences of their child consideration for epilepsy surgery to inform future service development and delivery. Read More

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Rapid temporal decline of mercury in Greenland halibut (Reinhardtius hippoglossoides).

Environ Pollut 2021 Jul 26;289:117843. Epub 2021 Jul 26.

Institute of Marine Research, Bergen, Norway.

Mercury (Hg) pollution in the ocean is an issue of global concern, however bioaccumulation regimes of this ubiquitous pollutant in marine apex predators have important knowledge gaps. Our fish length and stable isotope (δN and δC) normalized data of Greenland halibut (GH) (Reinhardtius hippoglossoides) showed that Hg bioaccumulation in fillet tissue decreased by ~35-50 %, over a ten-year period from 2006 to 2015 (n = 7 individual sampling years). Hg was predominantly in the methylmercury form (>77 %). Read More

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Refining diagnostic criteria for paediatric bronchiectasis using low-dose CT scan.

Respir Med 2021 Jul 24;187:106547. Epub 2021 Jul 24.

Department of Respiratory and Sleep Medicine, The Royal Children's Hospital, Melbourne, VIC, Australia; Infection and Immunity, Murdoch Children's Research Institute, Melbourne, VIC, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, VIC, Australia. Electronic address:

Background: There is a current lack of consensus amongst paediatric radiologists and respiratory paediatricians as to the correct CT definition of bronchiectasis in children. Using contemporary low-dose CT, our objectives were to determine the upper limit of normal for broncho-arterial ratio (BAR) in children and to evaluate the effect of age and general anaesthesia.

Methods: Measurements of 330 broncho-arterial ratios from 51 children (0-19 years) undergoing low-dose CT chest for non-respiratory indications were performed by 3 blinded observers (two radiologists, one respiratory physician) using four different methods. Read More

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Effect of hydrogel composite reinforced with natural char nanoparticles on improvement of soil biological properties and the growth of water deficit-stressed tomato plant.

Ecotoxicol Environ Saf 2021 Jul 30;223:112576. Epub 2021 Jul 30.

Department of Nanotechnology, Agricultural Biotechnology Research Institute of Iran (ABRII), Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.

Hydrogel polymers have been used to enhance water and nutrient retention in agricultural soils. The incorporation of nanoparticles to yield composite hydrogels has also gained substantial momentum over the years. The aim of the research was to investigate the effect of hydrogel-nano natural char composite (reinforced starch-based hydrogels with natural char nanoparticles) at three levels 0%, 0. Read More

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Diverse trauma profiles of youth in group care settings: A cluster analysis.

Child Abuse Negl 2021 Jul 30;120:105221. Epub 2021 Jul 30.

McMaster University, Department of Pediatrics, 1280 Main Street West, Room 3A, Hamilton L8S 4K1, Ontario, Canada.

Background: Many adolescents in group care have experienced higher rates of traumatic event exposure, behavior problems, and severe trauma sequelae compared to those outside of group care. Yet, little research has examined from a person-centered perspective their diverse trauma profiles and corresponding service needs.

Objective: This exploratory study aimed to examine the heterogeneity of trauma-related profiles among youth in group care to highlight potential distinct service needs among subgroups. Read More

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Immune checkpoint inhibitors at any treatment line in advanced NSCLC: Real-world overall survival in a large Italian cohort.

Lung Cancer 2021 Jul 17;159:145-152. Epub 2021 Jul 17.

Epidemiology Unit, Agency for Health Protection (ATS) of Milan, C.so Italia 52, 20122 Milano, Italy. Electronic address:

Objectives: To estimate the average treatment effect of immune checkpoint inhibitors in any line of treatment in a 2016-2018 population-based cohort of patients with advanced non-small-cell lung cancer (NSCLC).

Materials And Methods: The cohort, and information on the tumor, were derived from the cancer registry of the Agency for Health Protection of Milan, Italy. Inclusion criteria were adult age, microscopically confirmed NSCLC, stage IIIB or IV at diagnosis, and having received at least one line of treatment. Read More

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Chronic plantar fasciitis reduces rearfoot to medial-forefoot anti-phase coordination.

Clin Biomech (Bristol, Avon) 2021 Jul 26;88:105439. Epub 2021 Jul 26.

Biomechanics Laboratory, Department of Kinesiology, University of Massachusetts Amherst, Amherst 01003, USA.

Background: It is commonly assumed that abnormal foot biomechanics cause plantar fasciitis; however, this assumption is not well supported. In this study, we investigated rearfoot to medial-forefoot coordination of healthy and plantar fasciitis individuals. We hypothesized that chronic plantar fasciitis individuals would exhibit greater intersegmental rearfoot to medial-forefoot anti-phase coordination and greater coordinative variability than a healthy cohort. Read More

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The impact of indomethacin on the number of oocytes retrieved and IVF outcomes in patients with poor ovarian response.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 24;264:266-270. Epub 2021 Jul 24.

Center for Assisted Reproduction, Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.

Objective: The aim of this retrospective case-control study was to analyze the effect of administering indomethacin after triggering final oocyte maturation in patients with poor ovarian response (POR) on the cycle cancellation rate due to premature ovulation (PO), the number of oocytes retrieved and the clinical outcomes of IVF cycles.

Study Design: A total of 214 patients with POR, diagnosed according to the Bologna criteria, who underwent fresh IVF cycle via flexible gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol were enrolled in the study. The control group consisted of 100 patients, whereas the indomethacin group included 114 patients who received 100 mg rectal indomethacin administered twice within the same day (twelve hours apart) -starting at twelve hours after triggering. Read More

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High contribution of vehicle emissions to fine particulate pollutions in Lanzhou, Northwest China based on high-resolution online data source appointment.

Sci Total Environ 2021 Jul 29;798:149310. Epub 2021 Jul 29.

Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China; Collaborative Innovation Center for Western Ecological Safety, Lanzhou University, Lanzhou 730000, China.

The quantitative estimation of urban particulate matter (PM) sources is essential but limited because of various reasons. The hourly online data of PM, organic carbon (OC), elemental carbon (EC), water-soluble ions, and elements from December 2019 to November 2020 was used to conduct PM source appointment, with an emphasis on the contribution of vehicle emissions to fine PM pollution in downtown Lanzhou, Northwest China. Vehicle emissions, secondary formation, mineral dust, and coal combustion were found to be the major PM sources using the positive matrix factorization model. Read More

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Verifying the usefulness of macrophytes as an indicator of the status of small waterbodies.

Sci Total Environ 2021 Jul 26;798:149279. Epub 2021 Jul 26.

Department of Water Protection, Faculty of Biology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.

Small waterbodies are characterised by a high variability of physicochemical parameters. This has an impact on aquatic macrophytes, which are functional components of aquatic ecosystems that also exert a strong influence on other components of these ecosystems. Therefore, their importance in the classification of reservoirs is unquestionable. Read More

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The fate and contamination of trace metals in soils exposed to a railroad used by Diesel Multiple Units: Assessment of the railroad contribution with multi-tool source tracking.

Sci Total Environ 2021 Jul 29;798:149300. Epub 2021 Jul 29.

Gdańsk University of Technology, Faculty of Civil and Environmental Engineering, Narutowicza 11/12, 80-233 Gdańsk, Poland.

Soil samples from cut slopes from lightly loaded railway lines used by Diesel Multiple Units for 5 years in Gdansk (Poland) were collected and analyzed for trace metals (TMs): Zn, Pb, Cd, Ni, Cr, Cu, and Fe. The main aim was to assess soil enrichment, contamination status, and distribution of TMs relative to the distance from the railway track. Extensive source tracking analyses were performed using cluster analysis (CA) and the Pb isotope ratios approach (Pb, Pb, and Pb). Read More

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Concentrations and geographical patterns of persistent organic pollutants (POPs) in meat from semi-domesticated reindeer (Rangifer tarandus tarandus L.) in Norway.

Sci Total Environ 2021 Jul 29;798:149278. Epub 2021 Jul 29.

Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, N-9037 Tromsø, Norway; NILU - Norwegian Institute for Air Research, Fram Centre, N-9296 Tromsø, Norway.

The study aimed at investigating the concentrations and geographical patterns of 11 polychlorinated biphenyls (PCBs) and 15 organochlorine pesticides (OCPs) in reindeer muscle samples (n = 100) collected from 10 grazing districts in Norway, 2009. Concentrations were examined for patterns related to geographical region as well as age and sex of animals. Concentrations measured for PCBs and OCPs in reindeer meat samples were generally low. Read More

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Microplastics in agricultural soils, wastewater effluents and sewage sludge in Mauritius.

Sci Total Environ 2021 Jul 28;798:149326. Epub 2021 Jul 28.

Department of Chemical and Environmental Engineering, Faculty of Engineering, University of Mauritius, Réduit 80837, Mauritius. Electronic address:

The rapid and silent emergence of microplastics (MPs) in the environment has recently become a global problem with more and more studies are showing the harmful effects of MPs on different ecosystems. The aim of this study was to investigate the presence of MPs in agricultural soils, wastewater effluents and sewage sludge in Mauritius. The soil samples were collected randomly from three different agricultural lands which have been used for conventional agriculture for more than 25 years. Read More

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How to convince an editor to accept your paper quickly.

Authors:
Ronald A Hites

Sci Total Environ 2021 Jul 22;798:149243. Epub 2021 Jul 22.

O'Neill School of Public and Environmental Affairs, Indiana University, Bloomington, IN 47405, United States. Electronic address:

Let's imagine that you have just finished writing a scientific paper. The paper is well-structured and clearly written, and you are proud of it. Now is the time to submit it to a peer-reviewed journal and see what your colleagues think of it. Read More

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Predictors of clozapine discontinuation at 2 years in treatment-resistant schizophrenia.

Schizophr Res 2021 Jul 30;235:102-108. Epub 2021 Jul 30.

Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Chile. Electronic address:

Introduction: Little is known about predictors of clinical response to clozapine treatment in treatment-resistant psychosis. Most published cohorts are small, providing inconsistent results. We aimed to identify baseline clinical predictors of future clinical response in patients who initiate clozapine treatment, mainly focusing on the effect of age, duration of illness, baseline clinical symptoms and homelessness. Read More

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Increased Relative Functional Gain and Improved Stroke Outcomes: A Linked Registry Study of the Impact of Rehabilitation.

J Stroke Cerebrovasc Dis 2021 Jul 30;30(10):106015. Epub 2021 Jul 30.

Florey Institute of Neuroscience and Mental Health, Heidelberg, VIC, Australia; Translational Public Health and Evaluation Division, Stroke and Ageing Research, School of Clinical Sciences at Monash Health, Monash University, Level 3 Hudson Institute Building, 27-31 Wright Street, Clayton, VIC 3168, Australia. Electronic address:

Objectives: It is unclear how acute care influences patient outcomes in those who receive rehabilitation. We aimed to determine the associations between acute stroke therapies, outcomes during inpatient rehabilitation and self-reported outcomes at 90-180 days after stroke.

Materials And Methods: Patient-level data from adults with acute stroke registered in the Australian Stroke Clinical Registry (AuSCR, 2014-2017) were linked with data from the Australasian Rehabilitation Outcomes Centre (AROC). Read More

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