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Study of the Prevalence of Glaucoma in Kazakhstan.

Klin Monbl Augenheilkd 2021 Apr 14. Epub 2021 Apr 14.

Ophthalmology, Kazakh Scientific Research Institute of Eye Diseases, Almaty, Kazakhstan.

Background: Glaucoma is one of the leading causes of permanent visual disability around the world. However, the available literature lacks data on the prevalence of glaucoma in Central Asia, particularly in the Republic of Kazakhstan.

Objective: The study was aimed at assessing the prevalence of glaucoma in the population of the Republic of Kazakhstan over 40 years old in 2019. Read More

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Establishing Prediction Intervals for the SpeedWheel Acuity Test in Adults and Children.

Klin Monbl Augenheilkd 2021 Apr 14. Epub 2021 Apr 14.

Ophthalmology, Universitätsspital Basel Augenklinik, Basel, Switzerland.

Background: The SpeedWheel (SW) test is an objective test of visual acuity (VA) using suppression of the optokinetic nystagmus (OKN). Here, we established prediction intervals of the SW measures compared to Snellen acuity in adults and children.

Subjects And Methods: In this prospective, single center study, subjects aged at least 4 years underwent testing of VA with SW, Landolt-C, and Tumbling-E symbols (Freiburg acuity test: FrACT-C, FrACT-E). Read More

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Epidemiology of Childhood Uveitis in a Tertiary Care Center: A 20-Year Study.

Klin Monbl Augenheilkd 2021 Apr 14. Epub 2021 Apr 14.

Jules-Gonin Eye Hospital, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland.

Purpose: To investigate demographics and causes of pediatric uveitis in a Swiss tertiary reference center over a 20-year period.

Materials And Methods: Retrospective cohort study on patients with uveitis aged less than 16 years seen at Jules-Gonin Eye Hospital between 1 January 2000 and 31 December 2019.

Results: Out of 2846 patients with uveitis seen in the Jules-Gonin Eye Hospital Ocular Immune-Infectiology Department, 317 (11. Read More

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Large-Diameter Penetrating Keratoplasties are Mostly Due to Very Severe Infectious Keratitis and Cannot Always Prevent Secondary Enucleation.

Klin Monbl Augenheilkd 2021 Apr 14. Epub 2021 Apr 14.

Augenheilkunde, Universitätsklinikum des Saarlandes und Medizinische Fakultät der Universität des Saarlandes, Homburg (Saar), Germany.

Purpose: To report the indications and outcomes of penetrating keratoplasties with a graft diameter > 8.5 mm in severe corneal diseases at the Department of Ophthalmology at Saarland University Medical Centre.

Study Design: Retrospective (6 years), descriptive, and observational. Read More

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Outcome of Surgical Interventions and Deliveries in Patients with Bleeding of Unknown Cause: An Observational Study.

Thromb Haemost 2021 Apr 14. Epub 2021 Apr 14.

Department of Haematology, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Background:  The most optimal management for patients with bleeding of unknown cause (BUC) is unknown, as limited data are available.

Objective:  Evaluate management and outcome of surgical procedures and deliveries in patients with BUC.

Materials And Methods:  All patients ≥12 years of age, referred to a tertiary center for a bleeding tendency, were included. Read More

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Association between Adherence to SSRI Treatment and Mortality among Individuals with Metabolic Syndrome Components.

Pharmacopsychiatry 2021 Apr 14. Epub 2021 Apr 14.

Geha Mental Health Center, Petah-Tikva, Israel.

Introduction: Depression and anxiety have been associated with type 2 diabetes mellitus and metabolic syndrome, major causes of cardiovascular morbidity and mortality. The effect of antidepressants in this association is unknown. This study aimed to examine the association between adherence to selective serotonin receptor inhibitors (SSRIs) and all-cause mortality among individuals with metabolic syndrome components (hypertension, obesity, and diabetes mellitus). Read More

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Utility of Epilepsy Surgery in Survivors of Childhood Cancer.

Neuropediatrics 2021 Apr 14. Epub 2021 Apr 14.

Division of Neurology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States.

Resection of an epileptogenic focus improves seizure control in patients with drug-resistant epilepsy. There is little data available on usefulness of epilepsy surgery in childhood cancer survivors with drug-resistant epilepsy. To learn about seizure outcome after epilepsy surgery in childhood cancer survivors, we retrospectively reviewed charts of 42 children who were referred to an epilepsy center for surgical evaluation. Read More

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Homozygous UBA5 Variant Leads to Hypomyelination with Thalamic Involvement and Axonal Neuropathy.

Neuropediatrics 2021 Apr 14. Epub 2021 Apr 14.

Department of Child Neurology, Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam UMC, and Amsterdam Neuroscience, Vrije Universiteit, Amsterdam, The Netherlands.

The enzyme ubiquitin-like modifier activating enzyme 5 (UBA5) plays an important role in activating ubiquitin-fold modifier 1 (UFM1) and its associated cascade. is widely expressed and known to facilitate the post-translational modification of proteins. Variants in and are involved in neurodevelopmental disorders with early-onset epileptic encephalopathy as a frequently seen disease manifestation. Read More

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Potential Risk Factors for Autism in Children Requiring Neonatal Intensive Care Unit.

Neuropediatrics 2021 Apr 14. Epub 2021 Apr 14.

Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil.

Background:  The etiology of autism spectrum disorder (ASD) is complex and involves the interplay of genetic and environmental factors.

Aim:  We sought to identify potential prenatal, perinatal, and neonatal risk factors for ASD in a unique population of children who had perinatal complications and required care in a neonatal intensive care unit (NICU).

Methods:  This prospective cohort study included 73 patients discharged from a NICU who received long-term follow-up at the largest children's hospital in Brazil. Read More

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The fate of paratesticular masses: 13 years' experience in a tertiary referral centre.

Aktuelle Urol 2021 Apr 14. Epub 2021 Apr 14.

Şişli Hamidiye Etfal Training and Research Hospital, Urology, Şişli, Turkey.

Objective: Paratesticular neoplasms exhibit different behaviours, depending on the embryological tissue of origin. Treatment modalities can depend on the differential diagnosis. The aim of this study is to present the clinical, morphological and histopathological features of patients with paratesticular masses and their follow-ups and is intended to increase awareness of the issues. Read More

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Outcomes of Total Knee Arthroplasty in Patients with Prior Hardware: A Case-Control Study Using Handheld Navigation.

J Knee Surg 2021 Apr 14. Epub 2021 Apr 14.

Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India.

Presence of hardware in juxta-articular location poses challenge during total knee arthroplasty (TKA). When present in distal femur, it precludes the use of an intramedullary femoral jig during TKA often necessitating removal of hardware leading to prolonged surgery, higher risk of complications, and inferior results. We conducted a case-control study to assess the outcome of TKA among patients with post-traumatic arthritis using a handheld navigation system to perform bone cuts allowing retention of hardware in situ. Read More

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Risk Factors for Infection and Revision Surgery following Patellar Tendon and Quadriceps Tendon Repairs: An Analysis of 3,442 Patients.

J Knee Surg 2021 Apr 14. Epub 2021 Apr 14.

Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia.

Disruption of the extensor mechanism is debilitating with surgical repair being the accepted treatment. The incidence of infection and reoperation after extensor mechanism repair are not well reported in the literature. Thus, the objective of the current study was to (1) determine the incidence of surgical site infection and reoperation within 1 year of primary extensor mechanism repair and (2) identify independent risk factors for infection and reoperation following patellar and quadriceps tendon repair. Read More

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Reconstruction of the Anterior Cruciate Ligament Using Ruler-Assisted Positioning of the Femoral Tunnel Relative to the Posterior Apex of the Deep Cartilage: A Single-Center Case Series.

J Knee Surg 2021 Apr 14. Epub 2021 Apr 14.

Department of Orthopedics, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China.

The techniques available to locate the femoral tunnel during anterior cruciate ligament (ACL) reconstruction have notable limitations. To evaluate whether the femoral tunnel center could be located intraoperatively with a ruler, using the posterior apex of the deep cartilage (ADC) as a landmark. This retrospective case series included consecutive patients with ACL rupture who underwent arthroscopic single-bundle ACL reconstruction at the Department of Orthopedics, Beijing Tongren Hospital between January 2014 and May 2018. Read More

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Bioabsorbable Implant for Treatment of Nasal Valve Collapse with or without Concomitant Procedures.

Facial Plast Surg 2021 Apr 14. Epub 2021 Apr 14.

Madison ENT and Facial Plastic Surgery, New York, New York.

The aim of the study is to report outcomes after treatment of nasal valve collapse with a bioabsorbable nasal implant. It involves two prospective, multicenter, post-market studies evaluating long-term effectiveness of the LATERA implant for severe to extreme nasal obstruction. Participants underwent implant alone or with concomitant inferior turbinate reduction (ITR) and/or septoplasty. Read More

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Caudal Extension Graft of the Lower Lateral Cartilage: Technique and Aesthetic and Functional Results.

Facial Plast Surg 2021 Apr 14. Epub 2021 Apr 14.

Pontificia Universidade Catolica de Minas Gerais, Medical School, Belo Horizonte, Minas Gerais, Brazil.

Here we describe a new technique to deal with alar retraction, a highly undesirable imperfection of the nose. The procedure involves placing a caudal extension graft below the vestibular portion of the lower lateral cartilage (LLC) after its detachment from the vestibular skin. The graft is fixed to the cartilage and, subsequently, to the vestibular tissue. Read More

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[Evaluation of Weaning Success in Long-Term Invasively Ventilated Patients at a Weaning Center].

Pneumologie 2021 Apr 14. Epub 2021 Apr 14.

Universitätsmedizin Greifswald, Klinik für Innere Medizin B, Bereich Pneumologie und Weaningzentrum, Greifswald.

Despite the use of enormous personnel and other resources in German weaning centers, approximately 20 % of patients currently fail to get weaned from mechanical ventilation (MV) and need out-of-hospital ventilation.Between 03/2015 and 11/2019, we carried out a pilot project with 33 patients (48 % female, mean age 68 ± 11 years at hospital admission) in order to re-evaluate their options of a possible weaning from MV. At this stage the patients had been invasively ventilated for 475 ± 775 days. Read More

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[Young Respiratory Physicians in Germany - Current Situation and Future Perspectives].

Pneumologie 2021 Apr 14. Epub 2021 Apr 14.

Charité - Universitätsmedizin Berlin, Mitglied der Freien Universität Berlin, Humboldt-Universität zu Berlin und des Berlin Institute of Health, Medizinische Klinik m. S. Infektiologie und Pneumologie, Berlin.

Background:  Demographic changes in the society and among doctors, as well as changing attitudes towards and norms of how living should be structured are creating challenges regarding the organization of work environment in the hospital. In addition, organization of medical training is increasingly being influenced by economic considerations as well as a high level of medical specialization. We asked young respiratory physicians how they assessed their current situation with respect to quality of medical training and organization of their work environment. Read More

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Free Flap Reconstruction of Traumatic Pediatric Foot and Ankle Defects: An Analysis of Clinical and Functional Outcomes.

J Reconstr Microsurg 2021 Apr 14. Epub 2021 Apr 14.

Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Missouri.

Background:  Traumatic lower extremity injuries involving the foot and ankle can have devastating consequences and represent a complex reconstructive challenge. To date, there are limited reports on microsurgical reconstruction for foot and ankle defects in children. This study aims to evaluate clinical and functional outcomes of free flaps for pediatric foot and ankle injuries. Read More

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The Need to Improve Patient-Centered Outcome Reporting Following Lower Extremity Flap Reconstruction: A Systematic Review and Meta-analysis.

J Reconstr Microsurg 2021 Apr 14. Epub 2021 Apr 14.

Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital; Washington, District of Columbia.

Introduction:  Research in lower extremity (LE) wound management involving flap reconstruction has primarily focused on surgeon-driven metrics. There has been a paucity in research that evaluates patient-centered outcomes (PCO). This systematic review and meta-analysis examines articles published between 2012 and 2020 to assess whether reporting of functional and quality of life (QOL) outcomes have increased in frequency and cohesiveness, compared with the previous two decades. Read More

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Traumatic Brachial Plexus Palsy in Children: Long-Term Outcome and Strategy of Reconstruction.

J Reconstr Microsurg 2021 Apr 14. Epub 2021 Apr 14.

Department of Orthopedics and Traumatology, Reconstructive Microsurgery Unit, Assiut University Hospitals and School of Medicine, Assiut, Egypt.

Background:  Traumatic brachial plexus injuries in children represent a definite spectrum of injuries between adult and neonatal brachial plexus injuries. Their characteristics have been scarcely reported in the literature. The priority of functional restoration is not clear. Read More

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Do Patient Expectations of Discharge Affect Length of Stay after Deep Inferior Epigastric Perforator Flap for Breast Reconstruction?

J Reconstr Microsurg 2021 Apr 14. Epub 2021 Apr 14.

Division of Plastic Surgery, Indiana University School of Medicine, Indianapolis, Indiana.

Introduction:  Deep inferior epigastric artery perforator (DIEP) flap is a common method of breast reconstruction. Enhanced recovery after surgery (ERAS) postoperative protocols have been used to optimize patient outcomes and facilitate shorter hospital stays. The effect of patient expectations on length of stay (LOS) after DIEP has not been evaluated. Read More

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Clinical Profile and Mutations Associated with Multiple Endocrine Neoplasia-Type1 (MEN1) and Their First-Degree Relatives at Risk of Developing MEN1: A Prospective Study.

Horm Metab Res 2021 Apr 14;53(4):245-256. Epub 2021 Apr 14.

Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu, India.

Multiple Endocrine Neoplasia type-1 (MEN1) is an autosomal dominant disorder with a combined occurrence of tumours of parathyroid glands, pancreatic islets, and anterior pituitary. About 90% of these patients carry mutations in the MEN1 gene, though the spectrum is not well defined in India. Forty clinically suspected cases of MEN1 were enrolled prospectively over six years; 32 patients (23 index-cases and nine affected relatives) with≥2 classical endocrine tumours of MEN1 were considered definite, and eight were categorised as 'MEN1-like'. Read More

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Electrodermal Activity of Auricular Acupoints in Pediatric Patients with Functional Abdominal Pain Disorders.

J Pediatr Gastroenterol Nutr 2021 Apr 5. Epub 2021 Apr 5.

Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo NY Division of Pediatric Gastroenterology and Nutrition, UBMD Pediatrics Columbia University, New York, New York Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Columbia University Vagelos College of Physicians and Surgeons, New York, New York Heilbrunn Department of Population & Family Health, Columbia University Mailman School of Public Health, New York, New York Department of Pediatrics, Columbia University Irving Medical Center and Heilbrunn Department of Population & Family Health, Columbia University Mailman School of Public Health, New York, New York.

Objectives: Functional abdominal pain disorders (FAPD) affect approximately 13.5% of children. Pharmacotherapy is often ineffective, leaving providers and families seeking adjunctive therapies. Read More

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Transition Services for Paediatric Inflammatory Bowel Disease; A Multicentre Study of Practice in the United Kingdom.

J Pediatr Gastroenterol Nutr 2021 Apr 12. Epub 2021 Apr 12.

Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK Human Genetics and Genomic Medicine, University of Southampton, Southampton, UK Department of Paediatric Gastroenterology, Sheffield Children's NHS Foundation Trust, Sheffield, UK Department of Paediatric Gastroenterology, Great Ormond Street Hospital, London, UK Department of Paediatric Gastroenterology, Bristol Royal Hospital for Children, Bristol, UK Department of Paediatric Gastroenterology, The Royal Hospital for Sick Children, 9 Sciennes Rd, Edinburgh, UK Department of Paediatric Gastroenterology, Royal Hospital for Children Glasgow, 1345 Govan Road, Glasgow, UK Department of Paediatric Gastroenterology, Oxford University Hospitals, Oxford, UK Department of Paediatric Gastroenterology, Addenbrooke's Hospital, Cambridge, UK Department of Paediatric Gastroenterology, The Royal London Hospital, Barts Health NHS Trust, London, UK Department of Paediatric Gastroenterology, Alderhey Children's Hospital NHS Foundation Trust, West Derby, Eaton road, Liverpool L12 2AP,UK Department of Paediatric Gastroenterology, Birmingham Children's Hospital, Birmingham, UK Department of Paediatric Gastroenterology, St. Georges University Hospital NHS Foundation Trust, London, UK Department of Paediatric Gastroenterology, Chelsea and Westminster Hospital, 369 Fulham Road, London, UK Department of Paediatric Gastroenterology, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK Department of Paediatric Gastroenterology, University Hospitals of North Staffordshire NHS Trust, Stoke-On-Trent, UK Department of Paediatric Gastroenterology, Leeds Children's Hospital, Leeds Teaching Hospitals NHS trust, Leeds, UK Department of Paediatric Gastroenterology, Manchester Children's Hospital, Manchester, UK Department of Paediatric Gastroenterology, Nottingham Children's Hospital, Queens Medical Centre, Nottingham, UK Department of Paediatric Gastroenterology, University Hospitals of Leicester NHS Trust, Leicester, UK Department of Paediatric Gastroenterology, Evelina London Children's Hospital, UK.

Objectives: Patients with paediatric inflammatory bowel disease (IBD) constitute one of the largest cohorts requiring transition from paediatric to adult services. Standardised transition care improves short and long-term patient outcomes. This study aimed to detail the current state of transition services for IBD in the United Kingdom (UK). Read More

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Childhood vascular phenotypes have differing associations with prenatal and postnatal growth.

J Hypertens 2021 Apr 14. Epub 2021 Apr 14.

Department of Pediatric and Adolescents Medicine, Akershus University Hospital, Lørenskog, Norway MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK Institute of Clinical Medicine, University of Oslo, Campus AHUS, Lørenskog, Norway NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton Vascular Physiology Unit, Institute of Cardiovascular Science, University College London, London Institute of Developmental Sciences, University of Southampton, Southampton, UK.

Objective: In children aged 8--9 years, we examined the associations of linear and abdominal circumference growth during critical stages of prenatal and postnatal development with six vascular measurements commonly used as early markers of atherosclerosis and later cardiovascular disease (CVD) risk.

Methods: In 724 children from the UK Southampton Women's Survey mother--offspring cohort, offspring length/height and abdominal circumference measurements were collected at 10 ages between 11 weeks' gestation and age 8--9 years. Using residual growth modelling and linear regression, we examined the independent associations between growth and detailed vascular measures made at 8--9 years. Read More

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Favorable Outcomes From an In-person and Online Feasibility Mindful Moment Pilot Study.

Holist Nurs Pract 2021 May-Jun 01;35(3):158-166

Rush-Copley Medical Center Aurora, Illinois (Ms Patronis); and College of Nursing (Dr Staffileno) and Center for Clinical Research and Scholarship (Dr Staffileno), Rush University Medical Center, Chicago, Illinois.

Long hours, inadequate staff, and increasingly complicated patients make nurses more vulnerable to increased levels of stress and burnout. Nurses skilled in exercising self-care practices are better equipped to manage complex clinical situations. The purpose of this pilot study was to evaluate the feasibility of short mindfulness sessions (Mindful Moment) practiced prior to a shift, available in person and online, on nurse burnout and perceived levels of stress. Read More

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The Prevalence of Complementary and Integrative Health Approach Use and Quality of Life Among Patients With Heart Failure: A Cross-sectional, Descriptive, and Comparative Study.

Holist Nurs Pract 2021 May-Jun 01;35(3):123-132

Internal Medicine Nursing Department, Faculty of Nursing, Hacettepe University, Ankara, Turkey.

This study aimed to determine the prevalence of complementary and integrative health approach (CIHA) use in patients with heart failure (HF) and compare quality of life (QoL) between CIHA users and nonusers. This was a cross-sectional, descriptive, and comparative study including 130 patients with HF in Turkey. The data were collected using the sociodemographic and CIHA information form and the Kansas City Cardiomyopathy Questionnaire (KCCQ). Read More

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Facial Skin Biophysical Profile of Women in Malaysia: Significance of Facial Skincare Product Use.

Skin Pharmacol Physiol 2021 Apr 14:1-12. Epub 2021 Apr 14.

Discipline of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.

Introduction: At present, there is a lack of baseline data on the facial skin biophysical profile of women in Malaysia. The implications related to the daily habits and facial skincare product use on the skin biophysical condition are, thus, unknown. In this study, we aim to evaluate facial skin biophysical parameters of Malaysian women and examine the influence of demographic characteristics, daily habits, and facial skincare product use on these parameters. Read More

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