1,363,042 results match your criteria years diagnosed


Venetoclax combinations induce high response rates in newly diagnosed Acute Myeloid Leukemia patients ineligible for intensive chemotherapy in routine practice.

Am J Hematol 2021 Apr 9. Epub 2021 Apr 9.

Department of Hematology, Shamir Medical Center (formerly Assaf Harofe Medical Center), Zerifin, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Combinations of the BCL-2 inhibitor, venetoclax, with either hypomethylating agents (HMA), or low dose cytarabine (LDAC), have shown promising results in clinical trials of AML patients unfit for intensive therapy. We report on the efficacy and safety of AML patients that were treated with venetoclax combinations outside of clinical trials. Data on 133 patients with a mean age of 77 years is included. Read More

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Clinical outcomes of nonoperatively managed degenerative cervical myelopathy: an ambispective longitudinal cohort study in 117 patients.

J Neurosurg Spine 2021 Apr 9:1-9. Epub 2021 Apr 9.

1Division of Neurosurgery, Department of Surgery, University of Toronto.

Objective: Degenerative cervical myelopathy (DCM) is among the most common pathologies affecting the spinal cord but its natural history is poorly characterized. The purpose of this study was to investigate functional outcomes in patients with DCM who were managed nonoperatively as well as the utility of quantitative clinical measures and MRI to detect deterioration.

Methods: Patients with newly diagnosed DCM or recurrent myelopathic symptoms after previous surgery who were initially managed nonoperatively were included. Read More

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Effectiveness and safety of direct oral anticoagulants in patients with cancer associated venous thromboembolism.

Thromb Res 2021 Mar 29;202:128-133. Epub 2021 Mar 29.

Department of Medicine, McGill University, Montreal, QC, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada; Division of General Internal Medicine, Jewish General Hospital, Montreal, QC, Canada. Electronic address:

Introduction: Real-world evidence on the effects of direct oral anticoagulants (DOACs) in patients with cancer associated venous thromboembolism (VTE) is limited. Thus, our population-based cohort study aimed to assess the effectiveness and safety of DOACs compared to the standard of care low-molecular-weight heparin (LMWH) in this vulnerable population.

Materials And Methods: Using linked administrative healthcare databases from the province of Québec, Canada, we identified patients with incident VTE from 2012 to 2015 and a cancer diagnosis in the year before the VTE, who initiated treatment with anticoagulants within 30 days after the VTE. Read More

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Epilepsy Outcome at Four Years in a Randomized Clinical Trial Comparing Oral Prednisolone and Intramuscular ACTH in West Syndrome.

Pediatr Neurol 2021 Mar 8;119:22-26. Epub 2021 Mar 8.

Faculty of Medicine, Department of Paediatrics, University of Colombo, Colombo, Sri Lanka.

Background: This article explores the role of initial treatment on control of spasms and other epilepsies at four years in children previously treated for West syndrome.

Methods: The Sri Lanka Infantile Spasm Study is a prospective clinical trial evaluating response to intra-muscular adrenocorticotropic hormone (ACTH) versus oral prednisolone. A previous report documented response through age 12 months. Read More

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Cognitive complaints in individuals recently diagnosed with bipolar disorder: A cross-sectional study.

Psychiatry Res 2021 Mar 21;300:113894. Epub 2021 Mar 21.

Mood Disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Porto Alegre, Brazil. Electronic address:

Aim: To assess the differences in subjective cognitive dysfunction between major depressive disorder (MDD) and recently diagnosed Bipolar Disorder (BD) across euthymia and mood episodes.

Methods: This is a cross-sectional study corresponding to the second wave of a longitudinal study. The first wave consisted of subjects aged between 18 and 60 diagnosed with MDD. Read More

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Performance evaluation of the Roche cobas 6800 system for quantifying cytomegalovirus DNA in plasma and urine samples.

J Clin Virol 2021 Mar 31;138:104816. Epub 2021 Mar 31.

Department of Laboratory Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Introduction: Cytomegalovirus (CMV) nucleic acid amplification testing is important for CMV infection diagnosis and management. CMV DNA is found in plasma and various other fluids, including urine. If CMV can be reliably detected in urine, it may be considered a non-invasive alternative to blood tests. Read More

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Breast cancer in women under age 40: A decade of trend analysis at a single institution.

Clin Imaging 2021 Mar 31;78:165-170. Epub 2021 Mar 31.

Department of Radiology, Weill Cornell Medicine, 525 E 68(th) street, New York, NY 10065, USA.

Background: Women should be evaluated for breast cancer risk by age 30 to assess for screening need. Recent trends in breast cancer in this population may further inform recommendations.

Objective: The aim of this study was to analyze trends over time in the rate of breast cancer, tumor characteristics and treatment in women under age 40. Read More

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Early initiation of ambroxol treatment diminishes neurological manifestations of type 3 Gaucher disease: A long-term outcome of two siblings.

Eur J Paediatr Neurol 2021 Mar 31;32:66-72. Epub 2021 Mar 31.

Department of Pediatrics, University Hospital Centre Zagreb, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia. Electronic address:

Gaucher disease type 3 (GD3) is a severely debilitating disorder characterized by multisystemic manifestations and neurodegeneration. Enzyme replacement therapy alleviates visceral signs and symptoms but has no effect on neurological features. Ambroxol has been suggested as an enzyme enhancement agent. Read More

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Successful treatment of refractory cystitis associated with systemic lupus erythematosus with Belimumab.

Int Immunopharmacol 2021 Apr 6;96:107574. Epub 2021 Apr 6.

Department of Rheumatology and Immunology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Lupus cystitis (LC) is a rare manifestation of SLE, the diagnosis of LC is challenging, especially in the absence of other systemic manifestations or the obvious disease activity index of SLE, further cystoscopy and bladder biopsy are crucial. The symptoms of cystitis could be controlled with high-dose GC, but in the process of GC reduction, the condition repeated. Here we report one case of refractory LC treated with Belimumab. Read More

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Deep Venous Thrombosis and Pulmonary Embolism Among Hospitalized Coronavirus Disease 2019 (COVID-19) Positive Patients Predict Higher Mortality, Prolonged Intensive Care Unit and Hospital Stays in A Multi-Site Healthcare System.

J Vasc Surg Venous Lymphat Disord 2021 Apr 6. Epub 2021 Apr 6.

Department of Neurology, Mayo Clinic, Jacksonville, FL.

Objective: To assess the incidence of deep venous thrombosis (DVT) and pulmonary embolism (PE) in hospitalized patients with coronavirus disease 2019 (COVID-19) in comparison with a matched cohort with similar cardiovascular risk factors, as well as the impact of DVT/PE on hospital course.

Methods: A retrospective review of prospectively collected data on COVID-19 patients hospitalized from 03/11/2020 to 09/04/2020 was performed. Patients were randomly matched in a 1:1 ratio by age, sex, hospital of admission, smoking history, diabetes mellitus and coronary artery disease with a cohort of non-COVID-19 patients. Read More

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Prediction of parasitological cure in children infected with Trypanosoma cruzi using a novel multiplex serological approach: an observational, retrospective cohort study.

Lancet Infect Dis 2021 Apr 6. Epub 2021 Apr 6.

Parasitology Service, Hospital de Niños "Ricardo Gutierrez" and Instituto Multidisciplinario de Investigacion en Patologias Pediatricas (IMIPP)-CONICET-GCBA, Buenos Aires, Argentina.

Background: Assessment of therapeutic response with standard serological diagnostic assays in patients with chronic Chagas disease is a major challenge due to the long persistence of parasite-specific antibodies. The current consensus for parasitological cure is to monitor conversion from positive to negative Trypanosoma cruzi serology (seroreversion). However, because of robust humoral immune response, seroreversion by standard serological tests can take years to decades. Read More

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6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records.

Lancet Psychiatry 2021 Apr 1. Epub 2021 Apr 1.

Department of Psychiatry, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Oxford, UK. Electronic address:

Background: Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks of neurological and psychiatric diagnoses in patients in the 6 months following a COVID-19 diagnosis.

Methods: For this retrospective cohort study and time-to-event analysis, we used data obtained from the TriNetX electronic health records network (with over 81 million patients). Read More

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Bronchiectasis among Australian Aboriginal and non-Aboriginal patients in the regional and remote population of the Northern Territory of Australia.

Rural Remote Health 2021 Apr 10;21(2):6390. Epub 2021 Apr 10.

Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia; College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia; and Darwin Respiratory and Sleep Health, Darwin Private Hospital, Darwin, Northern Territory, Australia

Introduction: Chronic respiratory disorders are highly prevalent among Australian Aboriginal people living in the Top End Health Service region in the Northern Territory, Australia. Bronchiectasis is a heterogenous disease that features among these chronic respiratory conditions in this population. However, there are sparse comparative data between Aboriginal and non-Aboriginal patients with bronchiectasis from this region. Read More

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Trends in paediatric inflammatory bowel disease-attributable direct costs: a population-based analysis.

Aliment Pharmacol Ther 2021 Apr 9. Epub 2021 Apr 9.

IBD Clinical and Research Center, University of Manitoba, Winnipeg, MB, Canada.

Background: In addition to its morbidities, inflammatory bowel disease (IBD) has a major financial burden on patients and healthcare systems. However, there is a paucity of evidence on IBD-attributable costs in children.

Aims: To determine the trends of IBD-attributable direct costs over time using a population-based analysis. Read More

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Self-testing for HIV, HBV, and HCV using finger-stick whole-blood multiplex immunochromatographic rapid test: A pilot feasibility study in sub-Saharan Africa.

PLoS One 2021 9;16(4):e0249701. Epub 2021 Apr 9.

Laboratoire de virologie médicale et oncologique, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.

Background: The burden of HIV, HBV, and HCV infections remains disproportionately high in sub-Saharan Africa, with high rates of co-infections. Multiplex rapid diagnostic tests for HIV, HBV and HCV serological testing with high analytical performances may improve the "cascade of screening" and quite possibly the linkage-to-care with reduced cost. Based on our previous field experience of HIV self-testing, we herein aimed at evaluating the practicability and acceptability of a prototype finger-stick whole-blood Triplex HIV/HCV/HBsAg self-test as a simultaneous serological screening tool for HIV, HBV, and HCV in the Democratic Republic of the Congo (DRC). Read More

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A Novel Treatment for Metastatic Serous Cystadenocarcinoma Using a Microwave Ablation: Case Report and Review of the Literature.

Pancreas 2021 Mar;50(3):434-440

From the Division of Surgical Oncology, Department of Surgery.

Abstract: The incidence of pancreatic cystic neoplasms has grown because of increased detection. Among these lesions, serous cystadenoma was traditionally thought to be universally benign and indolent. However, there is an exceedingly rare malignant variant of serous cystadenoma known as serous cystadenocarcinoma (SCAC) that can exhibit local invasion into adjacent structures, hepatic implants, and metastatic spread to the abdominal viscera. Read More

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Utility of gastric and duodenal biopsy sampling in adult eosinophilic esophagitis patients to rule out other gastrointestinal disorders.

Scand J Gastroenterol 2021 Apr 9:1-8. Epub 2021 Apr 9.

Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Rationale: According to consensus guidelines, if eosinophilic esophagitis (EoE) is suspected, not only esophageal but also gastric and duodenal biopsy specimens should be sampled in order to exclude other generalized or eosinophilic gastrointestinal (GI) disorders, such as eosinophilic gastroenteritis or celiac disease. However, the diagnostic yield for this remains unclear.

Aim: To assess the diagnostic yield of biopsy sampling from the stomach and duodenum in adult EoE patients to rule out generalized or eosinophilic GI disorders. Read More

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A Descriptive Study Exploring Semen Quality Among Indian Cancer Patients.

J Adolesc Young Adult Oncol 2021 Apr 9. Epub 2021 Apr 9.

Department of Reproductive Medicine, Gunasheela Surgical and Maternity Hospital, Bangalore, India.

To descriptively explore semen quality among Indian men with various types of malignancies. We evaluated semen parameters of male patients referred to our hospital before commencing their cancer treatment. Four hundred sixty-one male patients who were within the age range of 15-50 years were recruited with diagnosed malignancies. Read More

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Changing Pattern of Chemsex Drug Use Among Newly Diagnosed HIV-Positive Taiwanese from 2015 to 2020 in the Era of Treat-All Policy.

AIDS Patient Care STDS 2021 Apr;35(4):134-143

Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Chemsex drug use (CDU) is a frequent, yet neglected issue in the era of treat-all policy. We evaluated the temporal pattern of CDU, factors associated with CDU, and drug-drug interactions (DDIs) between chemsex drugs and initial antiretroviral therapy (ART) by surveying 621 Taiwanese individuals (mean age: 29.7 years; 99. Read More

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Pregnancy in an Urban Cohort of Adolescents Living with Human Immunodeficiency Virus: Characteristics and Outcomes in Comparison to Adults.

AIDS Patient Care STDS 2021 Apr;35(4):103-109

Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Adolescents (13-24 years of age) account for more than one-fifth of new HIV diagnoses yearly, and the United States has one of the highest rates of adolescent pregnancy among high resource countries. However, there is limited information on the characteristics and outcomes of adolescents living with HIV (ALWHIV) during pregnancy and differences with pregnancy in adults living with HIV. We performed a retrospective cohort study to compare demographic characteristics, HIV viral suppression, and pregnancy outcomes in adolescents ( = 90) as compared with adults ( = 250) in an urban HIV pregnancy clinic from 2003 to 2015. Read More

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Clinical Features and Treatment Outcomes of Seronegative Pediatric Autoimmune Encephalitis.

J Clin Neurol 2021 Apr;17(2):300-306

Division of Pediatric Neurology, Epilepsy Research Institute, Severance Children's Hospital, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.

Background And Purpose: New diagnostic criteria for pediatric autoimmune encephalitis (AIE) have been introduced recently. A substantial proportion of cases of pediatric AIE are diagnosed as seronegative based on these criteria, and so the clinical characteristics of this group remain to be investigated.

Methods: This study included 46 pediatric patients younger than 18 years with suspected AIE. Read More

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Epidemiological Features and Economic Burden of Guillain-Barré Syndrome in South Korea: A Nationwide Population-Based Study.

J Clin Neurol 2021 Apr;17(2):257-264

College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Korea.

Background And Purpose: Guillain-Barré syndrome (GBS) is rare, but its symptoms are severe and they occasionally lead to long-term disability. Country-specific epidemiological evidence is useful for detecting potential problems at the population level. This study investigated the epidemiological and economic characteristics of GBS in South Korea. Read More

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Smoking History and Clinical Features of Cluster Headache: Results from the Korean Cluster Headache Registry.

J Clin Neurol 2021 Apr;17(2):229-235

Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.

Background And Purpose: Epidemiologic data suggest that cluster headache (CH) is significantly associated with cigarette smoking. The aim of this study was to determine differences in features between patients with a smoking history and those who are never-smokers, using data from a prospective multicenter registry.

Methods: Data used in this study were obtained from the Korean Cluster Headache Registry that collected data from consecutive patients diagnosed with CH. Read More

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Clinical and Genetic Features of Brainstem Glioma in Adults: A Report of 50 Cases in a Single Center.

J Clin Neurol 2021 Apr;17(2):220-228

Department of Neurosurgery, The Sixth Medical Center of PLA General Hospital, Beijing, China.

Background And Purpose: Brainstem gliomas (BSGs) in adults are rare brain tumors with dismal outcomes. The aim of this study was to determine the clinical and genetic features in a series of BSGs and their association with the prognosis.

Methods: Fifty patients who underwent a stereotactic biopsy between January 2016 and April 2018 at a single institution were collected. Read More

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Systematic Literature Review of Psychiatric Comorbidities in Adults with Epilepsy.

J Clin Neurol 2021 Apr;17(2):176-186

Departments of Neurology and Psychiatry, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Background And Purpose: Mental illness is disproportionately common in people with epilepsy (PWE). This systematic literature review identified original research articles that reported the prevalence of psychiatric comorbidities based upon clinical assessments in a sample of PWE and assessed the clinical features of the populations found in studies included in our review of mental health comorbidity.

Methods: The included articles were written in English and published from 2008 to 2018, and focused on adults aged ≥18 years who had psychiatric diagnoses determined in clinical assessments, such as those found in medical records, clinician psychiatric evaluations, structured diagnostic interviews, and mental health screening questionnaires specific for a psychiatric disorder. Read More

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Selective recognition of tumor cells by molecularly imprinted polymers.

J Sep Sci 2021 Apr 9. Epub 2021 Apr 9.

Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China.

Molecularly imprinted polymers developed fifty years ago have garnered enormous attention as receptor-like materials. Lately, molecularly imprinted polymers have been employed as a specific target tool in favor of cancer diagnosis and therapy by the selective recognition of tumor cells. Although the molecular imprinting technology has been well-innovated recently, cell still remain the most challenging target for imprinting. Read More

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A novel prognostic score to assess the risk of progression in relapsing-remitting multiple sclerosis patients.

Eur J Neurol 2021 Apr 9. Epub 2021 Apr 9.

University of Verona, Department Neurological and Movement Sciences, Verona, Italy.

Background: At patient-level, the prognostic value of several features that are known to be associated with an increased risk of converting from relapsing remitting (RR) to secondary phase (SP) multiple sclerosis (MS), remain limited.

Methods: Among 262 RRMS patients followed up for ten years, we assessed the probability of developing the SP course based on clinical and conventional and non-conventional magnetic resonance imaging (MRI) parameters at diagnosis and after two years. We used a machine learning method, the Random Survival Forests, to identify, according to their minimal depth (MD), the most predictive factors associated with the risk of SP conversion, which were then combined to compute the Secondary Progressive Risk Score (SP-RiSc). Read More

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Response to first antiseizure medication in patients diagnosed with epilepsy.

Acta Neurol Scand 2021 Apr 9. Epub 2021 Apr 9.

Department of Neurology (J.P), Tampere University, Tampere, Finland.

Objectives: To investigate the interaction among the efficacy, tolerability and overall effectiveness of the first antiseizure medication in patients 16 years or older with newly diagnosed epilepsy.

Materials And Methods: The study included 584 patients who were referred to the Tampere University Hospital between 1 January 1995 and 31 December 2005 and were diagnosed with epilepsy. All individuals were retrospectively followed up until 31 December 2006, until reaching at least one year of seizure freedom, or until death if before the cut-off date. Read More

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A surgical Case of Synchronous Multiple Primary Lung Cancers with Small Cell Carcinoma and Squamous Cell Carcinoma.

Tokai J Exp Clin Med 2021 Apr 20;46(1):29-32. Epub 2021 Apr 20.

Division of Thoracic Surgery, Tokai University Oiso Hospital, 21-1 Gakkyo, Oiso, Kanagawa 259-0198, Japan.

The incidence of synchronous multiple primary lung cancers has increased in recent years, however, there are few reports of cases involving small cell carcinoma. A 72-year-old man was referred to our department because of an abnormal shadow on chest radiography. He was receiving treatment for pulmonary fibrosis, emphysema, rheumatoid arthritis, and prostate cancer. Read More

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Exploring Noninvasive Biomarkers with the miRandola Database: A Tool for Translational Medicine.

Authors:
Francesco Russo

Methods Mol Biol 2021 ;2284:445-455

Danish Center for Newborn Screening, Department of Congenital Disorders, Clinical Metabolomics Lab, Statens Serum Institut, Copenhagen, Denmark.

Noninvasive biomarkers are required for addressing crucial clinical needs. The ideal biomarker should be easily accessible and provide a unique characteristic for a healthy status or a pathological condition. In the last years, microRNAs (miRNAs) have been proposed as promising tissue-based biomarkers for several diseases such as cancer and cardiovascular diseases. Read More

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January 2021