28,887 results match your criteria wound closure


Wound Closure with Transcutaneous Absorbable Polyglactin Sutures after Hidradenitis Suppurativa Excision.

Adv Skin Wound Care 2022 Feb;35(2):1-4

At the University of Maryland School of Medicine, Baltimore, Maryland, United States of America, Carolyn Drogt, MHS, is Medical Student, Division of Plastic Surgery, Department of Surgery; Philip Hanwright, MD, is Plastic Surgery Resident, Department of Plastic & Reconstructive Surgery; Michael Ha, MA Cantab MB BChirc, is Postdoctoral Research Fellow, Division of Plastic Surgery, Department of Surgery; Ledibabari M. Ngaage, MA Cantab MB BChirc, is Plastic Surgery Intern, Department of Plastic & Reconstructive Surgery; and Mary Lin, BS, Shealinna Ge, MD, Yinglun Wu, MD, Ronald P. Silverman, MD, and Yvonne M. Rasko, MD, are Medical Students, Division of Plastic Surgery, Department of Surgery. The authors have disclosed no financial relationships related to this article. Submitted February 4, 2021; accepted in revised form April 12, 2021.

Objective: Wide surgical excision is the standard treatment for severe hidradenitis suppurativa (HS). Because of the nature of HS, these wounds are often nonsterile, located in moist intertriginous regions, and closed under tension, increasing the risk for surgical site complications. Although uncommon, absorbable sutures may confer benefits over nonabsorbable material for skin closure. Read More

View Article and Full-Text PDF
February 2022

A low-swelling and toughened adhesive hydrogel with anti-microbial and hemostatic capacities for wound healing.

J Mater Chem B 2022 Jan 20. Epub 2022 Jan 20.

CAS Key Laboratory for Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123, China.

Hydrogel-based wound dressings with tissue adhesion abilities are widely used for wound closure. However, currently developed hydrogel adhesives are still poor at continuing to seal wounds while bleeding is ongoing. Herein, we demonstrate an antibacterial and hemostatic hydrogel adhesive with low-swelling properties and toughness for wound healing. Read More

View Article and Full-Text PDF
January 2022

Green Synthesis of Silver Nanoparticles by the Cyanobacteria sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions.

Mar Drugs 2022 Jan 6;20(1). Epub 2022 Jan 6.

Biological Sciences Department, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.

Green nanotechnology is now accepted as an environmentally friendly and cost-effective advance with various biomedical applications. The cyanobacterium sp. is a unicellular spherical cyanobacterium with photo- and hetero-trophic capabilities. Read More

View Article and Full-Text PDF
January 2022

Surgical management of a giant venous aneurysm in an autogenous arteriovenous fistula with the vessel loop shoelace technique for wound closure: A case report.

Authors:
Young Sun Yoo

Medicine (Baltimore) 2021 Dec;100(48):e28072

Department of Surgery, College of Medicine, Chosun University, Gwangju, South Korea.

Rationale: Giant venous aneurysm (GVA) is a complication of chronic arteriovenous fistula (AVF). The risks of thrombosis, rupture, and massive hemorrhage increase with the increasing size of GVA; therefore, GVA requires treatment. However, the optimal timing and treatments are yet to be established. Read More

View Article and Full-Text PDF
December 2021

Immune-modulating properties of blue light do not influence reepithelization in vitro.

Lasers Med Sci 2022 Jan 19. Epub 2022 Jan 19.

Clinic for Plastic, Reconstructive, Hand and Burn Surgery, BG Trauma Center, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.

Phototherapy is gaining more attention in the treatment of various diseases. Especially, blue light seems to be a promising approach for wound healing promotion due to its antimicrobial and immune-modulating properties. Despite this, there is only little research focusing on the immune-modulating properties of blue light and its possible effects on wound healing. Read More

View Article and Full-Text PDF
January 2022

A Novel Method to Assess the Microbial Barrier Function of Tissue Adhesives Using Bioluminescence Imaging Technique.

Biomed Res Int 2022 10;2022:3483238. Epub 2022 Jan 10.

Institute for Laboratory Animal Science, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.

. Tissue glues can minimize treatment invasiveness, mitigate the risk of infection, and reduce surgery time; ergo, they have been developed and used in surgical procedures as wound closure devices beside sutures, staples, and metallic grafts. Regardless of their structure or function, tissue glues should show an acceptable microbial barrier function before being used in humans. Read More

View Article and Full-Text PDF
January 2022

[Surgical Technique for Prevention of Incisional Hernia in Laparoscopic Small Bowel Resection in the Obese Patient].

Gan To Kagaku Ryoho 2021 Dec;48(13):1664-1666

Dept. of Surgery, Japan Community Health care Organization(JCHO)Osaka Hospital.

A 67-year-old woman reporting lower abdominal pain and anemia was examined. Small intestinal tumor was diagnosed by small intestinal radiographic contrast study and small intestinal endoscopy, and we decided to perform a laparoscopic partial resection of the small bowel. Since she was obese patients(BMI 36. Read More

View Article and Full-Text PDF
December 2021

Specialized pro-resolution mediators in the bladder: Receptor expression and recovery of bladder function from cystitis.

Exp Biol Med (Maywood) 2022 Jan 19:15353702211067465. Epub 2022 Jan 19.

Division of Urology, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

Inflammation is a central process in most benign bladder disorders, and its control is a delicate balance between initiating factors and resolving factors. While recent discoveries have shown a central role for the NLRP3 inflammasome in initiation, the resolving pathways remain unexplored. Resolution is controlled by specialized pro-resolution mediators (SPMs) functioning through seven receptors (six in rodents). Read More

View Article and Full-Text PDF
January 2022

Effectiveness of negative pressure wound therapy with instillation and dwelling after stoma closure: a retrospective and propensity score matching analysis.

Sci Rep 2022 Jan 18;12(1):916. Epub 2022 Jan 18.

Department of Surgery, Faculty of Medicine, Kindai University, 377-2 Ohno-Higashi, Osaka-sayama, Osaka, 589-8511, Japan.

The use of temporary diverting stoma has become more common in low colorectal anastomosis to reduce anastomotic complications. Surgical site infection (SSI) at the stoma closure site has been one of the most frequent postoperative complications. The aim of this study was to compare the short-term outcomes between conventional primary suture closure and negative pressure wound therapy with instillation and dwelling (NPWTi-d) therapy following purse-string suturing, using propensity score matching analysis. Read More

View Article and Full-Text PDF
January 2022

The solvent effect modulates the formation of homogeneous polyphenol composite hydrogels with improved transparency and mechanical strength for antibacterial delayed sternal closure films.

J Mater Chem B 2022 Jan 18. Epub 2022 Jan 18.

Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Material Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.

The usage of delayed sternal closure films after thoracotomy surgery helps doctors deal with emergency conveniently. There is a growing demand to develop suturable, antibacterial and transparent films for delayed sternal closure. Although polyphenol incorporated hydrogels provide good suture ability, they lose transparency because of the heterogeneous distribution of polyphenols during the post-immersion process. Read More

View Article and Full-Text PDF
January 2022

Therapeutic downregulation of () promotes surgical skin wound healing.

Elife 2022 Jan 18;11. Epub 2022 Jan 18.

Department of Surgery, University of California, Los Angeles, Los Angeles, United States.

Attempts to minimize scarring remain among the most difficult challenges facing surgeons, despite the use of optimal wound closure techniques. Previously, we reported improved healing of dermal excisional wounds in circadian clock neuronal PAS domain 2 ()-null mice. In this study, we performed high-throughput drug screening to identify a compound that downregulates activity. Read More

View Article and Full-Text PDF
January 2022

Muscle-inspired MXene/PVA hydrogel with high toughness and photothermal therapy for promoting bacteria-infected wound healing.

Biomater Sci 2022 Jan 17. Epub 2022 Jan 17.

Department of Food Quality and Safety/National R&D Center for Chinese Herbal Medicine Processing, College of Engineering, China Pharmaceutical University, Nanjing 211198, China.

The process of wound healing is often accompanied by bacterial infection, which is a serious threat to human health. The abuse of antibiotics in traditional therapy aggravates the resistance of bacteria and gradually reduces the therapeutic effect. Therefore, it is important to develop effective antibacterial dressings to promote wound healing and prevent infection. Read More

View Article and Full-Text PDF
January 2022

Substance P modulates BMSCs migration for tissue repair through NK-1R/CXCR4/p-Akt signal activation.

Mol Biol Rep 2022 Jan 16. Epub 2022 Jan 16.

Department of Essential Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan Province, People's Republic of China.

Background: The migration of bone marrow-derived mesenchymal stem cells (BMSCs) to the wound site played an important role in tissue repair. Substance P (SP) has been studied and reported to be involved in tissue repair by promoting the growth of endothelial cells and the migration of BMSCs. However, the complicated process and the molecular mechanisms were not fully understood. Read More

View Article and Full-Text PDF
January 2022

Complicated Wound Closure Following Mastectomy and Breast Reconstruction.

J Cosmet Dermatol 2022 Jan 13. Epub 2022 Jan 13.

Resident Doctor, Department of Plastic Surgery & Burns, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Breast reconstruction incidence increased, including preventive surgery. In this context, providing women best surgical care and results is crucial, with minimum complications, such as wound dehiscence and skin flap necrosis. Tension-free closure of skin flaps is mandatory for successful healing. Read More

View Article and Full-Text PDF
January 2022

A New Extraperitoneal Method for Entero-atmospheric Fistula Closure Using a Free Muscle Flap.

Plast Reconstr Surg Glob Open 2021 Nov 11;9(11):e3918. Epub 2021 Nov 11.

Medical Imaging Research Group, Department of Clinical Medicine, Uit The Arctic University of Norway, 9037 Tromsø, Norway.

Treatment of an entero-atmospheric fistula (EAF) is challenging and associated with significant morbidity and mortality. For an EAF with protrusion of mucosa, chances for spontaneous closure are minimal. Standard surgical procedures may be associated with a high risk for complications in patients with a hostile abdomen. Read More

View Article and Full-Text PDF
November 2021

Damage control in abdominal vascular trauma.

Colomb Med (Cali) 2021 Apr-Jun;52(2):e4064808. Epub 2021 Jun 30.

University of Pittsburgh. Critical Care Medicine. Pittsburgh, PA, USA. University of Pittsburgh University of Pittsburgh Critical Care Medicine PittsburghPA USA.

In patients with abdominal trauma who require laparotomy, up to a quarter or a third will have a vascular injury. The venous structures mainly injured are the vena cava (29%) and the iliac veins (20%), and arterial vessels are the iliac arteries (16%) and the aorta (14%). The initial approach is performed following the ATLS principles. Read More

View Article and Full-Text PDF
January 2022

Antimicrobial peptides/ciprofloxacin-loaded O-carboxymethyl chitosan/self-assembling peptides hydrogel dressing with sustained-release effect for enhanced anti-bacterial infection and wound healing.

Carbohydr Polym 2022 Mar 27;280:119033. Epub 2021 Dec 27.

College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.

Bacteria-induced wound infections and multifunctional hydrogels have received widespread attention in wound repair. In this study, self-assembling peptides (SAPs) were grafted on O-carboxymethyl chitosan (O-CMCS), and compact spatial structure and good drug sustained-release effect on mel-d1, a new AMP designed based on melittin with the same antimicrobial activity but lower cytotoxicity and ciprofloxacin (CIP) were obtained. In vivo test showed that the O-CMCS/SAP hydrogel loaded with CIP and mel-d1 accelerated the wound closure speed caused by infection of Escherichia coli and skin tissue regeneration. Read More

View Article and Full-Text PDF

Endoscopic pilonidal sinus treatment vs. laser-assisted endoscopic pilonidal sinus treatment: short-term results from a retrospective case-matched study.

Tech Coloproctol 2022 Jan 13. Epub 2022 Jan 13.

Department of Surgery, Bursa Medicana Hospital, 16110, Bursa, Turkey.

Background: The aim of this study was to investigate whether the addition of laser to the endoscopic pilonidal sinus treatment (EPSIT), laser-assisted EPSIT (LEPSIT) has an effect on the method and clinical results in the treatment of pilonidal sinus disease (PSD).

Methods: Between September 2019 and September 2020, patients who underwent LEPSIT and EPSIT procedures for PSD at Bursa Medicana Hospital, Turkey, were matched for age, pit location and number, body mass index (BMI), and sex. The primary endpoint was complete wound healing and the secondary endpoints were quality of life, cosmetic results, and cost. Read More

View Article and Full-Text PDF
January 2022

Reconstruction of Large Meningomyelocele Defects with Bipedicled Fasciocutaneous Flaps: Technical and Clinical Points.

Turk Neurosurg 2022 Jan 13. Epub 2022 Jan 13.

Kocaeli University, Faculty of Medicine, Department of Plastic, Reconstructive and Aesthetic Surgery, Kocaeli, Turkey.

Aim: The aim of this study was to evaluate the bilateral vertical bipedicled procedure for the closure of large meningomyelocele defects and to emphasise some technical and clinical considerations.

Material And Methods: This procedure was used to close large meningomyelocele defects in ten patients (six males and four females) between January 2016 and August 2020. Eight of the patients were operated on within the first 24 hours of birth, and the remaining two were operated on between 1-7 days from birth. Read More

View Article and Full-Text PDF
January 2022

Effectiveness of negative-pressure wound therapy compared to wet-dry dressing in pressure injuries.

J Tissue Viability 2022 Jan 3. Epub 2022 Jan 3.

Acibadem Mehmet Ali Aydinlar University, Health Science School, Istanbul, Turkey.

This study aims to compare the effects of Negative-Pressure Wound Therapy (NPWT) and wet-to-dry dressing on Stages 3 and 4 pressure injuries (PI), This study is a randomized controlled trial. A total of 30 patients with Stages 3 and 4 pressure injuries were included in the study. The patients were divided into two groups: NPWT group and the wet-to-dry dressing group. Read More

View Article and Full-Text PDF
January 2022

Postpneumonectomy MRSA empyema treated with vacuum therapy - case report and literature review.

Rozhl Chir 2021 ;100(10):502-506

Introduction: Postpneumonectomy empyema is one of serious complications with high mortality and lethality. In this paper, the authors describe the treatment of methicillin-resistant Staphylococcus aureus-induced postpneumonectomy empyema by vacuum therapy in a patient operated on for malignant pleural mesothelioma.

Case Report: A 64-year-old patient was operated on at our clinic for epithelioid mesothelioma of the right pleural cavity. Read More

View Article and Full-Text PDF
January 2022

GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis.

Cell 2022 Jan 7. Epub 2022 Jan 7.

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address:

Gasdermins are a family of structurally related proteins originally described for their role in pyroptosis. Gasdermin B (GSDMB) is currently the least studied, and while its association with genetic susceptibility to chronic mucosal inflammatory disorders is well established, little is known about its functional relevance during active disease states. Herein, we report increased GSDMB in inflammatory bowel disease, with single-cell analysis identifying epithelial specificity to inflamed colonocytes/crypt top colonocytes. Read More

View Article and Full-Text PDF
January 2022

Efficacy and safety of mesh closure in preventing wound failure following emergency laparotomy: a systematic review and meta-analysis.

Langenbecks Arch Surg 2022 Jan 12. Epub 2022 Jan 12.

Department of General Surgery, Sandwell and West, Birmingham Hospitals NHS Trust, Birmingham, UK.

Aims: To evaluate comparative outcomes of emergency laparotomy closure with and without prophylactic mesh.

Methods: A systematic review was performed via literature databases: PubMed, Cochrane Library, Science Direct, and Google Scholar. Studies were examined for eligibility and included if they compared prophylactic mesh closure to the conventional laparotomy closure following emergency abdominal surgery. Read More

View Article and Full-Text PDF
January 2022

Incidence and risk factors for poor perioperative blood glucose management in patients with diabetic foot: a retrospective study.

Ann Palliat Med 2021 Dec;10(12):12300-12309

Department of Burns and Plastic Surgery, the First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Diabetic foot (DF) is one of the most serious complications of diabetes mellitus (DM). In some cases of DF, life-saving amputation is necessary. This study set out to investigate the situation of preoperative blood glucose management in patients with DF. Read More

View Article and Full-Text PDF
December 2021

The Effectiveness of 0.2% Chlorhexidine Gel on Early Wound Healing after Tooth Extraction: A Randomized Controlled Trial.

Eur J Dent 2022 Jan 11. Epub 2022 Jan 11.

Department of Oral Surgery, Faculty of Dentistry, Universitas Padjadjaran, West Java, Indonesia.

Objective:  This study aimed to evaluate the effect of 0.2% chlorhexidine (CHX) gel on wound healing after tooth extraction.

Materials And Methods:  A single blind, randomized controlled trial was performed recruiting 32 participants who underwent dental extractions. Read More

View Article and Full-Text PDF
January 2022

In situ graphene oxide-gelatin hydrogels with enhanced mechanical property for tissue adhesive and regeneration.

Biochem Biophys Res Commun 2022 Jan 6;592:24-30. Epub 2022 Jan 6.

Department of Molecular Science and Technology, Ajou University, Suwon, 443-749, South Korea. Electronic address:

Extracellular matrix (ECM) is playing a critical role which is component of mammalian tissue that provide structural support to cells. In addition, ECM act as a local depot for growth factors that control cell phenotype and differentiation. In this regard, scaffold that mimicking the ECM structure is important to growth or wound healing process. Read More

View Article and Full-Text PDF
January 2022

Engineering Vascularizing Electrospun Dermal Grafts by Integrating Fish Collagen and Ion-Doped Bioactive Glass.

ACS Biomater Sci Eng 2022 Jan 11. Epub 2022 Jan 11.

Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata 700037, India.

Utilizing bioactive molecules from organic sources in combination with inorganic materials for enhanced tissue regeneration has been a focus of recent scientific advancements. Some recent studies showed the potential of some specialized bioactive glass for healing of soft tissues; the role of Rohu () skin-derived collagen, a biopolymer in tissue regeneration and cutaneous healing, is yet to be established. So, we have fabricated four different types of electrospun mats as wound dressing materials/dermal grafts by combining locally sourced fish (Rohu) skin-derived collagen with novel composition of bioactive glass (Fcol/BAG) without and with dopants (3% and 5% Cu and Co, respectively and their binary) aimed at achieving an accelerated wound healing. Read More

View Article and Full-Text PDF
January 2022