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CD177, a specific marker of neutrophil activation, is associated with COVID-19 severity and death.

iScience 2021 Jun 10:102711. Epub 2021 Jun 10.

Vaccine Research Institute, Université Paris-Est Créteil, Faculté de Médecine, INSERM U955, Team 16, Créteil, France.

The identification of COVID-19 patients with high-risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum and RNA-seq gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Read More

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Reversal of residual neuromuscular block with neostigmine or sugammadex and postoperative pulmonary complications: a prospective, randomised, double-blind trial in high-risk older patients.

Br J Anaesth 2021 Jun 11. Epub 2021 Jun 11.

Department of Anaesthesiology and Intensive Care, University of Debrecen, Debrecen, Hungary.

Background: Residual neuromuscular block is associated with an increased risk of postoperative pulmonary complications in retrospective studies. The aim of our study was to investigate prospectively the incidence of postoperative pulmonary complications after reversal with either sugammadex (SUG) or neostigmine (NEO) in high-risk older patients.

Methods: We randomly allocated 180 older patients with significant morbidity (ASA physical status 3) ≥75 yr old to reversal of rocuronium with either SUG or NEO. Read More

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Impact of acute total occlusion of the culprit artery on outcome in NSTEMI based on the results of a large national registry.

BMC Cardiovasc Disord 2021 Jun 14;21(1):297. Epub 2021 Jun 14.

Jagiellonian University Medical College, 1st Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Jakubowskiego St. 2, 30-688, Kraków, Poland.

Background: The impact of acute total occlusion (TO) of the culprit artery in non-ST-segment elevation myocardial infarction (NSTEMI) is not fully established. We aimed to evaluate the clinical and angiographic phenotype and outcome of NSTEMI patients with TO (NSTEMI) compared to NSTEMI patients without TO (NSTEMI) and those with ST-segment elevation and TO (STEMI).

Methods: Demographic, clinical and procedure-related data of patients with acute myocardial infarction who underwent percutaneous coronary intervention (PCI) between 2014 and 2017 from the Polish National Registry were analysed. Read More

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COVID-19 and diabetes mellitus: potential metabolic associations.

Curr Top Med Chem 2021 Jun 11. Epub 2021 Jun 11.

Departamento de Biologia Celular e Molecular (GCM), Instituto de Biologia (IB), Universidade Federal Fluminense (UFF), Niterói-RJ, Brazil.

The COVID-19 pandemic turned the SARS-CoV-2 into the main target of scientific research all around the world. Many advances have already been made, but there is still a long way to go to solve the molecular mechanisms related to the process of the SARS-CoV-2 infection, as well as the particularities of the disease, its course and the complex host-pathogen relationships. However, a lot has been theorized and associated with COVID-19, like the worst prognosis of the disease among individuals with some comorbidities, like diabetes mellitus. Read More

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Assessment of surface water of Gulf of Kachchh, west coast of India: A chemometric approach.

Mar Pollut Bull 2021 Jun 11;170:112589. Epub 2021 Jun 11.

Department of Biosciences, School of Sciences, Indrashil University, Rajpur-Kadi, Mehsana, Gujarat, India; Department of Life Sciences, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, Gujarat, India. Electronic address:

The present study is aimed at investigation of surface water quality of Gulf of Kachchh (GoK), Gujarat. The main objective of this study was to convert complex dataset of water quality parameters from GoK into comprehensive, simple and interpretable observations. Hence, physico-chemical parameters and nutrients of surface water from GoK were analyzed. Read More

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Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.

J Surg Res 2021 Jun 10;267:25-36. Epub 2021 Jun 10.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University, Chengdu, China. Electronic address:

Background: This study aimed to determine the disease characteristics and prognosis of patients with primary mediastinal nonseminomas (PMNS) in a Surveillance, Epidemiology, and End Results (SEER) analysis.

Materials And Methods: Demographic, treatment, and survival outcome data of cases with PMNS from 1975 to 2016 were retrieved. Cases with unknown variables mentioned in the analysis were excluded. Read More

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Significant Solvent Effect on Reactivity of Oxoiron(IV) Porphyrin π-Cation Radical Complex: Activation in -Alkane Solvent.

Inorg Chem 2021 Jun 14. Epub 2021 Jun 14.

Department of Chemistry, Graduate School of Humanities and Sciences, Nara Women's University, Kitauoyanishi, Nara 630-8506, Japan.

The solvent effect on the reactivity of high-valent metal oxo complexes has not been studied well, because of their solubility and stability. We synthesize oxoiron(IV) porphyrin π-cation radical complexes ( and ) having the -hexyl side chains. and are soluble in various solvents, even in hexane, at -80 °C, allowing for the study of their reactivity in various organic solvents. Read More

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The predicted trend of COVID-19 in the United States of America under the policy of "Opening Up America Again".

Infect Dis Model 2021 6;6:766-781. Epub 2021 Jun 6.

Department of Accounting, Finance and Economics, Griffith University, Nathan, Australia, 4111.

COVID-19 virus has been spreading worldwide for more than a year. At present, the situation of the new crown pneumonia epidemic remains full of tension and uncertainty. It is of concern is that the worst outbreak in the world is in the United States. Read More

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Establishment of Novel Prostate Cancer Risk Subtypes and A Twelve-Gene Prognostic Model.

Front Mol Biosci 2021 28;8:676138. Epub 2021 May 28.

Department of Urology, Shengjing Hospital of China Medical University, Shenyang, China.

Prostate cancer (PCa) is the most common malignancy among men worldwide. However, its complex heterogeneity makes treatment challenging. In this study, we aimed to identify PCa subtypes and a gene signature associated with PCa prognosis. Read More

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Patient satisfaction with the emergency department services at an academic teaching hospital.

J Family Med Prim Care 2021 Apr 29;10(4):1718-1725. Epub 2021 Apr 29.

Research Center, King Fahad Medical City, Riyadh, Saudi Arabia.

Introduction: Healthcare reform efforts focus on patient-centered care is measured by patient satisfaction. Emergency department (ED) satisfaction ratings are often the lowest. Since ED is the first point of contact for the patient care to receive primary care, we aimed to explore patient satisfaction related to ED healthcare services at our institution. Read More

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IP-10 (CXCL10) Can Trigger Emergence of Dormant Breast Cancer Cells in a Metastatic Liver Microenvironment.

Front Oncol 2021 27;11:676135. Epub 2021 May 27.

Department of Pathology, University of Pittsburgh, Pittsburgh, PA, United States.

Metastatic breast cancer remains a largely incurable and fatal disease with liver involvement bearing the worst prognosis. The danger is compounded by a subset of disseminated tumor cells that may lie dormant for years to decades before re-emerging as clinically detectable metastases. Pathophysiological signals can drive these tumor cells to emerge. Read More

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Metastasis Patterns and Prognosis of Elderly Patients With Esophageal Adenocarcinoma in Stage IVB: A Population-Based Study.

Front Oncol 2021 28;11:625720. Epub 2021 May 28.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: Esophageal adenocarcinoma (EAC) is the most common kind of esophageal cancer. Age at diagnosis of advanced EAC is greater. Studies about practice patterns for elderly EAC patients with distant metastasis (DM) in stage IVB are limited. Read More

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The Effect of a 3-Minute Mindfulness Intervention, and the Mediating Role of Maximization, on Critical Incident Decision-Making.

Front Psychol 2021 28;12:674694. Epub 2021 May 28.

Centre for Critical and Major Incident Psychology, University of Liverpool, Liverpool, United Kingdom.

Objective: In this study, we extend the impact of mindfulness to the concept of least-worst decision-making. Least-worst decisions involve high-uncertainty and require the individual to choose between a number of potentially negative courses of action. Research is increasingly exploring least-worst decisions, and real-world events (such as the COVID-19 pandemic) show the need for individuals to overcome uncertainty and commit to a least-worst course of action. Read More

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Cetuximab Can Be an Effective and Low-Toxicity Maintenance Treatment Drug in Patients With Metastatic Colorectal Cancer: A Real-World Study of Zhejiang Cancer Hospital.

Front Pharmacol 2021 28;12:632076. Epub 2021 May 28.

Department of Colorectal Medicine, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, China.

After initial treatment, maintenance therapy is now commonly used in mCRC patients, which can help patients live longer, have lower side effects, and higher quality of life. The maintenance treatment may include chemotherapy, targeted therapy, or combined with chemotherapy and targeted therapy. But the evidence of cetuximab maintenance is still scant. Read More

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Nonlinear models: a case of the COVID-19 confirmed rates in top 8 worst affected countries.

Nonlinear Dyn 2021 Jun 7:1-11. Epub 2021 Jun 7.

Department of Statistics, Faculty of Science and Letters, Eskisehir Osmangazi University, Meselik Yerleskesi, 26480 Eskisehir, Turkey.

Over the last 9 months, the most prominent global health threat has been COVID-19. It first appeared in Wuhan, China, and then rapidly spread throughout the world. Since no treatment or preventative strategy has been identified until this time, millions of people across the world have been seriously affected by COVID-19. Read More

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Trends in COVID-19 prevalence and mortality: A year in review.

Physica D 2021 Nov 7;425:132968. Epub 2021 Jun 7.

Yau Mathematical Sciences Centre, Tsinghua University, Beijing, China.

This paper introduces new methods to study the changing dynamics of COVID-19 cases and deaths among the 50 worst-affected countries throughout 2020. First, we analyse the trajectories and turning points of rolling mortality rates to understand at which times the disease was most lethal. We demonstrate five characteristic classes of mortality rate trajectories and determine structural similarity in mortality trends over time. Read More

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November 2021

Integrative analysis of TP73 profile prognostic significance in WHO grade II/III glioma.

Cancer Med 2021 Jun 13. Epub 2021 Jun 13.

Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Due to the extremely intrinsic heterogeneity among glioma patients, the outcomes of these patients are tremendously different. Therefore, the exploitation of novel biomarker classification of glioma is vitally important for deep insight into the essence and predicting the prognosis of glioma. We aim to analyze the correlation between TP73 mRNA expression, DNA methylated alteration and the prognosis of WHO grade II/III glioma, utilizing bioinformatics to evaluate its significance as a risk-factor in predicting the prognosis of these glioma patients. Read More

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A modified simplex based direct search optimization algorithm for adaptive transversal FIR filters.

Sci Prog 2021 Apr-Jun;104(2):368504211025409

Department of Electrical and Computer Engineering, COMSATS University Islamabad, Islamabad, Pakistan.

In this paper, a novel modified optimization algorithm is presented, which combines Nelder-Mead (NM) method with a gradient-based approach. The well-known Nelder Mead optimization technique is widely used but it suffers from convergence issues in higher dimensional complex problems. Unlike the NM, in this proposed technique we have focused on two issues of the NM approach, one is shape of the simplex which is reshaped at each iteration according to the objective function, so we used a fixed shape of the simplex and we regenerate the simplex at each iteration and the second issue is related to reflection and expansion steps of the NM technique in each iteration, NM used fixed value of , that is, = 1 for reflection and = 2 for expansion and replace the worst point of the simplex with that new point in each iteration. Read More

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Outcomes of extra-cranial stereotactic body radiotherapy for metastatic breast cancer: Treatment indication matters.

Radiother Oncol 2021 Jun 10. Epub 2021 Jun 10.

Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:

Background And Purpose: To summarize the clinical outcomes of stereotactic body radiotherapy (SBRT) for metastatic breast cancer (mBC) from a large institution.

Materials And Methods: Patients with mBC who received extra-cranial SBRT to metastatic lesions from 2011 to 2017 were identified. Treatment indications were: oligometastases, oligoprogression, and local control of dominant tumor (CDT). Read More

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Clinical outcomes and safety of the SpineJack vertebral augmentation system for the treatment of vertebral compression fractures in a United States patient population.

J Clin Neurosci 2021 Jul 13;89:237-242. Epub 2021 May 13.

Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, 1800 Orleans Street, Baltimore, MD 21287, United States; Department of Radiology, Thomas Jefferson University Hospital, 111 S 11(th) St, Philadelphia, PA 19107, United States.

The SpineJack implant system was recently FDA approved for treatment of vertebral compression fractures (VCF), however United States-based outcomes data is lacking. We sought to examine the safety and clinical outcomes following vertebral augmentation using the SpineJack implant for treatment of VCF in a U.S. Read More

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The Functional Assessment of Cancer Therapy Eight Dimension (FACT-8D), a Multi-Attribute Utility Instrument Derived From the Cancer-Specific FACT-General (FACT-G) Quality of Life Questionnaire: Development and Australian Value Set.

Value Health 2021 Jun 7;24(6):862-873. Epub 2021 May 7.

Northwestern University Feinberg School of Medicine, Department of Medical Social Sciences, Chicago, IL, USA.

Objectives: To develop a cancer-specific multi-attribute utility instrument derived from the Functional Assessment of Cancer Therapy - General (FACT-G) health-related quality of life (HRQL) questionnaire.

Methods: We derived a descriptive system based on a subset of the 27-item FACT-G. Item selection was informed by psychometric analyses of existing FACT-G data (n = 6912) and by patient input (n = 82). Read More

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Food-additive emulsifiers: the worst thing since sliced bread?

Lancet Gastroenterol Hepatol 2021 Jul;6(7):532

Alicia M Sandall is based at the Department of Nutritional Sciences, King's College London, UK; Department of Nutrition & Dietetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.

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A practical guide to estimating the light extinction coefficient with nonlinear models-a case study on maize.

Plant Methods 2021 Jun 12;17(1):60. Epub 2021 Jun 12.

Department of Agronomy, Kansas State University, 1712 Claflin Rd, Manhattan, KS, 66506, USA.

Background: The fraction of intercepted photosynthetically active radiation (fPARi) is typically described with a non-linear function of leaf area index (LAI) and k, the light extinction coefficient. The parameter k is used to make statistical inference, as an input into crop models, and for phenotyping. It may be estimated using a variety of statistical techniques that differ in assumptions, which ultimately influences the numerical value k and associated uncertainty estimates. Read More

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The incidence, treatment and survival of patients with rare types of rectal malignancies in the Netherlands: A population-based study between 1989 and 2018.

Eur J Cancer 2021 Jun 8;152:183-192. Epub 2021 Jun 8.

Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

Aim: To describe the incidence, treatment and survival of patients with rare types of rectal malignancies in the Netherlands.

Methods: Data of patients with rectal malignancies diagnosed in the Netherlands between 1989 and 2018 were retrieved from the Netherlands Cancer Registry and grouped according to the RARECARE cancer list. Age-standardised incidence rates were calculated using the European Standard Rate. Read More

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Study on bisphenol F, a bisphenol A analogue, at a dairy company: Health hazard and risk assessment.

Food Chem Toxicol 2021 Jun 10;154:112334. Epub 2021 Jun 10.

Department of Veterinary Medicine and Animal Production, University of Naples, Via F. Delpino, 1, 80137, Napoli, Italy. Electronic address:

The occurrence of analogues of bisphenol A (BPA), including bisphenol F(BPF) in milk is still not well known. BPF may enter the milk chain at the farm and during milk processing at the dairy company. This study identified the main BPF contamination pathways using a monitoring model based on the identification of the hazard at three stages along the dairy chain: raw milk from the storage tank, pasteurized milk from the storage tank, and cardboard packaged milk. Read More

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Impact of repeated irrigation of lettuce cultures with municipal wastewater on soil bacterial community diversity and composition.

Environ Sci Pollut Res Int 2021 Jun 12. Epub 2021 Jun 12.

AgroSup Dijon, INRAE, Univ. Bourgogne, Univ. Bourgogne Franche-Comté, UMR Agroécologie, INRAE, 17 rue Sully, BP86510, 21065, Dijon Cedex, France.

The effect of wastewater irrigation on the diversity and composition of bacterial communities of soil mesocosms planted with lettuces was studied over an experiment made of five cultivation campaigns. A limited effect of irrigation with either raw or treated wastewater was observed in both α-diversity and β-diversity of soil bacterial communities. However, the irrigation with wastewater fortified with a complex mixture of fourteen relevant chemicals at 10 μg/L each, including pharmaceutical, biocide, and pesticide active substances, led to a drift in the composition of soil bacterial community. Read More

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Secondary Hepatic Injury in Pediatric Intensive Care: Risk Factors and Prognostic Impact.

J Pediatr Gastroenterol Nutr 2021 Jun 7. Epub 2021 Jun 7.

Clínica Universitária de Pediatria, Faculdade de Medicina, Universidade de Coimbra, Coimbra, Portugal Serviço de Cuidados Intensivos Pediátricos, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Objectives: The aim of this study was to assess the profile of secondary hepatic injury (SHI), to determine risk factors and to evaluate its impact on prognosis of pediatric intensive care patients.

Methods: An exploratory observational and retrospective study was conducted in a Pediatric Intensive Care Unit. Two groups were defined: with SHI [alanine aminotransferase (ALT)≥100 IU/L or gamma glutamyl transpeptidase (GGT)≥100 IU/L or direct bilirubin ≥30 μmol/L] and without. Read More

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Statin therapy for patients with aortic stenosis who underwent transcatheter aortic valve implantation: a report from a Japanese multicentre registry.

BMJ Open 2021 06 11;11(6):e044319. Epub 2021 Jun 11.

Department of Cardiology, Keio University School of Medicine, Shinjuku-ku, Japan.

Objective: Data on statin for patients with aortic stenosis (AS) who underwent transcatheter aortic valve implantation (TAVI) are limited. The present study aimed to evaluate the impact of statin on midterm mortality of TAVI patients.

Design: Observational study. Read More

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Living in a rural area as a risk factor for worst outcomes in penile cancer.

Int Braz J Urol 2021 Jun 15;47. Epub 2021 Jun 15.

UROGIV Research Group, School of Medicine, Universidad del Valle, Cali, Colombia.

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The worst 2020 saline water intrusion disaster of the past century in the Mekong Delta: Impacts, causes, and management implications.

Ambio 2021 Jun 11. Epub 2021 Jun 11.

Water Resources Center, Disaster Prevention Research Institute, Kyoto University, Kyoto, Japan.

Vietnam Mekong Delta (VMD), the country's most important food basket, is constantly threatened by drought-infused salinity intrusion (SI). The SI disaster of 2020 is recognized as the worst in recent decades, hence inspiring this perspective article. The authors' viewpoints on the disaster's impacts and causes are presented. Read More

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