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promoter DNA-methylation level and glucose metabolism in Ecuadorian women with Turner syndrome.

Horm Mol Biol Clin Investig 2020 Dec 22;42(2):159-165. Epub 2020 Dec 22.

Institute of Biomedicine Research, Central University of Ecuador, Quito, Ecuador.

Objectives: Reduced gene expression of in subjects with insulin resistance (IR) has been reported. Insulin resistance occurs early on the course of Turner syndrome (TS). The main objective of this study was to evaluate the relationship between promoter DNA methylation status in lymphocytes and insulin sensitivity and secretion in Ecuadorian females with TS. Read More

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December 2020

Advancing health through research: A scoping review of and model for adjunctive psychosocial interventions to improve outcomes for perinatal women with bipolar disorder.

J Affect Disord 2021 Jul 18;294:586-591. Epub 2021 Jul 18.

Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, United States. Electronic address:

Background: We aimed to identify randomized clinical trials (RCTs) which evaluated the efficacy of adjunctive psychosocial interventions to improve outcomes during the perinatal period for women with bipolar disorder (BD).

Methods: We scanned the literature to identify RCTs evaluating the efficacy of adjunctive psychosocial therapies or interventions provided during the perinatal period to women with BD. We searched from 1946 to July 2020 using Embase, Ovid Medline, PsycINFO, and Scopus. Read More

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DeepCervix: A deep learning-based framework for the classification of cervical cells using hybrid deep feature fusion techniques.

Comput Biol Med 2021 Jul 20;136:104649. Epub 2021 Jul 20.

Cancer Hospital of China Medical University, Liaoning Hospital and Institute, Shenyang, 110042, China.

Cervical cancer, one of the most common fatal cancers among women, can be prevented by regular screening to detect any precancerous lesions at early stages and treat them. Pap smear test is a widely performed screening technique for early detection of cervical cancer, whereas this manual screening method suffers from high false-positive results because of human errors. To improve the manual screening practice, machine learning (ML) and deep learning (DL) based computer-aided diagnostic (CAD) systems have been investigated widely to classify cervical Pap cells. Read More

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Validating a scale to measure respectful maternity care in Australia: Challenges and recommendations.

Midwifery 2021 Jul 14;103:103090. Epub 2021 Jul 14.

University of the Sunshine Coast, Sippy Downs, Queensland, Australia; The University of Queensland, Australia; Sunshine Coast Health Institute, Australia.

Objective: Respectful maternity care is a pervasive human rights issue, but little is known about its realisation in Australia. Two scales, developed in North America, measure key aspects of respectful maternity care: the Mothers on Respect Index and Mothers Autonomy in Decision Making scale. This study aimed to validate these two scales in Queensland, Australia, and to determine the extent to which women currently experience respectful maternity care and autonomy in decision making. Read More

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Predicting probable eating disorder case-status in men using the Clinical Impairment Assessment: Evidence for a gender-specific threshold.

Eat Behav 2021 Jul 20;42:101541. Epub 2021 Jul 20.

Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.

The Clinical Impairment Assessment (CIA) is a widely used self-report measure of the psychosocial impairment associated with eating-disorder symptoms. Past studies recommended a global CIA score of 16 to identify clinically significant impairment associated with a probable eating disorder (ED). However, to date, research on the properties of the CIA has been conducted in majority-women samples. Read More

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A multi-pollutant assessment of preconception persistent endocrine disrupting chemicals and incident pregnancy loss.

Environ Int 2021 Jul 28;157:106788. Epub 2021 Jul 28.

Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Background: A few endocrine disrupting chemicals (EDCs) have been associated with pregnancy loss often as reported by women, though there has been no study of EDC mixtures and pregnancy loss in keeping with the nature of human exposure.

Objectives: To investigate preconception exposure to a mixture of EDCs to identify important drivers and inform multi-pollutant models of EDCs in relation to incident human gonadrophin chorionic (hCG) pregnancy loss.

Methods: A cohort of 501 couples were recruited from the general population and prospectively followed until a hCG-confirmed pregnancy or 12 months of trying to become pregnant. Read More

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Do socio-structural factors moderate the effects of health cognitions on COVID-19 protection behaviours?

Soc Sci Med 2021 Jul 23;285:114261. Epub 2021 Jul 23.

University of Sheffield, UK.

Objective: Adherence to protection behaviours remains key to curbing the spread of the SARS-CoV-2 virus that causes COVID-19, but there are substantial differences in individual adherence to recommendations according to socio-structural factors. To better understand such differences, the current research examines whether relationships between health cognitions based on the Reasoned Action Approach (RAA) and eight COVID-19 protection behaviours vary as a function of participant-level socio-structural factors.

Methods: Within-person design with behaviours nested within participants in a two-wave online survey (one week delay) conducted during the UK national lockdown in April 2020. Read More

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Transitioning to an obese India: Demographic and structural determinants of the rapid rise in overweight incidence.

Econ Hum Biol 2021 Jul 7;43:101041. Epub 2021 Jul 7.

Tata-Cornell Institute for Agriculture and Nutrition, Charles H. Dyson School of Applied Economics and Management, Cornell University, 375 Warren Hall, Ithaca, NY, 14853, United States. Electronic address:

India, which has long suffered from undernutrition, has seen a rapid rise in overweight incidence in the last decade and a half. These changes are characterized by significant within-country differences in overweight incidence that vary by gender and regional development levels. In this paper, we provide an integrative framework, linking the income-gradient hypothesis of obesity with biological, obesogenic, and environmental factors to provide an explanation on the emergence of within-country differences in overweight patterns. Read More

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Risk prediction of major haemorrhage with surgical treatment of live cesarean scar pregnancies.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 22;264:224-231. Epub 2021 Jul 22.

Institute for Women's Health, Faculty of Population Health Sciences, University College London, London, United Kingdom. Electronic address:

Objective: To evaluate the association between demographic and ultrasound variables and major intra-operative blood loss during surgical transcervical evacuation of live caesarean scar pregnancies.

Study Design: This was a retrospective cohort study conducted in a tertiary referral center between 2008 and 2019. We included all women diagnosed with a live caesarean scar ectopic pregnancy who chose to have surgical management in the study center. Read More

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Cytogenetic findings of ectopic endometriotic tissue in women with endometriosis and review of the literature.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 22;264:212-218. Epub 2021 Jul 22.

Laboratory of Health Physics, Radiobiology & Cytogenetics, National Center for Scientific Research (NCSR) "Demokritos", Athens, Greece.

Objective: To determine chromosome and gene alterations in ectopic endometrial (EM) tissue which may be implicated in the clinical course or the progression of endometriosis and to review the literature concerning the cytogenetic findings of women with endometriosis.

Study Design: 15 women who underwent laparoscopic endometriosis surgery at the Athens Genesis Clinic were enrolled in the study. Ectopic endometrial tissue was surgically removed and further analyzed by conventional and molecular cytogenetic techniques. Read More

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Induction of labour as compared with spontaneous labour in low-risk women: A multicenter study in Catalonia.

Sex Reprod Healthc 2021 Jul 26;29:100648. Epub 2021 Jul 26.

School of Health Sciences Blanquerna, Universitat Ramon Llull, Carrer Padilla 326, 08025 Barcelona, Spain; Catalan Health Service, Government of Catalonia, Travessera de les Corts 131, 08028 Barcelona, Spain. Electronic address:

Objective: To compare birth and neonatal outcomes in low-risk women undergoing induced labour with those undergoing spontaneous onset.

Methods: This retrospective multicentre study included 30 public maternity hospitals in Catalonia between 2016 and 2017. The study population consisted of 5,717 women. Read More

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Combination therapy of curcumin and fecal microbiota transplant: Potential treatment of polycystic ovarian syndrome.

Med Hypotheses 2021 Jul 15;154:110644. Epub 2021 Jul 15.

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India.

Polycystic ovarian syndrome (PCOS) is a combination of various symptoms like anovulation, hirsutism, chronic amenorrhea, infertility, obesity and polycystic ovaries. It affects over 7 million women worldwide. The current strategy to treat this disorder is based on the use of drugs that provide symptomatic relief. Read More

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Differential relationships between parent-child DXA and pQCT bone measures: Results from the Southampton Women's Survey.

Bone 2021 Jul 28:116134. Epub 2021 Jul 28.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. Electronic address:

Aim: To investigate the associations between indices of bone health in childhood and corresponding parental measures.

Methods: The Southampton Women's Survey characterised 12,583 non-pregnant women aged 20-34 years; 3158 subsequently had singleton live births. In a subset, dual-energy X-ray absorptiometry (DXA) measurements of bone area(BA), bone mineral content(BMC) and areal bone mineral density (aBMD) lumbar spine and total hip were obtained in the parent/offspring (aged 8-9 years) trios. Read More

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Long-term outcome after midline lumbar fusion for the treatment of lumbar spine instability due to degenerative disease.

World Neurosurg 2021 Jul 28. Epub 2021 Jul 28.

Department of Neurosurgery, Tomas Bata Regional Hospital, Zlin, Czech Republic (Havlickovo nabrezi 600, 762 75 Zlin). Electronic address:

Background: New surgical techniques have been developed to minimize perioperative damage to paravertebral stabilizing musculotendinous system. Among them, midline lumbar fusion (MIDLF) shows to be a viable option. With data on MIDLF remaining scarce, we assessed its long-term clinical and radiological effects. Read More

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Immune Checkpoint Inhibitor Induced Colitis: A Nationwide Population-Based Study.

Clin Res Hepatol Gastroenterol 2021 Jul 28:101778. Epub 2021 Jul 28.

Department of Gastroenterology, Hepatology & Nutrition, Cleveland Clinic Foundation, Cleveland, OH.

Background: ICIs are used in the management of several malignancies. However, they can result in immune-related adverse events, such as colitis. The aim of this study is to obtain an epidemiological survey of patients who develop immune checkpoint inhibitor (ICI)-induced colitis and identify underlying risk factors. Read More

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Influence of HIV infection on the distribution of high-risk HPV types among women with cervical precancerous lesions in Yaounde, Cameroon.

Int J Infect Dis 2021 Jul 28. Epub 2021 Jul 28.

Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.

Objectives: To characterise the high-risk HPV types associated with cervical precancerous lesions in women living in Yaounde Cameroon, and to determine their distribution with HIV status.

Methods: Women with abnormal pap smears recorded from February 2015 to May 2019 at Saint Martin de Porres' Health Centre, Yaounde, Cameroon were recruited in the study after obtaining informed consent. Pap smears were collected and re-examined. Read More

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Clinical Value of Weight-Bearing CT and Radiographs for Detecting Patellofemoral Cartilage Visualized by MRI in the MOST Study.

Osteoarthritis Cartilage 2021 Jul 28. Epub 2021 Jul 28.

Department of Epidemiology and Biostatistics, University of California-San Francisco, San Francisco, CA, USA. Electronic address:

Objective: The patellofemoral joint is frequently affected by osteoarthritis (PFOA) and is incompletely imaged on radiographs (XR). Weight-Bearing CT (WBCT) could offer advantages for visualization. This study determined the sensitivity, specificity, and accuracy of axial WBCT and lateral XR for detection of PFOA features in comparison with cartilage damage on MRI. Read More

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The association between adult ADHD and food addiction: A mediation analysis.

Appetite 2021 Jul 28:105613. Epub 2021 Jul 28.

Department of Human Sciences, Università Europea di Roma, 00163, Rome, Italy.

Objectives: The aim of this study was to investigate the association between food addiction severity (FA) and ADHD symptomatology. Furthermore, we investigated whether emotional distress, and the mentalization deficits could mediate this relationship.

Methods: Three hundred eighty-five Italian adults (307 women and 78 men) participated in the study and completed the Italian versions of the Modified Yale Food Addiction Scale version 2. Read More

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Association between preconceptional air pollution exposure and medical purposes for selective termination of pregnancy.

Environ Res 2021 Jul 28:111743. Epub 2021 Jul 28.

Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China; Department of Teaching Center for Preventive Medicine, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. Electronic address:

Background: Exposure to air pollutants is associated with adverse pregnancy outcomes. But evidence on the effects of preconceptional air pollution exposure on the risk of termination of pregnancy (TOP) caused by pregnancy losses and congenital malformations is lacking.

Methods: The distributed lag nonlinear model (DLNM) was used to evaluate the impact of short-term air pollutants exposure on the risk of TOP. Read More

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Extreme temperature exposure and acute myocardial infarction: Elevated risk within hours?

Environ Res 2021 Jul 28;202:111691. Epub 2021 Jul 28.

Department of Clinical Epidemiology and Biostatistics, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China; School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia; School of Public Health, Institute of Environment and Population Health, Anhui Medical University, Hefei, China. Electronic address:

Day-to-day change in ambient temperature is associated with acute myocardial infarction (AMI) attacks, but evidence is scarce about the effects of extreme temperatures on the risk of AMI within hours of exposure. This study investigated the hour-level associations between extreme temperatures and AMI occurrence. State-wide data on AMI patients and temperature during winter and summer of 2013-2015 were obtained for Queensland state of Australia. Read More

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Association between pregnancy and long-term cardiac outcomes in women with congenital heart disease.

Am J Obstet Gynecol 2021 Jul 28. Epub 2021 Jul 28.

University of Utah Health, Salt Lake City, UT; Intermountain Healthcare, Salt Lake City, UT.

Background: As early life interventions for congenital heart disease (CHD) improve, more patients are living to adulthood and considering pregnancy. Scoring and classification systems predict maternal cardiovascular risk of pregnancy in the context of congenital heart disease but these scoring systems do not assess the potential subsequent risks following pregnancy. Data on long-term cardiac outcomes after pregnancy are unknown for most lesion types. Read More

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The presence of Toxoplasma gondii in the terrestrial and marine environments and its importance for public health.

Ann Parasitol 2021 ;67(2):137-149

Institute of Health Sciences, Pomeranian University in Słupsk, ul. Bohaterów Westerplatte 64, Słupsk 76-200, Poland.

Toxoplasma gondii occurred in terrestrial and marine environments. Many people still do not realize that how important are the role of prevention, especially hygiene and proper food processing as well as diagnostics for pregnant women. Humans become infected with T. Read More

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January 2021

Urine organic acids may be useful biomarkers for metabolic syndrome and its components in Korean adults.

Clin Chem Lab Med 2021 Jul 30. Epub 2021 Jul 30.

Department of Family medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Objectives: Although metabolic syndrome (MetS) and its components are defined clinically, those with MetS may have various derangements in metabolic pathways. Thus, this study aimed to evaluate the traits of urine organic acid metabolites indicating the metabolic intermediates of the pathways in the subjects with MetS.

Methods: This cross-sectional study included 246 men and 283 women in a hospital health check-up setting. Read More

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Final 3-year clinical outcomes following transcatheter aortic valve implantation with a supra-annular self-expanding repositionable valve in a real-world setting: Results from the multicenter FORWARD study.

Catheter Cardiovasc Interv 2021 Jul 31. Epub 2021 Jul 31.

Department of Medicine, University of Bonn, Bonn, Germany.

Objectives: The Evolut R FORWARD study confirmed safety and effectivenesss of the Evolut R THV in routine clinical practice out to 1 year. Herein, we report the final 3-year clinical follow up of the FORWARD study.

Background: Transcatheter aortic valve replacement (TAVR) is a proven alternative to surgery in elderly patients with symptomatic severe aortic stenosis. Read More

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Bilateral lung transplantation during pregnancy after ECMO for influenza-A caused ARDS.

Am J Transplant 2021 Jul 31. Epub 2021 Jul 31.

Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-Maternal Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.

Pregnant women with influenza-A have an increased risk of developing acute respiratory distress syndrome (ARDS). Extracorporeal membrane oxygenation (ECMO) can be used as salvage therapy, with lung transplantation as a therapeutic option. However, successful bilateral lung transplantation during pregnancy has never been reported before. Read More

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Pancreatic damage in COVID-19: Why? How?

Int J Clin Pract 2021 Jul 31:e14692. Epub 2021 Jul 31.

University of Health Sciences, Diyabakır Gazi Yasargil Education and Research Hospital, Division of Gastroenterology, Diyarbakır, Turkey.

Object: We aimed to evaluate the elevation of amylase and lipase enzymes in coronavirus disease 2019 (COVID-19) patients and their relationship with the severity of COVID-19.

Method: In this study, 1378 patients with COVID-19 infection were included. Relation of elevated amylase and lipase levels and comorbidities with the severity of COVID-19 was analyzed. Read More

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Are we managing our patients correctly following treatment for cervical glandular intra-epithelial neoplasia (CGIN): a review of practice at the Jessop Wing Colposcopy Unit.

Cytopathology 2021 Jul 31. Epub 2021 Jul 31.

Consultant Gynaecological Oncologist, Sheffield Teaching Hospitals NHS Foundation Trust.

Objective: Women diagnosed with CGIN remain at risk of further pre-malignant and malignant disease hence post-treatment follow-up must be rigorous. We assess the effectiveness and safety of community cervical sampling follow-up in women treated for CGIN.

Methods: Retrospective cohort study of women diagnosed with CGIN between 1 April 2013 - 31 March 2019, Jessop Wing Colposcopy Unit, Sheffield, UK. Read More

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Sapropterin For Phenylketonuria: A Japanese Post-Marketing Surveillance Study.

Pediatr Int 2021 Jul 31. Epub 2021 Jul 31.

Daiichi Sankyo Company Limited, 3-5-1, Nihonbashi Honcho, Chuo-ku, Tokyo, 103-8426, Japan.

Background: To assess the long-term safety and efficacy of sapropterin in a real-world setting in Japanese patients with tetrahydrobiopterin (BH4)-responsive phenylketonuria (PKU).

Methods: This post-marketing surveillance study enrolled all patients in Japan with confirmed BH4-responsive PKU who were administrated sapropterin between July 2008 and October 2017. Patients were observed at least every 3 months during follow-up, with key data collected on treatment exposure/duration, effectiveness according to physician judgement, serum phenylalanine levels, and adverse events. Read More

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High prevalence of syphilis in women, minors, and precarious patients: a cross-sectional study in a Reunion Island sexually transmitted infection clinic, 2017-2020.

J Eur Acad Dermatol Venereol 2021 Jul 31. Epub 2021 Jul 31.

CHU Réunion, Service des Maladies Infectieuses - Dermatologie, Saint Pierre, La Réunion, France.

Background: Syphilis is a sexually transmitted infection (STI) with a global prevalence estimated at 0.5% in 2012. Syphilis has been on the rise among men who have sex with men (MSM) in high-income countries and remains at endemic levels in low- and middle-income countries. Read More

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Bariatric surgery prior to transplantation and risk of early hospital re-admission, graft failure, or death following kidney transplantation.

Am J Transplant 2021 Jul 31. Epub 2021 Jul 31.

Hennepin County Medical Center, Division of Nephrology, Department of Medicine, USA.

Bariatric surgery has been shown to be safe in the dialysis population. Whether bariatric surgery before kidney transplantation influences post-transplant outcomes has not been examined nationally. We included severely obese (BMI>35) dialysis patients between 18-70 years who received a kidney transplant according to the US Renal Data System. Read More

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