178,641 results match your criteria wound healing


Age-related differences in corneal nerve regeneration after SMILE and the mechanism revealed by metabolomics.

Exp Eye Res 2021 Jun 9:108665. Epub 2021 Jun 9.

Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. Electronic address:

Purpose: To investigate the effect of age on wound healing after small incision lenticule extraction (SMILE) and the underlying metabolomic mechanisms.

Methods: This prospective study was conducted on 216 patients in four groups: the 18-20 (n = 38, Group I), 21-30 (n = 84, Group Ⅱ), 31-40 (n = 58, Group Ⅲ), and 41-50 (n = 36, Group IV) age groups. The density of corneal epithelial wing cells, basal cells, corneal stromal cells, endothelial cells and corneal nerves were examined with a laser confocal microscope (HRT III-RCM) before and 1 month, 3 month, 6 month and 1 year after SMILE. Read More

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FGF21 promotes wound healing of rat brain microvascular endothelial cells through facilitating TNF-α-mediated VEGFA and ERK1/2 signaling pathway.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

No. 1 Department of Orthopedics, The Third People's Hospital, Cixi, China.

Background: Wound healing is an essential physiological process in recovery after microsurgery.

Objectives: To further understand the functions of fibroblast growth factor 21 (FGF21), the roles of this factor were examined and its correlations with inflammation, vascular endothelial growth factor A (VEGFA) and ERK1/2 signaling pathway activation were analyzed.

Material And Methods: Rat brain microvascular endothelial cells (RBMECs) were treated with interleukin (IL)-1β and used for the experiments. Read More

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Highly absorbent hydrogels comprised from interpenetrated networks of alginate-polyurethane for biomedical applications.

J Mater Sci Mater Med 2021 Jun 12;32(6):70. Epub 2021 Jun 12.

Universidad Politécnica de Pénjamo, Carretera Irapuato - La Piedad Km 44, Pénjamo, 36921, Guanajuato, México.

Developing new approaches to improve the swelling, degradation rate, and mechanical properties of alginate hydrogels without compromising their biocompatibility for biomedical applications represents a potential area of research. In this work, the generation of interpenetrated networks (IPN) comprised from alginate-polyurethane in an aqueous medium is proposed to design hydrogels with tailored properties for biomedical applications. Aqueous polyurethane (PU) dispersions can crosslink and interpenetrate alginate chains, forming amide bonds that allow the structure and water absorption capacity of these novel hydrogels to be regulated. Read More

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Microfibrillated cellulose films containing chitosan and tannic acid for wound healing applications.

J Mater Sci Mater Med 2021 Jun 12;32(6):67. Epub 2021 Jun 12.

Department of Paper sciences and engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran.

The effectiveness of tannic acid as antimicrobial and wound healing for burns have been shown for a century; however, uncontrolled target dosage may result in undesirable side-effects. Remarkably, tannic acid polyphenols compounds crosslinked with polymeric materials produce a strong composite containing the beneficial properties of this tannin. However, investigation of the crosslink structure and its antibacterial and regenerative properties are still unknown when using nanocellulose by mechanical defibrillation; additionally, due to the potential crosslink structure with chitosan, its structure can be complex. Read More

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Edible Materials in Tissue Regeneration.

Macromol Biosci 2021 Jun 12:e2100114. Epub 2021 Jun 12.

School of Biomedical Engineering, Sun Yat-sen University, Shenzhen, 518057, China.

Edible materials have attracted increasing attention because of their excellent properties including availability, biocompatibility, biological activity, and biodegradability. Natural polysaccharides, phenolic compounds, and proteins are widely used in tissue regeneration. To better characterize their healing effect, this review article describes the applications of edible materials in tissue regeneration including wound healing and bone tissue regeneration. Read More

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NPWT Resource Use Compared With Conventional Wound Treatment in Subcutaneous Abdominal Wounds With Healing Impairment After Surgery: SAWHI Randomized Clinical Trial Results.

Ann Surg 2021 Jun 10. Epub 2021 Jun 10.

Institute for Research in Operative Medicine, University of Witten/Herdecke, Cologne, Germany.

Objective: To compare resource utilization of NPWT and CWT for SAWHI after surgery.

Summary Of Background Data: NPWT is widely used in the management of complex wounds but high-level evidence of its resource use remains sparse.

Methods: The multicenter, multinational, randomized clinical SAWHI study enrolled a total of 539 consecutive, compliant adult patients with SAWHI after surgery without fascial dehiscence between August 2, 2011, and January 31, 2018. Read More

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Plant callus-derived shikimic acid regenerates human skin through converting human dermal fibroblasts into multipotent skin-derived precursor cells.

Stem Cell Res Ther 2021 Jun 11;12(1):346. Epub 2021 Jun 11.

Strategic Center of Cell and Bio Therapy for Heart, Diabetes & Cancer, Biomedical Research Institute, Seoul National University Hospital, Seoul, 03080, Republic of Korea.

Background: The human skin-derived precursors (SKPs) are a good cell source for regeneration. However, the isolation of SKP from human skin is limited. To overcome this drawback, we hypothesized that the component of plant stem cells could convert human fibroblasts to SKPs. Read More

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The LINC00922 aggravates ovarian cancer progression via sponging miR-361-3p.

J Ovarian Res 2021 Jun 11;14(1):77. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, Third Affiliated Hospital, Zhengzhou University, Henan Province, Zhengzhou, 450052, China.

Background: Long noncoding RNA (lncRNA) LINC00922 has been reported to promote tumorigenesis of lung and breast cancer. However, the functions and mechanisms of LINC00922 in ovarian cancer (OC) remain unclarified. The current study aims to clarify the detailed functions and underlying mechanisms of LINC00922 in the progression of OC. Read More

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Halting colorectal cancer metastasis via novel dual nanomolar MMP-9/MAO-A quinoxaline-based inhibitors; design, synthesis, and evaluation.

Eur J Med Chem 2021 May 29;222:113558. Epub 2021 May 29.

Chemistry Department, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria, 21321, Egypt; Department of Chemistry, College of Science, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia. Electronic address:

Matrix metalloproteinase-9 (MMP-9) and monoamine oxidase-A (MAO-A) are central signaling nodes in CRC and promotors of distant metastasis associated with high mortality rates. Novel series of quinoxaline-based dual MMP-9/MAO-A inhibitors were synthesized to suppress CRC progression. The design rationale combines the thematic pharmacophoric features of MMP-9 and MAO-A inhibitors in hybrid scaffolds. Read More

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Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicological profile of Glycosmis pentaphylla (Retz.) DC.: A review.

J Ethnopharmacol 2021 Jun 8:114313. Epub 2021 Jun 8.

Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh; Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia. Electronic address:

Ethnopharmacological Relevance: Glycosmis pentaphylla (Retz.) DC. is a perennial shrub indigenous to the tropical and subtropical regions of India, China, Sri Lanka, Myanmar, Bangladesh, Indonesia, Malaysia, Thailand, Vietnam, Philippine, Java, Sumatra, Borneo and Australia. Read More

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Role of chitosan based nanomedicines in the treatment of chronic respiratory diseases.

Int J Biol Macromol 2021 Jun 8. Epub 2021 Jun 8.

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India. Electronic address:

Chitosan-loaded nanomedicines provide a greater opportunity for the treatment of respiratory diseases. Natural biopolymer chitosan and its derivatives have a large number of proven pharmacological actions like antioxidant, wound healing, immuno-stimulant, hypocholesterolemic, antimicrobial, obesity treatment, anti-inflammatory, anticancer, bone tissue engineering, antifungal, regenerative medicine, anti-diabetic and mucosal adjuvant, etc. which attracted its use in the pharmaceutical industry. Read More

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A decision tree model for neuroimmune guidance of allergic immunity.

Immunol Cell Biol 2021 Jun 11. Epub 2021 Jun 11.

Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

The immune system defends the body from infectious and non-infectious threats. Distinct recognition strategies have evolved to generate antigen-specific immunity against pathogens or toxins versus antigen-independent tissue repair. Structural recognition, or the sensing of conserved motifs, guides the immune response to viruses, bacteria, fungi, and unicellular parasites. Read More

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miR-379-5p inhibits proliferation and invasion of the endometrial cancer cells by inhibiting expression of ROR1.

Acta Biochim Pol 2021 Jun 11. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430022, China.

Endometrial cancer is a common gynecological malignancy, and the incidence of this disease has increased in recent years. Recently, some studies suggested that the expression of miR-379-5p suppressed the metastasis of breast cancer cells. However, whether the expression of miR-379-5p could affect the proliferation, migration and invasion of endometrial cancer is unclear. Read More

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Limited added value of negative pressure wound therapy compared to calcium alginate dressings for second intention healing in a non-contaminated and contaminated equine distal limb wound model.

Equine Vet J 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery and Anaesthesiology of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium.

Background: Distal limb wounds in horses often show aberrant healing due to a slow inflammatory response. In human medicine, negative pressure wound therapy (NPWT) is used for treatment of chronic wounds with a similar inflammatory response.

Objectives: To compare the effect of NPWT to calcium alginate dressings on the healing of (non-) contaminated equine distal limb wounds. Read More

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Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis.

Dermatol Ther (Heidelb) 2021 Jun 11. Epub 2021 Jun 11.

Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.

Previous approaches to acne management have focused on the four main factors implicated in acne, namely, androgen-mediated sebogenesis (considered integral to acne), hyperkeratinization, colonization with Cutibacterium acnes, and inflammation related to both innate and adaptive mechanisms. Recent advances have facilitated potential novel approaches to acne management, as the pathophysiology and the immunological aspects related to acne and wound healing have evolved. Particular targets that have been shown to be closely involved in acne pathophysiology and wound healing include interleukin (IL)-1β, IL-17, IL-23, and tumor necrosis factor alpha (TNFα). Read More

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Therapeutic efficacy of arthroscopy-assisted transosseous fixation with the Versalok suture anchor for tibial eminence fractures in adults.

Medicine (Baltimore) 2021 Jun;100(23):e26284

Department of Orthopedics, Second Affiliated Hospital of Soochow University, No.1055 Sanxiang Road, Suzhou.

Abstract: To investigate the clinical outcomes of arthroscopy-assisted transosseous fixation of tibial eminence fractures with the Versalok suture anchor in adults.A total of 23 adult cases of tibial eminence fractures treated between June 2016 and March 2019 were retrospectively analyzed. The results of the preoperative drawer test and Lachman test were positive. Read More

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Retrospective study of the efficacy of vascularized tissue transfer for treating antibiotic-resistant bacteria-infected wound: Comparison with clean and antibiotic-sensitive bacteria-infected wound.

Medicine (Baltimore) 2021 Jun;100(23):e25907

Department of Plastic and Reconstructive Surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul.

Abstract: If wounds are infected with bacteria resistant to an empirical antibiotic regimen, effective wound treatment will be delayed. This can delay wound healing and lengthen hospital stays, increasing the costs to patients. Long-term antibiotic use can also result in minor and major complications, such as diarrhea, antibiotic resistance, or life-threatening leukopenia. Read More

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Use of oxidised regenerated cellulose/collagen dressings versus standard of care over multiple wound types: A systematic review and meta-analysis.

Int Wound J 2021 Jun 11. Epub 2021 Jun 11.

Medical Solutions Division, 3M, San Antonio, Texas, USA.

Oxidised regenerated cellulose (ORC)/collagen dressings help maintain physiologically moist wound environments conducive to wound healing. While evidence supporting ORC/collagen dressing use exists, comprehensive assessment is needed. This systematic review/meta-analysis evaluated the performance of ORC/collagen dressings compared with standard dressings. Read More

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Cellular reprogramming of diabetic foot ulcer fibroblasts triggers pro-healing miRNA-mediated epigenetic signature.

Exp Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Wound Healing and Regenerative Medicine Research Program, Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Diabetic foot ulcers (DFUs), a prevalent complication of diabetes, constitute a major medical challenge with a critical need for development of cell-based therapies. We previously generated induced pluripotent stem cells (iPSCs) from dermal fibroblasts derived from the DFU patients, location-matched skin of diabetic patients and normal healthy donors and re-differentiated them into fibroblasts. To assess the epigenetic microRNA (miR) regulated changes triggered by cellular reprogramming, we performed miRs expression profiling. Read More

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Mechanical Effects of a Maylard Scar During a Vaginal Birth After a Previous Caesarean.

Ann Biomed Eng 2021 Jun 10. Epub 2021 Jun 10.

INEGI - Institute of Science and Innovation in Mechanical and Industrial Engineering/DEMec, Faculty of Engineering, University of Porto, Porto, Portugal.

Caesarean section is one of the most common surgeries worldwide, even though there is no evidence supporting maternal and perinatal long-term benefits. Furthermore, the mechanical behavior of a caesarean scar during a vaginal birth after caesarean (VBAC) is not well understood since there are several questions regarding the uterine wound healing process. The aim of this study is to investigate the biomechanical Maylard fiber reorientation and stiffness influence during a VBAC through computational methods. Read More

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Comparison of Antibacterial Activity and Wound Healing in a Superficial Abrasion Mouse Model of Skin Infection Using Photodynamic Therapy Based on Methylene Blue or Mupirocin or Both.

Front Med (Lausanne) 2021 25;8:673408. Epub 2021 May 25.

Department of Microbiology, Hospital Universitario Miguel Servet, IIS Aragón, Zaragoza, Spain.

Antibiotic resistance and impaired wound healing are major concerns in superficial skin infections, and new therapies are needed. Antimicrobial photodynamic therapy (aPDT) is a new therapeutic approach for infections, but it also improves healing in many wound models. To compare the antimicrobial activity and the effects on wound healing of aPDT based on Methylene Blue (MB-aPDT) with mupirocin treatment, either alone or in combination, in superficial skin wounds of -infected mice. Read More

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Gene Expression Profile of the Human Colorectal Carcinoma LoVo Cells Treated With Sporamin and Thapsigargin.

Front Oncol 2021 25;11:621462. Epub 2021 May 25.

School of Public Health, Capital Medical University (CMU), Beijing, China.

Sporamin, a proteinase inhibitor isolated from the sweet potato (), has shown promising anticancer effect against colorectal cancer (CRC) and but its mechanisms of action are poorly understood. In the present study, high throughput RNA sequencing (RNA-seq) technology was applied to explore the transcriptomic changes induced by sporamin in the presence of thapsigargin (TG), a non-12-O-tetradecanolphorbol-13-acetate type cancer promoter, in the LoVo human CRC cells. Cellular total RNA was extracted from the cells after they were treated with vehicle (CTL), 1 μM of thapsigargin (TG), or 1 μM of TG plus 30 μM of sporamin (TGSP) for 24 h. Read More

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Ubenimex Suppresses the Ability of Migration and Invasion in Gastric Cancer Cells by Alleviating the Activity of the CD13/NAB1/MAPK Pathway.

Cancer Manag Res 2021 4;13:4483-4495. Epub 2021 Jun 4.

Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, 266071, Shandong, People's Republic of China.

Background: Gastric cancer (GC) is one of the most common malignant tumors in China. Most GC patients are diagnosed at an advanced stage, for that the prognosis is dismal and metastasis is common. Although there have been increasing numbers of studies indicating that Ubenimex can suppress metastasis in GC, the underlying mechanism is still unknown. Read More

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Promotes HCC Migration/Invasion via Increasing Aerobic Glycolysis.

Onco Targets Ther 2021 4;14:3649-3658. Epub 2021 Jun 4.

Department of Clinical Laboratory Diagnostics, School of Public Health, Gansu University of Chinese Medicine, Lanzhou, Gansu, People's Republic of China.

Background: The mortality and morbidity of hepatocellular carcinoma (HCC) are still unacceptably high, despite decades of extensive studies. Aerobic glycolysis is a hallmark of cancer metabolism, closely relating to invasion and metastasis of HCC. MicroRNAs (miRNAs) are involved in the regulation of aerobic glycolysis. Read More

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ITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway.

Onco Targets Ther 2021 3;14:3583-3596. Epub 2021 Jun 3.

Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Background: Integrin alpha 2 (ITGA2) is highly expressed in various cancers. ITGA2 up regulation promotes tumor proliferation, invasion, migration, and angiogenesis and ITGA2 is a poor prognostic factor in many tumors. However, the mechanism underlying its role in esophageal squamous cell carcinoma (ESCC) is unknown. Read More

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[Design and application of a multifunctional infrared wind heating medical rewarming equipment].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):618-602

Department of Critical Care Medicine, the First People's Hospital of Chenzhou (Group), Chenzhou 423000, Hunan, China.

Hypothermia can have adverse effects on various systems of trauma patients, and significantly increase the mortality. All of the current rewarming equipments are contact rewarming equipment, which have the shortcomings of single function and poor effect. The medical staff of the First People's Hospital of Chenzhou designed a multi-functional infrared heating medical rewarming equipment, and obtained the National Utility Model Patent of China (ZL 2018 2 1705172. Read More

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Epidermal stem cells maintain stemness via a biomimetic micro/nanofiber scaffold that promotes wound healing by activating the Notch signaling pathway.

Stem Cell Res Ther 2021 Jun 10;12(1):341. Epub 2021 Jun 10.

Department of Plastic Surgery, Tangdu Hospital, Airforce Military Medical University, Xi'an, 710038, China.

Background: Epidermal stem cells (EpSCs) play a vital role in wound healing and skin renewal. Although biomaterial scaffolds have been used for transplantation of EpSCs in wound healing, the ex vivo differentiation of EpSCs limits their application.

Methods: To inhibit the differentiation of EpSCs and maintain their stemness, we developed an electrospun polycaprolactone (PCL)+cellulose acetate (CA) micro/nanofiber for the culture and transplantation of EpSCs. Read More

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CircRNA NALCN acts as an miR-493-3p sponge to regulate PTEN expression and inhibit glioma progression.

Cancer Cell Int 2021 Jun 10;21(1):307. Epub 2021 Jun 10.

Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Background: An increasing number of studies have shown that circular RNAs (circRNAs) play important roles in the regulation of tumor progression. Therefore, we explored the expression characteristics, function, and related mechanism of the newly identified circNALCN in glioma.

Methods: RNA sequencing was used to analyze the expression profiles of circRNAs in brain tissue from five glioma cases and four normal controls. Read More

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Characterisation of baseline microbiological and host factors in an inception cohort of people with surgical wounds healing by secondary intention reveals circulating IL-6 levels as a potential predictive biomarker of healing.

Wellcome Open Res 2020 19;5:80. Epub 2020 Nov 19.

York Biomedical Research Institute, Hull York Medical School, University of York, York, YO10 5DD, UK.

More than 2 million people per year are treated for surgical wounds in the UK.  Over a quarter of these wounds are estimated to heal by secondary intention (from the "bottom up") resulting in further complications and requiring increased healthcare resources. Identification of microbiological or host biomarkers that can predict healing outcomes may help to optimize the management of surgical wounds healing by secondary intention. Read More

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November 2020

The Need for Perforator Treatment After VenaSeal and ClosureFast Endovenous Saphenous Vein Closure in CEAP 6 Patients.

J Vasc Surg Venous Lymphat Disord 2021 Jun 7. Epub 2021 Jun 7.

University of California San Francisco-Fresno, Fresno, CA.

Objectives: The authors have previously demonstrated that VenaSeal (Medtronic, Inc., Minneapolis, MN) adhesive, compared to radiofrequency ablation (RFA, ClosureFast, Medtronic, Inc., Minneapolis, MN), in treatment of refluxing saphenous veins in CEAP 6 limbs, results in shorter healing times of venous ulcers. Read More

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