23 results match your criteria x12 administration

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Preventive and Tumor-Suppressive Effects of Lactobacillus Paracasei X12 in Rat Model of Colorectal Cancer.

Iran J Pharm Res 2020 ;19(4):330-342

Department of Community Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

The paper in hand seeks to evaluate the tumor-suppressive and apoptotic effects of X12 in 1, 2-dimethylhydrazine (DMH)-induced rat colon carcinogenesis. The rats were divided into three groups (n = 8-12 per group X12 was administrated to these animals for forty weeks. The findings of this study indicated that X12 administration prevented severe weight loss in DMH-treated rats. Read More

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January 2020

Efficacy of PI3K inhibitors in advanced breast cancer.

Ann Oncol 2019 12;30(Suppl_10):x12-x20

Medical Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France.

The phosphoinositide 3 (PI3)-kinase/Akt signaling pathway has always been a focus of interest in breast cancer due to its role in cell growth, cell proliferation, cell migration and deregulated apoptosis. Its activation has been linked to endocrine resistance and worse prognosis in certain subgroups of breast cancer. In addition, deregulation of the PI3K/Akt pathway including PIK3CA activating mutation is frequently present in breast cancer. Read More

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December 2019

Peptides as a strategy against biofilm-forming microorganisms: Structure-activity relationship perspectives.

Eur J Pharm Sci 2018 Mar 11;114:114-137. Epub 2017 Nov 11.

Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, n.2752, CEP 90610-000, Bairro Azenha, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address:

Biofilm forming microorganisms substantially enhance their virulence and drug resistance causing and alternatives are need to combat this health problem. In this context, peptides are an exceptional strategy in drug design and pharmaceutical innovation due to their diverse chemical features, biological activity and biotechnological relevance. Therefore, this study proposes a comprehensive assessment of a wide range of peptides, targeting biofilms. Read More

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Curiosities of X chromosomal markers and haplotypes.

Authors:
Daniel Kling

Int J Legal Med 2018 Mar 26;132(2):361-371. Epub 2017 May 26.

Department of Forensic Services, Oslo University Hospital, P.O. Box 4950, Nydalen, 0424, Oslo, Norway.

Recent progress in forensic genetics has introduced a number of closely located short tandem repeat (STR) markers on the X chromosome. Inevitably, dependencies arise that have to be accounted for. This paper will in detail explore the complex statistical interpretation of X-chromosomal STR markers, focusing on likelihood calculations. Read More

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Treatment of chronic hepatitis C genotype 3 with Sofosbuvir-based therpy: a real-life study.

Hepatol Int 2017 May 31;11(3):277-285. Epub 2017 Mar 31.

Himalayan Institute of Medical Sciences, Dehradun, UttarKhand, India.

Background And Aims: Recently, Sofosbuvir was launched in India at affordable cost. We conducted a real-life study to determine the efficacy and safety of Sofosbuvir plus Ribavirin, with and without peginterferon-alfa 2a, in patients with chronic hepatitis C (CHC) genotype 3, the commonest genotype in South Asia.

Methods: This study included data of CHC patients from 11 sites in northern India between March 2015 and December 2015 (n = 1203). Read More

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12 Weeks of Daclatasvir in Combination With Sofosbuvir for HIV-HCV Coinfection (ALLY-2 Study): Efficacy and Safety by HIV Combination Antiretroviral Regimens.

Clin Infect Dis 2016 06 29;62(12):1489-96. Epub 2016 Mar 29.

Bristol-Myers Squibb, Wallingford, Connecticut.

Background: Highly effective hepatitis C virus (HCV) direct-acting antiviral therapies that do not require modification of human immunodeficiency virus (HIV) antiretroviral regimens are needed. We evaluated the efficacy and safety of daclatasvir + sofosbuvir (DCV + SOF) for 12 weeks by antiretroviral (ARV) regimen in HIV-HCV-coinfected patients.

Methods: In the randomized, open-label ALLY-2 study, HIV-HCV-coinfected patients received 8 or 12 weeks of once-daily DCV 60 mg (dose-adjusted as-necessary for concomitant ARVs) + SOF 400 mg. Read More

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Mifamurtide in metastatic and recurrent osteosarcoma: a patient access study with pharmacokinetic, pharmacodynamic, and safety assessments.

Pediatr Blood Cancer 2014 Feb 31;61(2):238-44. Epub 2013 Aug 31.

University of Texas M.D. Anderson Cancer Center, Houston, Texas.

Purpose: This non-randomized, patient-access protocol, assessed both safety and efficacy outcomes following liposomal muramyl-tripeptide-phosphatidylethanolamine (L-MTP-PE; mifamurtide) in patients with high-risk, recurrent and/or metastatic osteosarcoma.

Methods: Patients received mifamurtide 2 mg/m(2) intravenously twice-weekly ×12 weeks, then weekly ×24 weeks with and without chemotherapy. Serum concentration-time profiles were collected. Read More

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February 2014

Potential metabolomic biomarkers for evaluation of adriamycin efficacy using a urinary 1H-NMR spectroscopy.

J Appl Toxicol 2013 11 11;33(11):1251-9. Epub 2012 Jul 11.

College of Pharmacy, Dankook University, Dandae-ro, Cheonan, Chungnam, 330-714, Korea.

A metabolomics approach using proton nuclear magnetic resonance (NMR) was applied to investigate metabolic alterations following adriamycin (ADR) treatment for gastric adenocarcinoma. After BALB/c-nu/nu mice were implanted with human gastric adenocarcinoma, ADR (1 or 3 mg kg(-1) per day) was intraperitoneally administered for 5 days. Urine was collected on days 2 and 5 and analyzed by NMR. Read More

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November 2013

Hepatoprotective activity of the edible snail (Bellamia bengalensis) flesh extract in carbon tetrachloride induced hepatotoxicity in rats.

J Ethnopharmacol 2011 Oct 16;138(1):228-32. Epub 2011 Sep 16.

Laboratory of Toxinology & Experimental Pharmacodynamics, Department of Physiology, Calcutta University, 92 A P C Road, Kolkata 700 009, India.

Ethnopharmacological Relevance: In the folk-traditional medicine, snails were used to purify blood, boost immune system, prevent conjunctivitis and to treat liver problems.

Objectives: To evaluate the hepatoprotective activity of the edible snail (Bellamia bengalensis) flesh extract in male Wistar rats treated with carbon tetrachloride as an hepatotoxicant.

Materials And Methods: Live adult Bellamia bengalensis was collected commercially from the Kolkata market. Read More

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October 2011

Paclitaxel and bevacizumab as first line combined treatment in patients with metastatic breast cancer: the Hellenic Cooperative Oncology Group experience with biological marker evaluation.

Anticancer Res 2011 Sep;31(9):3007-18

Department of Medical Oncology, "Papageorgiou" Hospital, Ring Road, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.

Background: Randomized studies have shown that bevacizumab combined with taxane-based regimens increases response rates and prolongs progression-free survival (PFS) of patients with metastatic breast cancer (MBC). However predictive or prognostic biological markers that identify the appropriate target population, thus improving the cost-effectiveness ratio of this treatment, are still needed.

Patients And Methods: Retrospectively, 124 patients with MBC treated either with paclitaxel 90 mg/m² weekly x12 plus bevacizumab 10 μg/kg every 2 weeks or 15 μg/kg every 3 weeks (85 patients) or paclitaxel 175 mg/m² plus bevacizumab 15 μg/kg every 3 weeks for 6 cycles (36 patients) were identified. Read More

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September 2011

Renal anemia induced by chronic ingestion of depleted uranium in rats.

Toxicol Sci 2008 Jun 28;103(2):397-408. Epub 2008 Mar 28.

Institut de Radioprotection et de Sûreté Nucléaire, Direction de la RadioProtection de l'Homme, Service de Radiobiologie et d'Epidémiologie, F-92262 Fontenay-aux-Roses Cedex, France.

Kidney disease is a frequent consequence of heavy metal exposure and renal anemia occurs secondarily to the progression of kidney deterioration into chronic disease. In contrast, little is known about effects on kidney of chronic exposure to low levels of depleted uranium (DU). Study was performed with rats exposed to DU at 40 mg/l by chronic ingestion during 9 months. Read More

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The tripeptide analog feG ameliorates severity of acute pancreatitis in a caerulein mouse model.

Am J Physiol Gastrointest Liver Physiol 2008 Apr 28;294(4):G1094-9. Epub 2008 Feb 28.

Dept. of Surgery, Centre for Neuroscience, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.

Acute pancreatitis (AP) is associated with significant morbidity and mortality; however, there is no specific treatment for this disease. A novel salivary tripeptide analog, feG, reduces inflammation in several different animal models of inflammation. The aims of this study were to determine whether feG reduced the severity of AP and modifies the expression of pancreatic ICAM-1 mRNA during AP in a mouse model. Read More

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Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome.

Clin Cancer Res 2002 Nov;8(11):3611-21

Department of Radiation Medicine, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

Raf-1 protein serine threonine kinase plays an important role in cell survival and proliferation. Antisense inhibition of Raf-1 expression has been shown to enhance the cytotoxic effects of radiation and anticancer drugs. Here we have evaluated the toxicity, pharmacokinetics, and antitumor efficacy of a novel formulation of liposome-entrapped raf antisense oligodeoxyribonucleotide (LErafAON). Read More

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November 2002

Arthroscopic reduction and internal fixation (ARIF) of lateral tibial plateau fractures.

Knee Surg Sports Traumatol Arthrosc 2001 May;9(3):167-72

Department of Orthopaedic Trauma and Reconstructive Surgery, Lukas Hospital, Hindenburgstr. 56, 32257 Bünde, Germany.

Arthroscopic reduction and internal fixation of tibial plateau fractures has been well documented over the last 15 years. Better visualization, less traumatic surgery, reconstruction of accompanying injuries and early mobilization have encouraged arthroscopic surgeons to use this technique more widely. With experience, surgeons became more comfortable in using arthroscopy-assisted surgery not only in split fractures of the lateral tibial plateau (41-B1) but also in more complex tibial and femoral fractures. Read More

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Clinical data exchange standards and vocabularies for messages.

Authors:
S M Huff

Proc AMIA Symp 1998 :62-7

Intermountain Health Care, Salt Lake City, UT, USA.

Motivation for the creation of electronic data interchange (message) standards is discussed. The ISO Open Systems Interface model is described. Clinical information models, message syntax and structure, and the need for a standardized coded vocabulary are explained. Read More

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What is done, what is needed and what is realistic to expect from medical informatics standards.

Int J Med Inform 1998 Feb;48(1-3):5-12

Indiana University School of Medicine, Regenstrief Institute for Health Care, Indianapolis 46202, USA.

Medical informatic experts have made considerable progress in the development of standards for orders and clinical results (CEN, HL7, ASTM), EKG tracings (CEN), diagnostic images (DICOM), claims processing (X12 and EDIFAC) and in vocabulary and codes (SNOMED, Read Codes, the MED, LOINC). Considerable work still remains to be carried out. Abstract models of health care information have to be created, to cover the necessary domain, and yet be simple enough to assimilate, implement, and manage. Read More

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February 1998

Streamlining the accounts payable function with EDI.

Healthc Financ Manage 1997 Jan;51(1):64, 66-7

Kaiser Permanente Southern California, Pasadena, USA.

Kaiser Permanente of Southern California is expanding its use of EDI as a way to enhance the efficiency of its procurement effort and reduce administrative costs. Based on the results of surveys of key suppliers, Kaiser executives identified four EDI-based process improvements: 1) using the X12 832 standard to reconcile contracting data, which can eliminate up to 33 percent of mismatches among purchase orders, invoices, and receiving documents; 2) using procurement cards for many purchases, which can eliminate 20 percent of all invoices and related check payments; 3) using the X12 810 standard to obtain electronic invoices from Kaiser's largest suppliers; and 4) implementing the X12 820 standard, which lowers both supplier and claims payment costs. Read More

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January 1997

The need to manage and reconcile capitation payments.

Healthc Financ Manage 1995 Jan;49(1):84, 86, 88-9

McLure, Moynihan & Associates, Sherman Oaks, CA.

As capitation becomes a more common method of paying providers, healthcare financial managers must determine if these payments are being made correctly. The reconciliation process under capitation contracts is new for most financial managers. Standard industry conventions for payers and providers are needed to reduce the associated administrative costs for this type of payment. Read More

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January 1995

Pharmacology studies of 1-beta-D-arabinofuranosylcytosine in pediatric patients with leukemia and lymphoma after a biochemically optimal regimen of loading bolus plus continuous infusion of the drug.

Cancer Res 1989 Jan;49(1):241-7

Department of Pediatrics, School of Medicine, University of Southern California, Childrens Hospital of Los Angeles 90027.

In an attempt to maximize the therapeutic index and to overcome the large variations in 1-beta-D-arabinofuranosylcytosine (ara-C) plasma levels and host toxicities that have been documented with standard HDara-C regimens (3 g/m2 over 3 h every 12 h x 8 or x12 doses), pediatric patients with acute lymphocytic leukemia or lymphoma in relapse were treated with a regimen of loading bolus followed immediately by continuous infusion of ara-C. In addition, patients received a single dose of etoposide (VP-16, 1 g/m2) prior to the ara-C administration. In four patients, total body irradiation was administered as part of a bone marrow transplantation preparative regimen after the ara-C administration. Read More

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January 1989

Mohr-Wriedt (A2) brachydactyly: analysis of a large Brazilian kindred.

Hum Hered 1980 ;30(4):225-31

A large Brazilian kindred of German origin with 117 individuals with the A2 (Mohr-Wriedt) bradydactyly is presented. Some drawings based on radiographs and revealing the high phenotypic spectrum of the malformation are presented. Our corrected data suggest the presence of a segregation distortion in favor of the affected among the daughters of affected mothers (45:25; x12 = 5. Read More

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September 1980

Paraquat poisoning in man.

Arch Toxicol 1975 Oct;34(2):129-36

In three cases of intoxication by Gramoxone¿, the concentration of paraquat dichloride in blood, dialysate, feces, and urine was determined spectrophotometrically after a clean-up of the biological material by means of ion exchange chromatography (with Dowex 50W-X12 or Zeo-Karb 225). Although good results were obtained after clean-up with Dowex 50W-X12, Zeo-Karb was preferred as ion exchange resin, especially when large sample volumes were needed for the determination. The reported findings indicate that: only 5 to 10% of an ingested dose of paraquat dichloride is absorbed in man, Fullers' earth is very useful, and that primary, e. Read More

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October 1975

Studies on the development of chloramphenicol resistance in Salmonella typhimurium.

Res Vet Sci 1975 Jan;18(1):94-9

Chloramphenicol therapy of acute and chronic Salmonella typhimurium infection in mice did not lead to the development of chloramphenicol resistant mutants of this organism. However, chloramphenicol resistant organisms were readily produced in vitro. Transfer of chloramphenicol resistance from a donor strain of Escherichia coli X12 to a suitable recipient strain of S typhimurium 5235 occurred readily in the intestine of 15 out of 20 conventional mice, following oral administration of large doses of these strains supplemented by chloramphenicol therapy. Read More

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January 1975
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