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Long-Term Quality of Life in Patients Following Minimally Invasive Conjunctivodacryocystorhinostomy With StopLoss Jones Tube.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

Department of Ophthalmology, Jozef Strus City Hospital, Poznan, Poland Department of Ophthalmology, Military Institute of Medicine, Warsaw, Poland Govindram Seksaria Institute of Dacryology, L.V. Prasad Eye Institute, Hyderabad, India.

Purpose: To assess the long-term quality of life outcomes of minimally invasive conjunctivodacryocystorhinostomy with StopLoss Jones tubes.

Methods: A retrospective interventional case series was performed on all patients diagnosed with proximal bicanalicular obstruction who underwent a minimally invasive conjunctivodacryocystorhinostomy with StopLoss Jones tubes over a period of 5 years from October 2014 to September 2019. The procedure was performed as per standard published protocols of minimally invasive conjunctivodacryocystorhinostomy and StopLoss Jones tubes. Read More

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A French survey on the lockdown consequences of COVID-19 pandemic in Parkinson's disease. The ERCOPARK study.

Parkinsonism Relat Disord 2021 Jul 13;89:128-133. Epub 2021 Jul 13.

Service de Neurologie, Centre Hospitalier Universitaire, Toulouse, France; France CHU de Toulouse, Université de Toulouse-Toulouse 3, INSERM, UMR1214 Toulouse NeuroImaging Centre "TONIC," Center of Excellence in Neurodegeneration (CoEN), NeuroToul, Centre Expert Parkinson de Toulouse, Centre d'Investigation Clinique CIC1436, NS-Park/FCRIN Network, Services de Neurologie et de Pharmacologie Clinique, UMR 1048 Institute for Cardiovascular Diseases, Toulouse, France.

Background: In 2020 the coronavirus disease 19 (COVID-19) pandemic imposed a total and sudden lockdown. We aimed to investigate the consequences of the first COVID-19 lockdown (mid-March - mid-April 2020) on motor and non-motor symptoms (NMS) in a cohort of French people with Parkinson's disease (PwP).

Methods: PwP were enrolled either by an on-line survey sent from the national France Parkinson association (FP) to reach the French community of PwP or as part of outpatients' telemedicine visits followed by an hospital-based Parkinson Expert Center (PEC). Read More

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Transcondylar Odontoid Resection and Stabilization for Craniovertebral Degenerative Compression: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Non-neoplastic craniovertebral junction lesions are well known with various etiologies.1,2 They are frequently associated with craniovertebral junction instability. Many require only stabilization for their management. Read More

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US Trends in Opioid Access Among Patients With Poor Prognosis Cancer Near the End-of-Life.

J Clin Oncol 2021 Jul 22:JCO2100476. Epub 2021 Jul 22.

Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.

Purpose: Heightened regulations have decreased opioid prescribing across the United States, yet little is known about trends in opioid access among patients dying of cancer.

Methods: Among 270,632 Medicare fee-for-service decedents with poor prognosis cancers, we used part D data to examine trends from 2007 to 2017 in opioid prescription fills and opioid potency (morphine milligram equivalents per day [MMED]) near the end-of-life (EOL), defined as the 30 days before death or hospice enrollment. We used administrative claims to evaluate trends in pain-related emergency department (ED) visits near EOL. Read More

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Longitudinal Assessment of Quality of Life Following Molecular Testing for Indeterminate Thyroid Nodules.

Ann Surg Oncol 2021 Jul 22. Epub 2021 Jul 22.

Section of Endocrine Surgery, Department of Surgery, University of California Los Angeles David Geffen School of Medicine, 10833 Le Conte Ave. 72-227 CHS, Los Angeles, CA, 90095, USA.

Background: Molecular testing can refine the risk of malignancy in cytologically indeterminate thyroid nodules and can reduce the need for diagnostic thyroidectomy. However, quality of life (QOL) in patients mananged with molecular testing is not well studied.

Objective: We aimed to assess the QOL of patients undergoing surveillance after a benign molecular test result, or thyroidectomy after a suspicious molecular test result. Read More

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Perinatal use of lurasidone for the treatment of bipolar disorder.

Exp Clin Psychopharmacol 2021 Jul 22. Epub 2021 Jul 22.

Department of Psychiatry, The Asher Center for the Study and Treatment of Depressive Disorders, Northwestern University Feinberg School of Medicine.

Atypical antipsychotics are commonly prescribed for the treatment of severe mental illnesses during pregnancy. Evidence regarding the impact of physiologic changes during pregnancy on the concentration of atypical antipsychotics is limited, specifically in the case of lurasidone. Data to guide dosing in pregnancy that maximizes efficacy and minimizes adverse effects are lacking. Read More

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Comparative Analysis of Health Domains for Neuropathic Pain Patients.

Clin Nurs Res 2021 Jul 22:10547738211030640. Epub 2021 Jul 22.

University of Pennsylvania School of Nursing, Philadelphia, USA.

Active duty military members have significant service-related risks for developing pain from injury. Although estimates for neuropathic pain (NP) are available for civilian populations, the incidence and prevalence for NP in military members is less clear. Understanding correlates of pain in military members is vital to improving their physical, mental, and social health. Read More

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The usefulness of copeptin for the diagnosis of nephrogenic diabetes insipidus in infancy: a case report.

J Pediatr Endocrinol Metab 2021 Jul 22. Epub 2021 Jul 22.

Interdisciplinary Laboratory of Medical Investigation, Unit of Pediatric Nephrology, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.

Objectives: We report a case of an infant with nephrogenic diabetes insipidus (NDI) diagnosed by the measurement of serum copeptin. There is only one study that previously evaluated the use of copeptin measurement in a pediatric patient.

Case Presentation: We present a 10-month-old child with polyuria-polydipsia syndrome (PPS) and hypernatremia that could not support water restriction due to increased risk of dehydration and worsening of his condition. Read More

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Favorable Pregnancy Outcomes in Women With Well-Controlled Pulmonary Arterial Hypertension.

Front Med (Lausanne) 2021 5;8:689764. Epub 2021 Jul 5.

Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland.

Since pregnancy in women with pulmonary arterial hypertension (PAH) is associated with a high risk of morbidity and mortality, it is recommended that pregnancy should be avoided in PAH. However, some women with mild PAH may consider this recommendation as unsuitable. Unfortunately knowledge on pregnancy outcomes and best management of PAH during pregnancy is limited. Read More

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Vortioxetine Improved Depressive State In Parkinson's Disease.

Cureus 2021 Jun 18;13(6):e15750. Epub 2021 Jun 18.

Psychiatry, University of Occupational and Environmental Health, Kitakyushu, JPN.

We report the case of a 67-year-old Japanese Parkinson's disease (PD) patient with depression who was successfully treated with vortioxetine. The patient's PD was being treated with levodopa (100 mg/day). As improvement was noted in PD symptoms, levodopa was continued. Read More

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Hypertrophic Gastric folds with Hypomagnesemia, linking the dots.

Pak J Med Sci 2021 Jul-Aug;37(4):1237-1240

Dr. Muhammad Toqeer, MBBS, FCPS (Pakistan), MRCP (UK). Consultant Gastroenterology. Conquest Hospital. East Sussex Healthcare, NHS Trust. TN37 7RD, UK.

A Caucasian man in early 80s was seen in Gastroenterology Clinic, following, referral from the Endocrinology Clinic for concerns for CT Abdomen requested for tiredness and weight loss of three kilograms. The patient also had microcytic picture with low MCV and Ferritin and hypomagnesemia. The CT suggested gross circumferential thickening of the wall of stomach with advice for invasive investigations to further characterise the CT findings. Read More

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December 2020

Hypocupraemia-induced anaemia, sensory ataxia and cognitive impairment secondary to zinc-containing dental adhesive.

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Neurology, University Hospital Southampton NHS Foundation Trust, Southampton, Hampshire, UK.

A 67-year-old man presented with 5 months of worsening memory impairment and sensory gait ataxia on the background of symptomatic anaemia. He experienced falls, agitation and became socially withdrawn over 3 weeks, resulting in hospital admission. On examination, he had sensory gait ataxia consistent with a dorsal column syndrome. Read More

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Feasibility of patient-performed lung ultrasound self-exams (Patient-PLUS) as a potential approach to telemedicine in heart failure.

ESC Heart Fail 2021 Jul 20. Epub 2021 Jul 20.

Emergency Medicine, Olive View-UCLA Medical Center, 14445 Olive View Drive North Annex, Sylmar, Los Angeles, California, 91342, USA.

Aims: Patient-performed lung ultrasound (LUS) in a heart failure (HF) telemedicine model may be used to monitor worsening pulmonary oedema and to titrate therapy, potentially reducing HF admission. The aim of the study was to assess the feasibility of training HF patients to perform a LUS self-exam in a telemedicine model.

Methods And Results: A pilot study was conducted at a public hospital involving subjects with a history of HF. Read More

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COVID-19-related laboratory coagulation findings.

Int J Lab Hematol 2021 Jul;43 Suppl 1:36-42

Coagulation Laboratory, Department of Laboratory Medicine, Department of Diagnostic Sciences, Ghent University Hospital, Ghent University, Ghent, Belgium.

The alterations in the hemostatic balance in COVID-19 patients are strongly disturbed and contribute to a high prothrombotic status. The high rate of venous thromboembolism in COVID-19 patients goes along with derangements in coagulation laboratory parameters. Hemostasis testing has an important role in diagnosed COVID-19 patients. Read More

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Long-term outcomes of open versus closed rectal defect after Transanal Endoscopic Microscopic Surgery.

Colorectal Dis 2021 Jul 21. Epub 2021 Jul 21.

Department of Surgery, Royal Liverpool University Hospital, Liverpool University Hospitals, NHS Foundation Trust.

Background: Management of rectal defect after TEM is a matter of debate. Data are lacking on long term outcomes and continence of patients with open or closed rectal defect. We sought to analyse these in a retrospective cohort study. Read More

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Safety of the BNT162b2 COVID-19 vaccine in Multiple Sclerosis: Early experience from a tertiary MS Center in Israel.

Eur J Neurol 2021 Jul 21. Epub 2021 Jul 21.

Department of Neurology, Rabin Medical Center, Petah Tikva, Israel.

Background: Although the COVID-19 vaccines are currently recommended for people with multiple sclerosis (MS), the fact that they were not specifically tested in people with MS raises uncertainty regarding the safety of the vaccines in this population. The purpose of this study is to report real-life safety data of the BNT162b2 COVID-19 vaccine in a cohort of MS patients.

Methods: An anonymous survey was distributed to 425 MS patients. Read More

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Exercise and Worsening of Extrapyramidal Symptoms during Treatment with Long-Acting Injectable Antipsychotics.

Pharmacy (Basel) 2021 Jul 3;9(3). Epub 2021 Jul 3.

British Columbia Mental Health & Substance Use Services Research Institute, Vancouver, BC V5Z 3L7, Canada.

Second-generation antipsychotic medications are used to treat schizophrenia and a range of other psychotic disorders, although adverse effects, including cardiovascular and metabolic abnormalities and extrapyramidal symptoms, are often inevitable. Studies have shown that exercise, as an adjunct therapy, can be effective in reducing the core symptoms of schizophrenia as well as ameliorating intrinsic and antipsychotic-induced cardiometabolic abnormalities. However, it is noteworthy that exercise may need to be implemented with caution in some individuals receiving certain antipsychotic treatment regimens. Read More

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Novel technique of percutaneous bypass in a brachiocephalic arteriovenous fistula with cephalic arch occlusion: A case report.

J Vasc Access 2021 Jul 17;22(4):650-653. Epub 2020 Aug 17.

Vascular Service, Department of Surgery, Changi General Hospital, Singapore.

Objective: Arteriovenous fistulas are a principal mainstay of long-term dialysis access for patients with end stage renal failure. However, the patency of arteriovenous fistulas is limited, often requiring percutaneous transluminal angioplasty as a salvage procedure. We report a case of percutaneous method of arteriovenous fistula salvage. Read More

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Clinical characteristic, red blood cell indices, iron profile and prognosis of heart failure in females.

Glob Cardiol Sci Pract 2021 Jun 30;2021(2):e202113. Epub 2021 Jun 30.

Professor & Dean Academics, All India Institute of Medical Sciences, Jodhpur, Raj, India.

Heart failure is a leading killer worldwide, with concurrent anaemia and iron deficiency portending sepulchral prognosis. Anaemia is rampant, with 53% prevalence in Indian females, but iron deficiency can be present even without anaemia. Therefore, this study was planned to determine the clinical profile, red blood cell indices, and effects of iron deficiency, on the course and prognosis of heart failure in Indian females. Read More

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Abdominal Pain Caused by Occlusion of the Celiac Trunk and Superior Mesenteric Artery in Addition to Irritable Bowel Syndrome: Case Series and Literature Review.

Cureus 2021 Jun 17;13(6):e15729. Epub 2021 Jun 17.

Medicine, Qatar University, Doha, QAT.

Irritable bowel syndrome (IBS) is a benign condition of the gastrointestinal tract causing abdominal pain, bloating, diarrhea, and/or constipation. Symptoms of IBS usually improve on passing flatus and defecation. There is no known identifiable underlying pathology; however, several risk factors are known to contribute to the development of IBS, which include a stressful lifestyle and certain foods such as bread, coffee, alcohol, pasta, and chocolates. Read More

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Clinical Efficacy of Corticosteroids in the Early Stages of Deterioration in COVID-19 Pneumonia.

Infect Drug Resist 2021 12;14:2667-2674. Epub 2021 Jul 12.

Department of Respiratory Medicine, The Petroleum Clinical Medical College of Hebei Medical University, Langfang, Hebei, 065000, People's Republic of China.

Background: The World Health Organization (WHO) strongly suggests using corticosteroids in patients with severe coronavirus disease 2019 (COVID-19). Similarly, a large randomized controlled clinical trial (RCT) in the UK found that dexamethasone effectively reduced the mortality rate in severe COVID-19 patients. However, the safety profile of corticosteroids has been a controversial area of study. Read More

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Acta Clin Croat 2020 Dec;59(4):771-776

1Department of Psychiatry, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Department of Oncology and Nuclear Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 3Catholic University of Croatia, Zagreb, Croatia; 4School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Lewy body dementia is a progressive neurodegenerative disease and is considered to be the second most common cause of dementia in the elderly. Because of the complexity of clinical presentation, it is often misdiagnosed and mistaken for other dementias, which may result in administering inappropriate therapy, and thus worsening of the patient condition. We reviewed a case of a 71-year-old patient whose clinical presentation gradually occurred with complex visual hallucinations, atypical extrapyramidal motor symptoms, fluctuating cognitive impairments with delirious episodes, and oscillating syncope. Read More

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December 2020

Pediatric PTSD is characterized by age- and sex-related abnormalities in structural connectivity.

Neuropsychopharmacology 2021 Jul 20. Epub 2021 Jul 20.

Department of Psychiatry, University of Wisconsin School of Medicine & Public Health, Madison, USA.

Pediatric post-traumatic stress disorder (pPTSD) is a prevalent and pervasive form of mental illness comprising a disparate constellation of psychiatric symptoms. Emerging evidence suggests that pPTSD may be characterized by alterations in functional networks traversing the brain. Yet, little is known about pathological changes in the structural tracts underlying functional connectivity. Read More

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The severity progression of non-motor symptoms in Parkinson's disease: a 6-year longitudinal study in Taiwanese patients.

Sci Rep 2021 Jul 20;11(1):14781. Epub 2021 Jul 20.

Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, No. 5, Fuxing St., Guishan Dist., Taoyuan City, 333, Taiwan.

Nonmotor symptoms (NMSs) cause major burden in patients with Parkinson's disease (PD). Previous NMSs progression studies mostly focused on the prevalence. We conducted a longitudinal study to identify the progression pattern by the severity. Read More

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Retracing the tracks for SIAD: hyponatraemia due to post-traumatic brain injury hypopituitarism.

BMJ Case Rep 2021 Jul 20;14(7). Epub 2021 Jul 20.

Endocrinology & Diabetes, St Vincent's University Hospital, Dublin, Ireland.

Hyponatraemia is common in hospital practice, with the syndrome of inappropriate antidiuresis (SIAD) being the most common underlying aetiology. A relatively less frequent but important cause is adrenal insufficiency (AI). We describe the case of a 63-year-old man who presented with symptomatic hyponatraemia and hypoglycaemia associated with abnormal body movements (ballism). Read More

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COVID-19 social distancing: negative effects on people with Parkinson disease and their associations with confidence for self-management.

BMC Neurol 2021 Jul 20;21(1):284. Epub 2021 Jul 20.

Department of Physical Therapy, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel.

Background: The purpose of this study was to describe the effects of COVID-19 social distancing on the function, health, and well-being of people with Parkinson disease (PD), and test the association of these effects with patients' activation levels, i.e., their skills and confidence in managing their health. Read More

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Correlation of PET/CT and Brain MRI Findings in Human African Trypanosomiasis Encephalitis.

Clin Nucl Med 2021 Jul 20. Epub 2021 Jul 20.

From the Russell H. Morgan Department of Radiology and Radiological Science Pathology Department, Johns Hopkins University School of Medicine Division of Nuclear Medicine and Molecular Imaging, Johns Hopkins Medical Institutions, Baltimore, MD.

Abstract: A 49-year-old woman from Cameroon presented with history of several months of worsening headache, lethargy, left arm weakness, and generalized lymphadenopathy. Brain MRI demonstrated multifocal signal abnormality and enhancement involving the bilateral basal ganglia and cerebral white matter. FDG PET/CT performed as part of lymphadenopathy evaluation demonstrated patchy areas of increased metabolic activity of the brain parenchyma. Read More

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Clinical Features, Natural History and Outcomes of Intraneural Perineuriomas: A Systematic Review of the Literature.

World Neurosurg 2021 Jul 17. Epub 2021 Jul 17.

Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, MN. Electronic address:

Introduction: Intraneural perineurioma is a rare peripheral nerve sheath tumor characterized by localized proliferation of perineurial cells. Current literature consists predominantly of case reports and institutional series, with inconsistent and confusing nomenclature. Herein, we present a pooled analysis of all of the current reported cases of intraneural perineurioma in the literature. Read More

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Recovery of deepening of the upper eyelid sulcus after switching from prostaglandin FP receptor agonists to EP2 receptor agonist: a 3-month prospective analysis.

Jpn J Ophthalmol 2021 Jul 20. Epub 2021 Jul 20.

Department of Ophthalmology, Graduate of Medicine and Faculty of Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: To examine the effect of switching from a prostanoid FP receptor agonists to EP2 receptor agonist (omidenepag isopropyl) on the deepening of the upper eyelid sulcus (DUES) and intraocular pressure (IOP) in Japanese glaucoma patients over 3 months post treatment.

Study Design: Prospective observational study.

Methods: Patients with glaucoma who received FP receptor agonists treatment and had complained of DUES-related reduction in quality of life were included. Read More

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Changes in Health-Related Quality of Life After Transient Ischemic Attack.

JAMA Netw Open 2021 Jul 1;4(7):e2117403. Epub 2021 Jul 1.

Neurological Institute, Cleveland Clinic, Cleveland, Ohio.

Importance: Numerous studies have found that patients diagnosed with TIA have decreased health-related quality of life, which has been interpreted as suggesting that patients with TIA have residual symptoms after the event. Studies assessing health status in the same patients before and after an event are lacking but may allow a direct determination of the association of TIA with postevent health status.

Objective: To examine patient-reported health before transient ischemic attack (TIA) among individuals diagnosed with this event and evaluate change in patient-reported health after the event overall and by TIA characterization subgroups. Read More

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